EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000159140 (Gene tree)
Gene ID: 6651
Gene Symbol: SON
Alias: DBP-5|NREBP|KIAA1019|BASS1|FLJ21099|FLJ33914|C21orf50
Full Name: SON DNA binding protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 34,897 bases
Position: chr21:33,542,618-33,577,514
Accession: 11183
RBP type: canonical RBP
Summary: This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000400985	dsrm	PF00035.26	6.8e-10	1	1
ENSP00000400985	DND1_DSRM	PF14709.7	1.3e-11	1	1
ENSP00000371111	DND1_DSRM	PF14709.7	6.8e-08	1	1
ENSP00000348984	DND1_DSRM	PF14709.7	5.3e-07	1	1
ENSP00000371111	G-patch	PF01585.23	9.4e-16	1	1
ENSP00000400985	G-patch	PF01585.23	2.8e-15	1	1
ENSP00000348984	G-patch	PF01585.23	6e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20463024	Structural basis for the function of the Saccharomyces cerevisiae Gfd1 protein in mRNA nuclear export.	J Biol Chem	2010 Jul 2	Zheng C	doi: 10.1074/jbc.M110.107276
26730886	P(I) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5).	J Mol Biol	2016 Jan 29	Wong EV	doi: 10.1016/j.jmb.2015.12.018
18630756	Nuclear RNA export and its importance in abiotic stress responses of plants.	Curr Top Microbiol Immunol	2008	Chinnusamy V	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000421541	SON-205	1151	-	ENSP00000405807	343 (aa)	-	H7C2G8
ENST00000474355	SON-214	402	-	-	- (aa)	-	-
ENST00000473102	SON-213	575	-	-	- (aa)	-	-
ENST00000467616	SON-211	676	-	-	- (aa)	-	-
ENST00000491794	SON-219	995	-	-	- (aa)	-	-
ENST00000465834	SON-210	957	-	-	- (aa)	-	-
ENST00000478183	SON-217	1818	-	-	- (aa)	-	-
ENST00000455528	SON-208	8394	-	ENSP00000399783	2325 (aa)	-	P18583
ENST00000457208	SON-209	765	-	ENSP00000404135	97 (aa)	-	H7C257
ENST00000381692	SON-204	2463	-	ENSP00000371111	454 (aa)	-	J3QSZ5
ENST00000477419	SON-216	771	-	-	- (aa)	-	-
ENST00000356577	SON-202	8813	-	ENSP00000348984	2426 (aa)	-	P18583
ENST00000429093	SON-206	684	-	ENSP00000401942	92 (aa)	-	H7C1S4
ENST00000381679	SON-203	7860	-	ENSP00000371095	2108 (aa)	-	P18583
ENST00000475072	SON-215	658	-	-	- (aa)	-	-
ENST00000300278	SON-201	7477	-	ENSP00000300278	2303 (aa)	-	P18583
ENST00000484294	SON-218	500	-	-	- (aa)	-	-
ENST00000470533	SON-212	798	-	-	- (aa)	-	-
ENST00000492229	SON-220	306	-	-	- (aa)	-	-
ENST00000436227	SON-207	5269	-	ENSP00000400985	1454 (aa)	-	H7C1M2

Gene Model

Click here to download ENSG00000159140's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000159140	Child Development Disorders, Pervasive	9.2000000E-005	-
ENSG00000159140	Child Development Disorders, Pervasive	8.8000000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000159140	rs2070389	21	33557116	T	Educational attainment (MTAG)	30038396	[0.0056-0.0114] unit increase	0.0085	EFO_0004784
ENSG00000159140	rs61739710	21	33553383	A	Educational attainment (years of education)	30038396	[0.0068-0.013] unit decrease	0.0099	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159140's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000159140	SON	100	98.660	ENSAMEG00000014868	SON	79	78.583	Ailuropoda_melanoleuca
