EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160633 (Gene tree)
Gene ID: 6294
Gene Symbol: SAFB
Alias: HET|SAFB1
Full Name: scaffold attachment factor B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 45,444 bases
Position: chr19:5,623,035-5,668,478
Accession: 10520
RBP type: canonical RBP
Summary: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000415895	RRM_5	PF13893.6	1e-06	1	1
ENSP00000292123	RRM_5	PF13893.6	1.1e-06	1	1
ENSP00000464840	RRM_5	PF13893.6	1.1e-06	1	1
ENSP00000467423	RRM_5	PF13893.6	1.1e-06	1	1
ENSP00000415895	RRM_1	PF00076.22	1.2e-12	1	1
ENSP00000292123	RRM_1	PF00076.22	1.2e-12	1	1
ENSP00000467423	RRM_1	PF00076.22	1.2e-12	1	1
ENSP00000464840	RRM_1	PF00076.22	1.2e-12	1	1
ENSP00000415895	SAP	PF02037.27	3.4e-09	1	1
ENSP00000292123	SAP	PF02037.27	3.8e-09	1	1
ENSP00000464840	SAP	PF02037.27	3.8e-09	1	1
ENSP00000467423	SAP	PF02037.27	3.8e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11431691	Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.	Nat Genet	2001 Jul	Ma Z	-
29887524	Scaffold attachment factor B suppresses HIV-1 infection of CD4+ T cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat.	J Biol Chem	2018 Aug 3	Ma L	doi: 10.1074/jbc.RA118.002018
26273616	Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.	Biomed Res Int	2015	Hong E	doi: 10.1155/2015/395816
17630952	A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis.	Biochem J	2007 Nov 1	Chan CW	-
26694817	iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.	BMC Biol	2015 Dec 22	Rivers C	doi: 10.1186/s12915-015-0220-7.
17643427	SAFB re-distribution marks steps of the apoptotic process.	Exp Cell Res	2007 Nov 1	Lee YB	-
10212141	A novel hnRNP protein (HAP/SAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock.	J Cell Sci	1999 May	Weighardt F	-
12215442	Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA.	J Biol Chem	2002 Nov 8	Ge W	-
10899586	Cloning and recombinant expression of the La RNA-binding protein from Trypanosoma brucei.	Biochim Biophys Acta	2000 Jul 24	Westermann S	-
17200140	Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2.	J Cell Sci	2007 Jan 15	Sergeant KA	-
25800734	The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing.	Nucleic Acids Res	2015 Apr 20	Liu HW	doi: 10.1093/nar/gkv246
27888239	The increasing diversity of functions attributed to the SAFB family of RNA-/DNA-binding proteins.	Biochem J	2016 Dec 1	Norman M	-
9087430	Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation.	Genes Dev	1997 Mar 15	Gunderson SI	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000589006	SAFB-206	459	-	ENSP00000464758	153 (aa)	-	K7EII0
ENST00000292123	SAFB-201	3042	-	ENSP00000292123	915 (aa)	-	Q15424
ENST00000591991	SAFB-210	3471	-	-	- (aa)	-	-
ENST00000588852	SAFB-205	2842	-	ENSP00000467423	917 (aa)	-	Q15424
ENST00000590485	SAFB-208	548	-	-	- (aa)	-	-
ENST00000592555	SAFB-213	1360	-	-	- (aa)	-	-
ENST00000592707	SAFB-214	940	-	-	- (aa)	-	-
ENST00000589863	SAFB-207	2708	-	ENSP00000468543	106 (aa)	-	K7ES42
ENST00000454510	SAFB-202	2650	XM_017027114	ENSP00000415895	848 (aa)	XP_016882603	Q15424
ENST00000586281	SAFB-203	397	-	-	- (aa)	-	-
ENST00000592224	SAFB-211	3014	-	ENSP00000464840	916 (aa)	-	Q15424
ENST00000591666	SAFB-209	632	-	-	- (aa)	-	-
ENST00000592396	SAFB-212	620	-	-	- (aa)	-	-
ENST00000586934	SAFB-204	995	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000160633's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160633	Blood Pressure	5.6630000E-005	-
ENSG00000160633	Platelet Function Tests	6.9700000E-007	-
