EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000158710 (Gene tree)
Gene ID: 8407
Gene Symbol: TAGLN2
Alias: KIAA0120|HA1756
Full Name: transgelin 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 7,626 bases
Position: chr1:159,918,107-159,925,732
Accession: 11554
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368097	TAGLN2-203	1604	-	ENSP00000357077	199 (aa)	-	P37802
ENST00000368096	TAGLN2-202	1603	-	ENSP00000357076	220 (aa)	-	P37802
ENST00000320307	TAGLN2-201	709	-	ENSP00000357075	199 (aa)	-	P37802
ENST00000478033	TAGLN2-205	1051	-	-	- (aa)	-	-
ENST00000397334	TAGLN2-204	801	-	ENSP00000412429	187 (aa)	-	X6RJP6

Gene Model

Click here to download ENSG00000158710's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000158710	Platelet Function Tests	1.1629600E-005	-
ENSG00000158710	Platelet Function Tests	2.1000000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000158710	rs2789422	1	159922298	A	Mean platelet volume	27863252	[0.023-0.038] unit increase	0.03053915	EFO_0004584
ENSG00000158710	rs6427499	1	159922127	T	Platelet distribution width	27863252	[0.017-0.031] unit decrease	0.02413371	EFO_0007984

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000158710's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000158710	TAGLN2	100	96.482	ENSMUSG00000026547	Tagln2	100	96.482	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0005515	protein binding	21577206.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0030855	epithelial cell differentiation	21492153.	IDA	Process
GO:0031982	vesicle	19190083.	HDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29110682	TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas.	J Exp Clin Cancer Res	2017 Nov 6	Han MZ	doi: 10.1186/s13046-017-0619-9.
23527717	Clinical significance of pituitary tumor transforming gene 1 and transgelin-2 in pancreatic cancer.	Int J Immunopathol Pharmacol	2013 Jan-Mar	Lin H	-
19848416	Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma.	J Proteome Res	2009 Dec	Rho JH	doi: 10.1021/pr900705r.
24476357	Transgelins, cytoskeletal proteins implicated in different aspects of cancer development.	Expert Rev Proteomics	2014 Apr	Dvorakova M	doi: 10.1586/14789450.2014.860358
21378409	miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma.	Oncotarget	2011 Jan-Feb	Nohata N	-
21577206	A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility.	Oncogene	2011 Nov 3	Leung WK	doi: 10.1038/onc.2011.161
26081836	Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer.	Mol Cell Proteomics	2015 Sep	Chen CL	doi: 10.1074/mcp.M115.051524
30191639	Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cells.	Cancer Sci	2018 Nov	Kim IG	doi: 10.1111/cas.13791
26176734	Salvianolic acid A reverses the paclitaxel resistance and inhibits the migration and invasion abilities of human breast cancer cells by inactivating transgelin 2.	Cancer Biol Ther	2015	Zheng X	doi: 10.1080/15384047.2015.1070990.
28639888	Transgelin-2: A potential oncogenic factor.	Tumour Biol	2017 Jun	Meng T	doi: 10.1177/1010428317702650.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	159920522	5'UTR	rs187174577		0.45
BLCA	chr1	159919123	Intron	novel		0.14
BLCA	chr1	159918853	Missense_Mutation	rs777083394	G183R	0.8
BLCA	chr1	159919715	Missense_Mutation	novel	E101K	0.51
BRCA	chr1	159918967	Intron	NA		0.38
BRCA	chr1	159918701	3'Flank	novel		0.32
BRCA	chr1	159919335	Missense_Mutation	NA	G133R	0.18
BRCA	chr1	159919325	Frame_Shift_Del	novel	*L135Qfs2**	0.28
BRCA	chr1	159919019	Intron	novel		0.28
CESC	chr1	159918702	3'Flank	novel		0.16
CESC	chr1	159918501	3'Flank	novel		0.4
CESC	chr1	159918871	Nonsense_Mutation	novel	Q177*	0.36
COAD	chr1	159919252	Intron	rs186010726		0.3
COAD	chr1	159919817	Missense_Mutation	NA	N67H	0.33
COAD	chr1	159918856	Missense_Mutation	rs369414441	R182C	0.31
COAD	chr1	159918884	Silent	rs141740615	N172N	0.25
