EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160211 (Gene tree)
Gene ID: 2539
Gene Symbol: G6PD
Alias: G6PD1
Full Name: glucose-6-phosphate dehydrogenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 16,197 bases
Position: chrX:154,531,390-154,547,586
Accession: 4057
RBP type: non-canonical RBP
Summary: This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21204617	Ionising radiation triggers fat accumulation in white adipose tissue.	Int J Radiat Biol	2011 Mar	Jo SK	doi: 10.3109/09553002.2010.537429
28810828	Suitable reference gene for quantitative real-time PCR analysis of gene expression in gonadal tissues of minnow Puntius sophore under high-temperature stress.	BMC Genomics	2017 Aug 15	Mahanty A	doi: 10.1186/s12864-017-3974-1.
19014500	Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment.	BMC Mol Biol	2008 Nov 12	McCurley AT	doi: 10.1186/1471-2199-9-102.
17288598	Appropriate 'housekeeping' genes for use in expression profiling the effects of environmental estrogens in fish.	BMC Mol Biol	2007 Feb 8	Filby AL	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497281	G6PD-210	532	-	-	- (aa)	-	-
ENST00000488434	G6PD-207	432	-	-	- (aa)	-	-
ENST00000433845	G6PD-204	817	-	ENSP00000394690	256 (aa)	-	E9PD92
ENST00000393564	G6PD-203	1661	-	ENSP00000377194	515 (aa)	-	P11413
ENST00000393562	G6PD-202	2223	-	ENSP00000377192	515 (aa)	-	P11413
ENST00000647501	G6PD-212	471	-	-	- (aa)	-	-
ENST00000439227	G6PD-205	1074	-	ENSP00000395599	338 (aa)	-	E7EUI8
ENST00000621232	G6PD-211	2632	-	ENSP00000483686	515 (aa)	-	P11413
ENST00000440967	G6PD-206	1056	-	ENSP00000400648	320 (aa)	-	E7EM57
ENST00000489497	G6PD-208	512	-	-	- (aa)	-	-
ENST00000490651	G6PD-209	783	-	-	- (aa)	-	-
ENST00000369620	G6PD-201	1799	-	ENSP00000358633	561 (aa)	-	P11413

Gene Model

Click here to download ENSG00000160211's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00030	Pentose phosphate pathway	KEGG
hsa00480	Glutathione metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa05230	Central carbon metabolism in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160211	Erythrocyte Count	4E-13	23696099
ENSG00000160211	Erythrocyte Count	1E-14	23696099
ENSG00000160211	Erythrocyte Indices	9E-9	23696099
ENSG00000160211	Hematocrit	2E-16	23446634
ENSG00000160211	Hemoglobins	4E-18	23446634
ENSG00000160211	Erythrocyte Count	4E-14	23446634
ENSG00000160211	Hemoglobin A, Glycosylated	3E-11	26366553
ENSG00000160211	Hemoglobins	3E-11	26366553
ENSG00000160211	Erythrocyte Count	2E-11	23446634
ENSG00000160211	Erythrocyte Count	4E-19	23446634

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000160211	rs762516	X	154536448	T	Red blood cell traits	23446634	[0.34-0.56] % decrease	0.452	EFO_0004348
ENSG00000160211	rs762516	X	154536448	T	Red blood cell traits	23446634	[0.12-0.2] g/dL decrease	0.1614	EFO_0004509
ENSG00000160211	rs762516	X	154536448	T	Red blood cell traits	23446634	[1.17-1.99] fL increase	1.5768	EFO_0004526
ENSG00000160211	rs1050828	X	154536002	T	Red blood cell traits	23446634	[0.023-0.042] % decrease	0.0326	EFO_0005192
ENSG00000160211	rs5030868	X	154534419	A	Hemoglobin levels	26366553	[0.088-0.163] g/dl decrease	0.1256	EFO_0004509\|EFO_0007629
ENSG00000160211	rs1050828	X	154536002	A	Red blood cell traits	23696099	[0.14-0.26] x10^12/L decrease	0.2	EFO_0004305
ENSG00000160211	rs1050828	X	154536002	A	Red blood cell traits	23696099	[1.83-3.09] fL increase	2.46	EFO_0004526
ENSG00000160211	rs1050828	X	154536002	A	Red blood cell traits	23696099	[0.48-0.96] pg increase	0.72	EFO_0004527
ENSG00000160211	rs1050828	X	154536002	T	Glycated hemoglobin levels	28898252	[0.35-0.41] unit decrease	0.3819	EFO_0004541
ENSG00000160211	rs1050828	X	154536002	C	Iron status biomarkers (transferrin saturation)	28334935	[0.13-0.3] unit decrease	0.21441	EFO_0006333
