EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000158290 (Gene tree)
Gene ID: 8450
Gene Symbol: CUL4B
Alias: N
Full Name: cullin 4B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 51,241 bases
Position: chrX:120,524,589-120,575,829
Accession: 2555
RBP type: non-canonical RBP
Summary: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000486604	CUL4B-206	1024	-	-	- (aa)	-	-
ENST00000404115	CUL4B-204	3264	XM_005262481	ENSP00000384109	913 (aa)	XP_005262538	Q13620
ENST00000336592	CUL4B-201	3109	XM_006724784	ENSP00000338919	900 (aa)	XP_006724847	K4DI93
ENST00000371323	CUL4B-203	846	-	ENSP00000360374	234 (aa)	-	A6NE76
ENST00000371322	CUL4B-202	4902	XM_011531399	ENSP00000360373	895 (aa)	XP_011529701	Q13620
ENST00000467641	CUL4B-205	836	-	-	- (aa)	-	-
ENST00000497616	CUL4B-207	1011	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000158290's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03420	Nucleotide excision repair	KEGG
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000158290's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000158290	CUL4B	100	97.442	ENSMUSG00000031095	Cul4b	100	97.442	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	8681378.	NAS	Process
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	Process
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	-	TAS	Process
GO:0003684	damaged DNA binding	22334663.	IDA	Function
GO:0005515	protein binding	12609982.16949367.16964240.17041588.18775313.19651607.21778237.22466964.22939624.23238014.25036637.25435324.25910212.26496610.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	Process
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	Process
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	21873635.	IBA	Process
GO:0010498	proteasomal protein catabolic process	25970626.	IDA	Process
GO:0010498	proteasomal protein catabolic process	25970626.	IMP	Process
GO:0016567	protein ubiquitination	28437394.	IMP	Process
GO:0019005	SCF ubiquitin ligase complex	21873635.	IBA	Component
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0031175	neuron projection development	-	IEA	Process
GO:0031461	cullin-RING ubiquitin ligase complex	21873635.	IBA	Component
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	21873635.	IBA	Component
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	18794347.21628527.22334663.	IDA	Component
GO:0031625	ubiquitin protein ligase binding	21873635.	IBA	Function
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0035518	histone H2A monoubiquitination	22334663.	IDA	Process
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045732	positive regulation of protein catabolic process	-	IEA	Process
GO:0061630	ubiquitin protein ligase activity	21873635.	IBA	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070911	global genome nucleotide-excision repair	-	TAS	Process
GO:0070914	UV-damage excision repair	22334663.	IDA	Process
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	21873635.	IBA	Component
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	16949367.	IDA	Component
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23649548	Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis.	Med Oncol	2013	Jiang T	doi: 10.1007/s12032-013-0534-7
28685847	MicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells.	J Cell Biochem	2018 Jan	Zhang JQ	doi: 10.1002/jcb.26270
26617747	Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway.	Int J Clin Exp Pathol	2015 Sep 1	Song B	-
23238014	CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.	Cancer Cell	2012 Dec 11	Hu H	doi: 10.1016/j.ccr.2012.10.024.