ENSG00000160633	Platelet Function Tests	6.9000000E-007	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160633's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000160633	SAFB	65	64.486	ENSG00000137776	SLTM	94	35.535
ENSG00000160633	SAFB	100	69.874	ENSG00000130254	SAFB2	98	69.313

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160633	SAFB	95	47.802	ENSAPOG00000022508	safb	65	43.291	Acanthochromis_polyacanthus
ENSG00000160633	SAFB	100	92.174	ENSAMEG00000012254	SAFB	98	92.076	Ailuropoda_melanoleuca
ENSG00000160633	SAFB	94	40.112	ENSACIG00000006247	safb	95	43.523	Amphilophus_citrinellus
ENSG00000160633	SAFB	95	47.802	ENSAOCG00000006308	safb	71	42.834	Amphiprion_ocellaris
ENSG00000160633	SAFB	95	47.802	ENSAPEG00000023342	safb	66	42.882	Amphiprion_percula
ENSG00000160633	SAFB	78	63.115	ENSATEG00000004998	safb	66	42.400	Anabas_testudineus
ENSG00000160633	SAFB	89	63.528	ENSAPLG00000006355	-	99	64.839	Anas_platyrhynchos
ENSG00000160633	SAFB	93	65.668	ENSAPLG00000005780	-	100	64.821	Anas_platyrhynchos
ENSG00000160633	SAFB	80	70.161	ENSACAG00000016893	-	95	52.168	Anolis_carolinensis
ENSG00000160633	SAFB	100	98.253	ENSANAG00000028821	SAFB	100	98.253	Aotus_nancymaae
ENSG00000160633	SAFB	78	62.295	ENSACLG00000001926	safb	64	42.998	Astatotilapia_calliptera
ENSG00000160633	SAFB	85	57.447	ENSAMXG00000018154	safb	94	44.382	Astyanax_mexicanus
ENSG00000160633	SAFB	100	88.877	ENSBTAG00000007875	SAFB	100	88.877	Bos_taurus
ENSG00000160633	SAFB	88	92.473	ENSBTAG00000051794	-	91	90.164	Bos_taurus
ENSG00000160633	SAFB	100	93.464	ENSCJAG00000017081	SAFB	100	98.881	Callithrix_jacchus
ENSG00000160633	SAFB	100	93.457	ENSCAFG00000018803	SAFB	87	93.457	Canis_familiaris
ENSG00000160633	SAFB	100	93.457	ENSCAFG00020018943	SAFB	100	93.457	Canis_lupus_dingo
ENSG00000160633	SAFB	100	87.459	ENSCHIG00000007262	SAFB	98	92.453	Capra_hircus
ENSG00000160633	SAFB	88	62.500	ENSTSYG00000001851	-	100	76.514	Carlito_syrichta
ENSG00000160633	SAFB	93	71.542	ENSCAPG00000012121	SAFB	77	83.557	Cavia_aperea
ENSG00000160633	SAFB	100	87.473	ENSCPOG00000026322	SAFB	100	87.261	Cavia_porcellus
ENSG00000160633	SAFB	100	98.703	ENSCCAG00000020193	SAFB	100	98.703	Cebus_capucinus
ENSG00000160633	SAFB	100	99.345	ENSCATG00000029994	SAFB	100	99.345	Cercocebus_atys
ENSG00000160633	SAFB	100	88.486	ENSCLAG00000007734	SAFB	100	89.872	Chinchilla_lanigera
ENSG00000160633	SAFB	100	99.236	ENSCSAG00000009949	SAFB	100	99.236	Chlorocebus_sabaeus
ENSG00000160633	SAFB	100	90.909	ENSCHOG00000003208	SAFB	93	92.857	Choloepus_hoffmanni
ENSG00000160633	SAFB	91	65.325	ENSCPBG00000010928	-	99	64.573	Chrysemys_picta_bellii
ENSG00000160633	SAFB	78	77.686	ENSCPBG00000010936	-	99	61.808	Chrysemys_picta_bellii
ENSG00000160633	SAFB	100	100.000	ENSCANG00000004774	-	100	100.000	Colobus_angolensis_palliatus
ENSG00000160633	SAFB	100	92.576	ENSCANG00000019754	-	100	92.467	Colobus_angolensis_palliatus
ENSG00000160633	SAFB	100	83.493	ENSCGRG00001002254	Safb	100	83.582	Cricetulus_griseus_chok1gshd
ENSG00000160633	SAFB	81	93.600	ENSCGRG00000011529	Safb	96	80.871	Cricetulus_griseus_crigri
ENSG00000160633	SAFB	93	43.354	ENSCSEG00000019870	safb	69	42.883	Cynoglossus_semilaevis
ENSG00000160633	SAFB	76	62.791	ENSCVAG00000002226	safb	94	39.763	Cyprinodon_variegatus
ENSG00000160633	SAFB	92	42.421	ENSDARG00000020467	safb	99	44.528	Danio_rerio
ENSG00000160633	SAFB	100	92.157	ENSDNOG00000015746	SAFB	95	92.530	Dasypus_novemcinctus
ENSG00000160633	SAFB	100	82.503	ENSDORG00000016200	Safb	100	82.839	Dipodomys_ordii
ENSG00000160633	SAFB	80	85.507	ENSETEG00000018679	SAFB	85	85.507	Echinops_telfairi
ENSG00000160633	SAFB	100	88.829	ENSEASG00005023019	SAFB	100	88.829	Equus_asinus_asinus
