EuRBPDB

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  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000159176 (Gene tree)
Gene ID
1465
Gene Symbol
CSRP1
Alias
CSRP|D1S181E|CYRP
Full Name
cysteine and glycine rich protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
25,927 bases
Position
chr1:201,483,530-201,509,456
Accession
2469
RBP type
non-canonical RBP
Summary
This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22385657Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis.Cell Stem Cell2012 Mar 2Wagner DEdoi: 10.1016/j.stem.2012.01.016.
12391883[Functional interrelationship between elements of the Escherichia coli udp gene promotor responsible for binding regulatory proteins CytR, CRP, and RNA polymerase].Genetika2002 SepZolotukhina MA-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000458271CSRP1-2031324--- (aa)--
ENST00000531916CSRP1-214890-ENSP00000432110153 (aa)-E9PS42
ENST00000533432CSRP1-2191149-ENSP00000436792193 (aa)-P21291
ENST00000533402CSRP1-2188475--- (aa)--
ENST00000529975CSRP1-212548--- (aa)--
ENST00000533188CSRP1-217581--- (aa)--
ENST00000471596CSRP1-204758--- (aa)--
ENST00000524951CSRP1-206582-ENSP00000437218153 (aa)-E9PND2
ENST00000340006CSRP1-2011952-ENSP00000345079193 (aa)-P21291
ENST00000526723CSRP1-209574-ENSP00000436491160 (aa)-E9PP21
ENST00000527662CSRP1-2114208--- (aa)--
ENST00000532313CSRP1-2155239--- (aa)--
ENST00000526317CSRP1-208374--- (aa)--
ENST00000367306CSRP1-2022129-ENSP00000356275193 (aa)-P21291
ENST00000481851CSRP1-205741--- (aa)--
ENST00000526256CSRP1-207582-ENSP0000048386417 (aa)-A0A087X134
ENST00000530120CSRP1-213568--- (aa)--
ENST00000527573CSRP1-210567--- (aa)--
ENST00000532460CSRP1-2161469-ENSP00000434147193 (aa)-P21291
Gene Model
Click here to download ENSG00000159176's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000159176Personality9.344e-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159176's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000159176CSRP110099.482ENSMUSG00000026421Csrp110099.482Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005634nucleus26924529.IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0008270zinc ion binding1374386.TASFunction
GO:0070062extracellular exosome19056867.HDAComponent
GO:0070527platelet aggregation23382103.HMPProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17486081Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer.Oncogene2007 Oct 4Wang Q-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1201490297Missense_MutationnovelE54K0.22
BRCAchr1201486937Intronnovel0.31
BRCAchr1201496299Missense_MutationnovelP2R0.19
BRCAchr1201488878Nonsense_MutationNAE130*0.2
BRCAchr1201496262SilentnovelQ14Q0.25
BRCAchr1201490391Intronnovel0.24
CESCchr1201484770Silentrs565400818F175F0.5
CESCchr12014842483'UTRnovel0.36
CESCchr1201488883Missense_MutationnovelA128V0.1
CESCchr12014845483'UTRnovel0.16
CHOLchr1201486885Intronnovel0.24
COADchr1201488880Missense_Mutationrs760988527A129V0.26
COADchr1201490229Silentrs554244394G76G0.39
COADchr1201490443IntronNA0.31
COADchr1201485283Nonsense_MutationNAG169*0.26
COADchr12014846663'UTRrs7691108380.45
COADchr1201490197Missense_MutationNAS87L0.23
COADchr1201486920Intronnovel0.27
ESCAchr12014844293'UTRnovel0.34
GBMchr1201496205SilentnovelS33S0.32
GBMchr1201490260Missense_MutationnovelY66F0.11
HNSCchr1201496280Missense_MutationnovelK8N0.17
LUADchr1201485313Missense_MutationnovelA159T0.13
LUADchr12014846513'UTRnovel0.24
LUADchr1201484764SilentnovelP177P0.42
LUADchr1201496287Missense_MutationnovelG6E0.08
LUSCchr1201488888SilentnovelV126V0.17
LUSCchr1201488984Missense_MutationNAE94D0.19
LUSCchr1201496237Missense_MutationnovelV23I0.19
LUSCchr12014846143'UTRnovel0.67
OVchr1201496206Missense_MutationnovelS33F0.06
OVchr1201496221Missense_MutationnovelN28I0.15
OVchr1201490345Splice_SitenovelX38_splice0.06
READchr1201485355Nonsense_Mutationrs772065755R145*0.57
READchr1201490289Missense_MutationNAI56M0.41
SKCMchr1201496275Missense_MutationNAC10S0.28
SKCMchr1201484764SilentnovelP177P0.51
SKCMchr1201484765Missense_MutationnovelP177L0.51
SKCMchr1201484725SilentNAV190V0.34
SKCMchr1201485355Nonsense_Mutationrs772065755R145*0.46
STADchr1201485365Missense_MutationnovelK141N0.1
UCECchr1201490238Silentrs746313859Y73Y0.55
UCECchr1201488871Missense_MutationnovelV132A0.45
UCECchr1201486798Intronnovel0.2
UCECchr1201490181Silentrs143052124H92H0.26
UCECchr1201496229Silentrs149370653C25C0.2
UCECchr1201485306Missense_MutationnovelK161T0.46
UCECchr1201486840Intronnovel0.39
UCECchr1201490200Missense_Mutationrs754606251E86V0.39
UCECchr1201496298Silentrs754308439P2P0.18
UCECchr1201484770Silentrs565400818F175F0.24
UCECchr1201486961Intronnovel0.08
UCECchr1201486923Intronnovel0.25
UCECchr1201486898Intronnovel0.39
UCECchr1201490425Intronnovel0.38
UCECchr1201496229Silentrs149370653C25C0.11
UCECchr1201490488Intronnovel0.31
UCECchr1201485299Silentrs202219604G163G0.45
UCECchr1201490401Intronnovel0.39

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.11270.033566
DLBCDEL0.04170.0017831
KIRCAMP0.08520.059566
READAMP0.26670.14328
TGCTAMP0.35330.088103
THCAAMP0.04810.075436

Survival Analysis
CancerP-value Q-value
SARC0.0001

Kaplan-Meier Survival Analysis

MESO0.021

Kaplan-Meier Survival Analysis

HNSC0.00019

Kaplan-Meier Survival Analysis

SKCM0.012

Kaplan-Meier Survival Analysis

LUSC0.02

Kaplan-Meier Survival Analysis

BRCA0.044

Kaplan-Meier Survival Analysis

KIRP0.014

Kaplan-Meier Survival Analysis

BLCA0.0029

Kaplan-Meier Survival Analysis

UCEC0.03

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.023

Kaplan-Meier Survival Analysis

UVM0.0063

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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