ENSG00000160211	rs1050828	X	154536002	C	Red blood cell count	28453575	[0.11-0.15] cells x E9 increase	0.13	EFO_0004305
ENSG00000160211	rs1050828	X	154536002	C	Mean corpuscular volume	28453575	[1.49-2.35] fL decrease	1.92	EFO_0004526
ENSG00000160211	rs1050828	X	154536002	A	Mean corpuscular hemoglobin	28453575	[0.38-0.71] pg increase	0.546	EFO_0004527
ENSG00000160211	rs1050828	X	154536002	T	Red cell distribution width	28453575	[0.031-0.043] unit decrease	0.04	EFO_0005192
ENSG00000160211	rs1050828	X	154536002	C	Mean corpuscular volume	28453575	[1.49-2.35] fL decrease	1.92	EFO_0004526

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160211's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160211	G6PD	93	60.986	WBGene00007108	gspd-1	93	60.986	Caenorhabditis_elegans
ENSG00000160211	G6PD	94	47.853	YNL241C	ZWF1	94	47.853	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004345	glucose-6-phosphate dehydrogenase activity	15858258.	IDA	Function
GO:0004345	glucose-6-phosphate dehydrogenase activity	743300.2420826.5643703.	IMP	Function
GO:0005515	protein binding	21157431.24769394.	IPI	Function
GO:0005536	glucose binding	15858258.	IDA	Function
GO:0005536	glucose binding	5643703.	IMP	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	IDA	Component
GO:0005829	cytosol	743300.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006006	glucose metabolic process	-	IEA	Process
GO:0006098	pentose-phosphate shunt	2297768.	IDA	Process
GO:0006098	pentose-phosphate shunt	-	TAS	Process
GO:0006629	lipid metabolic process	17361089.	TAS	Process
GO:0006695	cholesterol biosynthetic process	12027950.	IMP	Process
GO:0006739	NADP metabolic process	15858258.	IDA	Process
GO:0006740	NADPH regeneration	17516514.	IMP	Process
GO:0006749	glutathione metabolic process	2420826.17516514.	IMP	Process
GO:0009051	pentose-phosphate shunt, oxidative branch	2420826.	IMP	Process
GO:0009898	cytoplasmic side of plasma membrane	743300.	IDA	Component
GO:0010041	response to iron(III) ion	-	IEA	Process
GO:0010734	negative regulation of protein glutathionylation	17516514.	IMP	Process
GO:0014070	response to organic cyclic compound	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019322	pentose biosynthetic process	5643703.	IDA	Process
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0032094	response to food	-	IEA	Process
GO:0034599	cellular response to oxidative stress	17516514.	IMP	Process
GO:0042802	identical protein binding	24769394.25416956.	IPI	Function
GO:0042803	protein homodimerization activity	15858258.	IPI	Function
GO:0043249	erythrocyte maturation	5643703.	IMP	Process
GO:0043523	regulation of neuron apoptotic process	-	IEA	Process
GO:0045471	response to ethanol	-	IEA	Process
GO:0046390	ribose phosphate biosynthetic process	2420826.	IMP	Process
GO:0050661	NADP binding	15858258.	IDA	Function
GO:0051156	glucose 6-phosphate metabolic process	15858258.	IDA	Process
GO:0051156	glucose 6-phosphate metabolic process	5643703.	IMP	Process
GO:0055114	oxidation-reduction process	2420826.	IMP	Process
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	-	IEA	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	-	IEA	Process
GO:2000378	negative regulation of reactive oxygen species metabolic process	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30066842	Modulation of G6PD affects bladder cancer via ROS accumulation and the AKT pathway in vitro.	Int J Oncol	2018 Oct	Chen X	doi: 10.3892/ijo.2018.4501
29845423	G6PD as a predictive marker for glioma risk, prognosis and chemosensitivity.	J Neurooncol	2018 Sep	Yang CA	doi: 10.1007/s11060-018-2911-8
30272333	Downregulation of glucose6phosphate dehydrogenase by microRNA1 inhibits the growth of pituitary tumor cells.	Oncol Rep	2018 Dec	He C	doi: 10.3892/or.2018.6755
26621836	BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas.	Oncotarget	2016 Jan 5	Kong DH	doi: 10.18632/oncotarget.6396.
