EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000159111 (Gene tree)
Gene ID: 124995
Gene Symbol: MRPL10
Alias: RPML8|MRP-L8|L10MT|MRP-L10|MRPL8|MGC17973
Full Name: mitochondrial ribosomal protein L10
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 8,270 bases
Position: chr17:47,823,272-47,831,541
Accession: 14055
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000324100	Ribosomal_L10	PF00466.20	1.1e-06	1	1
ENSP00000290208	Ribosomal_L10	PF00466.20	1.2e-06	1	1
ENSP00000395870	Ribosomal_L10	PF00466.20	1.2e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28134789	Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury.	Int J Mol Sci	2017 Jan 27	Wang Y	doi: 10.3390/ijms18020263.
30942461	Identification of suitable reference genes for gene expression studies in rat skeletal muscle following sciatic nerve crush injury.	Mol Med Rep	2019 May	Wang X	doi: 10.3892/mmr.2019.10102

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000414011	MRPL10-203	1622	XM_024450575	ENSP00000395870	271 (aa)	XP_024306343	Q7Z7H8
ENST00000466016	MRPL10-206	544	-	-	- (aa)	-	-
ENST00000421763	MRPL10-204	1576	-	ENSP00000404039	48 (aa)	-	F2Z2K7
ENST00000290208	MRPL10-201	2013	-	ENSP00000290208	271 (aa)	-	Q7Z7H8
ENST00000423147	MRPL10-205	612	-	ENSP00000390624	48 (aa)	-	F2Z2K7
ENST00000480901	MRPL10-207	578	-	-	- (aa)	-	-
ENST00000351111	MRPL10-202	1725	-	ENSP00000324100	261 (aa)	-	Q7Z7H8

Gene Model

Click here to download ENSG00000159111's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159111's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000159111	MRPL10	92	50.207	ENSAPOG00000015827	mrpl10	91	50.207	Acanthochromis_polyacanthus
ENSG00000159111	MRPL10	100	83.969	ENSAMEG00000004722	MRPL10	100	83.969	Ailuropoda_melanoleuca
ENSG00000159111	MRPL10	90	53.191	ENSACIG00000012855	mrpl10	97	51.837	Amphilophus_citrinellus
ENSG00000159111	MRPL10	92	50.622	ENSAOCG00000006653	mrpl10	77	50.622	Amphiprion_ocellaris
ENSG00000159111	MRPL10	92	50.622	ENSAPEG00000004939	mrpl10	97	50.622	Amphiprion_percula
ENSG00000159111	MRPL10	94	52.846	ENSATEG00000008279	mrpl10	100	52.846	Anabas_testudineus
ENSG00000159111	MRPL10	97	53.175	ENSACAG00000006889	MRPL10	98	53.175	Anolis_carolinensis
ENSG00000159111	MRPL10	100	94.275	ENSANAG00000022792	MRPL10	99	92.989	Aotus_nancymaae
ENSG00000159111	MRPL10	92	51.452	ENSACLG00000024106	mrpl10	97	51.020	Astatotilapia_calliptera
ENSG00000159111	MRPL10	100	50.379	ENSAMXG00000040331	mrpl10	98	50.379	Astyanax_mexicanus
ENSG00000159111	MRPL10	100	85.878	ENSBTAG00000001832	MRPL10	100	85.878	Bos_taurus
ENSG00000159111	MRPL10	100	91.912	ENSCJAG00000007787	MRPL10	100	93.333	Callithrix_jacchus
