EuRBPDB

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  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000159131 (Gene tree)
Gene ID
2618
Gene Symbol
GART
Alias
GARS-AIRS-GART|PRGS|PGFT
Full Name
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
39,561 bases
Position
chr21:33,503,931-33,543,491
Accession
4163
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000381839GART-2053469XM_005260941ENSP000003712611010 (aa)XP_005260998P22102
ENST00000366093GART-202805-ENSP00000409771145 (aa)-H7C366
ENST00000482663GART-215616--- (aa)--
ENST00000381815GART-2033341-ENSP000003712361010 (aa)-P22102
ENST00000381831GART-2043490XM_006723989ENSP000003712531010 (aa)XP_006724052P22102
ENST00000466882GART-212654--- (aa)--
ENST00000460305GART-211389--- (aa)--
ENST00000497313GART-218457--- (aa)--
ENST00000361093GART-2012149-ENSP00000354388433 (aa)-P22102
ENST00000467575GART-213922--- (aa)--
ENST00000438059GART-209697-ENSP00000413803138 (aa)-C9JKQ7
ENST00000430874GART-2081036-ENSP00000413040241 (aa)-C9JTV6
ENST00000487155GART-216786--- (aa)--
ENST00000424203GART-2063571-ENSP00000390003306 (aa)-F8WD69
ENST00000476524GART-214806--- (aa)--
ENST00000488791GART-217778--- (aa)--
ENST00000426819GART-207837-ENSP00000398631231 (aa)-C9JBJ1
ENST00000441403GART-210715-ENSP00000407783136 (aa)-C9JZG2
Gene Model
Click here to download ENSG00000159131's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa00670One carbon pool by folateKEGG
hsa01100Metabolic pathwaysKEGG
hsa01523Antifolate resistanceKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000159131Macular Degeneration6.963E-5-
ENSG00000159131Macular Degeneration6.963E-5-
ENSG00000159131Platelet Function Tests1.3932700E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159131's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000159131GART9958.025FBgn0000053ade39952.194Drosophila_melanogaster
ENSG00000159131GART9848.963YGL234W9945.044Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003360brainstem development-IEAProcess
GO:0004637phosphoribosylamine-glycine ligase activity21873635.IBAFunction
GO:0004637phosphoribosylamine-glycine ligase activity-TASFunction
GO:0004641phosphoribosylformylglycinamidine cyclo-ligase activity21873635.IBAFunction
GO:0004641phosphoribosylformylglycinamidine cyclo-ligase activity-TASFunction
GO:0004644phosphoribosylglycinamide formyltransferase activity-TASFunction
GO:0005524ATP binding-IEAFunction
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0006164purine nucleotide biosynthetic process21873635.IBAProcess
GO:0006189'de novo' IMP biosynthetic process-IEAProcess
GO:0006544glycine metabolic process-IEAProcess
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TASProcess
GO:0010033response to organic substance-IEAProcess
GO:0010035response to inorganic substance-IEAProcess
GO:0021549cerebellum development-IEAProcess
GO:0021987cerebral cortex development-IEAProcess
GO:0046084adenine biosynthetic process21873635.IBAProcess
GO:0046654tetrahydrofolate biosynthetic process-IEAProcess
GO:0046872metal ion binding-IEAFunction
GO:0070062extracellular exosome20458337.HDAComponent

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