ENSG00000160633	SAFB	100	90.840	ENSECAG00000018659	SAFB	89	90.949	Equus_caballus
ENSG00000160633	SAFB	78	64.228	ENSELUG00000022327	safb	59	55.000	Esox_lucius
ENSG00000160633	SAFB	100	93.246	ENSFCAG00000011835	SAFB	100	93.246	Felis_catus
ENSG00000160633	SAFB	100	65.591	ENSFALG00000013882	-	89	64.856	Ficedula_albicollis
ENSG00000160633	SAFB	91	59.842	ENSFALG00000013881	-	99	60.722	Ficedula_albicollis
ENSG00000160633	SAFB	100	83.333	ENSFDAG00000020306	SAFB	100	88.732	Fukomys_damarensis
ENSG00000160633	SAFB	77	62.810	ENSFHEG00000004219	safb	94	41.756	Fundulus_heteroclitus
ENSG00000160633	SAFB	69	62.963	ENSGMOG00000014280	safb	95	41.432	Gadus_morhua
ENSG00000160633	SAFB	100	65.231	ENSGALG00000013365	-	97	64.961	Gallus_gallus
ENSG00000160633	SAFB	100	62.055	ENSGALG00000001948	-	97	63.472	Gallus_gallus
ENSG00000160633	SAFB	76	61.719	ENSGAFG00000016162	safb	67	39.267	Gambusia_affinis
ENSG00000160633	SAFB	78	63.934	ENSGACG00000011385	safb	67	40.916	Gasterosteus_aculeatus
ENSG00000160633	SAFB	72	83.036	ENSGAGG00000017702	-	100	58.260	Gopherus_agassizii
ENSG00000160633	SAFB	78	80.165	ENSGAGG00000008424	-	97	63.404	Gopherus_agassizii
ENSG00000160633	SAFB	100	100.000	ENSGGOG00000015109	SAFB	100	100.000	Gorilla_gorilla
ENSG00000160633	SAFB	95	39.858	ENSHBUG00000009218	safb	70	42.757	Haplochromis_burtoni
ENSG00000160633	SAFB	100	90.471	ENSHGLG00000015883	SAFB	100	90.568	Heterocephalus_glaber_female
ENSG00000160633	SAFB	100	84.783	ENSHGLG00100004228	SAFB	77	89.401	Heterocephalus_glaber_male
ENSG00000160633	SAFB	88	55.102	ENSHCOG00000001705	safb	96	41.065	Hippocampus_comes
ENSG00000160633	SAFB	86	60.000	ENSIPUG00000024869	safb2	97	46.536	Ictalurus_punctatus
ENSG00000160633	SAFB	93	90.460	ENSSTOG00000002783	SAFB	100	90.564	Ictidomys_tridecemlineatus
ENSG00000160633	SAFB	100	85.547	ENSJJAG00000009021	Safb	100	85.987	Jaculus_jaculus
ENSG00000160633	SAFB	78	65.574	ENSKMAG00000022308	safb	95	42.974	Kryptolebias_marmoratus
ENSG00000160633	SAFB	78	63.115	ENSLBEG00000006015	safb	65	44.481	Labrus_bergylta
ENSG00000160633	SAFB	75	54.237	ENSLACG00000018090	SAFB	100	53.830	Latimeria_chalumnae
ENSG00000160633	SAFB	78	67.213	ENSLOCG00000003613	safb	90	58.407	Lepisosteus_oculatus
ENSG00000160633	SAFB	99	90.533	ENSLAFG00000003840	SAFB	100	89.336	Loxodonta_africana
ENSG00000160633	SAFB	100	99.346	ENSMFAG00000003885	SAFB	100	99.346	Macaca_fascicularis
ENSG00000160633	SAFB	100	99.345	ENSMMUG00000017970	SAFB	100	99.345	Macaca_mulatta
ENSG00000160633	SAFB	100	99.057	ENSMNEG00000035637	SAFB	100	99.057	Macaca_nemestrina
ENSG00000160633	SAFB	100	99.057	ENSMLEG00000038637	SAFB	100	99.057	Mandrillus_leucophaeus
ENSG00000160633	SAFB	78	62.295	ENSMAMG00000003357	safb	60	40.968	Mastacembelus_armatus
ENSG00000160633	SAFB	78	62.295	ENSMZEG00005009120	safb	66	43.450	Maylandia_zebra
ENSG00000160633	SAFB	97	64.103	ENSMGAG00000001101	-	100	63.434	Meleagris_gallopavo
ENSG00000160633	SAFB	81	68.000	ENSMGAG00000001051	-	97	60.745	Meleagris_gallopavo
ENSG00000160633	SAFB	81	93.600	ENSMAUG00000005013	Safb	100	90.760	Mesocricetus_auratus
ENSG00000160633	SAFB	99	86.667	ENSMICG00000034927	-	77	96.739	Microcebus_murinus
ENSG00000160633	SAFB	88	92.473	ENSMICG00000046795	-	98	92.553	Microcebus_murinus
ENSG00000160633	SAFB	100	92.344	ENSMICG00000008739	-	100	91.519	Microcebus_murinus
ENSG00000160633	SAFB	100	84.026	ENSMOCG00000014040	Safb	100	84.026	Microtus_ochrogaster
ENSG00000160633	SAFB	75	56.098	ENSMMOG00000020366	-	65	52.381	Mola_mola
ENSG00000160633	SAFB	100	75.558	ENSMODG00000001236	SAFB	98	76.118	Monodelphis_domestica