ENSG00000159111	MRPL10	100	85.496	ENSCAFG00000016800	MRPL10	100	85.496	Canis_familiaris
ENSG00000159111	MRPL10	100	85.496	ENSCAFG00020023232	MRPL10	100	85.496	Canis_lupus_dingo
ENSG00000159111	MRPL10	100	83.969	ENSCHIG00000027033	MRPL10	100	84.351	Capra_hircus
ENSG00000159111	MRPL10	97	89.723	ENSTSYG00000034759	MRPL10	100	89.354	Carlito_syrichta
ENSG00000159111	MRPL10	91	74.684	ENSCAPG00000014021	MRPL10	97	74.684	Cavia_aperea
ENSG00000159111	MRPL10	98	75.294	ENSCPOG00000037104	MRPL10	97	75.294	Cavia_porcellus
ENSG00000159111	MRPL10	100	93.893	ENSCCAG00000023150	MRPL10	100	93.893	Cebus_capucinus
ENSG00000159111	MRPL10	97	96.032	ENSCATG00000035686	MRPL10	100	95.420	Cercocebus_atys
ENSG00000159111	MRPL10	100	77.863	ENSCLAG00000015400	MRPL10	97	77.863	Chinchilla_lanigera
ENSG00000159111	MRPL10	97	95.635	ENSCSAG00000002576	MRPL10	99	95.019	Chlorocebus_sabaeus
ENSG00000159111	MRPL10	72	83.511	ENSCHOG00000006570	MRPL10	100	83.511	Choloepus_hoffmanni
ENSG00000159111	MRPL10	97	77.381	ENSCANG00000032099	MRPL10	100	77.481	Colobus_angolensis_palliatus
ENSG00000159111	MRPL10	100	79.008	ENSCGRG00001024199	Mrpl10	100	79.008	Cricetulus_griseus_chok1gshd
ENSG00000159111	MRPL10	100	79.008	ENSCGRG00000013001	Mrpl10	100	79.008	Cricetulus_griseus_crigri
ENSG00000159111	MRPL10	90	52.542	ENSCSEG00000014726	mrpl10	94	52.542	Cynoglossus_semilaevis
ENSG00000159111	MRPL10	92	49.793	ENSDARG00000045091	mrpl10	96	49.793	Danio_rerio
ENSG00000159111	MRPL10	100	88.168	ENSDNOG00000024176	MRPL10	100	88.168	Dasypus_novemcinctus
ENSG00000159111	MRPL10	58	85.430	ENSETEG00000007979	-	100	85.430	Echinops_telfairi
ENSG00000159111	MRPL10	92	40.000	ENSEBUG00000012756	mrpl10	88	40.000	Eptatretus_burgeri
ENSG00000159111	MRPL10	100	84.733	ENSEASG00005000681	MRPL10	100	84.733	Equus_asinus_asinus
ENSG00000159111	MRPL10	100	85.115	ENSECAG00000006884	MRPL10	73	85.115	Equus_caballus
ENSG00000159111	MRPL10	61	88.679	ENSEEUG00000003993	MRPL10	100	88.679	Erinaceus_europaeus
ENSG00000159111	MRPL10	85	55.405	ENSELUG00000008599	mrpl10	99	52.381	Esox_lucius
ENSG00000159111	MRPL10	97	86.508	ENSFCAG00000009360	MRPL10	100	86.260	Felis_catus
ENSG00000159111	MRPL10	91	76.891	ENSFDAG00000010861	MRPL10	97	76.891	Fukomys_damarensis
ENSG00000159111	MRPL10	92	50.000	ENSFHEG00000005890	mrpl10	97	49.388	Fundulus_heteroclitus
ENSG00000159111	MRPL10	87	52.609	ENSGMOG00000003023	mrpl10	100	52.609	Gadus_morhua
ENSG00000159111	MRPL10	79	55.399	ENSGALG00000014387	MRPL10	86	54.464	Gallus_gallus
ENSG00000159111	MRPL10	87	52.423	ENSGAFG00000012789	mrpl10	86	51.724	Gambusia_affinis
