EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160310 (Gene tree)
Gene ID: 3275
Gene Symbol: PRMT2
Alias: MGC111373|HRMT1L1
Full Name: protein arginine methyltransferase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 30,533 bases
Position: chr21:46,635,153-46,665,685
Accession: 5186
RBP type: canonical RBP
Summary: PRMT2 (Protein Arginine Methyltransferase 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription coactivator activity. An important paralog of this gene is CARM1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000406127	MTS	PF05175.14	3.9e-07	1	1
ENSP00000291705	MTS	PF05175.14	5.5e-07	1	1
ENSP00000380752	MTS	PF05175.14	6.8e-07	1	1
ENSP00000411984	MTS	PF05175.14	7.4e-07	1	1
ENSP00000335490	MTS	PF05175.14	8.3e-07	1	1
ENSP00000407463	MTS	PF05175.14	9.1e-07	1	1
ENSP00000397266	MTS	PF05175.14	9.3e-07	1	1
ENSP00000347906	MTS	PF05175.14	1.3e-06	1	1
ENSP00000380759	MTS	PF05175.14	1.3e-06	1	1
ENSP00000380760	MTS	PF05175.14	1.3e-06	1	1
ENSP00000406127	Met_10	PF02475.16	0.00099	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397637	PRMT2-205	2880	-	ENSP00000380759	433 (aa)	-	P55345
ENST00000455177	PRMT2-209	581	-	ENSP00000406127	194 (aa)	-	H7C2H9
ENST00000458387	PRMT2-210	1874	XM_006723998	ENSP00000407463	301 (aa)	XP_006724061	P55345
ENST00000440086	PRMT2-207	1932	-	ENSP00000397266	331 (aa)	-	P55345
ENST00000397628	PRMT2-204	954	XM_006723999	ENSP00000380752	253 (aa)	XP_006724062	A8MXR3
ENST00000397638	PRMT2-206	2131	-	ENSP00000380760	433 (aa)	-	P55345
ENST00000481861	PRMT2-211	1301	-	-	- (aa)	-	-
ENST00000621201	PRMT2-216	1301	-	ENSP00000482158	161 (aa)	-	A0A087WYX1
ENST00000482508	PRMT2-212	1478	-	-	- (aa)	-	-
ENST00000291705	PRMT2-201	1011	XM_006724000	ENSP00000291705	228 (aa)	XP_006724063	P55345
ENST00000355680	PRMT2-203	2688	XM_005261111	ENSP00000347906	433 (aa)	XP_005261168	P55345
ENST00000498151	PRMT2-215	493	-	-	- (aa)	-	-
ENST00000334494	PRMT2-202	1334	-	ENSP00000335490	284 (aa)	-	P55345
ENST00000491389	PRMT2-214	616	-	-	- (aa)	-	-
ENST00000486520	PRMT2-213	4031	-	-	- (aa)	-	-
ENST00000451211	PRMT2-208	1878	-	ENSP00000411984	289 (aa)	-	P55345

Gene Model

Click here to download ENSG00000160310's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000160310	rs2236617	21	46651618	G	Diverticular disease	30177863	[NR] unit decrease	0.0025658	EFO_1001460
ENSG00000160310	rs8133217	21	46643239	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160310's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160310	PRMT2	93	53.041	ENSAPOG00000019380	prmt2	98	52.404	Acanthochromis_polyacanthus
ENSG00000160310	PRMT2	100	88.710	ENSAMEG00000001108	PRMT2	100	88.710	Ailuropoda_melanoleuca
ENSG00000160310	PRMT2	93	53.285	ENSACIG00000009460	prmt2	97	53.285	Amphilophus_citrinellus
ENSG00000160310	PRMT2	94	52.415	ENSAOCG00000000897	prmt2	98	52.899	Amphiprion_ocellaris
