EuRBPDB

Description

Ensembl ID: ENSG00000160194 (Gene tree)
Gene ID: 4731
Gene Symbol: NDUFV3
Alias: CI-10k
Full Name: NADH:ubiquinone oxidoreductase subunit V3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 33,661 bases
Position: chr21:42,879,644-42,913,304
Accession: 7719
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000354250	NDUFV3-202	1575	XM_011529586	ENSP00000346196	473 (aa)	XP_011527888	P56181
ENST00000460740	NDUFV3-204	811	-	-	- (aa)	-	-
ENST00000460259	NDUFV3-203	2029	-	-	- (aa)	-	-
ENST00000340344	NDUFV3-201	4676	XM_017028359	ENSP00000342895	108 (aa)	XP_016883848	P56181

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00190	Oxidative phosphorylation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04714	Thermogenesis	KEGG
hsa04723	Retrograde endocannabinoid signaling	KEGG
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05012	Parkinson disease	KEGG
hsa05016	Huntington disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160194	Platelet Function Tests	8.6336435E-006	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160194	NDUFV3	100	65.138	ENSMUSG00000024038	Ndufv3	98	88.889	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	24344204.30021884.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005747	mitochondrial respiratory chain complex I	12611891.27626371.	IDA	Component
GO:0005747	mitochondrial respiratory chain complex I	24746669.	IMP	Component
GO:0005747	mitochondrial respiratory chain complex I	9878551.	NAS	Component
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	9878551.	NAS	Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	-	TAS	Process
GO:0008137	NADH dehydrogenase (ubiquinone) activity	9878551.	NAS	Function
GO:0032981	mitochondrial respiratory chain complex I assembly	-	TAS	Process
GO:0042775	mitochondrial ATP synthesis coupled electron transport	24746669.	IMP	Process