18302154	Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer.	Int J Cancer	2008 Jun 1	Langbein S	doi: 10.1002/ijc.23403.
23693134	Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model.	BMC Cancer	2013 May 22	Hu T	doi: 10.1186/1471-2407-13-251.
25616277	Elevated glucose-6-phosphate dehydrogenase expression in the cervical cancer cases is associated with the cancerigenic event of high-risk human papillomaviruses.	Exp Biol Med (Maywood)	2015 Oct	Hu T	doi: 10.1177/1535370214565971
22012600	Overexpression of G6PD is associated with poor clinical outcome in gastric cancer.	Tumour Biol	2012 Feb	Wang J	doi: 10.1007/s13277-011-0251-9
27217331	Effects of G6PD activity inhibition on the viability, ROS generation and mechanical properties of cervical cancer cells.	Biochim Biophys Acta	2016 Sep	Fang Z	doi: 10.1016/j.bbamcr.2016.05.016
28542136	PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth.	Cell Death Dis	2017 May 25	Zhang X	doi: 10.1038/cddis.2017.85.
26715276	Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.	Tumour Biol	2016 Jun	Dong T	doi: 10.1007/s13277-015-4729-8
25633909	iTRAQ-based quantitative proteomic analysis of cervical cancer.	Int J Oncol	2015 Apr	Ding Y	doi: 10.3892/ijo.2015.2859
24994855	Changes in glucose-6-phosphate dehydrogenase expression results in altered behavior of HBV-associated liver cancer cells.	Am J Physiol Gastrointest Liver Physiol	2014 Sep 15	Hu H	doi: 10.1152/ajpgi.00160.2014
24270845	A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation.	Cell Cycle	2013 Dec 15	Jiang P	doi: 10.4161/cc.27267

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	154532975	Missense_Mutation	rs369603624	V340I	0.35
ACC	chrX	154534462	Missense_Mutation	novel	G174R	0.43
BLCA	chrX	154532057	Silent	novel	K497K	0.69
BLCA	chrX	154534075	Missense_Mutation	novel	E244Q	0.61
BLCA	chrX	154532954	Missense_Mutation	novel	E347Q	0.06
BLCA	chrX	154532462	Splice_Site	novel	X430_splice	0.14
BLCA	chrX	154532202	Silent	novel	P481P	0.19
BRCA	chrX	154532772	Missense_Mutation	rs137852345	A361V	0.67
BRCA	chrX	154532021	Nonsense_Mutation	NA	W509*	0.58
BRCA	chrX	154533665	Missense_Mutation	rs782690505	V259M	0.2
BRCA	chrX	154536016	Missense_Mutation	novel	E63A	0.15
BRCA	chrX	154531710	3'Flank	novel		0.37
BRCA	chrX	154534055	Silent	rs140496395	F250F	0.13
CESC	chrX	154535242	Silent	NA	L137L	0.17
CESC	chrX	154531704	3'Flank	novel		0.4
CESC	chrX	154531966	3'Flank	novel		0.27
CESC	chrX	154532390	Missense_Mutation	rs398123546	R454C	0.44
CESC	chrX	154532785	Missense_Mutation	rs387906470	R357C	0.4