ENSG00000159140	SON	82	60.000	ENSACIG00000017870	-	94	64.356	Amphilophus_citrinellus
ENSG00000159140	SON	82	61.333	ENSATEG00000012732	-	58	53.470	Anabas_testudineus
ENSG00000159140	SON	93	73.349	ENSAPLG00000008908	-	91	76.087	Anas_platyrhynchos
ENSG00000159140	SON	99	73.068	ENSACAG00000004681	-	99	76.280	Anolis_carolinensis
ENSG00000159140	SON	100	100.000	ENSANAG00000035426	SON	100	100.000	Aotus_nancymaae
ENSG00000159140	SON	82	60.000	ENSACLG00000007098	-	88	50.898	Astatotilapia_calliptera
ENSG00000159140	SON	92	99.045	ENSBTAG00000008482	SON	76	85.292	Bos_taurus
ENSG00000159140	SON	100	98.678	ENSCJAG00000046975	SON	100	98.780	Callithrix_jacchus
ENSG00000159140	SON	100	98.660	ENSCAFG00000032306	-	79	87.952	Canis_familiaris
ENSG00000159140	SON	100	98.660	ENSCAFG00000009106	-	79	88.530	Canis_familiaris
ENSG00000159140	SON	100	98.678	ENSCAFG00020025305	SON	100	98.928	Canis_lupus_dingo
ENSG00000159140	SON	100	98.391	ENSCHIG00000022392	SON	79	85.974	Capra_hircus
ENSG00000159140	SON	100	98.391	ENSTSYG00000008371	SON	100	98.391	Carlito_syrichta
ENSG00000159140	SON	95	94.462	ENSCAPG00000017011	SON	82	94.309	Cavia_aperea
ENSG00000159140	SON	100	98.018	ENSCPOG00000024278	SON	100	98.928	Cavia_porcellus
ENSG00000159140	SON	100	100.000	ENSCCAG00000030234	SON	100	100.000	Cebus_capucinus
ENSG00000159140	SON	100	100.000	ENSCATG00000029812	SON	100	100.000	Cercocebus_atys
ENSG00000159140	SON	100	98.238	ENSCLAG00000011776	SON	100	98.928	Chinchilla_lanigera
ENSG00000159140	SON	93	99.686	ENSCSAG00000009823	SON	100	97.771	Chlorocebus_sabaeus
ENSG00000159140	SON	81	40.214	ENSCING00000007049	-	86	43.164	Ciona_intestinalis
ENSG00000159140	SON	100	100.000	ENSCANG00000025986	SON	100	100.000	Colobus_angolensis_palliatus
ENSG00000159140	SON	100	97.137	ENSCGRG00001016220	Son	100	98.660	Cricetulus_griseus_chok1gshd
ENSG00000159140	SON	94	97.664	ENSCGRG00000015260	Son	100	98.660	Cricetulus_griseus_crigri
ENSG00000159140	SON	98	97.808	ENSDNOG00000036246	SON	78	84.878	Dasypus_novemcinctus
ENSG00000159140	SON	100	98.238	ENSDORG00000028617	-	100	98.928	Dipodomys_ordii
ENSG00000159140	SON	82	98.667	ENSETEG00000019427	SON	83	98.326	Echinops_telfairi
ENSG00000159140	SON	100	98.780	ENSEASG00005006195	SON	78	86.705	Equus_asinus_asinus
ENSG00000159140	SON	98	98.780	ENSECAG00000018098	SON	78	89.781	Equus_caballus
ENSG00000159140	SON	82	100.000	ENSEEUG00000002352	SON	75	99.034	Erinaceus_europaeus
ENSG00000159140	SON	82	64.000	ENSELUG00000003878	-	73	61.832	Esox_lucius
ENSG00000159140	SON	100	98.899	ENSFCAG00000028680	-	100	98.928	Felis_catus
ENSG00000159140	SON	95	71.526	ENSFALG00000002365	-	95	76.019	Ficedula_albicollis
ENSG00000159140	SON	100	97.797	ENSFDAG00000019128	SON	100	98.660	Fukomys_damarensis
ENSG00000159140	SON	97	73.864	ENSGALG00000052354	-	98	76.323	Gallus_gallus
ENSG00000159140	SON	100	99.119	ENSGGOG00000010481	SON	100	100.000	Gorilla_gorilla
