EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160789 (Gene tree)
Gene ID: 4000
Gene Symbol: LMNA
Alias: HGPS|MADA|LMN1|CMD1A|LGMD1B|PRO1|LMNL1
Full Name: lamin A/C
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 57,544 bases
Position: chr1:156,082,546-156,140,089
Accession: 6636
RBP type: non-canonical RBP
Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31317183	Dilated cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy: a comprehensive genotype-imaging phenotype study.	Eur Heart J Cardiovasc Imaging	2019 Jul 16	Augusto JB	doi: 10.1093/ehjci/jez188

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508500	LMNA-222	848	-	ENSP00000424977	260 (aa)	-	A0A0C4DGC5
ENST00000498722	LMNA-217	1348	-	-	- (aa)	-	-
ENST00000515824	LMNA-225	393	-	-	- (aa)	-	-
ENST00000504687	LMNA-220	546	-	ENSP00000426535	182 (aa)	-	H0YAB0
ENST00000502751	LMNA-219	570	-	-	- (aa)	-	-
ENST00000469565	LMNA-210	591	-	-	- (aa)	-	-
ENST00000515711	LMNA-224	569	-	-	- (aa)	-	-
ENST00000470835	LMNA-212	472	-	-	- (aa)	-	-
ENST00000515459	LMNA-223	757	-	ENSP00000424518	38 (aa)	-	D6RB20
ENST00000506981	LMNA-221	576	-	-	- (aa)	-	-
ENST00000473598	LMNA-213	2015	-	ENSP00000421821	565 (aa)	-	P02545
ENST00000368301	LMNA-207	2461	-	ENSP00000357284	572 (aa)	-	P02545
ENST00000368300	LMNA-206	3190	XM_011509534	ENSP00000357283	664 (aa)	XP_011507836	P02545
ENST00000361308	LMNA-202	1713	-	ENSP00000355292	487 (aa)	-	Q3BDU5
ENST00000478063	LMNA-214	285	-	-	- (aa)	-	-
ENST00000347559	LMNA-201	3137	-	ENSP00000292304	634 (aa)	-	P02545
ENST00000448611	LMNA-208	1943	XM_011509533	ENSP00000395597	574 (aa)	XP_011507835	P02545
ENST00000459904	LMNA-209	916	-	-	- (aa)	-	-
ENST00000496738	LMNA-216	2405	-	-	- (aa)	-	-
ENST00000470199	LMNA-211	551	-	-	- (aa)	-	-
ENST00000502357	LMNA-218	537	-	-	- (aa)	-	-
ENST00000495341	LMNA-215	394	-	-	- (aa)	-	-
ENST00000368297	LMNA-203	1679	-	ENSP00000357280	491 (aa)	-	Q5TCI8
ENST00000368299	LMNA-205	2253	-	ENSP00000357282	614 (aa)	-	P02545
ENST00000368298	LMNA-204	1475	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000160789's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04210	Apoptosis	KEGG
hsa05410	Hypertrophic cardiomyopathy (HCM)	KEGG
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG
hsa05414	Dilated cardiomyopathy (DCM)	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160789	Platelet Function Tests	1.3511000E-005	-
ENSG00000160789	Platelet Function Tests	6.2900000E-006	-
ENSG00000160789	Platelet Function Tests	8.6800000E-006	-
ENSG00000160789	Platelet Function Tests	1.9100000E-006	-
ENSG00000160789	Platelet Function Tests	9.7600000E-007	-
ENSG00000160789	Stroke	3E-6	27997041

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000160789	rs116480793	1	156108585	T	Lung cancer in ever smokers	28604730	[1.153366335-1.439461007]	1.2884976	EFO_0006527\|EFO_0001071
ENSG00000160789	rs58799304	1	156110653	?	Ischemic stroke	27997041	z score decrease	4.644	HP_0002140
ENSG00000160789	rs188625872	1	156114696	C	Ovarian cancer	30557369	[2.17-6.49]	3.7593985	EFO_0001075
ENSG00000160789	rs112941217	1	156087626	C	Ischemic heart disease in rheumatoid arthritis	30251476	[2.61-8.87]	4.81	EFO_0000685\|EFO_0001425