ENSG00000159111	MRPL10	96	49.200	ENSGACG00000003841	mrpl10	97	49.004	Gasterosteus_aculeatus
ENSG00000159111	MRPL10	100	99.262	ENSGGOG00000015353	MRPL10	100	99.262	Gorilla_gorilla
ENSG00000159111	MRPL10	85	88.889	ENSGGOG00000027672	-	95	87.931	Gorilla_gorilla
ENSG00000159111	MRPL10	92	51.452	ENSHBUG00000004903	mrpl10	97	51.020	Haplochromis_burtoni
ENSG00000159111	MRPL10	98	81.176	ENSHGLG00000014715	MRPL10	97	81.176	Heterocephalus_glaber_female
ENSG00000159111	MRPL10	98	81.176	ENSHGLG00100004621	MRPL10	97	81.176	Heterocephalus_glaber_male
ENSG00000159111	MRPL10	87	50.000	ENSHCOG00000015812	mrpl10	99	49.583	Hippocampus_comes
ENSG00000159111	MRPL10	93	53.719	ENSIPUG00000018330	mrpl10	95	53.719	Ictalurus_punctatus
ENSG00000159111	MRPL10	97	86.905	ENSSTOG00000024617	MRPL10	100	86.641	Ictidomys_tridecemlineatus
ENSG00000159111	MRPL10	100	80.534	ENSJJAG00000004046	Mrpl10	100	80.534	Jaculus_jaculus
ENSG00000159111	MRPL10	91	52.941	ENSLBEG00000010523	mrpl10	90	52.941	Labrus_bergylta
ENSG00000159111	MRPL10	90	53.617	ENSLOCG00000013385	mrpl10	71	53.617	Lepisosteus_oculatus
ENSG00000159111	MRPL10	100	85.878	ENSLAFG00000028127	MRPL10	100	85.878	Loxodonta_africana
ENSG00000159111	MRPL10	97	96.183	ENSMFAG00000030335	MRPL10	100	95.588	Macaca_fascicularis
ENSG00000159111	MRPL10	97	96.429	ENSMMUG00000021486	MRPL10	100	95.802	Macaca_mulatta
ENSG00000159111	MRPL10	97	96.429	ENSMNEG00000030905	MRPL10	100	95.802	Macaca_nemestrina
ENSG00000159111	MRPL10	97	95.635	ENSMLEG00000042780	MRPL10	100	95.038	Mandrillus_leucophaeus
ENSG00000159111	MRPL10	93	50.000	ENSMAMG00000006625	mrpl10	99	50.000	Mastacembelus_armatus
ENSG00000159111	MRPL10	92	51.452	ENSMZEG00005008005	mrpl10	97	51.020	Maylandia_zebra
ENSG00000159111	MRPL10	97	79.762	ENSMAUG00000000820	Mrpl10	100	79.008	Mesocricetus_auratus
ENSG00000159111	MRPL10	100	86.641	ENSMICG00000048091	MRPL10	100	86.641	Microcebus_murinus
ENSG00000159111	MRPL10	98	80.392	ENSMOCG00000019451	Mrpl10	97	80.392	Microtus_ochrogaster
ENSG00000159111	MRPL10	92	52.245	ENSMMOG00000000787	mrpl10	98	52.083	Mola_mola
ENSG00000159111	MRPL10	100	71.103	ENSMODG00000012477	MRPL10	100	71.103	Monodelphis_domestica
ENSG00000159111	MRPL10	91	55.042	ENSMALG00000013684	mrpl10	97	55.172	Monopterus_albus
ENSG00000159111	MRPL10	100	83.969	ENSMPUG00000015278	MRPL10	100	83.969	Mustela_putorius_furo
ENSG00000159111	MRPL10	100	83.206	ENSNGAG00000022195	Mrpl10	100	83.206	Nannospalax_galili
ENSG00000159111	MRPL10	92	51.452	ENSNBRG00000023367	mrpl10	97	51.020	Neolamprologus_brichardi
ENSG00000159111	MRPL10	100	97.786	ENSNLEG00000001803	MRPL10	100	97.786	Nomascus_leucogenys
ENSG00000159111	MRPL10	97	85.827	ENSNLEG00000034199	-	94	85.551	Nomascus_leucogenys