CESC	chrX	154546067	Missense_Mutation	novel	D30G	0.33
CESC	chrX	154532435	Missense_Mutation	novel	R439C	0.17
CESC	chrX	154535343	Missense_Mutation	rs782372471	R104C	0.16
COAD	chrX	154546130	Missense_Mutation	NA	R9Q	0.18
COAD	chrX	154536017	Missense_Mutation	rs782674059	E63K	0.59
COAD	chrX	154533629	Missense_Mutation	NA	V271M	0.54
COAD	chrX	154533056	Missense_Mutation	rs150589041	D313N	0.75
COAD	chrX	154534102	Missense_Mutation	novel	L235I	0.55
COAD	chrX	154546087	Silent	NA	G23G	0.1
COAD	chrX	154533648	Silent	novel	L264L	0.09
COAD	chrX	154534055	Silent	rs140496395	F250F	0.8
COAD	chrX	154546100	Frame_Shift_Del	novel	*R17Afs23**	0.11
COAD	chrX	154534126	Missense_Mutation	novel	R227W	0.18
COAD	chrX	154533590	Missense_Mutation	novel	V284I	0.33
COAD	chrX	154534114	Missense_Mutation	novel	A231T	0.38
GBM	chrX	154532695	Missense_Mutation	rs137852334	R387C	0.24
GBM	chrX	154535237	Missense_Mutation	novel	Y139C	0.18
GBM	chrX	154532601	Missense_Mutation	novel	S418L	0.46
GBM	chrX	154534055	Silent	rs140496395	F250F	0.41
GBM	chrX	154535943	Missense_Mutation	novel	F87L	0.13
GBM	chrX	154532456	Missense_Mutation	novel	K432Q	0.26
GBM	chrX	154532221	Missense_Mutation	NA	E475G	0.11
HNSC	chrX	154532018	Silent	novel	V510V	0.41
HNSC	chrX	154532574	Missense_Mutation	novel	R427T	0.5
HNSC	chrX	154535175	Missense_Mutation	novel	S160R	0.51
HNSC	chrX	154534462	Missense_Mutation	novel	G174R	0.25
HNSC	chrX	154534463	Silent	rs200111236	F173F	0.15
KIRC	chrX	154534397	Missense_Mutation	NA	Q195H	0.46
KIRC	chrX	154532228	Missense_Mutation	novel	E473K	0.33
LAML	chrX	154535207	Missense_Mutation	NA	A149V	0.26
LAML	chrX	154534357	Nonsense_Mutation	novel	Q209*	0.25
LGG	chrX	154534419	Missense_Mutation	rs5030868	S188F	0.29
LGG	chrX	154533611	Missense_Mutation	NA	A277T	0.1
LGG	chrX	154532675	Silent	rs782459284	R393R	0.26
LGG	chrX	154534385	Silent	rs369516039	I199I	0.4
LGG	chrX	154546087	Silent	NA	G23G	0.46
LUAD	chrX	154534051	Missense_Mutation	NA	E252Q	0.77
LUAD	chrX	154532434	Missense_Mutation	rs137852337	R439H	0.22
LUAD	chrX	154534151	Silent	NA	N218N	0.12
LUAD	chrX	154535961	Silent	novel	R81R	0.23
LUAD	chrX	154532280	Missense_Mutation	novel	S455R	0.31
LUAD	chrX	154532605	Nonsense_Mutation	NA	E417*	0.15
LUSC	chrX	154534437	Missense_Mutation	novel	R182L	0.7
LUSC	chrX	154546134	Missense_Mutation	NA	S8C	0.18
LUSC	chrX	154532996	Missense_Mutation	novel	T333A	0.48
LUSC	chrX	154533646	Missense_Mutation	novel	L265Q	0.17
MESO	chrX	154546869	Intron	novel		0.58
OV	chrX	154532639	Missense_Mutation	NA	M405I	0.17