27974468	Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.	J Biol Chem	2017 Feb 17	Jia L	doi: 10.1074/jbc.M116.765230
28164432	Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma.	Mol Oncol	2017 Mar	Mi J	doi: 10.1002/1878-0261.12038
29106389	CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2.	Oncogene	2018 Feb 22	Qi M	doi: 10.1038/onc.2017.380
29274277	CUL4B promotes metastasis and proliferation in pancreatic cancer cells by inducing epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.	J Cell Biochem	2018 Jul	He YM	doi: 10.1002/jcb.26643

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	120560475	Missense_Mutation	NA	R73K	0.24
BLCA	chrX	120537028	Nonsense_Mutation	NA	Q667*	0.1
BLCA	chrX	120537013	Missense_Mutation	novel	P672S	0.35
BLCA	chrX	120539374	Splice_Site	novel	X564_splice	0.14
BLCA	chrX	120543791	Missense_Mutation	novel	H416Y	0.21
BLCA	chrX	120535920	Missense_Mutation	NA	F708L	0.66
BLCA	chrX	120557934	Missense_Mutation	novel	E239V	0.67
BLCA	chrX	120557955	Missense_Mutation	novel	S232L	0.3
BRCA	chrX	120538690	Missense_Mutation	novel	E626K	0.26
BRCA	chrX	120544512	Missense_Mutation	NA	R369Q	0.15
BRCA	chrX	120524803	3'Flank	novel		0.2
BRCA	chrX	120545476	Nonsense_Mutation	NA	Y314*	0.24
BRCA	chrX	120539369	Missense_Mutation	NA	K565M	0.13
BRCA	chrX	120544615	Missense_Mutation	rs750144966	H335Y	0.13
BRCA	chrX	120560280	Missense_Mutation	NA	S138C	0.15
BRCA	chrX	120530179	Missense_Mutation	novel	I857V	0.03
BRCA	chrX	120534481	Nonsense_Mutation	novel	E774*	0.06
BRCA	chrX	120558007	Missense_Mutation	NA	E215K	0.22
BRCA	chrX	120538205	Silent	rs148700620	C637C	0.1
BRCA	chrX	120532574	Nonsense_Mutation	novel	*R780_T781insLEPCKNI**	0.06
BRCA	chrX	120526820	Missense_Mutation	NA	D895N	0.3
BRCA	chrX	120557955	Missense_Mutation	novel	S232L	0.07
CESC	chrX	120524717	3'Flank	novel		0.24
CESC	chrX	120544197	Missense_Mutation	NA	Q382E	0.11
CESC	chrX	120540419	Silent	NA	A547A	0.14
CESC	chrX	120560364	Missense_Mutation	novel	S110Y	0.49
CESC	chrX	120525009	3'Flank	novel		0.25
CESC	chrX	120535907	Silent	novel	L713L	0.09
CESC	chrX	120535832	Missense_Mutation	NA	E738Q	0.07
CESC	chrX	120544493	Silent	NA	L375L	0.37
CESC	chrX	120526837	Missense_Mutation	novel	R889I	0.37
CESC	chrX	120526405	3'Flank	novel		0.32
CESC	chrX	120524901	3'Flank	novel		0.51
CESC	chrX	120560442	Missense_Mutation	novel	S84F	0.22
CHOL	chrX	120525024	3'Flank	novel		0.37
COAD	chrX	120544512	Missense_Mutation	NA	R369Q	0.18
COAD	chrX	120560137	Missense_Mutation	novel	F186I	0.3
COAD	chrX	120532427	Nonsense_Mutation	novel	E830*	0.77
COAD	chrX	120544512	Missense_Mutation	NA	R369Q	0.11
COAD	chrX	120526810	Missense_Mutation	novel	Y898C	0.06
COAD	chrX	120535857	Silent	novel	H729H	0.07
COAD	chrX	120536980	Missense_Mutation	NA	T683S	0.4
COAD	chrX	120530099	Splice_Region	novel		0.22
COAD	chrX	120560305	Missense_Mutation	novel	F130L	0.44
