EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000159915 (Gene tree)
Gene ID: 353355
Gene Symbol: ZNF233
Alias: FLJ38032
Full Name: zinc finger protein 233
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 15,438 bases
Position: chr19:44,259,880-44,275,317
Accession: 30946
RBP type: canonical RBP
Summary: ZNF233 (Zinc Finger Protein 233) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF285.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000375820	zf-C2H2	PF00096.26	6.9e-38	1	6
ENSP00000375820	zf-C2H2	PF00096.26	6.9e-38	2	6
ENSP00000375820	zf-C2H2	PF00096.26	6.9e-38	3	6
ENSP00000375820	zf-C2H2	PF00096.26	6.9e-38	4	6
ENSP00000375820	zf-C2H2	PF00096.26	6.9e-38	5	6
ENSP00000375820	zf-C2H2	PF00096.26	6.9e-38	6	6
ENSP00000375820	zf-met	PF12874.7	2.2e-05	1	2
ENSP00000375820	zf-met	PF12874.7	2.2e-05	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000588489	ZNF233-202	528	XM_017026761	ENSP00000465136	116 (aa)	XP_016882250	K7EJE5
ENST00000590668	ZNF233-204	574	-	ENSP00000466781	162 (aa)	-	K7EN46
ENST00000391958	ZNF233-201	2784	XM_024451489	ENSP00000375820	670 (aa)	XP_024307257	A6NK53
ENST00000589522	ZNF233-203	1120	-	ENSP00000465307	83 (aa)	-	K7EJT0
ENST00000592581	ZNF233-205	2938	XM_017026758	ENSP00000468154	140 (aa)	XP_016882247	K7ER86

Gene Model

Click here to download ENSG00000159915's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05168	Herpes simplex virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159915's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000159915	ZNF233	95	79.747	ENSAMEG00000006122	ZNF233	98	71.233	Ailuropoda_melanoleuca
ENSG00000159915	ZNF233	99	92.801	ENSCATG00000015076	ZNF233	98	92.801	Cercocebus_atys
ENSG00000159915	ZNF233	98	94.198	ENSCSAG00000003326	ZNF233	99	94.163	Chlorocebus_sabaeus
ENSG00000159915	ZNF233	99	64.114	ENSCHOG00000010443	ZNF233	98	64.231	Choloepus_hoffmanni
ENSG00000159915	ZNF233	100	93.284	ENSCANG00000032081	ZNF233	98	93.607	Colobus_angolensis_palliatus
ENSG00000159915	ZNF233	98	50.968	ENSCGRG00000015809	-	99	51.140	Cricetulus_griseus_crigri
ENSG00000159915	ZNF233	91	42.122	ENSCGRG00000015629	-	95	42.071	Cricetulus_griseus_crigri
ENSG00000159915	ZNF233	99	75.228	ENSDNOG00000038729	ZNF233	99	75.229	Dasypus_novemcinctus
ENSG00000159915	ZNF233	61	51.190	ENSFALG00000009044	-	100	51.190	Ficedula_albicollis
ENSG00000159915	ZNF233	89	97.306	ENSGGOG00000013940	ZNF233	98	97.306	Gorilla_gorilla
ENSG00000159915	ZNF233	100	90.179	ENSMFAG00000039215	ZNF233	99	90.895	Macaca_fascicularis
ENSG00000159915	ZNF233	100	90.179	ENSMMUG00000012797	ZNF233	99	90.895	Macaca_mulatta
ENSG00000159915	ZNF233	68	51.515	ENSMZEG00005024630	-	96	51.515	Maylandia_zebra
