EuRBPDB

Description

Ensembl ID: ENSG00000159593 (Gene tree)
Gene ID: 8883
Gene Symbol: NAE1
Alias: ula-1|APP-BP1|APPBP1
Full Name: NEDD8 activating enzyme E1 subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 70,382 bases
Position: chr16:66,802,875-66,873,256
Accession: 621
RBP type: non-canonical RBP
Summary: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000561579	NAE1-205	728	-	ENSP00000464119	124 (aa)	-	J3QRA5
ENST00000290810	NAE1-201	1837	-	ENSP00000290810	534 (aa)	-	Q13564
ENST00000562428	NAE1-207	473	-	ENSP00000463546	112 (aa)	-	J3QLH4
ENST00000569963	NAE1-222	719	-	-	- (aa)	-	-
ENST00000566336	NAE1-215	686	-	ENSP00000462040	162 (aa)	-	J3KRK3
ENST00000564040	NAE1-213	536	-	-	- (aa)	-	-
ENST00000565535	NAE1-214	580	-	ENSP00000455967	167 (aa)	-	H3BQW6
ENST00000562074	NAE1-206	571	-	-	- (aa)	-	-
ENST00000563221	NAE1-210	532	-	-	- (aa)	-	-
ENST00000566663	NAE1-216	576	-	ENSP00000462937	129 (aa)	-	J3KTE3
ENST00000563419	NAE1-212	649	-	-	- (aa)	-	-
ENST00000359087	NAE1-202	1825	-	ENSP00000351990	537 (aa)	-	Q13564
ENST00000567743	NAE1-218	1460	-	ENSP00000455562	25 (aa)	-	H3BQ16
ENST00000563253	NAE1-211	566	-	ENSP00000454471	23 (aa)	-	H3BMN8
ENST00000394074	NAE1-204	1654	XM_005256215	ENSP00000377637	445 (aa)	XP_005256272	Q13564
ENST00000567521	NAE1-217	765	-	-	- (aa)	-	-
ENST00000569388	NAE1-221	562	-	ENSP00000456847	85 (aa)	-	H3BSS8
ENST00000568672	NAE1-219	523	-	-	- (aa)	-	-
ENST00000563185	NAE1-209	401	-	ENSP00000454506	109 (aa)	-	H3BMR3
ENST00000569348	NAE1-220	567	-	ENSP00000456564	64 (aa)	-	H3BS69
ENST00000562757	NAE1-208	585	-	-	- (aa)	-	-
ENST00000379463	NAE1-203	1909	-	ENSP00000368776	528 (aa)	-	Q13564

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa05010	Alzheimer disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000159593	Blood Pressure	6.8050755579474E-5	17903302
ENSG00000159593	Blood Vessels	9.19147722232086E-5	17903301

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	8626687.10722740.12694406.14557245.15361859.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0007165	signal transduction	8626687.	TAS	Process
GO:0019781	NEDD8 activating enzyme activity	21873635.	IBA	Function
GO:0019781	NEDD8 activating enzyme activity	12740388.	IDA	Function
GO:0031625	ubiquitin protein ligase binding	18627766.	IPI	Function
GO:0032446	protein modification by small protein conjugation	21873635.	IBA	Process
GO:0032991	protein-containing complex	12740388.	IDA	Component
GO:0033314	mitotic DNA replication checkpoint	10722740.	IDA	Process
GO:0042981	regulation of apoptotic process	14557245.	IDA	Process
GO:0042981	regulation of apoptotic process	10722740.	IMP	Process
GO:0043523	regulation of neuron apoptotic process	10722740.	IDA	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045116	protein neddylation	21873635.	IBA	Process
GO:0045116	protein neddylation	10207026.12740388.	IDA	Process
GO:0045116	protein neddylation	-	IEA	Process
GO:0046982	protein heterodimerization activity	12740388.	IPI	Function
GO:0051402	neuron apoptotic process	14557245.	IDA	Process