COAD	chrX	120540485	Missense_Mutation	NA	K525N	0.26
COAD	chrX	120534536	Missense_Mutation	novel	M755I	0.64
COAD	chrX	120526638	3'Flank	novel		0.4
COAD	chrX	120544506	Missense_Mutation	NA	L371H	0.29
COAD	chrX	120526632	3'Flank	novel		0.35
COAD	chrX	120526667	3'UTR	novel		0.33
ESCA	chrX	120526819	Missense_Mutation	novel	D895A	0.36
GBM	chrX	120538205	Silent	rs148700620	C637C	0.27
GBM	chrX	120544545	Missense_Mutation	novel	R358T	0.26
GBM	chrX	120544513	Nonsense_Mutation	NA	R369*	0.41
HNSC	chrX	120543745	Missense_Mutation	novel	Y431S	0.39
HNSC	chrX	120535867	Missense_Mutation	novel	T726S	0.22
HNSC	chrX	120536964	Missense_Mutation	novel	P688Q	0.16
HNSC	chrX	120532481	Missense_Mutation	novel	D812H	0.25
HNSC	chrX	120526805	Missense_Mutation	novel	E900K	0.31
HNSC	chrX	120538748	Missense_Mutation	novel	F606L	0.74
HNSC	chrX	120538673	Silent	novel	S631S	0.2
HNSC	chrX	120560587	Nonsense_Mutation	novel	Q36*	0.22
KIRC	chrX	120536948	Missense_Mutation	novel	M693I	0.64
LGG	chrX	120560285	Missense_Mutation	novel	E136D	0.22
LGG	chrX	120543758	Nonsense_Mutation	novel	R427*	0.46
LGG	chrX	120544152	Missense_Mutation	novel	Y397H	0.19
LGG	chrX	120535832	Missense_Mutation	NA	E738Q	0.26
LGG	chrX	120538679	Missense_Mutation	novel	M629I	0.09
LGG	chrX	120540432	Missense_Mutation	novel	A543D	0.35
LGG	chrX	120560103	Missense_Mutation	novel	L197S	0.32
LGG	chrX	120558041	Splice_Site	novel	X204_splice	0.45
LIHC	chrX	120543768	Silent	novel	E423E	0.32
LIHC	chrX	120535882	Missense_Mutation	NA	L721R	0.23
LIHC	chrX	120538171	Missense_Mutation	novel	F649L	0.27
LUAD	chrX	120539362	Silent	NA	V567V	0.23
LUAD	chrX	120560321	Silent	NA	T124T	0.2
LUAD	chrX	120544205	Splice_Site	NA	X380_splice	0.41
LUAD	chrX	120530159	Silent	NA	T863T	0.17
LUAD	chrX	120532536	Silent	NA	L793L	0.7
LUAD	chrX	120544553	Silent	NA	E355E	0.23
LUAD	chrX	120560298	Missense_Mutation	novel	A132G	0.23
LUAD	chrX	120560379	Missense_Mutation	novel	V105D	0.05
LUAD	chrX	120534500	Silent	NA	I767I	0.14
LUAD	chrX	120530243	Missense_Mutation	novel	Q835H	0.29
LUAD	chrX	120532580	Missense_Mutation	novel	R779W	0.77
LUAD	chrX	120557988	Frame_Shift_Del	novel	*D214Rfs9**	0.09
LUAD	chrX	120538206	Missense_Mutation	novel	C637Y	0.12
LUSC	chrX	120530251	Nonsense_Mutation	novel	E833*	0.66
LUSC	chrX	120530134	Missense_Mutation	novel	E872K	0.17
LUSC	chrX	120532511	Missense_Mutation	novel	I802V	0.32
LUSC	chrX	120526753	3'UTR	novel		0.58
LUSC	chrX	120560348	Missense_Mutation	rs779144333	I115M	0.87
LUSC	chrX	120560119	Missense_Mutation	NA	G192R	0.22
LUSC	chrX	120560313	Missense_Mutation	novel	F127Y	0.29
LUSC	chrX	120526757	3'UTR	novel		0.19
LUSC	chrX	120546602	Missense_Mutation	NA	S282I	0.11
OV	chrX	120560343	Missense_Mutation	novel	K117R	0.11
OV	chrX	120544184	Missense_Mutation	novel	E386G	0.11
PAAD	chrX	120540389	Missense_Mutation	novel	N557K	0.32
PAAD	chrX	120534548	Silent	novel	L751L	0.19
