EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000157036 (Gene tree)
Gene ID: 9941
Gene Symbol: EXOG
Alias: ENGL-a|ENGL|ENGL-b|ENDOGL1|ENDOGL2
Full Name: exo/endonuclease G
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 46,035 bases
Position: chr3:38,496,127-38,542,161
Accession: 3347
RBP type: canonical RBP
Summary: This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000287675	Endonuclease_NS	PF01223.23	2.6e-59	1	1
ENSP00000404305	Endonuclease_NS	PF01223.23	4.2e-50	1	1
ENSP00000397124	Endonuclease_NS	PF01223.23	7.8e-42	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000431472	EXOG-204	1255	-	ENSP00000394977	107 (aa)	-	F8WE28
ENST00000443942	EXOG-207	576	-	ENSP00000412841	56 (aa)	-	F2Z2D3
ENST00000422077	EXOG-203	1317	XM_017007584	ENSP00000404305	318 (aa)	XP_016863073	Q9Y2C4
ENST00000412107	EXOG-202	1467	-	ENSP00000400239	56 (aa)	-	F2Z2D3
ENST00000489813	EXOG-216	580	-	-	- (aa)	-	-
ENST00000454803	EXOG-211	1548	-	ENSP00000412756	146 (aa)	-	F8WC11
ENST00000447573	EXOG-208	1750	-	ENSP00000406101	56 (aa)	-	F2Z2D3
ENST00000470291	EXOG-213	455	-	ENSP00000421649	15 (aa)	-	H0Y8P1
ENST00000630638	EXOG-217	197	-	ENSP00000487559	56 (aa)	-	F2Z2D3
ENST00000474071	EXOG-214	1799	-	-	- (aa)	-	-
ENST00000457367	EXOG-212	2075	-	ENSP00000402164	143 (aa)	-	F8WE38
ENST00000436414	EXOG-205	1679	-	ENSP00000413176	81 (aa)	-	F8WEP0
ENST00000483749	EXOG-215	871	-	-	- (aa)	-	-
ENST00000438992	EXOG-206	1440	-	ENSP00000407641	56 (aa)	-	F2Z2D3
ENST00000450732	EXOG-209	710	-	ENSP00000415568	107 (aa)	-	H7C451
ENST00000287675	EXOG-201	2792	XM_006713442	ENSP00000287675	368 (aa)	XP_006713505	Q9Y2C4
ENST00000453767	EXOG-210	576	XM_005265635	ENSP00000397124	187 (aa)	XP_005265692	H7C0W6

Gene Model

Click here to download ENSG00000157036's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000157036	Body Fat Distribution	7.7260000E-005	-
ENSG00000157036	Body Fat Distribution	3.3350000E-005	-
ENSG00000157036	Electrocardiography	1E-12	27659466
ENSG00000157036	Electrocardiography	3E-23	27577874

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000157036	rs10865879	3	38535871	?	QRS duration	27659466			EFO_0005054\|EFO_0005055
ENSG00000157036	rs2051211	3	38518258	?	QRS duration	27659466			EFO_0005054\|EFO_0005055
ENSG00000157036	rs10865879	3	38535871	?	QRS complex (Cornell)	27659466			EFO_0007742\|EFO_0005054
ENSG00000157036	rs10865879	3	38535871	?	QRS complex (12-leadsum)	27659466			EFO_0007742\|EFO_0005054
ENSG00000157036	rs2051211	3	38518258	G	QRS duration	27577874	[0.28-0.6] millisecond decrease	0.44	EFO_0005055
ENSG00000157036	rs6762565	3	38540700	T	QT interval	29213071	[1.08-2.22] ms decrease	1.65	EFO_0004682
ENSG00000157036	rs7630012	3	38510759	A	Alcohol consumption (drinks per week)	30643258	[0.0086-0.0175] unit increase	0.013055859	EFO_0007878
ENSG00000157036	rs2300669	3	38499827	A	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0048-0.0101] unit decrease	0.00741178	EFO_0007878

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000157036's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000157036	EXOG	82	42.581	ENSG00000167136	ENDOG	81	38.115

