EuRBPDB

Description

Ensembl ID: ENSG00000157483 (Gene tree)
Gene ID: 4643
Gene Symbol: MYO1E
Alias: MYO1C|HuncM-IC|MGC104638
Full Name: myosin IE
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 240,467 bases
Position: chr15:59,132,434-59,372,900
Accession: 7599
RBP type: non-canonical RBP
Summary: This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558814	MYO1E-205	768	-	-	- (aa)	-	-
ENST00000288235	MYO1E-201	8673	-	ENSP00000288235	1108 (aa)	-	Q12965
ENST00000559412	MYO1E-207	541	-	ENSP00000453936	73 (aa)	-	H0YNB0
ENST00000559269	MYO1E-206	828	-	ENSP00000453232	276 (aa)	-	H0YLJ4
ENST00000558571	MYO1E-203	557	-	ENSP00000453811	112 (aa)	-	H0YN00
ENST00000560642	MYO1E-209	559	-	-	- (aa)	-	-
ENST00000558646	MYO1E-204	578	-	-	- (aa)	-	-
ENST00000558182	MYO1E-202	544	-	-	- (aa)	-	-
ENST00000559489	MYO1E-208	562	-	ENSP00000453178	187 (aa)	-	H0YLE5
ENST00000560749	MYO1E-210	952	-	ENSP00000454113	317 (aa)	-	H0YNQ8

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000157483	Alcoholism	5.73905e-005	22978509
ENSG00000157483	Alcoholism	1.26726e-005	22978509
ENSG00000157483	Blood Pressure	9.0620000E-006	-
ENSG00000157483	Blood Pressure	1.6510000E-005	-
ENSG00000157483	Blood Pressure	7.5330000E-005	-
ENSG00000157483	Platelet Function Tests	2.3700000E-010	-
ENSG00000157483	Platelet Function Tests	8.5600000E-006	-
ENSG00000157483	Platelet Function Tests	6.8400000E-006	-
ENSG00000157483	Vascular Calcification	1E-10	22916037
ENSG00000157483	Communication Disorders	1E-7	24047820

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000157483	rs2306786	15	59195731	?	Metabolite levels	22916037			EFO_0004723
ENSG00000157483	rs4218	15	59136459	G	Social communication problems	24047820	[0.063-0.137] unit increase	0.1	EFO_0005427
ENSG00000157483	rs114625006	15	59361839	?	Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes	29221444	[0.085-0.309] unit increase	0.197	EFO_0004723\|EFO_0001360
ENSG00000157483	rs78595738	15	59179319	?	Measles	28928442	[0.4-0.99] unit decrease	0.6929	EFO_0008414
ENSG00000157483	rs7175642	15	59157880	?	Body mass index	30595370			EFO_0004340
ENSG00000157483	rs3191402	15	59136961	A	Pulse pressure	30224653	[0.084-0.155] unit decrease	0.1191	EFO_0005763

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000146	microfilament motor activity	7932763.	TAS	Function
GO:0001570	vasculogenesis	-	IEA	Process
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0003094	glomerular filtration	-	ISS	Process
GO:0003774	motor activity	7932763.	TAS	Function
GO:0005515	protein binding	17257598.19846667.21458045.	IPI	Function
GO:0005516	calmodulin binding	11940582.	IDA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	-	ISS	Component
GO:0005856	cytoskeleton	17257598.	IDA	Component
GO:0005903	brush border	-	IEA	Component
GO:0005911	cell-cell junction	-	ISS	Component
GO:0005912	adherens junction	-	ISS	Component
GO:0006807	nitrogen compound metabolic process	-	IEA	Process
GO:0006897	endocytosis	17257598.	IMP	Process
GO:0015629	actin cytoskeleton	7932763.	TAS	Component
GO:0016459	myosin complex	11940582.	TAS	Component
GO:0030048	actin filament-based movement	7932763.	TAS	Process
GO:0032836	glomerular basement membrane development	-	ISS	Process
GO:0035091	phosphatidylinositol binding	20860408.	IDA	Function
GO:0035166	post-embryonic hemopoiesis	-	IEA	Process
GO:0042623	ATPase activity, coupled	11940582.	IDA	Function
GO:0045334	clathrin-coated endocytic vesicle	17257598.	IDA	Component
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	IEA	Process
GO:0051015	actin filament binding	11940582.	IDA	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0072015	glomerular visceral epithelial cell development	-	ISS	Process