ENSG00000159915	ZNF233	99	81.089	ENSMICG00000016725	ZNF233	98	80.974	Microcebus_murinus
ENSG00000159915	ZNF233	89	52.247	MGP_CAROLIEiJ_G0029327	Zfp93	99	52.247	Mus_caroli
ENSG00000159915	ZNF233	99	45.359	MGP_CAROLIEiJ_G0029326	Zfp108	99	47.283	Mus_caroli
ENSG00000159915	ZNF233	99	46.619	MGP_CAROLIEiJ_G0029322	Zfp235	100	50.351	Mus_caroli
ENSG00000159915	ZNF233	99	46.619	ENSMUSG00000047603	Zfp235	100	50.351	Mus_musculus
ENSG00000159915	ZNF233	99	49.361	ENSMUSG00000030486	Zfp108	100	50.784	Mus_musculus
ENSG00000159915	ZNF233	60	82.000	ENSMUSG00000068962	Zfp114	99	45.000	Mus_musculus
ENSG00000159915	ZNF233	99	52.247	ENSMUSG00000055305	Zfp93	99	52.247	Mus_musculus
ENSG00000159915	ZNF233	99	45.492	MGP_PahariEiJ_G0021173	Zfp235	100	51.084	Mus_pahari
ENSG00000159915	ZNF233	99	47.826	MGP_PahariEiJ_G0021177	Zfp108	99	47.826	Mus_pahari
ENSG00000159915	ZNF233	87	45.777	MGP_PahariEiJ_G0021178	Zfp93	95	54.124	Mus_pahari
ENSG00000159915	ZNF233	69	53.041	MGP_SPRETEiJ_G0030421	-	99	53.202	Mus_spretus
ENSG00000159915	ZNF233	99	49.616	MGP_SPRETEiJ_G0030420	Zfp108	100	48.098	Mus_spretus
ENSG00000159915	ZNF233	99	46.619	MGP_SPRETEiJ_G0030416	Zfp235	100	50.351	Mus_spretus
ENSG00000159915	ZNF233	96	46.784	MGP_SPRETEiJ_G0030417	Zfp114	99	46.175	Mus_spretus
ENSG00000159915	ZNF233	69	54.144	ENSORLG00015017539	-	83	56.842	Oryzias_latipes_hsok
ENSG00000159915	ZNF233	90	86.667	ENSOGAG00000001912	ZNF233	100	75.535	Otolemur_garnettii
ENSG00000159915	ZNF233	100	97.531	ENSPPAG00000030145	ZNF233	100	97.015	Pan_paniscus
ENSG00000159915	ZNF233	100	98.765	ENSPTRG00000011111	ZNF233	100	97.463	Pan_troglodytes
ENSG00000159915	ZNF233	98	93.303	ENSPANG00000010670	ZNF233	98	93.303	Papio_anubis
ENSG00000159915	ZNF233	99	55.970	ENSPEMG00000018022	-	100	56.030	Peromyscus_maniculatus_bairdii
ENSG00000159915	ZNF233	100	94.444	ENSPPYG00000010085	ZNF233	93	95.282	Pongo_abelii
ENSG00000159915	ZNF233	97	79.784	ENSPCOG00000015292	ZNF233	98	79.908	Propithecus_coquereli
ENSG00000159915	ZNF233	95	65.823	ENSPVAG00000004388	ZNF233	98	53.139	Pteropus_vampyrus
ENSG00000159915	ZNF233	99	94.251	ENSRBIG00000035218	ZNF233	99	94.216	Rhinopithecus_bieti
ENSG00000159915	ZNF233	98	94.064	ENSRROG00000030619	ZNF233	98	94.064	Rhinopithecus_roxellana
ENSG00000159915	ZNF233	100	74.074	ENSTTRG00000011818	ZNF233	98	73.556	Tursiops_truncatus
ENSG00000159915	ZNF233	89	69.983	ENSUMAG00000023065	ZNF233	98	69.779	Ursus_maritimus
ENSG00000159915	ZNF233	95	73.418	ENSVPAG00000007465	ZNF233	100	67.643	Vicugna_pacos
ENSG00000159915	ZNF233	65	51.955	ENSXMAG00000027300	-	57	52.841	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	44273989	Silent	NA	Q443Q	0.28
BLCA	chr19	44266198	Nonsense_Mutation	novel	E6*	0.19