ENSG00000160633	SAFB	78	64.754	ENSMALG00000020330	safb	70	42.097	Monopterus_albus
ENSG00000160633	SAFB	100	84.255	MGP_CAROLIEiJ_G0021780	Safb	100	84.255	Mus_caroli
ENSG00000160633	SAFB	100	84.362	ENSMUSG00000071054	Safb	100	84.362	Mus_musculus
ENSG00000160633	SAFB	100	84.166	MGP_PahariEiJ_G0020769	Safb	100	84.166	Mus_pahari
ENSG00000160633	SAFB	100	92.702	ENSMPUG00000006123	SAFB	94	92.702	Mustela_putorius_furo
ENSG00000160633	SAFB	100	91.068	ENSMLUG00000001081	SAFB	100	91.068	Myotis_lucifugus
ENSG00000160633	SAFB	100	82.185	ENSNGAG00000019882	Safb	100	82.185	Nannospalax_galili
ENSG00000160633	SAFB	75	54.651	ENSNBRG00000000496	-	81	54.651	Neolamprologus_brichardi
ENSG00000160633	SAFB	96	99.658	ENSNLEG00000013551	SAFB	100	99.658	Nomascus_leucogenys
ENSG00000160633	SAFB	81	93.548	ENSOPRG00000011561	-	100	85.468	Ochotona_princeps
ENSG00000160633	SAFB	100	90.502	ENSODEG00000014838	SAFB	100	90.502	Octodon_degus
ENSG00000160633	SAFB	78	61.475	ENSONIG00000002318	safb	66	43.528	Oreochromis_niloticus
ENSG00000160633	SAFB	90	81.490	ENSOCUG00000014628	SAFB	65	85.261	Oryctolagus_cuniculus
ENSG00000160633	SAFB	78	64.463	ENSORLG00000016989	safb	66	39.365	Oryzias_latipes
ENSG00000160633	SAFB	94	40.662	ENSORLG00020000404	safb	98	39.326	Oryzias_latipes_hni
ENSG00000160633	SAFB	78	63.934	ENSORLG00015010733	safb	66	39.524	Oryzias_latipes_hsok
ENSG00000160633	SAFB	78	62.810	ENSOMEG00000009066	safb	67	39.652	Oryzias_melastigma
ENSG00000160633	SAFB	100	90.672	ENSOGAG00000027769	SAFB	100	90.022	Otolemur_garnettii
ENSG00000160633	SAFB	100	84.967	ENSOARG00000007662	-	100	84.423	Ovis_aries
ENSG00000160633	SAFB	78	82.353	ENSOARG00000007856	-	100	82.073	Ovis_aries
ENSG00000160633	SAFB	100	100.000	ENSPPAG00000035129	SAFB	100	100.000	Pan_paniscus
ENSG00000160633	SAFB	100	93.246	ENSPPRG00000017197	SAFB	100	93.246	Panthera_pardus
ENSG00000160633	SAFB	100	100.000	ENSPTRG00000010335	SAFB	100	100.000	Pan_troglodytes
ENSG00000160633	SAFB	100	99.237	ENSPANG00000007770	SAFB	100	99.237	Papio_anubis
ENSG00000160633	SAFB	95	43.133	ENSPKIG00000009902	safb	67	45.997	Paramormyrops_kingsleyae
ENSG00000160633	SAFB	99	61.684	ENSPSIG00000009367	-	97	61.255	Pelodiscus_sinensis
ENSG00000160633	SAFB	100	62.211	ENSPSIG00000011679	-	100	63.585	Pelodiscus_sinensis
ENSG00000160633	SAFB	75	60.241	ENSPMGG00000015973	-	61	61.972	Periophthalmus_magnuspinnatus
ENSG00000160633	SAFB	100	84.632	ENSPEMG00000020428	Safb	100	84.632	Peromyscus_maniculatus_bairdii
ENSG00000160633	SAFB	88	84.559	ENSPCIG00000009504	-	99	82.766	Phascolarctos_cinereus
ENSG00000160633	SAFB	76	65.254	ENSPFOG00000007745	safb	94	41.507	Poecilia_formosa
ENSG00000160633	SAFB	76	61.719	ENSPLAG00000001614	safb	95	40.185	Poecilia_latipinna
ENSG00000160633	SAFB	76	61.719	ENSPMEG00000021023	safb	98	41.455	Poecilia_mexicana
ENSG00000160633	SAFB	76	62.500	ENSPREG00000012496	safb	95	41.176	Poecilia_reticulata
ENSG00000160633	SAFB	100	99.672	ENSPPYG00000009428	SAFB	100	99.672	Pongo_abelii
ENSG00000160633	SAFB	100	86.645	ENSPCAG00000006475	SAFB	100	86.645	Procavia_capensis
ENSG00000160633	SAFB	100	87.736	ENSPCOG00000010436	-	94	87.736	Propithecus_coquereli
ENSG00000160633	SAFB	100	88.498	ENSPCOG00000014090	SAFB	100	88.146	Propithecus_coquereli
ENSG00000160633	SAFB	100	86.024	ENSPVAG00000004913	SAFB	100	84.406	Pteropus_vampyrus
ENSG00000160633	SAFB	93	45.394	ENSPNAG00000021838	safb	97	45.455	Pygocentrus_nattereri
ENSG00000160633	SAFB	100	84.166	ENSRNOG00000050543	Safb	100	84.803	Rattus_norvegicus
ENSG00000160633	SAFB	100	100.000	ENSRBIG00000042509	SAFB	100	100.000	Rhinopithecus_bieti