ENSG00000160310	PRMT2	91	52.750	ENSAPEG00000015165	prmt2	89	53.250	Amphiprion_percula
ENSG00000160310	PRMT2	94	53.012	ENSATEG00000021156	prmt2	98	53.976	Anabas_testudineus
ENSG00000160310	PRMT2	100	96.998	ENSANAG00000030484	PRMT2	100	96.998	Aotus_nancymaae
ENSG00000160310	PRMT2	93	54.054	ENSACLG00000017462	prmt2	97	54.054	Astatotilapia_calliptera
ENSG00000160310	PRMT2	93	57.568	ENSAMXG00000032742	prmt2	83	57.568	Astyanax_mexicanus
ENSG00000160310	PRMT2	100	85.945	ENSBTAG00000005503	PRMT2	100	85.945	Bos_taurus
ENSG00000160310	PRMT2	100	96.522	ENSCJAG00000001571	PRMT2	100	96.522	Callithrix_jacchus
ENSG00000160310	PRMT2	100	88.479	ENSCAFG00000012237	PRMT2	100	88.479	Canis_familiaris
ENSG00000160310	PRMT2	96	88.128	ENSCAFG00020020694	-	98	88.696	Canis_lupus_dingo
ENSG00000160310	PRMT2	100	86.636	ENSCHIG00000011147	PRMT2	100	86.636	Capra_hircus
ENSG00000160310	PRMT2	100	94.783	ENSTSYG00000003437	PRMT2	100	94.783	Carlito_syrichta
ENSG00000160310	PRMT2	100	97.391	ENSCCAG00000028685	PRMT2	100	97.391	Cebus_capucinus
ENSG00000160310	PRMT2	100	97.691	ENSCATG00000031360	PRMT2	100	97.691	Cercocebus_atys
ENSG00000160310	PRMT2	100	90.455	ENSCLAG00000006778	PRMT2	100	90.455	Chinchilla_lanigera
ENSG00000160310	PRMT2	100	98.261	ENSCSAG00000007062	PRMT2	100	97.921	Chlorocebus_sabaeus
ENSG00000160310	PRMT2	93	98.485	ENSCANG00000032129	PRMT2	100	86.159	Colobus_angolensis_palliatus
ENSG00000160310	PRMT2	100	88.696	ENSCGRG00001010555	Prmt2	100	87.191	Cricetulus_griseus_chok1gshd
ENSG00000160310	PRMT2	100	88.696	ENSCGRG00000002449	Prmt2	100	87.191	Cricetulus_griseus_crigri
ENSG00000160310	PRMT2	89	55.385	ENSCSEG00000010235	prmt2	100	55.385	Cynoglossus_semilaevis
ENSG00000160310	PRMT2	94	54.034	ENSCVAG00000019527	prmt2	98	54.034	Cyprinodon_variegatus
ENSG00000160310	PRMT2	93	55.583	ENSDARG00000063212	prmt2	98	55.583	Danio_rerio
ENSG00000160310	PRMT2	93	42.208	FBgn0032329	Art8	79	38.571	Drosophila_melanogaster
ENSG00000160310	PRMT2	100	89.195	ENSEASG00005002664	PRMT2	100	89.195	Equus_asinus_asinus
ENSG00000160310	PRMT2	100	89.401	ENSECAG00000012406	PRMT2	100	89.401	Equus_caballus
ENSG00000160310	PRMT2	90	52.062	ENSELUG00000009758	prmt2	99	52.727	Esox_lucius
ENSG00000160310	PRMT2	100	89.310	ENSFCAG00000014823	PRMT2	100	89.310	Felis_catus
ENSG00000160310	PRMT2	100	92.035	ENSFDAG00000017639	PRMT2	100	90.909	Fukomys_damarensis
ENSG00000160310	PRMT2	93	54.680	ENSFHEG00000008467	prmt2	96	54.258	Fundulus_heteroclitus
ENSG00000160310	PRMT2	89	56.354	ENSGAFG00000012554	prmt2	97	54.229	Gambusia_affinis
ENSG00000160310	PRMT2	94	54.523	ENSGACG00000006286	prmt2	98	54.523	Gasterosteus_aculeatus
ENSG00000160310	PRMT2	100	99.336	ENSGGOG00000010719	PRMT2	100	99.336	Gorilla_gorilla
ENSG00000160310	PRMT2	93	53.808	ENSHBUG00000002521	prmt2	97	53.808	Haplochromis_burtoni
ENSG00000160310	PRMT2	96	90.265	ENSHGLG00000015854	PRMT2	99	84.597	Heterocephalus_glaber_female