BLCA	chr19	44273234	Missense_Mutation	novel	Q192K	0.13
BLCA	chr19	44274718	3'UTR	novel		0.15
BLCA	chr19	44274257	Missense_Mutation	NA	E533Q	0.13
BLCA	chr19	44267023	Intron	novel		0.11
BLCA	chr19	44273245	Silent	novel	Q195Q	0.13
BLCA	chr19	44273816	Missense_Mutation	novel	D386N	0.19
BLCA	chr19	44273268	Missense_Mutation	NA	V203A	0.39
BRCA	chr19	44266289	Missense_Mutation	novel	V36A	0.06
BRCA	chr19	44266285	Missense_Mutation	NA	D35N	0.26
BRCA	chr19	44266910	Missense_Mutation	novel	E63Q	0.06
BRCA	chr19	44274505	Silent	rs751008846	T615T	0.22
BRCA	chr19	44274021	Missense_Mutation	novel	C454Y	0.1
BRCA	chr19	44273688	Missense_Mutation	novel	R343K	0.04
CESC	chr19	44274089	Missense_Mutation	NA	E477Q	0.18
CESC	chr19	44259989	5'UTR	novel		0.79
CESC	chr19	44273273	Missense_Mutation	novel	N205H	0.2
CESC	chr19	44273636	Missense_Mutation	NA	G326S	0.28
CESC	chr19	44273441	Missense_Mutation	NA	D261H	0.52
CESC	chr19	44273949	Missense_Mutation	novel	V430A	0.45
COAD	chr19	44273240	Missense_Mutation	novel	Y194H	0.39
COAD	chr19	44273787	Missense_Mutation	novel	G376E	0.25
COAD	chr19	44273167	Frame_Shift_Del	NA	*N171Ifs6**	0.29
COAD	chr19	44274427	Silent	NA	E589E	0.16
COAD	chr19	44266922	Missense_Mutation	rs372189870	R67W	0.24
COAD	chr19	44273043	Missense_Mutation	novel	G128D	0.33
COAD	chr19	44272918	Silent	NA	E86E	0.3
COAD	chr19	44273599	Nonsense_Mutation	NA	C313*	0.3
COAD	chr19	44267060	Intron	novel		0.27
DLBC	chr19	44273706	Missense_Mutation	rs569951523	R349Q	0.3
ESCA	chr19	44273086	Silent	novel	Q142Q	0.42
ESCA	chr19	44259994	5'UTR	novel		0.32
GBM	chr19	44274311	Missense_Mutation	novel	L551F	0.38
GBM	chr19	44274471	Missense_Mutation	novel	N604T	0.47
GBM	chr19	44273913	Missense_Mutation	NA	R418K	0.13
GBM	chr19	44264332	5'UTR	novel		0.16
GBM	chr19	44274586	Missense_Mutation	novel	H642Q	0.06
HNSC	chr19	44274023	Missense_Mutation	novel	E455K	0.16
HNSC	chr19	44274505	Silent	novel	T615T	0.39
HNSC	chr19	44273706	Missense_Mutation	rs569951523	R349Q	0.32
HNSC	chr19	44273707	Silent	NA	R349R	0.33
HNSC	chr19	44273358	Missense_Mutation	novel	A233D	0.26
HNSC	chr19	44272979	Nonsense_Mutation	novel	Q107*	0.14
HNSC	chr19	44274597	Missense_Mutation	novel	K646T	0.42
HNSC	chr19	44264325	5'UTR	novel		0.32
HNSC	chr19	44274365	Missense_Mutation	novel	C569R	0.06
HNSC	chr19	44273602	Silent	rs768613329	Y314Y	0.47
HNSC	chr19	44273047	Silent	novel	K129K	0.12
KIRC	chr19	44266989	Intron	novel		0.24
KIRC	chr19	44273137	Missense_Mutation	NA	I159M	0.33
KIRC	chr19	44273952	Frame_Shift_Ins	novel	*D432Sfs2**	0.06
LAML	chr19	44273263	Missense_Mutation	novel	I201M	0.24
LAML	chr19	44273435	Missense_Mutation	novel	T259S	0.14
LUAD	chr19	44272899	Missense_Mutation	NA	G80E	0.23
