EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160752 (Gene tree)
Gene ID: 2224
Gene Symbol: FDPS
Alias: N
Full Name: farnesyl diphosphate synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 11,919 bases
Position: chr1:155,308,748-155,320,666
Accession: 3631
RBP type: non-canonical RBP
Summary: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000611010	FDPS-220	1196	XM_024454076	ENSP00000483188	248 (aa)	XP_024309844	A0A087X090
ENST00000356657	FDPS-201	1478	XM_024454070	ENSP00000349078	419 (aa)	XP_024309838	P14324
ENST00000461507	FDPS-204	1022	-	-	- (aa)	-	-
ENST00000368356	FDPS-202	1431	XM_024454066	ENSP00000357340	419 (aa)	XP_024309834	P14324
ENST00000474345	FDPS-210	713	-	ENSP00000478032	80 (aa)	-	A0A087WTP2
ENST00000470171	FDPS-208	746	-	-	- (aa)	-	-
ENST00000489003	FDPS-213	976	-	-	- (aa)	-	-
ENST00000477057	FDPS-211	741	-	-	- (aa)	-	-
ENST00000447866	FDPS-203	1256	XM_024454071	ENSP00000391755	353 (aa)	XP_024309839	P14324
ENST00000491013	FDPS-216	912	-	ENSP00000479557	274 (aa)	-	A0A087WVN4
ENST00000490140	FDPS-215	680	-	-	- (aa)	-	-
ENST00000492244	FDPS-217	673	-	-	- (aa)	-	-
ENST00000495308	FDPS-219	808	-	-	- (aa)	-	-
ENST00000467076	FDPS-206	1178	XM_024454072	ENSP00000480142	353 (aa)	XP_024309840	P14324
ENST00000487002	FDPS-212	2017	-	-	- (aa)	-	-
ENST00000465559	FDPS-205	677	-	ENSP00000484099	174 (aa)	-	A0A087X1D8
ENST00000471117	FDPS-209	630	-	-	- (aa)	-	-
ENST00000492887	FDPS-218	554	-	-	- (aa)	-	-
ENST00000489324	FDPS-214	475	-	-	- (aa)	-	-
ENST00000468479	FDPS-207	938	-	-	- (aa)	-	-
ENST00000612683	FDPS-221	1198	XM_005244962	ENSP00000478235	353 (aa)	XP_005245019	P14324

Gene Model

Click here to download ENSG00000160752's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00900	Terpenoid backbone biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa05164	Influenza A	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160752's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160752	FDPS	100	49.200	YJL167W	ERG20	98	45.376	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004161	dimethylallyltranstransferase activity	21873635.	IBA	Function
GO:0004337	geranyltranstransferase activity	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006695	cholesterol biosynthetic process	-	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0033384	geranyl diphosphate biosynthetic process	-	IEA	Process
GO:0045337	farnesyl diphosphate biosynthetic process	21873635.	IBA	Process
GO:0045337	farnesyl diphosphate biosynthetic process	-	IEA	Process
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15713990	Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis.	Oncology	2004	Notarnicola M	-
22407328	Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?	World J Urol	2013 Apr	Todenhfer T	doi: 10.1007/s00345-012-0844-y
29337059	FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway.	Biochem Biophys Res Commun	2018 Feb 5	Lin L	doi: 10.1016/j.bbrc.2018.01.066

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	155318905	Missense_Mutation	NA	P275A	0.46
BLCA	chr1	155318312	Intron	rs759269192		0.36
BLCA	chr1	155318304	Intron	novel		0.24
BLCA	chr1	155319864	Missense_Mutation	novel	K332T	0.07
BLCA	chr1	155309901	Missense_Mutation	novel	G38W	0.32
BLCA	chr1	155318674	Missense_Mutation	novel	Q232E	0.15
BLCA	chr1	155310121	Missense_Mutation	novel	Q85H	0.09
BRCA	chr1	155312373	Missense_Mutation	NA	T153N	0.15
BRCA	chr1	155320486	Silent	NA	V379V	0.54
BRCA	chr1	155320489	Silent	NA	F380F	0.21
BRCA	chr1	155318278	Missense_Mutation	novel	E224V	0.13
