EuRBPDB

Description

Ensembl ID: ENSG00000160294 (Gene tree)
Gene ID: 8888
Gene Symbol: MCM3AP
Alias: Map80|KIAA0572|GANP|SAC3
Full Name: minichromosome maintenance complex component 3 associated protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 51,435 bases
Position: chr21:46,235,125-46,286,559
Accession: 6946
RBP type: non-canonical RBP
Summary: The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28334829	Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex.	Nucleic Acids Res	2017 May 19	Gordon JMB	doi: 10.1093/nar/gkx158.
12885157	Involvement of GANP in B cell activation in T cell-dependent antigen response.	Dev Immunol	2002 Sep	Sakaguchi N	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000481113	MCM3AP-206	570	-	-	- (aa)	-	-
ENST00000467026	MCM3AP-204	2671	-	-	- (aa)	-	-
ENST00000496607	MCM3AP-210	4075	-	-	- (aa)	-	-
ENST00000291688	MCM3AP-201	6193	-	ENSP00000291688	1980 (aa)	-	O60318
ENST00000495475	MCM3AP-209	199	-	-	- (aa)	-	-
ENST00000486937	MCM3AP-207	4593	-	-	- (aa)	-	-
ENST00000397708	MCM3AP-202	6333	XM_005261203	ENSP00000380820	1980 (aa)	XP_005261260	O60318
ENST00000479557	MCM3AP-205	364	-	-	- (aa)	-	-
ENST00000494755	MCM3AP-208	669	-	-	- (aa)	-	-
ENST00000426537	MCM3AP-203	876	-	ENSP00000408934	94 (aa)	-	A0A0A0MSZ7

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160294	Testicular Germ Cell Tumor	3E-6	25877299
ENSG00000160294	Testicular Neoplasms	1E-9	23666240

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000160294	rs2839186	21	46270154	T	Testicular germ cell tumor	25877299	[NR]	1.23	EFO_1000566
ENSG00000160294	rs2839186	21	46270154	T	Testicular germ cell tumor	23666240	[1.15-1.38]	1.26	EFO_0005088
ENSG00000160294	rs149024257	21	46266299	G	Blood protein levels	30072576	[0.19-0.39] unit decrease	0.287	EFO_0007937
ENSG00000160294	rs9982623	21	46271302	C	Periodontitis	30218097	[1.13-1.33]	1.23	EFO_0000649

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0003682	chromatin binding	23652018.	IDA	Function
GO:0004402	histone acetyltransferase activity	23652018.	IDA	Function
GO:0005515	protein binding	23591820.23652018.	IPI	Function
GO:0005634	nucleus	16780588.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	16780588.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006406	mRNA export from nucleus	21873635.	IBA	Process
GO:0010484	H3 histone acetyltransferase activity	23652018.	IDA	Function
GO:0016446	somatic hypermutation of immunoglobulin genes	23652018.	IDA	Process
GO:0016973	poly(A)+ mRNA export from nucleus	21873635.	IBA	Process
GO:0016973	poly(A)+ mRNA export from nucleus	23591820.	IMP	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0034728	nucleosome organization	23652018.	IDA	Process
GO:0042393	histone binding	23652018.	IDA	Function
GO:0043966	histone H3 acetylation	-	IEA	Process
GO:0044615	nuclear pore nuclear basket	23591820.	IDA	Component
GO:0070390	transcription export complex 2	21873635.	IBA	Component
GO:0070390	transcription export complex 2	23591820.	IDA	Component