ENSG00000160789	rs584025	1	156118735	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160789's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160789	LMNA	100	99.087	ENSMUSG00000028063	Lmna	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005198	structural molecule activity	-	IEA	Function
GO:0005515	protein binding	10514485.10727209.11801724.15140953.15161933.15671068.16247757.19323649.19933576.20000738.20580717.20618440.21418524.21949239.21988832.22399800.22555292.23658700.25416956.29568061.29997244.30021884.	IPI	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	18809582.20810912.	IDA	Component
GO:0005635	nuclear envelope	18606848.27534416.	IDA	Component
GO:0005635	nuclear envelope	21610090.	IMP	Component
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005638	lamin filament	-	IEA	Component
GO:0005654	nucleoplasm	27534416.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006606	protein import into nucleus	-	IEA	Process
GO:0007084	mitotic nuclear envelope reassembly	-	TAS	Process
GO:0008285	negative regulation of cell proliferation	27534416.	IMP	Process
GO:0010628	positive regulation of gene expression	-	IEA	Process
GO:0016607	nuclear speck	-	IEA	Component
GO:0030334	regulation of cell migration	-	ISS	Process
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	-	ISS	Process
GO:0031647	regulation of protein stability	-	IEA	Process
GO:0031965	nuclear membrane	16791210.	HDA	Component
GO:0034504	protein localization to nucleus	-	ISS	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0055015	ventricular cardiac muscle cell development	-	IEA	Process
GO:0071456	cellular response to hypoxia	20810912.	IEP	Process
GO:0072201	negative regulation of mesenchymal cell proliferation	-	IEA	Process
GO:0090201	negative regulation of release of cytochrome c from mitochondria	-	IEA	Process
GO:0090343	positive regulation of cell aging	20458013.	IDA	Process
GO:1900114	positive regulation of histone H3-K9 trimethylation	-	IEA	Process
GO:1900180	regulation of protein localization to nucleus	-	IEA	Process
GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	-	ISS	Process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28919351	Suspension state increases reattachment of breast cancer cells by up-regulating lamin A/C.	Biochim Biophys Acta Mol Cell Res	2017 Dec	Zhang X	doi: 10.1016/j.bbamcr.2017.09.006
30190500	Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation.	Nat Commun	2018 Sep 6	Zhang Y	doi: 10.1038/s41467-018-05808-y.
23049808	LMNA knock-down affects differentiation and progression of human neuroblastoma cells.	PLoS One	2012	Maresca G	doi: 10.1371/journal.pone.0045513
26439802	Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.	Oncotarget	2015 Oct 20	Nardella M	doi: 10.18632/oncotarget.5104.
26447202	Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress.	Am J Physiol Cell Physiol	2015 Dec 1	Mitchell MJ	doi: 10.1152/ajpcell.00050.2015
21627864	Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer.	Chin J Cancer	2011 Jun	Capo-chichi CD	-
29378184	miR-218 and miR-129 regulate breast cancer progression by targeting Lamins.	Biochem Biophys Res Commun	2018 Feb 12	Setijono SR	doi: 10.1016/j.bbrc.2018.01.146
21439080	Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer.	BMC Med	2011 Mar 26	Capo-chichi CD	doi: 10.1186/1741-7015-9-28.
22057372	Methylation status of lamin A/C in gastric cancer cell lines.	Hepatogastroenterology	2012 Jun	Lee WS	doi: 10.5754/hge11610.