PAAD	chrX	120540552	Missense_Mutation	novel	S503I	0.22
PCPG	chrX	120538721	Silent	novel	L615L	0.12
PRAD	chrX	120560148	Missense_Mutation	novel	T182I	0.8
READ	chrX	120544513	Nonsense_Mutation	NA	R369*	0.54
READ	chrX	120547220	Missense_Mutation	NA	S249Y	0.43
READ	chrX	120574555	Silent	rs769112172	D21D	0.76
READ	chrX	120539334	Nonsense_Mutation	novel	E577*	0.07
SARC	chrX	120526378	3'Flank	novel		0.04
SARC	chrX	120526685	3'UTR	novel		0.06
SARC	chrX	120557979	Missense_Mutation	novel	V224E	0.37
SARC	chrX	120557994	Missense_Mutation	novel	K219T	0.19
SARC	chrX	120537011	Silent	novel	P672P	0.83
SKCM	chrX	120544512	Missense_Mutation	NA	R369Q	0.26
SKCM	chrX	120540402	Frame_Shift_Del	novel	*N553Tfs11**	0.3
SKCM	chrX	120526680	3'UTR	novel		0.85
SKCM	chrX	120541631	Missense_Mutation	rs267606335	L490F	0.15
SKCM	chrX	120574553	Missense_Mutation	rs145808703	G22D	0.69
SKCM	chrX	120546561	Missense_Mutation	NA	H296Y	0.43
SKCM	chrX	120540432	Missense_Mutation	NA	A543V	0.3
SKCM	chrX	120574586	Missense_Mutation	NA	G11E	0.24
SKCM	chrX	120530255	Splice_Site	NA	X832_splice	0.89
SKCM	chrX	120537017	Missense_Mutation	novel	N670K	0.54
SKCM	chrX	120560277	Missense_Mutation	NA	S139F	0.36
SKCM	chrX	120526786	Missense_Mutation	NA	P906L	0.41
SKCM	chrX	120534556	Nonsense_Mutation	novel	Q749*	0.66
SKCM	chrX	120574598	Missense_Mutation	rs757896094	G7E	0.43
SKCM	chrX	120530255	Splice_Site	NA	X832_splice	0.72
STAD	chrX	120546589	Frame_Shift_Ins	NA	*L286Ffs5**	0.3
STAD	chrX	120546601	Silent	rs201566181	S282S	0.71
STAD	chrX	120539308	Missense_Mutation	NA	K585N	0.74
STAD	chrX	120560470	Missense_Mutation	NA	D75Y	0.69
STAD	chrX	120540551	Silent	NA	S503S	0.26
STAD	chrX	120535860	Silent	rs751669743	G728G	0.44
THYM	chrX	120560262	In_Frame_Del	rs766883719	S146del	0.13
UCEC	chrX	120544513	Nonsense_Mutation	NA	R369*	0.28
UCEC	chrX	120560234	Missense_Mutation	NA	Q153H	0.33
UCEC	chrX	120547153	Silent	rs746547887	Q271Q	0.28
UCEC	chrX	120524871	3'Flank	novel		0.39
UCEC	chrX	120526210	3'Flank	novel		0.36
UCEC	chrX	120526457	3'Flank	novel		0.34
UCEC	chrX	120541649	Nonsense_Mutation	NA	R484*	0.35
UCEC	chrX	120560199	Missense_Mutation	NA	S165Y	0.43
UCEC	chrX	120530182	Nonsense_Mutation	NA	R856*	0.35
UCEC	chrX	120545483	Missense_Mutation	NA	R312I	0.16
UCEC	chrX	120526284	3'Flank	novel		0.42
UCEC	chrX	120530149	Missense_Mutation	novel	N867D	0.38
UCEC	chrX	120560467	Missense_Mutation	novel	F76L	0.1
UCEC	chrX	120538191	Missense_Mutation	rs769166770	T642I	0.4
UCEC	chrX	120544118	Missense_Mutation	NA	R408K	0.41
UCEC	chrX	120557961	Missense_Mutation	NA	S230I	0.42
UCEC	chrX	120560415	Missense_Mutation	rs747997744	S93L	0.49
UCEC	chrX	120530182	Nonsense_Mutation	NA	R856*	0.44
UCEC	chrX	120543729	Splice_Region	NA	T436T	0.36
UCEC	chrX	120526598	3'Flank	novel		0.39
UCEC	chrX	120560187	Missense_Mutation	novel	S169L	0.42
UCEC	chrX	120535857	Missense_Mutation	novel	H729Q	0.31