ENSG00000159111	MRPL10	92	76.033	ENSMEUG00000007293	-	99	76.033	Notamacropus_eugenii
ENSG00000159111	MRPL10	68	82.022	ENSOPRG00000003949	MRPL10	100	81.915	Ochotona_princeps
ENSG00000159111	MRPL10	98	78.039	ENSODEG00000017536	MRPL10	100	77.099	Octodon_degus
ENSG00000159111	MRPL10	92	51.037	ENSONIG00000018221	mrpl10	97	50.612	Oreochromis_niloticus
ENSG00000159111	MRPL10	79	72.947	ENSOANG00000006797	MRPL10	90	72.947	Ornithorhynchus_anatinus
ENSG00000159111	MRPL10	97	83.004	ENSOCUG00000009452	MRPL10	100	81.679	Oryctolagus_cuniculus
ENSG00000159111	MRPL10	92	50.826	ENSORLG00000025561	mrpl10	96	50.826	Oryzias_latipes
ENSG00000159111	MRPL10	92	50.413	ENSORLG00020021971	mrpl10	92	50.413	Oryzias_latipes_hni
ENSG00000159111	MRPL10	93	50.204	ENSORLG00015021162	mrpl10	94	50.204	Oryzias_latipes_hsok
ENSG00000159111	MRPL10	90	54.237	ENSOMEG00000000741	mrpl10	82	54.237	Oryzias_melastigma
ENSG00000159111	MRPL10	100	86.641	ENSOGAG00000006173	MRPL10	100	86.641	Otolemur_garnettii
ENSG00000159111	MRPL10	100	84.733	ENSOARG00000008051	MRPL10	100	84.733	Ovis_aries
ENSG00000159111	MRPL10	97	88.189	ENSPPAG00000028133	-	95	85.214	Pan_paniscus
ENSG00000159111	MRPL10	100	99.617	ENSPPAG00000034452	MRPL10	100	99.617	Pan_paniscus
ENSG00000159111	MRPL10	97	86.508	ENSPPRG00000001188	MRPL10	100	86.260	Panthera_pardus
ENSG00000159111	MRPL10	97	86.111	ENSPTIG00000018968	MRPL10	100	85.878	Panthera_tigris_altaica
ENSG00000159111	MRPL10	89	86.383	ENSPTRG00000047188	-	96	85.537	Pan_troglodytes
ENSG00000159111	MRPL10	100	99.631	ENSPTRG00000009337	MRPL10	100	99.631	Pan_troglodytes
ENSG00000159111	MRPL10	100	94.656	ENSPANG00000022926	MRPL10	100	94.656	Papio_anubis
ENSG00000159111	MRPL10	90	49.580	ENSPKIG00000000749	mrpl10	93	49.367	Paramormyrops_kingsleyae
ENSG00000159111	MRPL10	95	52.419	ENSPMGG00000003941	mrpl10	99	52.419	Periophthalmus_magnuspinnatus
ENSG00000159111	MRPL10	100	78.358	ENSPEMG00000014613	Mrpl10	100	78.358	Peromyscus_maniculatus_bairdii
ENSG00000159111	MRPL10	86	45.982	ENSPMAG00000008771	mrpl10	96	43.154	Petromyzon_marinus
ENSG00000159111	MRPL10	85	52.466	ENSPFOG00000018077	mrpl10	86	52.466	Poecilia_formosa
ENSG00000159111	MRPL10	85	52.466	ENSPLAG00000021066	mrpl10	86	52.466	Poecilia_latipinna
ENSG00000159111	MRPL10	85	52.466	ENSPMEG00000022090	mrpl10	86	52.466	Poecilia_mexicana
ENSG00000159111	MRPL10	62	50.920	ENSPREG00000012907	mrpl10	77	50.920	Poecilia_reticulata
ENSG00000159111	MRPL10	100	98.467	ENSPPYG00000008881	MRPL10	100	98.467	Pongo_abelii
ENSG00000159111	MRPL10	99	86.923	ENSPCOG00000025492	MRPL10	97	86.923	Propithecus_coquereli