26732077	Altered Lamin A/C splice variant expression as a possible diagnostic marker in breast cancer.	Cell Oncol (Dordr)	2016 Apr	Aljada A	doi: 10.1007/s13402-015-0265-1
25499720	Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis.	Pathol Res Pract	2015 Feb	Gong G	doi: 10.1016/j.prp.2014.11.008
21621406	Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrence.	Eur J Cancer	2011 Aug	Belt EJ	doi: 10.1016/j.ejca.2011.04.025
26537870	Lamin A/C deficiency is an independent risk factor for cervical cancer.	Cell Oncol (Dordr)	2016 Feb	Capo-chichi CD	doi: 10.1007/s13402-015-0252-6
24293108	The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer.	Cell Mol Biol Lett	2013 Dec	Wazir U	doi: 10.2478/s11658-013-0109-9
29665450	Lamin A/C might be involved in the EMT signalling pathway.	Gene	2018 Jul 15	Zuo L	doi: 10.1016/j.gene.2018.04.040

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	156135918	Silent	rs397517914	A318A	0.31
BLCA	chr1	156126760	Intron	novel		0.67
BLCA	chr1	156138655	Silent	novel	V622V	0.27
BLCA	chr1	156139079	Splice_Site	novel	X657_splice	0.08
BLCA	chr1	156130666	Missense_Mutation	NA	D136N	0.69
BLCA	chr1	156136218	Missense_Mutation	rs58133342	R388C	0.13
BLCA	chr1	156136889	Intron	novel		0.33
BLCA	chr1	156115032	Silent	novel	L38L	0.55
BLCA	chr1	156130693	Frame_Shift_Del	novel	*E145Mfs14**	0.26
BLCA	chr1	156130716	Silent	NA	L152L	0.44
BLCA	chr1	156115261	Missense_Mutation	novel	E115K	0.31
BLCA	chr1	156139130	3'UTR	rs745421199		0.23
BLCA	chr1	156139131	3'UTR	novel		0.24
BLCA	chr1	156115090	Missense_Mutation	novel	G58R	0.5
BLCA	chr1	156126860	Intron	novel		0.45
BRCA	chr1	156136858	Intron	novel		0.12
BRCA	chr1	156134458	Missense_Mutation	rs267607571	R190Q	0.21
BRCA	chr1	156137705	Missense_Mutation	novel	E554K	0.06
BRCA	chr1	156115168	Missense_Mutation	rs794728602	E84K	0.22
CESC	chr1	156139360	3'UTR	novel		0.27
CESC	chr1	156126911	Intron	novel		0.15
CESC	chr1	156115256	Frame_Shift_Del	novel	*F113Wfs3**	0.12
CESC	chr1	156135865	Intron	NA		0.4
CESC	chr1	156135244	Missense_Mutation	rs397517912	E290K	0.21
COAD	chr1	156135950	Missense_Mutation	rs397517913	R329H	0.41
COAD	chr1	156114832	5'UTR	novel		0.43
COAD	chr1	156138314	Intron	novel		0.44
COAD	chr1	156139243	3'UTR	novel		0.5
COAD	chr1	156136379	Silent	novel	A441A	0.48
COAD	chr1	156115072	Missense_Mutation	rs397517895	L52V	0.08
COAD	chr1	156137830	Intron	novel		0.22
COAD	chr1	156136352	Silent	novel	Q432Q	0.09
COAD	chr1	156139131	3'UTR	novel		0.29
COAD	chr1	156130726	Missense_Mutation	rs760743233	R156C	0.19
COAD	chr1	156139165	3'UTR	novel		0.18
DLBC	chr1	156136873	Intron	novel		0.38
DLBC	chr1	156137751	Splice_Region	novel		0.21
ESCA	chr1	156137842	Intron	novel		0.21
ESCA	chr1	156115010	In_Frame_Del	novel	K32del	0.14
ESCA	chr1	156136414	Missense_Mutation	rs267607598	R453Q	0.06
GBM	chr1	156135163	Intron	novel		0.26
GBM	chr1	156139169	3'UTR	novel		0.11
GBM	chr1	156115030	Missense_Mutation	novel	L38F	0.56
HNSC	chr1	156137107	Splice_Region	novel		0.26
HNSC	chr1	156130634	Missense_Mutation	novel	G125A	0.11
HNSC	chr1	156136956	Silent	novel	Q472Q	0.56
KIRC	chr1	156138602	Missense_Mutation	novel	A605T	0.23
KIRP	chr1	156115052	Missense_Mutation	rs58436778	Y45C	0.29
KIRP	chr1	156135313	Splice_Site	novel	X312_splice	0.21
KIRP	chr1	156137683	Silent	NA	S546S	0.39