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000157036	EXOG	100	88.587	ENSAMEG00000017693	EXOG	100	88.587	Ailuropoda_melanoleuca
ENSG00000157036	EXOG	87	77.914	ENSAPLG00000012196	EXOG	95	67.521	Anas_platyrhynchos
ENSG00000157036	EXOG	83	79.355	ENSACAG00000009138	EXOG	86	66.258	Anolis_carolinensis
ENSG00000157036	EXOG	100	94.837	ENSANAG00000025128	EXOG	100	94.837	Aotus_nancymaae
ENSG00000157036	EXOG	86	69.375	ENSAMXG00000033038	EXOG	85	63.158	Astyanax_mexicanus
ENSG00000157036	EXOG	100	85.326	ENSBTAG00000019305	EXOG	100	85.326	Bos_taurus
ENSG00000157036	EXOG	100	94.293	ENSCJAG00000010063	EXOG	100	94.293	Callithrix_jacchus
ENSG00000157036	EXOG	100	85.870	ENSCAFG00000005039	EXOG	100	85.870	Canis_familiaris
ENSG00000157036	EXOG	100	85.870	ENSCAFG00020025813	-	100	85.870	Canis_lupus_dingo
ENSG00000157036	EXOG	100	86.413	ENSCHIG00000013450	EXOG	100	86.413	Capra_hircus
ENSG00000157036	EXOG	100	89.623	ENSTSYG00000013524	EXOG	100	89.623	Carlito_syrichta
ENSG00000157036	EXOG	86	90.625	ENSCAPG00000007560	EXOG	99	89.137	Cavia_aperea
ENSG00000157036	EXOG	97	87.430	ENSCPOG00000038521	EXOG	100	87.430	Cavia_porcellus
ENSG00000157036	EXOG	100	96.196	ENSCCAG00000022851	EXOG	100	96.196	Cebus_capucinus
ENSG00000157036	EXOG	98	97.756	ENSCATG00000017315	EXOG	100	97.756	Cercocebus_atys
ENSG00000157036	EXOG	100	86.957	ENSCLAG00000009371	EXOG	100	86.957	Chinchilla_lanigera
ENSG00000157036	EXOG	98	88.674	ENSCSAG00000014513	EXOG	100	88.950	Chlorocebus_sabaeus
ENSG00000157036	EXOG	99	86.813	ENSCHOG00000013861	EXOG	99	86.813	Choloepus_hoffmanni
ENSG00000157036	EXOG	95	73.596	ENSCPBG00000018302	EXOG	95	68.876	Chrysemys_picta_bellii
ENSG00000157036	EXOG	98	98.050	ENSCANG00000043429	EXOG	96	98.050	Colobus_angolensis_palliatus
ENSG00000157036	EXOG	100	81.301	ENSCGRG00001016541	Exog	100	81.301	Cricetulus_griseus_chok1gshd
ENSG00000157036	EXOG	100	80.759	ENSCGRG00000007736	Exog	100	80.759	Cricetulus_griseus_crigri
ENSG00000157036	EXOG	100	85.870	ENSDNOG00000047715	EXOG	100	85.870	Dasypus_novemcinctus
ENSG00000157036	EXOG	100	77.116	ENSDORG00000004332	Exog	100	76.489	Dipodomys_ordii
ENSG00000157036	EXOG	98	76.190	ENSETEG00000013331	EXOG	100	72.826	Echinops_telfairi
ENSG00000157036	EXOG	96	50.000	ENSEBUG00000009844	EXOG	80	55.518	Eptatretus_burgeri
ENSG00000157036	EXOG	80	49.333	ENSEBUG00000014671	EXOG	77	46.939	Eptatretus_burgeri
ENSG00000157036	EXOG	100	90.217	ENSEASG00005007541	EXOG	100	90.217	Equus_asinus_asinus
ENSG00000157036	EXOG	100	90.489	ENSECAG00000015682	EXOG	97	90.489	Equus_caballus
ENSG00000157036	EXOG	85	88.679	ENSEEUG00000004027	EXOG	99	75.238	Erinaceus_europaeus
ENSG00000157036	EXOG	81	70.395	ENSELUG00000018250	EXOG	85	60.458	Esox_lucius
ENSG00000157036	EXOG	100	89.308	ENSFCAG00000003159	EXOG	100	89.308	Felis_catus
ENSG00000157036	EXOG	84	81.013	ENSFALG00000006795	EXOG	95	73.064	Ficedula_albicollis
ENSG00000157036	EXOG	99	88.556	ENSFDAG00000013071	EXOG	99	88.556	Fukomys_damarensis
ENSG00000157036	EXOG	93	75.723	ENSGALG00000006153	EXOG	91	69.231	Gallus_gallus