ENSG00000159140	SON	100	98.018	ENSHGLG00000010432	SON	100	98.928	Heterocephalus_glaber_female
ENSG00000159140	SON	82	100.000	ENSHGLG00100014915	SON	77	83.987	Heterocephalus_glaber_male
ENSG00000159140	SON	100	98.018	ENSSTOG00000020593	SON	100	98.928	Ictidomys_tridecemlineatus
ENSG00000159140	SON	100	98.018	ENSJJAG00000013491	-	100	98.660	Jaculus_jaculus
ENSG00000159140	SON	98	65.934	ENSLACG00000013385	-	91	69.624	Latimeria_chalumnae
ENSG00000159140	SON	82	66.667	ENSLOCG00000011021	-	75	65.842	Lepisosteus_oculatus
ENSG00000159140	SON	100	98.396	ENSLAFG00000016307	SON	56	98.660	Loxodonta_africana
ENSG00000159140	SON	100	100.000	ENSMFAG00000034427	SON	100	100.000	Macaca_fascicularis
ENSG00000159140	SON	100	99.119	ENSMMUG00000005511	SON	100	100.000	Macaca_mulatta
ENSG00000159140	SON	100	100.000	ENSMNEG00000031671	SON	100	100.000	Macaca_nemestrina
ENSG00000159140	SON	100	100.000	ENSMLEG00000035039	SON	100	100.000	Mandrillus_leucophaeus
ENSG00000159140	SON	80	71.351	ENSMGAG00000014526	-	95	72.488	Meleagris_gallopavo
ENSG00000159140	SON	100	97.357	ENSMAUG00000002086	-	100	98.660	Mesocricetus_auratus
ENSG00000159140	SON	100	98.780	ENSMICG00000033920	SON	100	98.780	Microcebus_murinus
ENSG00000159140	SON	100	97.137	ENSMOCG00000012860	-	100	98.660	Microtus_ochrogaster
ENSG00000159140	SON	100	97.587	ENSMODG00000021061	SON	54	97.849	Monodelphis_domestica
ENSG00000159140	SON	82	61.333	ENSMALG00000006263	-	91	53.106	Monopterus_albus
ENSG00000159140	SON	100	98.391	MGP_CAROLIEiJ_G0020965	Son	100	98.391	Mus_caroli
ENSG00000159140	SON	100	98.391	ENSMUSG00000022961	Son	100	98.391	Mus_musculus
ENSG00000159140	SON	100	98.391	MGP_PahariEiJ_G0016670	Son	100	98.391	Mus_pahari
ENSG00000159140	SON	100	98.391	MGP_SPRETEiJ_G0021871	Son	100	98.391	Mus_spretus
ENSG00000159140	SON	98	98.082	ENSMPUG00000001290	SON	78	86.873	Mustela_putorius_furo
ENSG00000159140	SON	100	98.123	ENSMLUG00000002449	SON	79	85.357	Myotis_lucifugus
ENSG00000159140	SON	100	97.357	ENSNGAG00000000062	-	100	98.391	Nannospalax_galili
ENSG00000159140	SON	100	100.000	ENSNLEG00000004002	SON	100	100.000	Nomascus_leucogenys
ENSG00000159140	SON	100	98.928	ENSOPRG00000005068	SON	96	99.041	Ochotona_princeps
ENSG00000159140	SON	100	97.797	ENSODEG00000003658	-	100	98.928	Octodon_degus
ENSG00000159140	SON	82	58.667	ENSONIG00000003775	-	79	57.393	Oreochromis_niloticus
ENSG00000159140	SON	99	98.928	ENSOCUG00000003867	SON	79	84.691	Oryctolagus_cuniculus
ENSG00000159140	SON	90	47.101	ENSORLG00020014016	-	91	47.101	Oryzias_latipes_hni
ENSG00000159140	SON	82	62.667	ENSORLG00015016415	-	78	50.234	Oryzias_latipes_hsok
ENSG00000159140	SON	82	100.000	ENSOGAG00000027319	SON	82	89.276	Otolemur_garnettii
ENSG00000159140	SON	98	97.808	ENSOARG00000013038	SON	78	84.052	Ovis_aries
ENSG00000159140	SON	100	99.119	ENSPPAG00000033712	SON	100	100.000	Pan_paniscus
ENSG00000159140	SON	100	98.899	ENSPPRG00000019353	SON	100	98.928	Panthera_pardus
ENSG00000159140	SON	100	98.899	ENSPTIG00000017100	SON	100	98.928	Panthera_tigris_altaica