OV	chrX	154532676	Missense_Mutation	NA	R393L	0.13
OV	chrX	154534443	Missense_Mutation	NA	S180F	0.25
OV	chrX	154532456	Missense_Mutation	novel	K432E	0.05
READ	chrX	154532705	Missense_Mutation	NA	Q383H	0.93
READ	chrX	154531918	3'Flank	novel		0.34
SARC	chrX	154535114	Intron	novel		0.31
SKCM	chrX	154535940	Silent	novel	F88F	0.54
SKCM	chrX	154533094	Missense_Mutation	novel	A300V	0.31
SKCM	chrX	154534080	Missense_Mutation	novel	G242D	0.32
SKCM	chrX	154532191	Missense_Mutation	novel	G485V	0.42
SKCM	chrX	154533057	Silent	NA	P312P	0.11
SKCM	chrX	154532792	Silent	novel	F354F	0.9
SKCM	chrX	154533016	Missense_Mutation	NA	P326L	0.43
SKCM	chrX	154532711	Silent	NA	F381F	0.78
SKCM	chrX	154534408	Missense_Mutation	NA	R192C	0.89
SKCM	chrX	154532440	Missense_Mutation	NA	Y437F	0.43
SKCM	chrX	154534351	Missense_Mutation	novel	L211F	0.17
SKCM	chrX	154535176	Missense_Mutation	novel	M159I	0.15
SKCM	chrX	154532204	Missense_Mutation	rs202122673	P481S	0.55
SKCM	chrX	154546042	Silent	NA	G38G	0.22
STAD	chrX	154546086	Missense_Mutation	novel	D24N	0.11
STAD	chrX	154534456	Missense_Mutation	NA	D176N	0.5
STAD	chrX	154534059	Missense_Mutation	NA	Y249C	0.1
STAD	chrX	154532761	Missense_Mutation	NA	R365C	0.83
STAD	chrX	154535180	Missense_Mutation	NA	C158F	0.19
STAD	chrX	154533045	Silent	rs782587403	G316G	0.6
STAD	chrX	154534430	Frame_Shift_Del	novel	*R182Qfs9**	0.23
STAD	chrX	154533003	Silent	rs782064465	R330R	0.39
STAD	chrX	154534069	Missense_Mutation	NA	R246C	0.16
STAD	chrX	154532585	Silent	NA	T423T	0.12
UCEC	chrX	154531479	3'Flank	novel		0.23
UCEC	chrX	154531703	3'Flank	novel		0.17
UCEC	chrX	154535363	Missense_Mutation	novel	K97R	0.07
UCEC	chrX	154532204	Missense_Mutation	rs202122673	P481S	0.47
UCEC	chrX	154531481	3'Flank	novel		0.43
UCEC	chrX	154532606	Missense_Mutation	novel	E416D	0.14
UCEC	chrX	154535350	Silent	novel	F101F	0.42
UCEC	chrX	154532720	Silent	rs200195961	G378G	0.38
UCEC	chrX	154534108	Missense_Mutation	rs781948754	V233I	0.44
UCEC	chrX	154536170	Silent	novel	L43L	0.42
UCEC	chrX	154532206	Missense_Mutation	novel	I480T	0.21
UCEC	chrX	154531464	3'Flank	novel		0.33
UCEC	chrX	154532950	Missense_Mutation	novel	R348M	0.46
UCEC	chrX	154534054	Missense_Mutation	rs782324339	D251N	0.3
UCEC	chrX	154532752	Missense_Mutation	rs387906468	E368K	0.16
UCEC	chrX	154535948	Missense_Mutation	novel	P86S	0.16
UCEC	chrX	154531447	3'Flank	novel		0.42
UCEC	chrX	154531448	3'Flank	novel		0.29
UCEC	chrX	154531719	3'Flank	novel		0.31
UCEC	chrX	154535237	Missense_Mutation	novel	Y139C	0.45