ENSG00000157036	EXOG	93	73.410	ENSGAGG00000025600	EXOG	82	68.323	Gopherus_agassizii
ENSG00000157036	EXOG	100	99.057	ENSGGOG00000010779	EXOG	100	99.057	Gorilla_gorilla
ENSG00000157036	EXOG	99	88.556	ENSHGLG00000012874	EXOG	99	88.556	Heterocephalus_glaber_female
ENSG00000157036	EXOG	98	84.762	ENSHGLG00100008527	EXOG	99	82.289	Heterocephalus_glaber_male
ENSG00000157036	EXOG	88	66.463	ENSIPUG00000024721	exog	87	61.238	Ictalurus_punctatus
ENSG00000157036	EXOG	100	91.033	ENSSTOG00000031572	EXOG	100	91.033	Ictidomys_tridecemlineatus
ENSG00000157036	EXOG	97	61.453	ENSLACG00000012619	EXOG	96	60.615	Latimeria_chalumnae
ENSG00000157036	EXOG	93	60.933	ENSLOCG00000009933	EXOG	94	60.933	Lepisosteus_oculatus
ENSG00000157036	EXOG	100	83.152	ENSLAFG00000018139	EXOG	100	83.152	Loxodonta_africana
ENSG00000157036	EXOG	98	98.066	ENSMFAG00000040794	EXOG	100	98.066	Macaca_fascicularis
ENSG00000157036	EXOG	98	98.050	ENSMMUG00000018792	EXOG	99	98.058	Macaca_mulatta
ENSG00000157036	EXOG	98	98.066	ENSMNEG00000023586	EXOG	100	98.066	Macaca_nemestrina
ENSG00000157036	EXOG	100	96.739	ENSMLEG00000041016	EXOG	99	96.739	Mandrillus_leucophaeus
ENSG00000157036	EXOG	85	79.245	ENSMGAG00000004394	EXOG	96	72.277	Meleagris_gallopavo
ENSG00000157036	EXOG	100	81.250	ENSMAUG00000013540	Exog	100	81.250	Mesocricetus_auratus
ENSG00000157036	EXOG	100	93.082	ENSMICG00000049024	EXOG	100	93.082	Microcebus_murinus
ENSG00000157036	EXOG	99	83.471	ENSMOCG00000020900	Exog	99	83.471	Microtus_ochrogaster
ENSG00000157036	EXOG	97	60.393	ENSMODG00000013358	EXOG	99	60.393	Monodelphis_domestica
ENSG00000157036	EXOG	100	82.337	MGP_CAROLIEiJ_G0032802	Exog	100	82.337	Mus_caroli
ENSG00000157036	EXOG	100	83.152	ENSMUSG00000042787	Exog	100	83.152	Mus_musculus
ENSG00000157036	EXOG	100	81.522	MGP_PahariEiJ_G0015669	Exog	100	81.522	Mus_pahari
ENSG00000157036	EXOG	100	82.337	MGP_SPRETEiJ_G0033950	Exog	100	84.186	Mus_spretus
ENSG00000157036	EXOG	98	88.643	ENSMPUG00000002594	EXOG	98	88.643	Mustela_putorius_furo
ENSG00000157036	EXOG	100	86.413	ENSMLUG00000002789	EXOG	100	86.413	Myotis_lucifugus
ENSG00000157036	EXOG	75	87.342	ENSNGAG00000007089	Exog	100	84.884	Nannospalax_galili
ENSG00000157036	EXOG	100	96.855	ENSNLEG00000005421	EXOG	100	96.855	Nomascus_leucogenys
ENSG00000157036	EXOG	98	65.746	ENSMEUG00000013617	EXOG	98	65.746	Notamacropus_eugenii
ENSG00000157036	EXOG	98	78.095	ENSOPRG00000001088	EXOG	99	74.309	Ochotona_princeps
ENSG00000157036	EXOG	100	86.141	ENSODEG00000005422	EXOG	100	86.141	Octodon_degus
ENSG00000157036	EXOG	80	91.275	ENSOCUG00000016460	-	68	91.333	Oryctolagus_cuniculus
ENSG00000157036	EXOG	100	89.946	ENSOGAG00000011881	EXOG	100	89.946	Otolemur_garnettii
ENSG00000157036	EXOG	100	85.326	ENSOARG00000001455	EXOG	100	84.783	Ovis_aries
ENSG00000157036	EXOG	100	99.457	ENSPPAG00000032881	EXOG	100	99.457	Pan_paniscus
ENSG00000157036	EXOG	100	87.027	ENSPPRG00000015275	EXOG	100	87.027	Panthera_pardus
ENSG00000157036	EXOG	100	87.027	ENSPTIG00000020710	EXOG	100	87.027	Panthera_tigris_altaica
ENSG00000157036	EXOG	100	99.686	ENSPTRG00000014761	EXOG	100	99.686	Pan_troglodytes