ENSG00000160633	SAFB	100	100.000	ENSRROG00000029278	SAFB	100	100.000	Rhinopithecus_roxellana
ENSG00000160633	SAFB	100	98.703	ENSSBOG00000026291	SAFB	100	98.703	Saimiri_boliviensis_boliviensis
ENSG00000160633	SAFB	95	44.647	ENSSFOG00015008156	safb	95	46.587	Scleropages_formosus
ENSG00000160633	SAFB	78	60.656	ENSSMAG00000009316	safb	66	42.381	Scophthalmus_maximus
ENSG00000160633	SAFB	78	64.754	ENSSDUG00000009652	safb	72	41.158	Seriola_dumerili
ENSG00000160633	SAFB	78	66.393	ENSSLDG00000001670	safb	65	41.838	Seriola_lalandi_dorsalis
ENSG00000160633	SAFB	93	85.246	ENSSARG00000010475	SAFB	100	85.246	Sorex_araneus
ENSG00000160633	SAFB	91	72.143	ENSSPUG00000009747	-	99	58.426	Sphenodon_punctatus
ENSG00000160633	SAFB	82	59.227	ENSSPUG00000009820	-	99	62.162	Sphenodon_punctatus
ENSG00000160633	SAFB	92	49.425	ENSSPAG00000015682	safb	69	40.931	Stegastes_partitus
ENSG00000160633	SAFB	100	92.465	ENSSSCG00000013522	SAFB	99	93.702	Sus_scrofa
ENSG00000160633	SAFB	93	62.073	ENSTGUG00000000489	-	97	64.554	Taeniopygia_guttata
ENSG00000160633	SAFB	96	64.653	ENSTGUG00000000502	-	97	65.052	Taeniopygia_guttata
ENSG00000160633	SAFB	78	63.115	ENSTRUG00000003567	safb	98	43.243	Takifugu_rubripes
ENSG00000160633	SAFB	87	56.322	ENSTNIG00000015470	safb	90	56.322	Tetraodon_nigroviridis
ENSG00000160633	SAFB	74	90.977	ENSTBEG00000013124	-	66	90.977	Tupaia_belangeri
ENSG00000160633	SAFB	94	98.413	ENSTTRG00000013588	SAFB	92	98.413	Tursiops_truncatus
ENSG00000160633	SAFB	92	92.233	ENSUAMG00000024667	-	88	92.233	Ursus_americanus
ENSG00000160633	SAFB	88	96.324	ENSUAMG00000024543	SAFB	100	89.740	Ursus_americanus
ENSG00000160633	SAFB	88	97.849	ENSUMAG00000009734	SAFB	97	91.115	Ursus_maritimus
ENSG00000160633	SAFB	73	94.531	ENSVPAG00000012043	SAFB	79	94.531	Vicugna_pacos
ENSG00000160633	SAFB	100	93.355	ENSVVUG00000013720	SAFB	87	93.355	Vulpes_vulpes
ENSG00000160633	SAFB	81	62.069	ENSXETG00000008755	safb	91	62.385	Xenopus_tropicalis
ENSG00000160633	SAFB	78	55.294	ENSXCOG00000010246	-	66	62.687	Xiphophorus_couchianus
ENSG00000160633	SAFB	76	61.719	ENSXMAG00000003458	safb	94	41.388	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	Function
GO:0003682	chromatin binding	-	ISS	Function
GO:0003690	double-stranded DNA binding	1324173.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	12660241.14559993.19282290.19674106.20562859.21130767.21900206.27731383.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006325	chromatin organization	1324173.	TAS	Process
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0030520	intracellular estrogen receptor signaling pathway	21873635.	IBA	Process
GO:0040008	regulation of growth	-	IEA	Process
GO:0042445	hormone metabolic process	-	IEA	Process
GO:0043565	sequence-specific DNA binding	21873635.	IBA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0050684	regulation of mRNA processing	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
14587024	Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?	J Cell Biochem	2003 Nov 1	Oesterreich S	-
18772145	Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene.	J Biol Chem	2008 Oct 31	Lin J	doi: 10.1074/jbc.M802076200
19137425	Low SAFB levels are associated with worse outcome in breast cancer patients.	Breast Cancer Res Treat	2010 Jun	Hammerich-Hille S	doi: 10.1007/s10549-008-0297-6
19077293	No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.	BMC Med Genet	2008 Dec 13	Bergman A	doi: 10.1186/1471-2350-9-108.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	5626451	Missense_Mutation	novel	S79F	0.19
BLCA	chr19	5657266	Missense_Mutation	novel	S594L	0.28