ENSG00000160310	PRMT2	96	87.611	ENSHGLG00100000914	PRMT2	99	83.886	Heterocephalus_glaber_male
ENSG00000160310	PRMT2	93	56.110	ENSIPUG00000009647	prmt2	96	56.110	Ictalurus_punctatus
ENSG00000160310	PRMT2	100	91.224	ENSSTOG00000016495	PRMT2	100	91.224	Ictidomys_tridecemlineatus
ENSG00000160310	PRMT2	100	84.086	ENSJJAG00000010743	Prmt2	100	84.086	Jaculus_jaculus
ENSG00000160310	PRMT2	89	55.641	ENSKMAG00000020308	prmt2	100	55.641	Kryptolebias_marmoratus
ENSG00000160310	PRMT2	94	51.699	ENSLBEG00000004134	prmt2	98	51.699	Labrus_bergylta
ENSG00000160310	PRMT2	93	57.921	ENSLOCG00000010568	prmt2	97	57.921	Lepisosteus_oculatus
ENSG00000160310	PRMT2	91	93.651	ENSLAFG00000009604	PRMT2	100	91.584	Loxodonta_africana
ENSG00000160310	PRMT2	100	97.691	ENSMFAG00000003831	PRMT2	100	97.691	Macaca_fascicularis
ENSG00000160310	PRMT2	100	97.691	ENSMMUG00000015803	PRMT2	100	97.691	Macaca_mulatta
ENSG00000160310	PRMT2	100	97.229	ENSMNEG00000038764	PRMT2	100	97.229	Macaca_nemestrina
ENSG00000160310	PRMT2	100	96.540	ENSMLEG00000041912	PRMT2	100	96.540	Mandrillus_leucophaeus
ENSG00000160310	PRMT2	91	54.523	ENSMAMG00000019701	prmt2	97	54.523	Mastacembelus_armatus
ENSG00000160310	PRMT2	93	54.054	ENSMZEG00005009630	prmt2	97	54.054	Maylandia_zebra
ENSG00000160310	PRMT2	97	82.366	ENSMAUG00000017688	Prmt2	100	91.026	Mesocricetus_auratus
ENSG00000160310	PRMT2	100	93.913	ENSMICG00000015531	PRMT2	100	93.913	Microcebus_murinus
ENSG00000160310	PRMT2	100	88.696	ENSMOCG00000017602	Prmt2	100	87.191	Microtus_ochrogaster
ENSG00000160310	PRMT2	86	57.225	ENSMMOG00000003927	prmt2	88	53.866	Mola_mola
ENSG00000160310	PRMT2	89	57.065	ENSMALG00000017717	prmt2	92	51.529	Monopterus_albus
ENSG00000160310	PRMT2	100	88.696	MGP_CAROLIEiJ_G0015463	Prmt2	100	85.618	Mus_caroli
ENSG00000160310	PRMT2	100	89.565	ENSMUSG00000020230	Prmt2	100	85.843	Mus_musculus
ENSG00000160310	PRMT2	100	90.435	MGP_PahariEiJ_G0030877	Prmt2	100	86.742	Mus_pahari
ENSG00000160310	PRMT2	100	88.696	MGP_SPRETEiJ_G0016276	Prmt2	100	85.618	Mus_spretus
ENSG00000160310	PRMT2	100	87.671	ENSMPUG00000001331	PRMT2	100	83.807	Mustela_putorius_furo
ENSG00000160310	PRMT2	100	88.479	ENSMLUG00000007631	PRMT2	100	88.479	Myotis_lucifugus
ENSG00000160310	PRMT2	80	77.863	ENSNGAG00000017453	-	79	95.652	Nannospalax_galili
ENSG00000160310	PRMT2	93	51.103	ENSNBRG00000017273	prmt2	85	51.149	Neolamprologus_brichardi
ENSG00000160310	PRMT2	100	99.130	ENSNLEG00000003330	PRMT2	100	99.130	Nomascus_leucogenys
ENSG00000160310	PRMT2	94	75.123	ENSMEUG00000000174	PRMT2	97	75.123	Notamacropus_eugenii
ENSG00000160310	PRMT2	94	90.465	ENSOPRG00000006235	-	99	90.465	Ochotona_princeps
ENSG00000160310	PRMT2	92	92.509	ENSODEG00000013920	PRMT2	87	91.339	Octodon_degus
ENSG00000160310	PRMT2	98	51.740	ENSONIG00000004127	prmt2	99	51.740	Oreochromis_niloticus
ENSG00000160310	PRMT2	98	74.528	ENSOANG00000013551	PRMT2	93	74.528	Ornithorhynchus_anatinus
ENSG00000160310	PRMT2	99	92.793	ENSOCUG00000016126	-	100	90.596	Oryctolagus_cuniculus