LUAD	chr19	44266991	Intron	rs750523558		0.26
LUAD	chr19	44273589	Missense_Mutation	novel	G310E	0.24
LUAD	chr19	44274476	Missense_Mutation	novel	Y606N	0.32
LUAD	chr19	44274718	3'UTR	novel		0.18
LUAD	chr19	44273439	Missense_Mutation	novel	S260F	0.22
LUAD	chr19	44274235	Silent	novel	A525A	0.11
LUAD	chr19	44274413	Missense_Mutation	novel	V585I	0.23
LUAD	chr19	44274718	3'UTR	novel		0.3
LUAD	chr19	44273841	Missense_Mutation	NA	G394A	0.16
LUAD	chr19	44267052	Intron	novel		0.47
LUAD	chr19	44274575	Missense_Mutation	novel	Q639K	0.26
LUAD	chr19	44274411	Missense_Mutation	NA	R584K	0.2
LUAD	chr19	44273888	Missense_Mutation	NA	T410P	0.13
LUSC	chr19	44272916	Missense_Mutation	novel	E86K	0.22
LUSC	chr19	44273318	Missense_Mutation	novel	H220N	0.27
LUSC	chr19	44273394	Missense_Mutation	rs752172996	K245T	0.27
LUSC	chr19	44273728	Nonsense_Mutation	NA	C356*	0.13
LUSC	chr19	44273087	Missense_Mutation	novel	V143M	0.42
OV	chr19	44274530	Missense_Mutation	NA	M624L	0.1
OV	chr19	44274225	Missense_Mutation	novel	H522P	0.09
PAAD	chr19	44274040	Silent	novel	G460G	0.19
PRAD	chr19	44273847	Missense_Mutation	NA	R396T	0.63
PRAD	chr19	44273773	Silent	rs761278530	T371T	0.51
READ	chr19	44274306	Missense_Mutation	rs200116301	S549L	0.33
READ	chr19	44274474	Missense_Mutation	novel	S605L	0.36
READ	chr19	44274603	Missense_Mutation	NA	Y648C	0.11
SARC	chr19	44273672	Missense_Mutation	novel	G338R	0.2
SARC	chr19	44274073	Silent	rs765181652	Q471Q	0.21
SKCM	chr19	44273427	Missense_Mutation	NA	G256E	0.24
SKCM	chr19	44273212	Silent	novel	R184R	0.26
SKCM	chr19	44273535	Missense_Mutation	novel	G292E	0.52
SKCM	chr19	44274593	Missense_Mutation	NA	E645K	0.36
SKCM	chr19	44273049	Missense_Mutation	NA	R130K	0.19
SKCM	chr19	44273683	Silent	NA	L341L	0.32
SKCM	chr19	44273173	Missense_Mutation	NA	N171K	0.37
SKCM	chr19	44273048	Silent	NA	R130R	0.33
SKCM	chr19	44273707	Silent	NA	R349R	0.19
SKCM	chr19	44274295	Missense_Mutation	NA	F545L	0.24
SKCM	chr19	44266942	Silent	novel	I73I	0.08
SKCM	chr19	44273540	Missense_Mutation	novel	G294S	0.54
SKCM	chr19	44274653	Missense_Mutation	NA	D665N	0.55
SKCM	chr19	44266305	Silent	NA	F41F	0.4
SKCM	chr19	44266282	Nonsense_Mutation	NA	Q34*	0.32
STAD	chr19	44273678	Missense_Mutation	novel	N340H	0.17
STAD	chr19	44273610	Missense_Mutation	novel	G317D	0.3
STAD	chr19	44274307	Silent	rs146745646	S549S	0.27
STAD	chr19	44274333	Missense_Mutation	NA	H558R	0.39
STAD	chr19	44273774	Missense_Mutation	novel	C372R	0.35
STAD	chr19	44273508	Missense_Mutation	NA	D283A	0.06
STAD	chr19	44274300	Missense_Mutation	NA	Q547R	0.05
STAD	chr19	44273076	Frame_Shift_Del	novel	*C141Vfs18**	0.22
STAD	chr19	44274603	Missense_Mutation	NA	Y648C	0.17
STAD	chr19	44274638	Missense_Mutation	novel	S660R	0.44