BLCA	chr19	5661525	Missense_Mutation	novel	R624C	0.29
BLCA	chr19	5626472	Nonsense_Mutation	novel	S86*	0.15
BLCA	chr19	5668265	Missense_Mutation	novel	D908H	0.12
BLCA	chr19	5668265	Missense_Mutation	rs756589107	D908N	0.34
BLCA	chr19	5668184	Missense_Mutation	rs778094826	G881R	0.38
BLCA	chr19	5668389	3'UTR	novel		0.44
BLCA	chr19	5653155	Missense_Mutation	novel	G445A	0.42
BLCA	chr19	5654134	Missense_Mutation	novel	E534K	0.06
BLCA	chr19	5654382	Missense_Mutation	rs751387449	E561K	0.08
BLCA	chr19	5668265	Missense_Mutation	novel	D908Y	0.15
BRCA	chr19	5664416	Missense_Mutation	NA	M771L	0.26
BRCA	chr19	5654068	Missense_Mutation	NA	N512D	0.69
BRCA	chr19	5653365	Missense_Mutation	NA	T491S	0.52
BRCA	chr19	5641902	Missense_Mutation	rs770745797	E168K	0.28
BRCA	chr19	5641883	Silent	rs747968577	S161S	0.34
BRCA	chr19	5657310	Missense_Mutation	NA	K609E	0.37
CESC	chr19	5667841	Missense_Mutation	rs755838374	G858A	0.38
CESC	chr19	5654174	Missense_Mutation	novel	S547L	0.21
CESC	chr19	5641845	Missense_Mutation	rs754213071	E149K	0.44
CESC	chr19	5653168	Nonsense_Mutation	novel	Y449*	0.19
CESC	chr19	5641850	Silent	rs757607710	D150D	0.38
CESC	chr19	5661786	Missense_Mutation	novel	R711W	0.49
CESC	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.14
CESC	chr19	5653392	Frame_Shift_Del	novel	*K501Rfs64**	0.5
CESC	chr19	5654174	Nonsense_Mutation	novel	S547*	0.32
CESC	chr19	5651045	Silent	rs777904505	L422L	0.25
CESC	chr19	5641623	Missense_Mutation	novel	D102H	0.43
COAD	chr19	5667375	Nonsense_Mutation	novel	R826*	0.24
COAD	chr19	5650990	In_Frame_Del	rs762859329	G405del	0.28
COAD	chr19	5654179	Nonsense_Mutation	novel	R549*	0.24
COAD	chr19	5623286	Silent	novel	G27G	0.29
COAD	chr19	5641842	Missense_Mutation	novel	V148I	0.37
COAD	chr19	5661760	Missense_Mutation	rs765557822	Y702C	0.21
COAD	chr19	5664093	Missense_Mutation	rs138286283	R742H	0.35
COAD	chr19	5667355	Missense_Mutation	novel	R819H	0.28
COAD	chr19	5668370	3'UTR	novel		0.7
COAD	chr19	5661598	Missense_Mutation	NA	A648V	0.38
COAD	chr19	5641908	Missense_Mutation	novel	E170K	0.25
COAD	chr19	5668370	3'UTR	novel		0.5
COAD	chr19	5653231	Silent	rs541754798	T470T	0.43
COAD	chr19	5654417	Silent	novel	V572V	0.13
COAD	chr19	5664053	Missense_Mutation	NA	R729W	0.2
COAD	chr19	5661558	Missense_Mutation	NA	A635S	0.36
COAD	chr19	5668370	3'UTR	novel		0.36
COAD	chr19	5661525	Missense_Mutation	novel	R624C	0.08
COAD	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.41
COAD	chr19	5667361	Frame_Shift_Del	NA	*D823Tfs19**	0.2
COAD	chr19	5649943	Missense_Mutation	rs575162668	S389L	0.21
COAD	chr19	5667358	Missense_Mutation	novel	D820G	0.07
COAD	chr19	5661699	Missense_Mutation	NA	R682C	0.56
COAD	chr19	5668425	3'UTR	novel		1
COAD	chr19	5623225	Missense_Mutation	NA	G7V	0.31
ESCA	chr19	5661525	Missense_Mutation	novel	R624C	0.16
ESCA	chr19	5653388	Silent	rs749049469	D498D	0.39
ESCA	chr19	5661728	Silent	novel	R691R	0.08
ESCA	chr19	5661780	Missense_Mutation	novel	A709T	0.1
ESCA	chr19	5641925	Silent	rs758696281	P175P	0.25
GBM	chr19	5664428	Nonsense_Mutation	NA	R775*	0.25
GBM	chr19	5667824	Silent	rs148221587	G852G	0.49
GBM	chr19	5648052	Intron	novel		0.39
GBM	chr19	5668166	Missense_Mutation	rs781691891	G875S	0.05
HNSC	chr19	5664414	Nonsense_Mutation	novel	S770*	0.27
HNSC	chr19	5654175	Silent	novel	S547S	0.49
HNSC	chr19	5657256	Missense_Mutation	novel	D591N	0.27
HNSC	chr19	5657257	Missense_Mutation	novel	D591A	0.27
HNSC	chr19	5661601	Missense_Mutation	novel	R649Q	0.15
HNSC	chr19	5641782	Missense_Mutation	novel	I128V	0.37
HNSC	chr19	5649933	Missense_Mutation	rs200348280	E386K	0.11
HNSC	chr19	5626451	Missense_Mutation	novel	S79F	0.07
