EuRBPDB

Description

Ensembl ID: ENSG00000160299 (Gene tree)
Gene ID: 5116
Gene Symbol: PCNT
Alias: KEN|KIAA0402|PCN|PCNTB|SCKL4|PCNT2
Full Name: pericentrin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 121,670 bases
Position: chr21:46,324,100-46,445,769
Accession: 16068
RBP type: non-canonical RBP
Summary: The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000480896	PCNT-205	10485	-	-	- (aa)	-	-
ENST00000466474	PCNT-204	895	-	-	- (aa)	-	-
ENST00000482575	PCNT-206	578	-	-	- (aa)	-	-
ENST00000465356	PCNT-203	767	-	-	- (aa)	-	-
ENST00000418394	PCNT-202	796	-	ENSP00000404708	228 (aa)	-	H7C2A3
ENST00000359568	PCNT-201	10560	XM_005261124	ENSP00000352572	3336 (aa)	XP_005261181	O95613
ENST00000483844	PCNT-207	734	-	-	- (aa)	-	-
ENST00000490468	PCNT-208	1415	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160299	Triglycerides	4.85617449787244E-7	17903299
ENSG00000160299	Glomerular Filtration Rate	1.61346814966265E-5	17903292
ENSG00000160299	Bone Density	6.37908382546055E-6	17903296
ENSG00000160299	Neuropsychological Tests	1.10964137041948E-5	17903297
ENSG00000160299	Blood Pressure	9.5980000E-005	-
ENSG00000160299	Platelet Function Tests	8.0920147E-008	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000160299	rs59500178	21	46433244	?	Heel bone mineral density	30048462	[0.0085-0.0167] unit increase	0.0125968	EFO_0009270
ENSG00000160299	rs9975345	21	46423090	T	Heel bone mineral density	30598549	[0.008-0.0153] unit increase	0.0116839	EFO_0009270
ENSG00000160299	rs9975345	21	46423090	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000160299	rs9808759	21	46360308	C	Breast cancer	29059683	[0.037-0.083] unit decrease	0.0597	EFO_0000305

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160299	PCNT	82	39.381	ENSG00000127914	AKAP9	71	33.000	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000226	microtubule cytoskeleton organization	18955030.	IMP	Process
GO:0005515	protein binding	12812986.15094396.16980960.18955030.20466722.22797915.24816561.25503564.26496610.26638075.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005813	centrosome	18955030.19543530.20186884.21399614.22797915.27137183.	IDA	Component
GO:0005814	centriole	24421332.	IDA	Component
GO:0005815	microtubule organizing center	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	-	IEA	Component
GO:0007052	mitotic spindle organization	25220058.	IMP	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0034451	centriolar satellite	22797915.	IDA	Component
GO:0060090	molecular adaptor activity	-	IEA	Function
GO:0060271	cilium assembly	15337773.	IDA	Process
GO:0090316	positive regulation of intracellular protein transport	22797915.	IMP	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process