ENSG00000160310	PRMT2	94	53.641	ENSORLG00000016240	prmt2	97	53.641	Oryzias_latipes
ENSG00000160310	PRMT2	92	55.102	ENSORLG00020001935	prmt2	97	52.913	Oryzias_latipes_hni
ENSG00000160310	PRMT2	89	53.708	ENSORLG00015002566	prmt2	85	53.708	Oryzias_latipes_hsok
ENSG00000160310	PRMT2	94	54.369	ENSOMEG00000001593	prmt2	99	54.369	Oryzias_melastigma
ENSG00000160310	PRMT2	97	93.128	ENSOGAG00000013155	PRMT2	100	93.128	Otolemur_garnettii
ENSG00000160310	PRMT2	100	86.406	ENSOARG00000013469	PRMT2	100	86.406	Ovis_aries
ENSG00000160310	PRMT2	100	99.130	ENSPPAG00000035050	PRMT2	100	99.076	Pan_paniscus
ENSG00000160310	PRMT2	100	88.966	ENSPPRG00000011758	PRMT2	100	88.966	Panthera_pardus
ENSG00000160310	PRMT2	100	88.966	ENSPTIG00000007482	PRMT2	100	88.966	Panthera_tigris_altaica
ENSG00000160310	PRMT2	100	99.769	ENSPTRG00000014027	PRMT2	100	99.769	Pan_troglodytes
ENSG00000160310	PRMT2	100	97.460	ENSPANG00000019949	PRMT2	100	97.460	Papio_anubis
ENSG00000160310	PRMT2	90	55.080	ENSPMGG00000000296	prmt2	96	51.990	Periophthalmus_magnuspinnatus
ENSG00000160310	PRMT2	100	91.304	ENSPEMG00000016675	-	100	88.539	Peromyscus_maniculatus_bairdii
ENSG00000160310	PRMT2	98	55.963	ENSPMAG00000008584	prmt2	100	53.935	Petromyzon_marinus
ENSG00000160310	PRMT2	93	71.564	ENSPCIG00000008734	-	93	69.597	Phascolarctos_cinereus
ENSG00000160310	PRMT2	94	53.883	ENSPFOG00000018449	prmt2	99	53.883	Poecilia_formosa
ENSG00000160310	PRMT2	92	53.598	ENSPLAG00000022074	prmt2	93	53.598	Poecilia_latipinna
ENSG00000160310	PRMT2	92	55.612	ENSPMEG00000015959	prmt2	98	50.455	Poecilia_mexicana
ENSG00000160310	PRMT2	82	58.282	ENSPREG00000010427	prmt2	93	53.846	Poecilia_reticulata
ENSG00000160310	PRMT2	100	99.130	ENSPPYG00000011540	PRMT2	100	98.845	Pongo_abelii
ENSG00000160310	PRMT2	94	92.424	ENSPCAG00000006496	PRMT2	98	77.724	Procavia_capensis
ENSG00000160310	PRMT2	100	93.913	ENSPCOG00000028679	PRMT2	100	93.913	Propithecus_coquereli
ENSG00000160310	PRMT2	100	86.605	ENSPVAG00000005428	PRMT2	100	86.605	Pteropus_vampyrus
ENSG00000160310	PRMT2	86	57.627	ENSPNYG00000019621	prmt2	94	54.198	Pundamilia_nyererei
ENSG00000160310	PRMT2	94	56.373	ENSPNAG00000010918	prmt2	99	56.373	Pygocentrus_nattereri
ENSG00000160310	PRMT2	100	89.565	ENSRNOG00000001297	Prmt2	100	86.517	Rattus_norvegicus
ENSG00000160310	PRMT2	100	98.383	ENSRBIG00000040835	PRMT2	100	98.383	Rhinopithecus_bieti
ENSG00000160310	PRMT2	100	98.270	ENSRROG00000041142	PRMT2	100	98.270	Rhinopithecus_roxellana
ENSG00000160310	PRMT2	100	96.998	ENSSBOG00000030953	PRMT2	100	96.998	Saimiri_boliviensis_boliviensis
ENSG00000160310	PRMT2	93	49.510	ENSSFOG00015013865	prmt2	93	57.214	Scleropages_formosus
ENSG00000160310	PRMT2	94	51.515	ENSSDUG00000016811	prmt2	98	51.981	Seriola_dumerili
ENSG00000160310	PRMT2	94	51.878	ENSSLDG00000006377	prmt2	98	51.878	Seriola_lalandi_dorsalis