ENSG00000159140	SON	100	99.119	ENSPTRG00000052356	-	100	100.000	Pan_troglodytes
ENSG00000159140	SON	100	100.000	ENSPTRG00000013872	SON	100	100.000	Pan_troglodytes
ENSG00000159140	SON	100	100.000	ENSPANG00000024077	SON	100	100.000	Papio_anubis
ENSG00000159140	SON	96	73.077	ENSPSIG00000008097	-	91	77.174	Pelodiscus_sinensis
ENSG00000159140	SON	82	62.667	ENSPMGG00000015598	-	93	51.566	Periophthalmus_magnuspinnatus
ENSG00000159140	SON	100	96.696	ENSPCIG00000012884	-	100	97.319	Phascolarctos_cinereus
ENSG00000159140	SON	98	100.000	ENSPPYG00000011380	SON	98	98.511	Pongo_abelii
ENSG00000159140	SON	93	98.428	ENSPCAG00000010170	SON	55	99.104	Procavia_capensis
ENSG00000159140	SON	100	98.780	ENSPCOG00000015502	SON	100	98.780	Propithecus_coquereli
ENSG00000159140	SON	100	99.196	ENSPVAG00000011186	SON	75	89.060	Pteropus_vampyrus
ENSG00000159140	SON	100	98.391	ENSRNOG00000002021	Son	79	82.709	Rattus_norvegicus
ENSG00000159140	SON	100	99.119	ENSRBIG00000044269	-	100	100.000	Rhinopithecus_bieti
ENSG00000159140	SON	100	100.000	ENSRROG00000042156	SON	100	100.000	Rhinopithecus_roxellana
ENSG00000159140	SON	100	100.000	ENSSBOG00000020885	SON	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000159140	SON	100	93.902	ENSSHAG00000008266	SON	93	89.488	Sarcophilus_harrisii
ENSG00000159140	SON	100	96.552	ENSSARG00000012369	SON	73	89.417	Sorex_araneus
ENSG00000159140	SON	100	98.391	ENSSSCG00000023674	SON	79	87.844	Sus_scrofa
ENSG00000159140	SON	95	69.932	ENSTGUG00000000486	-	91	72.554	Taeniopygia_guttata
ENSG00000159140	SON	98	52.980	ENSTNIG00000014468	-	98	52.980	Tetraodon_nigroviridis
ENSG00000159140	SON	92	99.369	ENSTBEG00000003193	SON	76	99.595	Tupaia_belangeri
ENSG00000159140	SON	94	98.182	ENSTTRG00000004692	SON	76	90.021	Tursiops_truncatus
ENSG00000159140	SON	99	97.561	ENSUAMG00000015025	SON	80	87.797	Ursus_americanus
ENSG00000159140	SON	100	98.660	ENSUMAG00000020052	SON	80	85.707	Ursus_maritimus
ENSG00000159140	SON	94	96.515	ENSVPAG00000009150	SON	55	96.535	Vicugna_pacos
ENSG00000159140	SON	98	97.561	ENSVVUG00000022974	SON	80	86.950	Vulpes_vulpes
ENSG00000159140	SON	80	71.196	ENSXETG00000014115	son	94	69.324	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	21504830.	IMP	Process
GO:0000281	mitotic cytokinesis	21504830.	IMP	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	21504830.	IDA	Function
GO:0005515	protein binding	21504830.	IPI	Function
GO:0006397	mRNA processing	21873635.	IBA	Process
GO:0006397	mRNA processing	21504830.	IDA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016607	nuclear speck	21504830.	IDA	Component
GO:0043066	negative regulation of apoptotic process	10509013.	IDA	Process
GO:0043484	regulation of RNA splicing	27545680.	IMP	Process
GO:0048024	regulation of mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0048024	regulation of mRNA splicing, via spliceosome	21504830.	IDA	Process
GO:0050733	RS domain binding	-	IEA	Function
GO:0051726	regulation of cell cycle	21504830.	IMP	Process