UCEC	chrX	120534572	Silent	novel	L743L	0.46
UCEC	chrX	120544591	Nonsense_Mutation	novel	Q343*	0.4
UCEC	chrX	120560335	Missense_Mutation	novel	R120C	0.4
UCEC	chrX	120530225	Missense_Mutation	novel	R841S	0.3
UCEC	chrX	120544512	Missense_Mutation	NA	R369Q	0.26
UCEC	chrX	120544513	Nonsense_Mutation	NA	R369*	0.32
UCEC	chrX	120560269	Missense_Mutation	novel	S142P	0.21
UCEC	chrX	120557977	Missense_Mutation	NA	E225K	0.42
UCEC	chrX	120526548	3'Flank	novel		0.19
UCEC	chrX	120540419	Silent	novel	A547A	0.1
UCEC	chrX	120535865	Missense_Mutation	rs17853573	L727I	0.14
UCEC	chrX	120536973	Missense_Mutation	novel	G685A	0.1
UCEC	chrX	120560101	Missense_Mutation	novel	V198M	0.22
UCEC	chrX	120530244	Missense_Mutation	novel	Q835R	0.29
UCEC	chrX	120532551	Silent	novel	G788G	0.06
UCEC	chrX	120534497	Silent	novel	K768K	0.04
UCEC	chrX	120524766	3'Flank	novel		0.12
UCEC	chrX	120526505	3'Flank	novel		0.09
UCEC	chrX	120526819	Missense_Mutation	novel	D895G	0.38
UCEC	chrX	120530182	Nonsense_Mutation	NA	R856*	0.37
UCEC	chrX	120537010	Missense_Mutation	novel	G673R	0.57
UCEC	chrX	120537012	Missense_Mutation	novel	P672L	0.59
UCEC	chrX	120560653	Intron	novel		0.13
UCEC	chrX	120526680	3'UTR	novel		0.23
UCEC	chrX	120544513	Nonsense_Mutation	NA	R369*	0.3
UCEC	chrX	120545495	Frame_Shift_Del	NA	*L308Cfs30**	0.41
UCEC	chrX	120560227	Nonsense_Mutation	novel	Q156*	0.27
UCEC	chrX	120535844	Frame_Shift_Ins	novel	*A734Sfs4**	0.45
UCEC	chrX	120526275	3'Flank	novel		0.29
UCEC	chrX	120538201	Missense_Mutation	NA	A639T	0.21
UCEC	chrX	120526828	Missense_Mutation	novel	S892Y	0.51
UCEC	chrX	120535934	Missense_Mutation	novel	L704F	0.23
UCEC	chrX	120541649	Nonsense_Mutation	NA	R484*	0.06
UCEC	chrX	120560226	Missense_Mutation	novel	Q156L	0.5
UCEC	chrX	120525183	3'Flank	novel		0.35
UCEC	chrX	120541694	Nonsense_Mutation	novel	R469*	0.47
UCEC	chrX	120544589	Missense_Mutation	novel	Q343H	0.68
UCEC	chrX	120539311	Missense_Mutation	novel	E584D	0.37
UCEC	chrX	120560678	Intron	novel		0.14
UCEC	chrX	120526185	3'Flank	novel		0.52
UCEC	chrX	120544544	Silent	NA	R358R	0.33
UCEC	chrX	120558015	Missense_Mutation	NA	Y212C	0.36
UCEC	chrX	120538164	Missense_Mutation	NA	D651G	0.38
UCEC	chrX	120540407	Missense_Mutation	novel	F551L	0.41
UCEC	chrX	120544524	Missense_Mutation	NA	R365I	0.39
UCEC	chrX	120545494	Frame_Shift_Ins	novel	*L308Ffs5**	0.25
UCEC	chrX	120524981	3'Flank	novel		0.22
UCEC	chrX	120526292	3'Flank	novel		0.28
UCEC	chrX	120544570	Missense_Mutation	novel	I350V	0.42
UCEC	chrX	120532462	Missense_Mutation	novel	L818P	0.48
UCEC	chrX	120545495	Frame_Shift_Del	NA	*L308Cfs30**	0.38
UCEC	chrX	120546589	Frame_Shift_Ins	NA	*L286Ffs5**	0.39
UCEC	chrX	120526111	3'Flank	novel		0.28
UCEC	chrX	120539330	Missense_Mutation	novel	A578V	0.14
UCEC	chrX	120547137	Nonsense_Mutation	NA	E277*	0.35
UCEC	chrX	120545494	Frame_Shift_Ins	novel	*L308Ffs5**	0.42