TGCT	chr19	44274364	Silent	novel	V568V	0.2
THCA	chr19	44267023	Intron	novel		0.11
THYM	chr19	44264335	5'UTR	novel		0.09
UCEC	chr19	44273128	Missense_Mutation	NA	N156K	0.31
UCEC	chr19	44274343	Missense_Mutation	NA	E561D	0.32
UCEC	chr19	44274692	3'UTR	novel		0.37
UCEC	chr19	44273544	Missense_Mutation	rs150005688	I295T	0.24
UCEC	chr19	44273813	Missense_Mutation	novel	F385V	0.09
UCEC	chr19	44274764	3'UTR	novel		0.2
UCEC	chr19	44274243	Missense_Mutation	novel	R528I	0.23
UCEC	chr19	44274075	Missense_Mutation	NA	R472I	0.28
UCEC	chr19	44274479	Missense_Mutation	novel	L607I	0.12
UCEC	chr19	44274469	Missense_Mutation	NA	W603C	0.29
UCEC	chr19	44273599	Silent	NA	C313C	0.09
UCEC	chr19	44274549	Missense_Mutation	NA	S630I	0.22
UCEC	chr19	44266252	Frame_Shift_Ins	novel	*L24Sfs63**	0.02
UCEC	chr19	44259950	5'UTR	rs527279715		0.43
UCEC	chr19	44267063	Intron	rs777152677		0.17
UCEC	chr19	44266285	Missense_Mutation	novel	D35Y	0.32
UCEC	chr19	44264375	Missense_Mutation	NA	Q5H	0.32
UCEC	chr19	44274306	Missense_Mutation	rs200116301	S549L	0.43
UCEC	chr19	44273647	Silent	novel	L329L	0.25
UCEC	chr19	44274668	Missense_Mutation	novel	P670T	0.56
UCEC	chr19	44272995	Missense_Mutation	NA	F112C	0.4
UCEC	chr19	44272915	Silent	novel	N85N	0.39
UCEC	chr19	44272991	Missense_Mutation	NA	Q111K	0.37
UCEC	chr19	44273128	Missense_Mutation	NA	N156K	0.36
UCEC	chr19	44272979	Nonsense_Mutation	novel	Q107*	0.57
UCEC	chr19	44273346	Nonsense_Mutation	novel	*K229delinsNFSPGV**	0.09
UCEC	chr19	44273348	Nonsense_Mutation	novel	R230delinsSS*	0.07
UCEC	chr19	44274642	Missense_Mutation	novel	S661L	0.29
UCEC	chr19	44273827	Silent	novel	C389C	0.29
UCEC	chr19	44273036	Missense_Mutation	rs772891548	L126I	0.36
UCEC	chr19	44273033	Missense_Mutation	novel	N125H	0.43
UCEC	chr19	44273281	Silent	novel	L207L	0.51
UCEC	chr19	44273130	Missense_Mutation	novel	Y157C	0.18
UCEC	chr19	44274628	Silent	NA	G656G	0.07
UCEC	chr19	44273294	Missense_Mutation	NA	H212N	0.47
UCEC	chr19	44267071	Intron	novel		0.06
UCEC	chr19	44267073	Intron	novel		0.03
UCEC	chr19	44273533	Silent	rs183103711	Y291Y	0.41
UCEC	chr19	44274080	Missense_Mutation	novel	H474N	0.2
UCEC	chr19	44273437	Silent	NA	T259T	0.37
UCS	chr19	44273113	Silent	novel	V151V	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0417	0.054726
READ	DEL	0.0727	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1964	0.12448

Survival Analysis

Cancer	P-value	Q-value
STAD	0.048	Kaplan-Meier Survival Analysis
HNSC	0.042	Kaplan-Meier Survival Analysis
PAAD	0.008	Kaplan-Meier Survival Analysis
LAML	0.0076	Kaplan-Meier Survival Analysis
LIHC	0.00082	Kaplan-Meier Survival Analysis
CHOL	0.013	Kaplan-Meier Survival Analysis
UVM	0.0022	Kaplan-Meier Survival Analysis