HNSC	chr19	5664429	Missense_Mutation	novel	R775Q	0.11
HNSC	chr19	5667055	Missense_Mutation	novel	E782K	0.11
HNSC	chr19	5664408	Nonsense_Mutation	novel	S768*	0.24
HNSC	chr19	5668265	Missense_Mutation	rs756589107	D908N	0.4
HNSC	chr19	5641935	Nonsense_Mutation	novel	Q179*	0.5
KIRC	chr19	5668342	3'UTR	novel		0.38
KIRC	chr19	5641830	Missense_Mutation	rs753148563	V144I	0.61
KIRP	chr19	5653137	Missense_Mutation	NA	T439I	0.32
KIRP	chr19	5664074	Missense_Mutation	novel	Y736H	0.5
KIRP	chr19	5668383	3'UTR	novel		0.54
LGG	chr19	5648064	Intron	novel		0.06
LIHC	chr19	5661668	Silent	novel	R671R	0.08
LIHC	chr19	5668370	3'UTR	novel		0.35
LIHC	chr19	5653388	Silent	rs749049469	D498D	0.28
LIHC	chr19	5645339	Missense_Mutation	novel	I183M	0.26
LUAD	chr19	5661708	Missense_Mutation	novel	E685K	0.27
LUAD	chr19	5651048	Missense_Mutation	NA	K423N	0.24
LUAD	chr19	5654139	Missense_Mutation	NA	K535N	0.48
LUSC	chr19	5668195	Silent	novel	R884R	0.22
LUSC	chr19	5664110	Missense_Mutation	rs754569943	D748N	0.06
LUSC	chr19	5664425	Missense_Mutation	NA	E774Q	0.29
LUSC	chr19	5661601	Missense_Mutation	novel	R649Q	0.28
LUSC	chr19	5641778	Silent	rs764882015	I126I	0.12
LUSC	chr19	5661775	In_Frame_Del	novel	R707_D715delinsH	0.13
OV	chr19	5641830	Missense_Mutation	rs753148563	V144I	0.34
OV	chr19	5641920	Missense_Mutation	novel	L174I	0.06
OV	chr19	5668351	3'UTR	novel		0.83
OV	chr19	5668280	Missense_Mutation	NA	R913G	0.35
PAAD	chr19	5654152	Missense_Mutation	novel	D540N	0.09
PAAD	chr19	5641858	Missense_Mutation	novel	A153D	0.18
PRAD	chr19	5664397	Missense_Mutation	novel	R764S	0.23
READ	chr19	5645344	Missense_Mutation	NA	D185G	0.31
READ	chr19	5651064	Missense_Mutation	NA	Y429H	0.76
READ	chr19	5648205	Intron	novel		0.44
READ	chr19	5641901	Silent	rs762779310	V167V	0.2
READ	chr19	5657348	Splice_Site	NA	X621_splice	0.08
SARC	chr19	5667081	Silent	rs373577698	H790H	0.23
SKCM	chr19	5653160	Missense_Mutation	novel	R447C	0.15
SKCM	chr19	5661599	Silent	novel	A648A	0.44
SKCM	chr19	5667157	Missense_Mutation	novel	P816S	0.27
SKCM	chr19	5667848	Silent	NA	S860S	0.16
SKCM	chr19	5648032	Missense_Mutation	NA	S209F	0.3
SKCM	chr19	5667157	Missense_Mutation	novel	P816S	0.38
SKCM	chr19	5653254	Missense_Mutation	NA	S478F	0.47
SKCM	chr19	5668424	3'UTR	novel		1
SKCM	chr19	5623320	Silent	rs762619043	L39L	0.36
SKCM	chr19	5667070	Missense_Mutation	novel	P787S	0.37
SKCM	chr19	5667119	Missense_Mutation	NA	S803F	0.17
SKCM	chr19	5667154	Missense_Mutation	NA	P815S	0.5
SKCM	chr19	5653144	Silent	NA	A441A	0.13
SKCM	chr19	5651057	Silent	NA	F426F	0.13
STAD	chr19	5668370	3'UTR	novel		0.44
STAD	chr19	5667081	Silent	rs373577698	H790H	0.24
STAD	chr19	5661531	Missense_Mutation	rs140739982	R626C	0.2
STAD	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.21
STAD	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.49
STAD	chr19	5661742	Missense_Mutation	NA	R696H	0.31
STAD	chr19	5668273	Silent	NA	R910R	0.43
STAD	chr19	5667156	Frame_Shift_Ins	novel	*R818Qfs3**	0.32
STAD	chr19	5668370	3'UTR	novel		0.42
STAD	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.36
STAD	chr19	5668370	3'UTR	novel		0.29
STAD	chr19	5657295	Missense_Mutation	novel	S604T	0.61
STAD	chr19	5668370	3'UTR	novel		0.33
STAD	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.13
STAD	chr19	5667058	Missense_Mutation	NA	R783C	0.16
STAD	chr19	5668370	3'UTR	novel		0.5
TGCT	chr19	5667107	Missense_Mutation	novel	G799V	0.19
THYM	chr19	5667344	Intron	novel		0.13
THYM	chr19	5667059	Missense_Mutation	rs368894379	R783H	0.21
UCEC	chr19	5668370	3'UTR	novel		0.27
UCEC	chr19	5653188	Missense_Mutation	NA	T456I	0.39