ENSG00000157036	EXOG	98	98.329	ENSPANG00000004803	EXOG	96	98.329	Papio_anubis
ENSG00000157036	EXOG	98	57.182	ENSPKIG00000002329	EXOG	88	61.392	Paramormyrops_kingsleyae
ENSG00000157036	EXOG	87	76.074	ENSPSIG00000009009	EXOG	99	68.471	Pelodiscus_sinensis
ENSG00000157036	EXOG	100	84.511	ENSPEMG00000019449	Exog	100	84.511	Peromyscus_maniculatus_bairdii
ENSG00000157036	EXOG	94	73.714	ENSPCIG00000013788	EXOG	98	71.588	Phascolarctos_cinereus
ENSG00000157036	EXOG	100	97.011	ENSPPYG00000014005	EXOG	100	97.011	Pongo_abelii
ENSG00000157036	EXOG	65	91.667	ENSPCAG00000001366	EXOG	76	91.667	Procavia_capensis
ENSG00000157036	EXOG	100	91.848	ENSPCOG00000019058	EXOG	100	91.848	Propithecus_coquereli
ENSG00000157036	EXOG	100	87.772	ENSPVAG00000012780	EXOG	100	87.772	Pteropus_vampyrus
ENSG00000157036	EXOG	90	64.943	ENSPNAG00000027216	EXOG	89	59.937	Pygocentrus_nattereri
ENSG00000157036	EXOG	100	82.065	ENSRNOG00000014801	Exog	100	82.065	Rattus_norvegicus
ENSG00000157036	EXOG	98	97.772	ENSRBIG00000029194	EXOG	97	97.772	Rhinopithecus_bieti
ENSG00000157036	EXOG	98	97.790	ENSRROG00000045132	EXOG	100	97.790	Rhinopithecus_roxellana
ENSG00000157036	EXOG	100	95.597	ENSSBOG00000031108	EXOG	100	95.597	Saimiri_boliviensis_boliviensis
ENSG00000157036	EXOG	68	68.519	ENSSHAG00000000073	-	99	68.837	Sarcophilus_harrisii
ENSG00000157036	EXOG	95	84.746	ENSSARG00000009026	EXOG	96	80.337	Sorex_araneus
ENSG00000157036	EXOG	84	78.981	ENSSPUG00000018164	EXOG	85	68.831	Sphenodon_punctatus
ENSG00000157036	EXOG	100	87.500	ENSSSCG00000011258	EXOG	100	87.500	Sus_scrofa
ENSG00000157036	EXOG	85	82.390	ENSTGUG00000000538	EXOG	95	71.473	Taeniopygia_guttata
ENSG00000157036	EXOG	95	79.245	ENSTBEG00000011185	EXOG	72	88.626	Tupaia_belangeri
ENSG00000157036	EXOG	100	85.054	ENSTTRG00000005449	EXOG	100	85.054	Tursiops_truncatus
ENSG00000157036	EXOG	100	87.772	ENSUAMG00000006239	EXOG	100	87.772	Ursus_americanus
ENSG00000157036	EXOG	95	88.136	ENSUMAG00000005378	EXOG	99	89.458	Ursus_maritimus
ENSG00000157036	EXOG	94	89.143	ENSVPAG00000001597	EXOG	100	86.512	Vicugna_pacos
ENSG00000157036	EXOG	100	85.054	ENSVVUG00000005960	EXOG	92	85.054	Vulpes_vulpes
ENSG00000157036	EXOG	96	54.722	ENSXETG00000021000	exog	100	54.722	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	21873635.	IBA	Function
GO:0000737	DNA catabolic process, endonucleolytic	21873635.	IBA	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004519	endonuclease activity	21873635.	IBA	Function
GO:0004519	endonuclease activity	18187503.	IDA	Function
GO:0004519	endonuclease activity	10231028.	NAS	Function
GO:0004521	endoribonuclease activity	21873635.	IBA	Function
GO:0004529	exodeoxyribonuclease activity	21873635.	IBA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	18187503.	IDA	Component
GO:0006309	apoptotic DNA fragmentation	21873635.	IBA	Process
GO:0008150	biological_process	-	ND	Process
GO:0008409	5'-3' exonuclease activity	21873635.	IBA	Function
GO:0008409	5'-3' exonuclease activity	18187503.	IDA	Function
GO:0032991	protein-containing complex	25378300.	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process