BRCA	chr1	155318279	In_Frame_Ins	novel	E224_L225insSTLTLL	0.13
BRCA	chr1	155320499	Missense_Mutation	novel	E384K	0.36
BRCA	chr1	155319905	Missense_Mutation	NA	P346A	0.2
BRCA	chr1	155320531	Silent	NA	L394L	0.15
BRCA	chr1	155320616	3'UTR	novel		0.38
BRCA	chr1	155319820	Frame_Shift_Del	NA	*S319Vfs2**	0.29
BRCA	chr1	155319905	Missense_Mutation	NA	P346A	0.13
CESC	chr1	155312363	Missense_Mutation	novel	R150W	0.21
CESC	chr1	155310160	Missense_Mutation	NA	E98D	0.25
CESC	chr1	155318282	Silent	NA	L225L	0.32
CESC	chr1	155318016	Missense_Mutation	NA	Q186E	0.31
CESC	chr1	155318898	Missense_Mutation	NA	F272L	0.14
CESC	chr1	155318736	Silent	NA	V252V	0.36
CESC	chr1	155320529	Missense_Mutation	NA	L394V	0.14
COAD	chr1	155320581	Missense_Mutation	NA	A411V	0.28
COAD	chr1	155317840	Intron	NA		0.64
COAD	chr1	155317840	Intron	NA		0.34
COAD	chr1	155309853	Frame_Shift_Del	NA	*R23Gfs45**	0.31
COAD	chr1	155310155	Missense_Mutation	novel	D97H	0.13
COAD	chr1	155309955	Missense_Mutation	NA	E56K	0.4
COAD	chr1	155317840	Intron	NA		0.08
COAD	chr1	155317840	Intron	NA		0.1
COAD	chr1	155318678	Missense_Mutation	NA	T233S	0.12
COAD	chr1	155320515	Missense_Mutation	NA	S389N	0.4
COAD	chr1	155317947	Missense_Mutation	novel	A163T	0.08
COAD	chr1	155317840	Intron	NA		0.29
COAD	chr1	155312310	Missense_Mutation	novel	V132E	0.32
COAD	chr1	155317840	Intron	NA		0.32
DLBC	chr1	155318240	Silent	novel	L211L	0.28
ESCA	chr1	155318676	Silent	novel	Q232Q	0.13
ESCA	chr1	155319642	Missense_Mutation	novel	N293S	0.1
ESCA	chr1	155317840	Intron	NA		0.3
ESCA	chr1	155320556	Missense_Mutation	novel	P403T	0.18
GBM	chr1	155317992	Missense_Mutation	rs749581999	R178C	0.34
GBM	chr1	155318242	Missense_Mutation	NA	Y212C	0.39
GBM	chr1	155312277	Missense_Mutation	novel	G121E	0.16
HNSC	chr1	155318358	Intron	novel		0.13
HNSC	chr1	155319680	Nonsense_Mutation	novel	Q306*	0.17
HNSC	chr1	155310152	Missense_Mutation	novel	E96K	0.22
KIRC	chr1	155309945	Silent	NA	Q52Q	0.31
KIRP	chr1	155309918	Silent	novel	A43A	0.42
LAML	chr1	155319949	Intron	novel		0.11
LIHC	chr1	155312367	Missense_Mutation	novel	A151V	0.09
LIHC	chr1	155317840	Intron	NA		0.11
LIHC	chr1	155319895	Silent	NA	Q342Q	0.6
LUAD	chr1	155318914	Missense_Mutation	novel	A278P	0.14
LUAD	chr1	155319833	Missense_Mutation	novel	G322S	0.1
LUAD	chr1	155318240	Silent	NA	L211L	0.05
LUAD	chr1	155319833	Missense_Mutation	NA	G322R	0.04
LUAD	chr1	155320581	Missense_Mutation	NA	A411V	0.14
LUAD	chr1	155317848	Intron	novel		0.3
LUAD	chr1	155317961	Silent	NA	V167V	0.13
LUSC	chr1	155320635	3'UTR	novel		0.18
LUSC	chr1	155310152	Missense_Mutation	novel	E96Q	0.19
LUSC	chr1	155318749	Missense_Mutation	novel	K257Q	0.37
LUSC	chr1	155319953	Intron	novel		0.52
LUSC	chr1	155318876	Missense_Mutation	NA	Y265F	0.26
OV	chr1	155319659	Missense_Mutation	novel	L299M	0.04
OV	chr1	155319625	Silent	rs775781022	G287G	0.48
PAAD	chr1	155318351	Intron	novel		0.21
PAAD	chr1	155319682	Silent	novel	Q306Q	0.19
READ	chr1	155320659	3'UTR	novel		0.15
READ	chr1	155317840	Intron	NA		0.1
SARC	chr1	155320543	In_Frame_Del	novel	A399_P401del	0.43
SARC	chr1	155318232	Missense_Mutation	novel	L209V	0.4
SARC	chr1	155317857	Intron	novel		0.35
SKCM	chr1	155318360	Intron	novel		0.14
SKCM	chr1	155310133	Silent	novel	Q89Q	0.47
SKCM	chr1	155309913	Silent	novel	L42L	0.6
SKCM	chr1	155320583	Missense_Mutation	NA	R412C	0.56
SKCM	chr1	155318270	Silent	novel	N221N	0.24
SKCM	chr1	155310115	Silent	rs765803031	F83F	0.15
SKCM	chr1	155319932	Splice_Region	novel		0.33
SKCM	chr1	155319933	Splice_Region	novel		0.33