COAD	chr1	159918836	Silent	rs147762227	G188G	0.29
COAD	chr1	159919177	Intron	novel		0.43
COAD	chr1	159920381	Silent	NA	G43G	0.23
ESCA	chr1	159920362	Missense_Mutation	novel	E50K	0.34
GBM	chr1	159919302	Missense_Mutation	NA	F144L	0.2
GBM	chr1	159919012	Intron	novel		0.23
GBM	chr1	159919006	Intron	novel		0.2
GBM	chr1	159918942	Splice_Site	novel	X153_splice	0.26
GBM	chr1	159919691	Missense_Mutation	novel	D109Y	0.44
GBM	chr1	159920394	Missense_Mutation	rs757315588	R39Q	0.08
HNSC	chr1	159920423	Silent	novel	I29I	0.2
HNSC	chr1	159919303	Silent	novel	L143L	0.09
KICH	chr1	159919358	Missense_Mutation	novel	V125A	0.06
KIRC	chr1	159919158	Intron	novel		0.24
KIRP	chr1	159919128	Intron	novel		0.27
LGG	chr1	159920359	Missense_Mutation	NA	N51D	0.9
LIHC	chr1	159918822	Missense_Mutation	NA	G193E	0.65
LUAD	chr1	159918887	Silent	novel	K171K	0.07
LUAD	chr1	159920455	Missense_Mutation	NA	E19Q	0.25
LUAD	chr1	159920330	Splice_Region	novel	T60T	0.11
LUAD	chr1	159920515	5'UTR	novel		0.25
LUAD	chr1	159918908	Silent	NA	D164D	0.12
LUAD	chr1	159920432	Silent	novel	L26L	0.21
LUAD	chr1	159918828	Missense_Mutation	novel	G191V	0.31
LUAD	chr1	159918829	Missense_Mutation	novel	G191C	0.3
LUAD	chr1	159918698	3'Flank	novel		0.1
LUAD	chr1	159919735	Missense_Mutation	novel	S94C	0.17
LUAD	chr1	159919749	Missense_Mutation	NA	Q89H	0.32
LUSC	chr1	159918863	In_Frame_Ins	novel	G179_T180insLCDISLNRR	0.08
LUSC	chr1	159919057	Intron	novel		0.25
OV	chr1	159919367	Missense_Mutation	novel	M122R	0.12
OV	chr1	159918603	3'Flank	novel		0.15
PAAD	chr1	159918814	Missense_Mutation	novel	R196C	0.03
PAAD	chr1	159920531	5'UTR	novel		0.31
PRAD	chr1	159919835	Missense_Mutation	NA	V61M	0.2
READ	chr1	159919779	Missense_Mutation	NA	K79N	0.45
SARC	chr1	159919781	In_Frame_Ins	novel	K78_K79insL	0.22
SKCM	chr1	159920489	Silent	rs761159852	A7A	0.35
SKCM	chr1	159919213	Intron	novel		0.49
SKCM	chr1	159920408	Silent	NA	I34I	0.26
SKCM	chr1	159918698	3'Flank	novel		0.25
SKCM	chr1	159918631	3'Flank	novel		0.35
SKCM	chr1	159918617	3'Flank	novel		0.1
STAD	chr1	159918767	3'Flank	novel		0.08
STAD	chr1	159918877	Missense_Mutation	novel	G175R	0.48
STAD	chr1	159919711	Missense_Mutation	rs148732133	R102H	0.09
STAD	chr1	159918676	3'Flank	novel		0.33
STAD	chr1	159919737	Silent	NA	I93I	0.18
STAD	chr1	159918952	Intron	novel		0.07
UCEC	chr1	159920453	Silent	NA	E19E	0.21
UCEC	chr1	159919122	Intron	novel		0.24
UCEC	chr1	159918532	3'Flank	novel		0.45
UCEC	chr1	159919743	Missense_Mutation	novel	E91D	0.36
UCEC	chr1	159918941	Splice_Region	novel	K153K	0.32
UCEC	chr1	159920532	5'UTR	rs373828343		0.47
UCEC	chr1	159919712	Missense_Mutation	rs140206246	R102C	0.24
UCEC	chr1	159918683	3'Flank	novel		0.34
UCEC	chr1	159918532	3'Flank	novel		0.31
UCEC	chr1	159918747	3'Flank	novel		0.16
UCEC	chr1	159920334	Missense_Mutation	novel	G59D	0.25
UCEC	chr1	159918755	3'Flank	novel		0.38
UCEC	chr1	159919737	Silent	novel	I93I	0.15
UCEC	chr1	159919257	Intron	rs561335586		0.46
UCEC	chr1	159918878	Silent	rs751643569	I174I	0.46
UCEC	chr1	159920523	5'UTR	rs780297039		0.44
UCEC	chr1	159919323	Missense_Mutation	NA	V137I	0.33
UCEC	chr1	159918941	Missense_Mutation	novel	K153N	0.14
UCEC	chr1	159920531	5'UTR	novel		0.37
UCEC	chr1	159919067	Intron	novel		0.36
UCEC	chr1	159920506	Missense_Mutation	NA	A2T	0.19
UCEC	chr1	159918878	Silent	rs751643569	I174I	0.17
UCEC	chr1	159919044	Intron	novel		0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.413	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2174	0.085665
READ	AMP	0.2727	0.025154
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.3333	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.0007	Kaplan-Meier Survival Analysis
ACC	0.017	Kaplan-Meier Survival Analysis
BRCA	0.034	Kaplan-Meier Survival Analysis
KIRP	0.025	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
LAML	0.00013	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742