EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160014 (Gene tree)
Gene ID: 808
Gene Symbol: CALM3
Alias: PHKD
Full Name: calmodulin 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 9,720 bases
Position: chr19:46,601,074-46,610,793
Accession: 1449
RBP type: non-canonical RBP
Summary: This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000595072	CALM3-207	721	-	-	- (aa)	-	-
ENST00000291295	CALM3-201	2289	-	ENSP00000291295	149 (aa)	-	P0DP25
ENST00000596362	CALM3-208	1203	-	ENSP00000472141	149 (aa)	-	P0DP25
ENST00000602169	CALM3-213	590	-	-	- (aa)	-	-
ENST00000482455	CALM3-204	650	-	-	- (aa)	-	-
ENST00000486500	CALM3-205	2536	-	-	- (aa)	-	-
ENST00000477244	CALM3-203	696	-	-	- (aa)	-	-
ENST00000598871	CALM3-211	561	-	ENSP00000470502	113 (aa)	-	Q96HY3
ENST00000597868	CALM3-210	927	-	-	- (aa)	-	-
ENST00000597743	CALM3-209	577	-	ENSP00000470308	83 (aa)	-	M0QZ52
ENST00000599839	CALM3-212	1355	-	ENSP00000471225	113 (aa)	-	Q96HY3
ENST00000391918	CALM3-202	702	-	ENSP00000375785	113 (aa)	-	Q96HY3
ENST00000594523	CALM3-206	540	-	ENSP00000468877	113 (aa)	-	Q96HY3

Gene Model

Click here to download ENSG00000160014's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04014	Ras signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04020	Calcium signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04371	Apelin signaling pathway	KEGG
hsa04625	C-type lectin receptor signaling pathway	KEGG
hsa04713	Circadian entrainment	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04740	Olfactory transduction	KEGG
hsa04744	Phototransduction	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04912	GnRH signaling pathway	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa04916	Melanogenesis	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG
hsa04924	Renin secretion	KEGG
hsa04925	Aldosterone synthesis and secretion	KEGG
hsa04970	Salivary secretion	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05031	Amphetamine addiction	KEGG
hsa05034	Alcoholism	KEGG
hsa05133	Pertussis	KEGG
hsa05152	Tuberculosis	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05214	Glioma	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160014's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160014	CALM3	100	100.000	ENSDARG00000021811	calm3a	100	100.000	Danio_rerio
ENSG00000160014	CALM3	100	100.000	ENSMUSG00000001175	Calm1	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	IEA	Process
GO:0000922	spindle pole	16760425.	IDA	Component
GO:0001975	response to amphetamine	-	IEA	Process
GO:0002027	regulation of heart rate	23040497.	IMP	Process
GO:0005509	calcium ion binding	7607248.8631777.11807546.23040497.27516456.	IDA	Function
GO:0005513	detection of calcium ion	23040497.	IMP	Process
GO:0005515	protein binding	3111527.7607248.10692436.10880439.11807546.11807557.12577052.14594800.14960328.14978283.15063758.15140941.15161933.15719022.16189514.16299511.16338416.16478480.16505387.16512683.16760425.16799092.17568776.17620599.17719545.18570893.18694559.18786401.18940602.19279214.19632986.19651602.19855925.20029029.20103772.20618440.20668654.20708613.20953164.21167176.21299499.21565611.21602787.22405011.22705208.23446637.23893133.24658140.25268113.25416956.25437912.25441029.25703379.26638075.29724949.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005737	cytoplasm	10899953.	TAS	Component
GO:0005813	centrosome	16760425.	IDA	Component
GO:0005876	spindle microtubule	16760425.	IDA	Component
GO:0005886	plasma membrane	10899953.	TAS	Component
GO:0007186	G protein-coupled receptor signaling pathway	10899953.	TAS	Process
GO:0007190	activation of adenylate cyclase activity	-	IEA	Process
GO:0008076	voltage-gated potassium channel complex	-	IEA	Component
GO:0008179	adenylate cyclase binding	11807546.	IPI	Function
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	20668654.	TAS	Process
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	20668654.	TAS	Process
GO:0010856	adenylate cyclase activator activity	11807546.	IDA	Function
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	20226167.	IDA	Process
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	-	IC	Process
GO:0019901	protein kinase binding	20668654.	IPI	Function
GO:0019904	protein domain specific binding	11984006.	IPI	Function
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0030017	sarcomere	20226167.	IDA	Component
GO:0030235	nitric-oxide synthase regulator activity	-	IEA	Function
GO:0030426	growth cone	-	IEA	Component
GO:0030672	synaptic vesicle membrane	-	IEA	Component
GO:0031432	titin binding	7607248.	IPI	Function
GO:0031800	type 3 metabotropic glutamate receptor binding	-	IEA	Function
GO:0031954	positive regulation of protein autophosphorylation	20668654.	TAS	Process
GO:0031966	mitochondrial membrane	-	IEA	Component
GO:0031982	vesicle	19190083.	HDA	Component
GO:0031997	N-terminal myristoylation domain binding	15632291.	IPI	Function
GO:0032465	regulation of cytokinesis	16760425.	IMP	Process
GO:0032516	positive regulation of phosphoprotein phosphatase activity	8631777.	IDA	Process
GO:0032991	protein-containing complex	19855925.	IDA	Component
GO:0034704	calcium channel complex	23040497.	IDA	Component
GO:0035307	positive regulation of protein dephosphorylation	8631777.	IDA	Process
GO:0043209	myelin sheath	-	IEA	Component
GO:0043388	positive regulation of DNA binding	-	IEA	Process
GO:0043539	protein serine/threonine kinase activator activity	20668654.	TAS	Function
GO:0043548	phosphatidylinositol 3-kinase binding	-	IEA	Function
GO:0044325	ion channel binding	21167176.23040497.	IPI	Function
GO:0048306	calcium-dependent protein binding	-	IEA	Function
GO:0050998	nitric-oxide synthase binding	-	IEA	Function
GO:0051000	positive regulation of nitric-oxide synthase activity	-	IEA	Process
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	8631777.	IDA	Process
GO:0051412	response to corticosterone	-	IEA	Process
GO:0051592	response to calcium ion	7607248.	IDA	Process
GO:0055117	regulation of cardiac muscle contraction	23040497.	IMP	Process
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	-	ISS	Process
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	20226167.	IDA	Process
GO:0071902	positive regulation of protein serine/threonine kinase activity	20668654.	TAS	Process
GO:0072542	protein phosphatase activator activity	8631777.	IDA	Function
GO:0075206	positive regulation by host of symbiont cAMP-mediated signal transduction	11807546.	IDA	Process
GO:0090151	establishment of protein localization to mitochondrial membrane	-	IEA	Process
GO:0097718	disordered domain specific binding	19855925.	IPI	Function
GO:1900242	regulation of synaptic vesicle endocytosis	-	IEA	Process
GO:1901841	regulation of high voltage-gated calcium channel activity	-	IEA	Process
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	-	IC	Process
GO:1902494	catalytic complex	11807546.	IDA	Component
GO:2000300	regulation of synaptic vesicle exocytosis	-	IEA	Process