UCEC	chr19	5654186	Missense_Mutation	rs188904085	R551Q	0.37
UCEC	chr19	5657288	Silent	rs151067758	S601S	0.27
UCEC	chr19	5668317	3'UTR	rs747162969		0.38
UCEC	chr19	5651003	Missense_Mutation	novel	F408L	0.15
UCEC	chr19	5664156	Missense_Mutation	novel	D763G	0.13
UCEC	chr19	5664090	Frame_Shift_Ins	rs369219386	*R742Pfs9**	0.43
UCEC	chr19	5641745	Silent	novel	D115D	0.42
UCEC	chr19	5654089	Missense_Mutation	novel	C519R	0.42
UCEC	chr19	5626455	Silent	novel	E80E	0.19
UCEC	chr19	5648152	Intron	novel		0.37
UCEC	chr19	5668163	Missense_Mutation	NA	R874C	0.3
UCEC	chr19	5654407	Missense_Mutation	novel	S569F	0.39
UCEC	chr19	5661807	Missense_Mutation	novel	R718W	0.44
UCEC	chr19	5667076	Missense_Mutation	novel	R789C	0.37
UCEC	chr19	5654385	Missense_Mutation	NA	R562W	0.41
UCEC	chr19	5654424	Missense_Mutation	NA	I575V	0.47
UCEC	chr19	5626434	Silent	rs760922137	D73D	0.26
UCEC	chr19	5641837	Frame_Shift_Ins	novel	*D146Efs11**	0.04
UCEC	chr19	5650980	Missense_Mutation	novel	R401C	0.18
UCEC	chr19	5654373	Nonsense_Mutation	NA	R558*	0.17
UCEC	chr19	5667390	Missense_Mutation	NA	R831W	0.57
UCEC	chr19	5668284	Missense_Mutation	rs754159539	R914H	0.39
UCEC	chr19	5623196	5'UTR	novel		0.25
UCEC	chr19	5661748	Missense_Mutation	novel	Q698R	0.39
UCEC	chr19	5654437	Missense_Mutation	novel	T579M	0.33
UCEC	chr19	5661609	Missense_Mutation	novel	L652M	0.36
UCEC	chr19	5667390	Missense_Mutation	NA	R831W	0.45
UCEC	chr19	5650980	Missense_Mutation	novel	R401C	0.15
UCEC	chr19	5653231	Silent	rs541754798	T470T	0.45
UCEC	chr19	5651023	Missense_Mutation	novel	S415Y	0.48
UCEC	chr19	5668348	3'UTR	novel		0.1
UCEC	chr19	5667103	Frame_Shift_Ins	rs747412640	*Y801Lfs4**	0.26
UCEC	chr19	5667363	Missense_Mutation	NA	G822W	0.38
UCEC	chr19	5661548	Silent	NA	Q631Q	0.41
UCEC	chr19	5667447	Nonsense_Mutation	novel	Q850*	0.42
UCEC	chr19	5641844	Silent	rs745473423	V148V	0.22
UCEC	chr19	5664408	Nonsense_Mutation	novel	S768*	0.35
UCEC	chr19	5649932	Silent	rs75289952	P385P	0.37
UCEC	chr19	5664053	Missense_Mutation	NA	R729W	0.45
UCEC	chr19	5650980	Missense_Mutation	novel	R401C	0.38
UCEC	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.5
UCEC	chr19	5654373	Nonsense_Mutation	NA	R558*	0.26
UCEC	chr19	5667104	Frame_Shift_Del	NA	*G800Afs8**	0.36
UCEC	chr19	5661572	Silent	rs769414838	R639R	0.5
UCEC	chr19	5667093	Silent	novel	S794S	0.37
UCEC	chr19	5661578	Silent	novel	E641E	0.27
UCEC	chr19	5668163	Missense_Mutation	NA	R874C	0.33
UCEC	chr19	5668305	3'UTR	novel		0.14
UCEC	chr19	5654424	Missense_Mutation	NA	I575V	0.16
UCEC	chr19	5654373	Nonsense_Mutation	NA	R558*	0.37
UCEC	chr19	5645348	Missense_Mutation	NA	K186N	0.32
UCEC	chr19	5641778	Silent	rs764882015	I126I	0.34
UCEC	chr19	5654408	Silent	novel	S569S	0.16
UCEC	chr19	5668183	Silent	rs555050155	G880G	0.54
UCEC	chr19	5664075	Missense_Mutation	novel	Y736C	0.43
UCEC	chr19	5664053	Missense_Mutation	NA	R729W	0.44
UCEC	chr19	5668370	3'UTR	novel		0.46
UCS	chr19	5661681	Missense_Mutation	novel	V676M	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PAAD	DEL	0.1359	0.0060878
READ	DEL	0.1152	0.23023
THCA	DEL	0.012	0.10598

Survival Analysis

Cancer	P-value	Q-value
THYM	0.012	Kaplan-Meier Survival Analysis
KIRC	0.026	Kaplan-Meier Survival Analysis
STAD	0.0063	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
TGCT	0.043	Kaplan-Meier Survival Analysis
KIRP	0.01	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.00081	Kaplan-Meier Survival Analysis
CESC	0.014	Kaplan-Meier Survival Analysis
UCEC	0.0054	Kaplan-Meier Survival Analysis
LIHC	0.0094	Kaplan-Meier Survival Analysis
UVM	0.016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742