ENSG00000160310	PRMT2	85	92.941	ENSSARG00000014488	PRMT2	100	75.844	Sorex_araneus
ENSG00000160310	PRMT2	94	52.038	ENSSPAG00000021664	prmt2	98	52.038	Stegastes_partitus
ENSG00000160310	PRMT2	95	84.545	ENSSSCG00000022575	PRMT2	98	84.545	Sus_scrofa
ENSG00000160310	PRMT2	94	52.068	ENSTRUG00000013061	prmt2	98	52.068	Takifugu_rubripes
ENSG00000160310	PRMT2	93	52.099	ENSTNIG00000016455	prmt2	100	52.099	Tetraodon_nigroviridis
ENSG00000160310	PRMT2	97	92.601	ENSTBEG00000008289	PRMT2	99	92.601	Tupaia_belangeri
ENSG00000160310	PRMT2	100	87.558	ENSTTRG00000005777	PRMT2	100	87.558	Tursiops_truncatus
ENSG00000160310	PRMT2	94	90.931	ENSUAMG00000012491	PRMT2	100	90.931	Ursus_americanus
ENSG00000160310	PRMT2	100	88.940	ENSUMAG00000025033	PRMT2	100	88.940	Ursus_maritimus
ENSG00000160310	PRMT2	100	88.249	ENSVVUG00000020492	-	86	88.249	Vulpes_vulpes
ENSG00000160310	PRMT2	100	57.437	ENSXETG00000031494	PRMT2	100	57.437	Xenopus_tropicalis
ENSG00000160310	PRMT2	88	54.663	ENSXCOG00000001517	prmt2	94	55.013	Xiphophorus_couchianus
ENSG00000160310	PRMT2	92	54.342	ENSXMAG00000015793	prmt2	97	54.680	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003713	transcription coactivator activity	12039952.	IDA	Function
GO:0005515	protein binding	11513728.12039952.16616919.16648481.17925405.22093364.26420826.26871637.	IPI	Function
GO:0005634	nucleus	11513728.17587566.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	11513728.17587566.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	17587566.	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0006479	protein methylation	9545638.	TAS	Process
GO:0007165	signal transduction	9545638.	TAS	Process
GO:0008469	histone-arginine N-methyltransferase activity	21873635.	IBA	Function
GO:0008469	histone-arginine N-methyltransferase activity	-	ISS	Function
GO:0016274	protein-arginine N-methyltransferase activity	-	ISS	Function
GO:0016571	histone methylation	19405910.	IDA	Process
GO:0016571	histone methylation	-	ISS	Process
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	21873635.	IBA	Process
GO:0030331	estrogen receptor binding	17587566.	IDA	Function
GO:0030331	estrogen receptor binding	12039952.	IPI	Function
GO:0032088	negative regulation of NF-kappaB transcription factor activity	16648481.	IDA	Process
GO:0033142	progesterone receptor binding	12039952.	IPI	Function
GO:0034969	histone arginine methylation	21873635.	IBA	Process
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	21873635.	IBA	Function
GO:0042054	histone methyltransferase activity	19405910.	IDA	Function
GO:0042803	protein homodimerization activity	12039952.	IPI	Function
GO:0042974	retinoic acid receptor binding	12039952.	IPI	Function
GO:0042975	peroxisome proliferator activated receptor binding	12039952.	IPI	Function
GO:0043065	positive regulation of apoptotic process	16648481.	IGI	Process
GO:0044877	protein-containing complex binding	-	ISS	Function