KIRP	chr1	156138424	Intron	novel		0.42
KIRP	chr1	156135294	Silent	NA	L306L	0.35
LGG	chr1	156136116	Silent	novel	E384E	0.27
LGG	chr1	156134893	Missense_Mutation	NA	D243G	0.22
LGG	chr1	156135196	Missense_Mutation	novel	A274T	0.09
LIHC	chr1	156136370	Silent	novel	G438G	0.23
LIHC	chr1	156130615	Splice_Site	NA	X119_splice	0.29
LIHC	chr1	156138694	Silent	NA	G635G	0.21
LIHC	chr1	156136391	Silent	novel	V445V	0.53
LIHC	chr1	156136392	Missense_Mutation	novel	D446N	0.53
LUAD	chr1	156130632	Silent	NA	E124E	0.31
LUAD	chr1	156137144	Frame_Shift_Ins	novel	*T510Yfs42**	0.54
LUAD	chr1	156114954	Silent	NA	S12S	0.59
LUAD	chr1	156134963	Silent	novel	T266T	0.05
LUAD	chr1	156126815	Intron	novel		0.39
LUAD	chr1	156136091	Missense_Mutation	NA	Y376C	0.27
LUAD	chr1	156136892	Intron	novel		0.19
LUAD	chr1	156135180	Splice_Region	novel		0.11
LUSC	chr1	156130643	Missense_Mutation	novel	I128K	0.09
LUSC	chr1	156135151	Intron	novel		0.18
LUSC	chr1	156136993	Missense_Mutation	novel	P485T	0.35
LUSC	chr1	156130720	Missense_Mutation	novel	E154K	0.26
LUSC	chr1	156115134	Silent	NA	R72R	0.52
LUSC	chr1	156138712	Silent	novel	L641L	0.16
OV	chr1	156126897	Intron	rs760318158		0.21
OV	chr1	156139194	3'UTR	novel		0.13
OV	chr1	156134932	Missense_Mutation	NA	V256G	0.13
OV	chr1	156126807	Intron	novel		0.09
OV	chr1	156134517	Missense_Mutation	NA	I210V	0.07
OV	chr1	156138529	Missense_Mutation	NA	N580K	0.42
PAAD	chr1	156136017	Silent	novel	R351R	0.05
PAAD	chr1	156126615	Intron	novel		0.23
PCPG	chr1	156136320	Nonsense_Mutation	novel	E422*	0.27
PRAD	chr1	156135949	Missense_Mutation	NA	R329C	0.2
PRAD	chr1	156134427	Frame_Shift_Del	novel	*K180Rfs21**	0.3
PRAD	chr1	156130727	Missense_Mutation	rs764475194	R156H	0.53
PRAD	chr1	156136378	Missense_Mutation	novel	A441V	0.5
PRAD	chr1	156139115	3'UTR	novel		0.33
READ	chr1	156134857	Missense_Mutation	rs760388350	N231S	0.41
READ	chr1	156137027	Missense_Mutation	rs200466188	T496M	0.29
READ	chr1	156138593	Missense_Mutation	rs60662302	G602S	0.39
READ	chr1	156135885	Intron	novel		0.17
SARC	chr1	156137768	Intron	rs727504435		0.19
SKCM	chr1	156134853	Missense_Mutation	NA	D230Y	0.14
SKCM	chr1	156135148	Intron	novel		0.2
SKCM	chr1	156136077	Missense_Mutation	novel	M371I	0.19
SKCM	chr1	156115123	Missense_Mutation	NA	V69M	0.68
SKCM	chr1	156136265	Silent	rs776975256	S403S	0.54
SKCM	chr1	156136001	Missense_Mutation	novel	A346V	0.09
SKCM	chr1	156136002	Silent	novel	A346A	0.09
SKCM	chr1	156137158	Silent	novel	L512L	0.25
SKCM	chr1	156115230	Silent	NA	L104L	0.22
SKCM	chr1	156135948	Silent	NA	A328A	0.12
SKCM	chr1	156138493	Silent	novel	S568S	0.28
SKCM	chr1	156114998	Missense_Mutation	NA	T27I	0.05
SKCM	chr1	156130614	Splice_Region	novel		0.17
SKCM	chr1	156139252	3'UTR	novel		0.5
SKCM	chr1	156138688	Silent	novel	G633G	0.29
SKCM	chr1	156136013	Missense_Mutation	NA	A350V	0.38
SKCM	chr1	156136904	Intron	novel		0.15
SKCM	chr1	156135282	Silent	NA	L302L	0.47
SKCM	chr1	156115122	Silent	rs753304214	E68E	0.16
STAD	chr1	156137030	Splice_Site	NA	X496_splice	0.12
STAD	chr1	156138675	Frame_Shift_Ins	rs770335541	*S632Qfs72**	0.19
STAD	chr1	156135234	Silent	NA	G286G	0.08
STAD	chr1	156137095	Intron	novel		0.14
STAD	chr1	156138660	Missense_Mutation	rs13768	R624H	0.43
STAD	chr1	156134936	Silent	novel	E257E	0.11
STAD	chr1	156136224	Frame_Shift_Ins	novel	*S392Qfs34**	0.29