UCEC	chrX	154546087	Silent	NA	G23G	0.41
UCEC	chrX	154535378	Frame_Shift_Del	novel	*P92Qfs34**	0.29
UCEC	chrX	154533069	Silent	rs782732731	Y308Y	0.38
UCEC	chrX	154532210	Missense_Mutation	novel	P479T	0.33
UCEC	chrX	154534384	Missense_Mutation	rs782514319	D200N	0.38
UCEC	chrX	154533112	Missense_Mutation	novel	C294Y	0.45
UCEC	chrX	154534151	Silent	NA	N218N	0.31
UCEC	chrX	154534088	Missense_Mutation	NA	E239D	0.4
UCEC	chrX	154546078	Missense_Mutation	NA	F26L	0.12
UCEC	chrX	154533111	Silent	novel	C294C	0.52
UCEC	chrX	154532722	Missense_Mutation	rs371489738	G378S	0.38
UCEC	chrX	154532981	Frame_Shift_Ins	novel	*A338Cfs10**	0.43
UCEC	chrX	154534108	Missense_Mutation	rs781948754	V233I	0.08
UCEC	chrX	154531542	3'Flank	novel		0.24
UCEC	chrX	154546087	Silent	NA	G23G	0.44
UCEC	chrX	154531501	3'Flank	novel		0.46
UCEC	chrX	154532601	Missense_Mutation	novel	S418L	0.39
UCEC	chrX	154535964	Silent	novel	I80I	0.42
UCEC	chrX	154535335	Silent	novel	S106S	0.08
UCEC	chrX	154532585	Silent	NA	T423T	0.24
UCEC	chrX	154532460	Splice_Region	rs782761811	N430N	0.42
UCEC	chrX	154531732	3'Flank	novel		0.26
UCEC	chrX	154534133	Silent	NA	I224I	0.41
UCEC	chrX	154531588	3'Flank	novel		0.38
UCEC	chrX	154531544	3'Flank	novel		0.22
UCEC	chrX	154532753	Silent	novel	A367A	0.38
UCEC	chrX	154534142	Silent	rs782530472	F221F	0.7
UCEC	chrX	154534385	Silent	rs369516039	I199I	0.88
UCEC	chrX	154532967	Silent	novel	L342L	0.36
UCEC	chrX	154532761	Missense_Mutation	NA	R365C	0.3
UCEC	chrX	154531890	3'Flank	novel		0.07
UCEC	chrX	154532216	Missense_Mutation	novel	P477T	0.32
UCEC	chrX	154533041	Missense_Mutation	novel	A318T	0.17
UCEC	chrX	154535278	Missense_Mutation	novel	M125I	0.41
UCEC	chrX	154532700	Missense_Mutation	novel	C385Y	0.09
UCEC	chrX	154534385	Silent	rs369516039	I199I	0.46
UCS	chrX	154534119	Missense_Mutation	novel	N229S	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1898	3.2002e-05
DLBC	AMP	0.1458	0.24013
HNSC	AMP	0.2107	0.0095371
KIRC	AMP	0.0436	0.12739
LIHC	AMP	0.1541	0.011319
LUAD	AMP	0.2171	1.4252e-08
LUSC	AMP	0.1796	0.08275
OV	AMP	0.3126	2.176e-06
PAAD	AMP	0.0761	0.041079
READ	AMP	0.1576	0.14805
STAD	AMP	0.1134	0.0021069
TGCT	DEL	0.0667	0.08422
THCA	DEL	0.006	0.21991
UCS	DEL	0.2857	0.063955

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.032	Kaplan-Meier Survival Analysis
ACC	0.015	Kaplan-Meier Survival Analysis
HNSC	0.013	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
KIRP	0.00086	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
CESC	0.0092	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742