ENSG00000159111	MRPL10	93	85.656	ENSPVAG00000004251	MRPL10	100	85.656	Pteropus_vampyrus
ENSG00000159111	MRPL10	92	50.622	ENSPNYG00000000847	mrpl10	97	50.204	Pundamilia_nyererei
ENSG00000159111	MRPL10	97	95.635	ENSRBIG00000008990	MRPL10	100	95.038	Rhinopithecus_bieti
ENSG00000159111	MRPL10	97	95.635	ENSRROG00000033938	MRPL10	100	95.038	Rhinopithecus_roxellana
ENSG00000159111	MRPL10	100	93.130	ENSSBOG00000004214	MRPL10	100	93.130	Saimiri_boliviensis_boliviensis
ENSG00000159111	MRPL10	100	70.611	ENSSHAG00000003583	MRPL10	100	70.611	Sarcophilus_harrisii
ENSG00000159111	MRPL10	92	47.521	ENSSFOG00015001414	mrpl10	95	46.888	Scleropages_formosus
ENSG00000159111	MRPL10	87	52.193	ENSSMAG00000009358	mrpl10	90	52.193	Scophthalmus_maximus
ENSG00000159111	MRPL10	94	49.796	ENSSDUG00000010218	mrpl10	97	49.388	Seriola_dumerili
ENSG00000159111	MRPL10	94	49.796	ENSSLDG00000023900	mrpl10	97	49.796	Seriola_lalandi_dorsalis
ENSG00000159111	MRPL10	61	86.164	ENSSARG00000001586	MRPL10	100	86.164	Sorex_araneus
ENSG00000159111	MRPL10	85	57.919	ENSSPUG00000017695	MRPL10	91	55.794	Sphenodon_punctatus
ENSG00000159111	MRPL10	92	48.548	ENSSPAG00000002058	mrpl10	75	48.548	Stegastes_partitus
ENSG00000159111	MRPL10	97	85.317	ENSSSCG00000017519	MRPL10	99	84.674	Sus_scrofa
ENSG00000159111	MRPL10	92	50.833	ENSTRUG00000020176	mrpl10	95	50.833	Takifugu_rubripes
ENSG00000159111	MRPL10	98	51.765	ENSTNIG00000010101	mrpl10	100	51.779	Tetraodon_nigroviridis
ENSG00000159111	MRPL10	75	82.653	ENSTBEG00000002523	MRPL10	100	82.524	Tupaia_belangeri
ENSG00000159111	MRPL10	93	84.426	ENSTTRG00000012452	MRPL10	100	84.426	Tursiops_truncatus
ENSG00000159111	MRPL10	100	84.733	ENSUAMG00000017142	MRPL10	100	84.733	Ursus_americanus
ENSG00000159111	MRPL10	100	84.351	ENSUMAG00000016024	MRPL10	100	84.351	Ursus_maritimus
ENSG00000159111	MRPL10	89	85.776	ENSVPAG00000004498	MRPL10	100	84.836	Vicugna_pacos
ENSG00000159111	MRPL10	100	85.496	ENSVVUG00000003141	MRPL10	100	85.496	Vulpes_vulpes
ENSG00000159111	MRPL10	87	51.542	ENSXCOG00000003647	mrpl10	90	51.542	Xiphophorus_couchianus
ENSG00000159111	MRPL10	87	51.101	ENSXMAG00000013700	mrpl10	90	51.101	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	-	ISS	Function
GO:0005515	protein binding	25416956.25910212.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0005762	mitochondrial large ribosomal subunit	-	ISS	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0006412	translation	-	ISS	Process
GO:0015934	large ribosomal subunit	21873635.	IBA	Component
GO:0042254	ribosome biogenesis	-	IEA	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process
GO:1990904	ribonucleoprotein complex	-	ISS	Component