STAD	chr1	156135890	Intron	novel		0.11
STAD	chr1	156130636	Missense_Mutation	novel	D126N	0.29
STAD	chr1	156138537	Missense_Mutation	rs59601651	S583L	0.34
STAD	chr1	156138659	In_Frame_Del	novel	Y626_S628del	0.58
STAD	chr1	156136952	Missense_Mutation	rs267607578	R471H	0.14
STAD	chr1	156138680	Missense_Mutation	NA	G631S	0.32
STAD	chr1	156135263	Missense_Mutation	NA	R296H	0.31
STAD	chr1	156136252	Missense_Mutation	rs267607563	R399H	0.42
THCA	chr1	156136458	Intron	novel		0.22
THYM	chr1	156135925	Frame_Shift_Ins	novel	*L327Rfs162**	0.06
UCEC	chr1	156139085	Silent	novel	P658P	0.22
UCEC	chr1	156136240	Missense_Mutation	rs267607561	S395L	0.34
UCEC	chr1	156137849	Intron	novel		0.29
UCEC	chr1	156137068	Intron	novel		0.2
UCEC	chr1	156138675	Frame_Shift_Ins	rs770335541	*S632Qfs72**	0.18
UCEC	chr1	156139234	3'UTR	novel		0.46
UCEC	chr1	156135991	Missense_Mutation	rs749784223	R343W	0.34
UCEC	chr1	156136336	Missense_Mutation	rs747139279	R427H	0.28
UCEC	chr1	156135955	Missense_Mutation	NA	R331W	0.32
UCEC	chr1	156134827	Missense_Mutation	rs372567202	R221H	0.25
UCEC	chr1	156136257	Missense_Mutation	rs61094188	R401C	0.23
UCEC	chr1	156134891	Silent	rs763625309	A242A	0.5
UCEC	chr1	156139090	Missense_Mutation	novel	N660S	0.12
UCEC	chr1	156137125	Nonsense_Mutation	novel	G501*	0.08
UCEC	chr1	156139243	3'UTR	novel		0.51
UCEC	chr1	156134811	Missense_Mutation	rs794728591	R216C	0.2
UCEC	chr1	156136294	Missense_Mutation	novel	G413D	0.3
UCEC	chr1	156130697	Missense_Mutation	novel	A146V	0.17
UCEC	chr1	156134824	Missense_Mutation	rs780066296	R220H	0.41
UCEC	chr1	156135926	Missense_Mutation	novel	R321Q	0.21
UCEC	chr1	156137203	Missense_Mutation	rs57318642	R527C	0.45
UCEC	chr1	156115183	Missense_Mutation	NA	R89S	0.21
UCEC	chr1	156129872	Intron	novel		0.13
UCEC	chr1	156139227	3'UTR	novel		0.33
UCEC	chr1	156139243	3'UTR	novel		0.18
UCEC	chr1	156136700	Intron	novel		0.78
UCEC	chr1	156137097	Intron	novel		0.41
UCEC	chr1	156139211	3'UTR	novel		0.35
UCEC	chr1	156135263	Missense_Mutation	NA	R296H	0.47
UCEC	chr1	156136413	Missense_Mutation	rs58932704	R453W	0.23
UCEC	chr1	156139243	3'UTR	novel		0.4
UCEC	chr1	156139184	3'UTR	novel		0.48
UCEC	chr1	156135166	Intron	novel		0.13
UCEC	chr1	156135286	Missense_Mutation	novel	A304T	0.32
UCEC	chr1	156134519	Silent	novel	I210I	0.59
UCEC	chr1	156134869	Missense_Mutation	rs759829161	R235H	0.34
UCEC	chr1	156135821	Intron	novel		0.42
UCEC	chr1	156136090	Missense_Mutation	novel	Y376H	0.35
UCEC	chr1	156136928	Missense_Mutation	rs778099589	S463F	0.46
UCEC	chr1	156139227	3'UTR	novel		0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3967	0.0022446
KIRC	AMP	0.0928	0.059566
LGG	AMP	0.0682	0.029503
PAAD	AMP	0.2283	0.085665
READ	AMP	0.2667	0.025154
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.34	0.088103
UCEC	AMP	0.449	1.3482e-23

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.0049	Kaplan-Meier Survival Analysis
UCS	0.05	Kaplan-Meier Survival Analysis
COAD	0.048	Kaplan-Meier Survival Analysis
PAAD	0.02	Kaplan-Meier Survival Analysis
BLCA	0.021	Kaplan-Meier Survival Analysis
READ	0.015	Kaplan-Meier Survival Analysis
LAML	0.00013	Kaplan-Meier Survival Analysis
GBM	0.011	Kaplan-Meier Survival Analysis
LIHC	0.0082	Kaplan-Meier Survival Analysis
LUAD	0.027	Kaplan-Meier Survival Analysis
UVM	0.0079	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742