EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160679 (Gene tree)
Gene ID: 26097
Gene Symbol: CHTOP
Alias: DKFZP547E1010|SRAG|FOP|C1orf77
Full Name: chromatin target of PRMT1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 12,325 bases
Position: chr1:153,633,982-153,646,306
Accession: 24511
RBP type: non-canonical RBP
Summary: This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368687	CHTOP-202	1094	-	ENSP00000357676	223 (aa)	-	X6R700
ENST00000403433	CHTOP-205	1923	XM_017000993	ENSP00000385228	202 (aa)	XP_016856482	Q9Y3Y2
ENST00000495554	CHTOP-206	2553	-	-	- (aa)	-	-
ENST00000368694	CHTOP-204	2096	-	ENSP00000357683	248 (aa)	-	Q9Y3Y2
ENST00000614256	CHTOP-207	1840	-	ENSP00000484038	76 (aa)	-	A0A087X1B7
ENST00000368686	CHTOP-201	2250	-	ENSP00000357675	101 (aa)	-	Q5T7Y7
ENST00000368690	CHTOP-203	2165	-	ENSP00000357679	249 (aa)	-	Q9Y3Y2

Gene Model

Click here to download ENSG00000160679's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160679	Myocardial Infarction	5.5974747E-004	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160679's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160679	CHTOP	100	99.197	ENSMUSG00000001017	Chtop	100	99.197	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000346	transcription export complex	23299939.	IDA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	14667819.19858291.23299939.25284789.25416956.30021884.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	23299939.	IDA	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008284	positive regulation of cell proliferation	25284789.	IMP	Process
GO:0008327	methyl-CpG binding	25284789.	IDA	Function
GO:0016607	nuclear speck	23299939.	IDA	Component
GO:0031062	positive regulation of histone methylation	25284789.	IMP	Process
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0032781	positive regulation of ATPase activity	23299939.	IDA	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0051096	positive regulation of helicase activity	23299939.	IDA	Process