GO:0045892	negative regulation of transcription, DNA-templated	16648481.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	12039952.	IDA	Process
GO:0046966	thyroid hormone receptor binding	12039952.	IPI	Function
GO:0048588	developmental cell growth	-	ISS	Process
GO:0050681	androgen receptor binding	17587566.	IPI	Function
GO:0060765	regulation of androgen receptor signaling pathway	17587566.	IDA	Process
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22093364	Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma.	FEBS J	2012 Jan	Zhong J	doi: 10.1111/j.1742-4658.2011.08426.x
29620287	Protein arginine N-methyltransferase2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-α36.	Oncol Rep	2018 Jun	Shen Y	doi: 10.3892/or.2018.6350
24911119	PRMT2 and RORγ expression are associated with breast cancer survival outcomes.	Mol Endocrinol	2014 Jul	Oh TG	doi: 10.1210/me.2013-1403
28677794	PRMT2β, a C-terminal splice variant of PRMT2, inhibits the growth of breast cancer cells.	Oncol Rep	2017 Aug	Zhong J	doi: 10.3892/or.2017.5786

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr21	46661056	Intron	novel		0.18
BLCA	chr21	46661057	Intron	novel		0.18
BLCA	chr21	46648457	Splice_Site	novel	X110_splice	0.13
BLCA	chr21	46651991	Intron	novel		0.11
BRCA	chr21	46664318	Silent	NA	I431I	0.27
BRCA	chr21	46648587	Missense_Mutation	NA	L153V	0.24	MTS
BRCA	chr21	46660859	Nonsense_Mutation	rs754046386	S286*	0.23
BRCA	chr21	46636921	5'UTR	novel		0.21
BRCA	chr21	46651962	Intron	novel		0.32
BRCA	chr21	46649724	Frame_Shift_Ins	novel	*G214Kfs10**	0.04
BRCA	chr21	46651980	Intron	NA		0.23
BRCA	chr21	46651969	Intron	novel		0.08
BRCA	chr21	46643592	Missense_Mutation	novel	E33K	0.23
CESC	chr21	46663454	Missense_Mutation	rs774024852	T390M	0.41
CESC	chr21	46643565	Missense_Mutation	NA	G24S	0.31
CESC	chr21	46661038	Intron	novel		0.21
COAD	chr21	46664428	3'UTR	rs183194632		0.29
COAD	chr21	46661077	Intron	novel		0.67
COAD	chr21	46636978	Missense_Mutation	NA	R9S	0.35
COAD	chr21	46661871	Silent	rs775674424	S344S	0.27
COAD	chr21	46649661	Silent	novel	Y192Y	0.22
COAD	chr21	46648488	Missense_Mutation	novel	P120T	0.4	MTS
COAD	chr21	46660870	Missense_Mutation	novel	Y290H	0.26
COAD	chr21	46658745	Frame_Shift_Del	novel	*F219Lfs4**	0.13
COAD	chr21	46658778	Missense_Mutation	novel	R230W	0.4
COAD	chr21	46659031	Intron	novel		0.38
COAD	chr21	46644325	Frame_Shift_Del	novel	*I57Ffs4**	0.47
COAD	chr21	46658976	Intron	novel		0.43
COAD	chr21	46659010	Intron	novel		0.41
COAD	chr21	46644448	Missense_Mutation	rs753071757	T96M	0.42	MTS
COAD	chr21	46660852	Frame_Shift_Del	NA	*S286Qfs9**	0.85
COAD	chr21	46664420	3'UTR	rs752153791		0.41
COAD	chr21	46661819	Missense_Mutation	NA	R327H	0.22
COAD	chr21	46660852	Frame_Shift_Del	NA	*S286Qfs9**	0.44
COAD	chr21	46636947	5'UTR	novel		0.32
COAD	chr21	46648530	Missense_Mutation	NA	E134K	0.38	MTS
COAD	chr21	46664334	3'UTR	novel		0.32
COAD	chr21	46658998	Intron	novel		0.36