SKCM	chr1	155309861	Missense_Mutation	NA	E24D	0.28
SKCM	chr1	155310129	Missense_Mutation	NA	S88F	0.27
STAD	chr1	155317978	Missense_Mutation	NA	D173A	0.22
STAD	chr1	155318710	Frame_Shift_Ins	novel	*Q246Pfs32**	0.11
STAD	chr1	155320592	Missense_Mutation	NA	Y415H	0.34
STAD	chr1	155312364	Missense_Mutation	rs373639609	R150Q	0.44
STAD	chr1	155319950	Intron	novel		0.39
STAD	chr1	155318277	Missense_Mutation	rs139546057	E224K	0.18
STAD	chr1	155320582	Silent	rs779964878	A411A	0.36
STAD	chr1	155318711	Frame_Shift_Del	novel	*Q246Rfs31**	0.21
STAD	chr1	155320541	Missense_Mutation	NA	Y398H	0.07
STAD	chr1	155319821	Missense_Mutation	novel	P318S	0.19
STAD	chr1	155318175	Missense_Mutation	rs757544890	V190M	0.07
UCEC	chr1	155317840	Intron	NA		0.28
UCEC	chr1	155318277	Missense_Mutation	rs139546057	E224K	0.37
UCEC	chr1	155317848	Intron	novel		0.18
UCEC	chr1	155318170	Missense_Mutation	novel	P188L	0.36
UCEC	chr1	155318373	Intron	novel		0.18
UCEC	chr1	155320422	In_Frame_Del	rs771519284	K359del	0.12
UCEC	chr1	155318895	In_Frame_Del	NA	F272del	0.03
UCEC	chr1	155318898	Missense_Mutation	NA	F272L	0.13
UCEC	chr1	155317840	Intron	NA		0.24
UCEC	chr1	155310071	Missense_Mutation	rs775764683	G69R	0.28
UCEC	chr1	155320565	Missense_Mutation	NA	V406I	0.3
UCEC	chr1	155320547	Missense_Mutation	NA	A400T	0.14
UCEC	chr1	155318312	Intron	rs759269192		0.32
UCEC	chr1	155317993	Missense_Mutation	rs771194005	R178H	0.5
UCEC	chr1	155318272	Missense_Mutation	novel	L222P	0.34
UCEC	chr1	155318267	Silent	novel	L220L	0.33
UCEC	chr1	155317840	Intron	NA		0.34
UCEC	chr1	155320515	Missense_Mutation	novel	S389I	0.49
UCEC	chr1	155309789	Splice_Region	novel		0.59
UCEC	chr1	155318197	Missense_Mutation	NA	D197G	0.33
UCEC	chr1	155318698	Missense_Mutation	NA	D240Y	0.44
UCEC	chr1	155310047	Missense_Mutation	NA	L61I	0.21
UCEC	chr1	155317863	Intron	novel		0.36
UCEC	chr1	155320423	Silent	novel	Q358Q	0.43
UCEC	chr1	155317840	Intron	NA		0.31
UCEC	chr1	155312281	Silent	novel	G122G	0.42
UCEC	chr1	155309910	Missense_Mutation	novel	V41F	0.5
UCEC	chr1	155319932	Splice_Region	rs767089569		0.43
UCEC	chr1	155318349	Intron	novel		0.29
UCEC	chr1	155310081	Missense_Mutation	novel	N72I	0.52
UCEC	chr1	155310079	Missense_Mutation	NA	Q71H	0.37
UCEC	chr1	155319838	Missense_Mutation	NA	K323N	0.06
UCEC	chr1	155320456	Silent	rs186015551	A369A	0.24
UCEC	chr1	155317840	Intron	NA		0.27
UCEC	chr1	155318322	Intron	novel		0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1444	0.11282
CESC	AMP	0.4814	3.2002e-05
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3859	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2228	0.085665
PRAD	AMP	0.0732	0.00077815
READ	AMP	0.2667	0.025154
SKCM	AMP	0.4905	9.6912e-06
TGCT	AMP	0.34	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00012	Kaplan-Meier Survival Analysis
MESO	0.00046	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.00026	Kaplan-Meier Survival Analysis
PRAD	0.037	Kaplan-Meier Survival Analysis
ESCA	0.037	Kaplan-Meier Survival Analysis
KIRP	0.007	Kaplan-Meier Survival Analysis
PCPG	0.038	Kaplan-Meier Survival Analysis
CESC	0.00037	Kaplan-Meier Survival Analysis
LAML	0.0063	Kaplan-Meier Survival Analysis
KICH	0.026	Kaplan-Meier Survival Analysis
UCEC	0.044	Kaplan-Meier Survival Analysis
GBM	0.02	Kaplan-Meier Survival Analysis
LIHC	0.0012	Kaplan-Meier Survival Analysis
DLBC	0.016	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
LUAD	0.00078	Kaplan-Meier Survival Analysis
UVM	0.00014	Kaplan-Meier Survival Analysis
OV	0.002	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742