UCEC	chrX	120524939	3'Flank	novel		0.41
UCEC	chrX	120538165	Missense_Mutation	novel	D651Y	0.45
UCEC	chrX	120539279	Missense_Mutation	novel	R595I	0.38
UCEC	chrX	120540381	Missense_Mutation	novel	A560G	0.3
UCEC	chrX	120544513	Nonsense_Mutation	NA	R369*	0.25
UCEC	chrX	120544630	Nonsense_Mutation	novel	E330*	0.22
UCEC	chrX	120536929	Nonsense_Mutation	novel	E700*	0.44
UCEC	chrX	120544507	Missense_Mutation	novel	L371I	0.4
UCEC	chrX	120541648	Missense_Mutation	NA	R484Q	0.43
UCEC	chrX	120538668	Missense_Mutation	novel	L633R	0.09
UCEC	chrX	120546611	Nonsense_Mutation	NA	S279*	0.36
UCEC	chrX	120538668	Missense_Mutation	novel	L633R	0.11
UCEC	chrX	120539349	Missense_Mutation	novel	R572S	0.2
UCEC	chrX	120543750	Missense_Mutation	novel	I429M	0.22
UCEC	chrX	120547135	Splice_Site	novel	X277_splice	0.29
UCEC	chrX	120560696	Intron	novel		0.2
UCEC	chrX	120526830	Frame_Shift_Ins	novel	*S892Ffs10**	0.05
UCEC	chrX	120526832	Missense_Mutation	novel	E891K	0.01
UCEC	chrX	120544125	Nonsense_Mutation	novel	Q406*	0.09
UCEC	chrX	120546590	Frame_Shift_Del	NA	L286*	0.14
UCEC	chrX	120543794	Missense_Mutation	rs151254898	H415Y	0.15
UCEC	chrX	120560647	Intron	novel		0.22
UCEC	chrX	120526830	Frame_Shift_Ins	novel	*S892Ffs10**	0.06
UCEC	chrX	120526832	Missense_Mutation	novel	E891K	0.02
UCEC	chrX	120530171	Missense_Mutation	NA	K859N	0.38
UCEC	chrX	120560199	Missense_Mutation	NA	S165Y	0.4
UCEC	chrX	120524770	3'Flank	novel		0.2
UCEC	chrX	120538734	Nonsense_Mutation	novel	L611*	0.06
UCEC	chrX	120560187	Missense_Mutation	novel	S169L	0.31
UCEC	chrX	120560460	Missense_Mutation	novel	S78F	0.26
UCEC	chrX	120544562	Silent	novel	L352L	0.48
UCEC	chrX	120541613	Missense_Mutation	NA	E496K	0.47
UCEC	chrX	120560469	Missense_Mutation	novel	D75G	0.22
UCEC	chrX	120534578	Missense_Mutation	novel	K741N	0.07
UCEC	chrX	120536976	Missense_Mutation	novel	M684T	0.21
UCEC	chrX	120540397	Missense_Mutation	novel	R555G	0.36
UCEC	chrX	120546586	Missense_Mutation	novel	K287N	0.42
UCEC	chrX	120540535	Missense_Mutation	novel	P509S	0.34
UCEC	chrX	120544513	Nonsense_Mutation	NA	R369*	0.53
UCS	chrX	120526729	3'UTR	novel		0.27
UCS	chrX	120536941	Missense_Mutation	novel	H696N	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.0284	0.12739
TGCT	DEL	0.0733	0.08422
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0063	Kaplan-Meier Survival Analysis
SARC	0.038	Kaplan-Meier Survival Analysis
SKCM	0.00051	Kaplan-Meier Survival Analysis
PRAD	0.016	Kaplan-Meier Survival Analysis
BRCA	0.045	Kaplan-Meier Survival Analysis
KIRP	0.00016	Kaplan-Meier Survival Analysis
LAML	0.03	Kaplan-Meier Survival Analysis
KICH	0.037	Kaplan-Meier Survival Analysis
UCEC	0.00057	Kaplan-Meier Survival Analysis
GBM	0.037	Kaplan-Meier Survival Analysis
LIHC	0.00047	Kaplan-Meier Survival Analysis
DLBC	0.023	Kaplan-Meier Survival Analysis
LUAD	0.012	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742