DLBC	chr21	46649703	Silent	rs111614078	D206D	0.15
GBM	chr21	46636964	Missense_Mutation	novel	G5S	0.04
GBM	chr21	46663475	Missense_Mutation	novel	R397I	0.44
GBM	chr21	46651871	Intron	novel		0.45
HNSC	chr21	46658756	Missense_Mutation	novel	M222I	0.14
HNSC	chr21	46658795	Missense_Mutation	novel	K235N	0.35
HNSC	chr21	46660973	Intron	novel		0.12
KIRP	chr21	46661069	Intron	novel		0.32
LGG	chr21	46643610	Missense_Mutation	novel	A39T	0.43
LIHC	chr21	46661757	Intron	novel		0.4
LIHC	chr21	46644336	Missense_Mutation	novel	I59F	0.41
LUAD	chr21	46648617	Missense_Mutation	novel	A163T	0.2
LUAD	chr21	46644380	Silent	novel	A73A	0.42
LUAD	chr21	46651879	Intron	novel		0.44
LUSC	chr21	46663402	Missense_Mutation	novel	T373S	0.12
LUSC	chr21	46648609	Missense_Mutation	NA	R160L	0.25	MTS
LUSC	chr21	46663517	Nonsense_Mutation	novel	W411*	0.24
LUSC	chr21	46648457	Splice_Site	NA	X110_splice	0.23
OV	chr21	46660844	Missense_Mutation	NA	V281G	0.22
OV	chr21	46636931	5'UTR	novel		0.5
OV	chr21	46658891	Silent	rs781148398	N267N	0.54
OV	chr21	46648615	Missense_Mutation	novel	R162I	0.11
OV	chr21	46663403	Missense_Mutation	novel	T373R	0.3
OV	chr21	46644464	Missense_Mutation	novel	E101D	0.14	MTS
READ	chr21	46663423	Missense_Mutation	NA	P380S	0.24
READ	chr21	46636947	5'UTR	novel		0.34
READ	chr21	46661824	Missense_Mutation	novel	D329N	0.17
READ	chr21	46648553	Silent	rs763946678	I141I	0.6
SARC	chr21	46663443	Silent	novel	G386G	0.52
SARC	chr21	46644374	Missense_Mutation	novel	E71D	0.08
SARC	chr21	46663456	Missense_Mutation	novel	G391S	0.33
SARC	chr21	46664301	Frame_Shift_Ins	novel	*V428Kfs10**	0.12
SKCM	chr21	46649610	Silent	novel	H175H	0.47
SKCM	chr21	46661829	Silent	novel	I330I	0.27
SKCM	chr21	46661010	Intron	novel		0.35
SKCM	chr21	46661922	Silent	rs764678168	T361T	0.72
SKCM	chr21	46648467	Silent	NA	L113L	0.5
SKCM	chr21	46644407	Silent	novel	N82N	0.73
SKCM	chr21	46644408	Missense_Mutation	NA	H83Y	0.73	MTS
SKCM	chr21	46644400	Missense_Mutation	NA	P80L	0.15	MTS
SKCM	chr21	46648492	Missense_Mutation	NA	R121L	0.32	MTS
SKCM	chr21	46648592	Silent	rs748532696	F154F	0.42
SKCM	chr21	46651835	Intron	novel		0.44
SKCM	chr21	46644338	Silent	NA	I59I	0.23
SKCM	chr21	46659004	Intron	novel		1
STAD	chr21	46658876	Silent	NA	V262V	0.54
STAD	chr21	46663501	Missense_Mutation	novel	S406P	0.06
STAD	chr21	46651957	Intron	novel		0.17
STAD	chr21	46663544	Missense_Mutation	NA	T420R	0.38
STAD	chr21	46644325	Missense_Mutation	NA	E55G	0.08
STAD	chr21	46648608	Missense_Mutation	rs771042090	R160W	0.25	MTS
STAD	chr21	46661881	Nonsense_Mutation	NA	Q348*	0.29
STAD	chr21	46648621	Splice_Site	NA	X163_splice	0.22
STAD	chr21	46661858	Missense_Mutation	rs149476373	T340M	0.24
STAD	chr21	46660852	Frame_Shift_Del	NA	*S286Qfs9**	0.21
STAD	chr21	46660852	Frame_Shift_Del	NA	*S286Qfs9**	0.38
STAD	chr21	46644448	Missense_Mutation	rs753071757	T96M	0.07	MTS
TGCT	chr21	46651855	Intron	novel		0.21
TGCT	chr21	46663524	Frame_Shift_Del	novel	*T414Kfs20**	0.14
THCA	chr21	46661048	Intron	novel		0.15
UCEC	chr21	46643349	Intron	novel		0.33
UCEC	chr21	46661146	Intron	novel		0.4
UCEC	chr21	46651866	Intron	rs374324960		0.42
UCEC	chr21	46658978	Intron	novel		0.15
UCEC	chr21	46663404	Silent	rs546308106	T373T	0.41
UCEC	chr21	46660937	Missense_Mutation	novel	R312I	0.41
UCEC	chr21	46664327	Nonstop_Mutation	novel	434Wext35	0.38
UCEC	chr21	46661803	Missense_Mutation	novel	L322M	0.56
UCEC	chr21	46643434	Intron	novel		0.32
UCEC	chr21	46658888	Silent	novel	D266D	0.25
UCEC	chr21	46644311	Frame_Shift_Del	novel	L52*	0.44
UCEC	chr21	46661851	Missense_Mutation	novel	G338S	0.4
UCEC	chr21	46663495	Missense_Mutation	novel	H404Y	0.07
UCEC	chr21	46659034	Intron	novel		0.22
UCEC	chr21	46664535	3'UTR	novel		0.45
UCEC	chr21	46643618	Silent	rs146609111	Y41Y	0.38
UCEC	chr21	46658856	Missense_Mutation	novel	K256E	0.32
UCEC	chr21	46660947	Missense_Mutation	novel	Q315H	0.33
UCEC	chr21	46636987	Silent	rs776700720	S12S	0.33
UCEC	chr21	46648541	Silent	rs762707577	T137T	0.26
UCEC	chr21	46649675	Missense_Mutation	novel	E197G	0.33
UCEC	chr21	46636987	Silent	rs776700720	S12S	0.27
UCEC	chr21	46661063	Intron	novel		0.2
UCEC	chr21	46664400	3'UTR	novel		0.48
UCEC	chr21	46644475	Missense_Mutation	novel	S105N	0.38	MTS
UCEC	chr21	46648540	Missense_Mutation	rs575840670	T137M	0.31	MTS
UCEC	chr21	46661824	Missense_Mutation	novel	D329N	0.28
UCEC	chr21	46658807	Silent	novel	V239V	0.46
UCEC	chr21	46664312	Silent	NA	F429F	0.04
UCEC	chr21	46658894	Silent	rs756310635	A268A	0.31
UCEC	chr21	46660848	Missense_Mutation	novel	K282N	0.38
UCEC	chr21	46649580	Silent	rs780317001	Y165Y	0.3
UCEC	chr21	46644441	Missense_Mutation	NA	E94K	0.3	MTS
UCEC	chr21	46661010	Intron	novel		0.46
UCEC	chr21	46644376	Missense_Mutation	rs770525653	R72H	0.44
UCEC	chr21	46661025	Intron	novel		0.32
UCEC	chr21	46648619	Splice_Region	rs368673121	A163A	0.18
UCEC	chr21	46663475	Missense_Mutation	novel	R397I	0.43
UCEC	chr21	46661768	Intron	novel		0.35
UCEC	chr21	46651985	Intron	NA		0.23
UCEC	chr21	46663494	Silent	NA	R403R	0.2
UCEC	chr21	46651901	Intron	rs774377515		0.46
UCEC	chr21	46644374	Silent	rs777274657	E71E	0.41
UCEC	chr21	46648610	Silent	novel	R160R	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
OV	DEL	0.3523	0.022578
SARC	DEL	0.2101	0.00082565
THYM	AMP	0.0163	0.24554

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.034	Kaplan-Meier Survival Analysis
STAD	0.0049	Kaplan-Meier Survival Analysis
ACC	0.031	Kaplan-Meier Survival Analysis
SKCM	0.046	Kaplan-Meier Survival Analysis
ESCA	0.0092	Kaplan-Meier Survival Analysis
TGCT	0.048	Kaplan-Meier Survival Analysis
KIRP	0.0028	Kaplan-Meier Survival Analysis
COAD	0.0033	Kaplan-Meier Survival Analysis
PAAD	0.0059	Kaplan-Meier Survival Analysis
LIHC	0.0069	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.0018	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742