EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000160862 (Gene tree)
Gene ID
563
Gene Symbol
AZGP1
Alias
ZA2G|ZAG
Full Name
alpha-2-glycoprotein 1, zinc-binding
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
9,438 bases
Position
chr7:99,966,720-99,976,157
Accession
910
RBP type
non-canonical RBP
Summary
(Alpha-2-Glycoprotein 1, Zinc-Binding) is a Protein Coding gene. Diseases associated with AZGP1 include Hidrocystoma and Breast Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include antigen binding and peptide antigen binding. An important paralog of this gene is HLA-B.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27325561Loss of Expression of AZGP1 Is Associated With Worse Clinical Outcomes in a Multi-Institutional Radical Prostatectomy Cohort.Prostate2016 NovBrooks JDdoi: 10.1002/pros.23225
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000411734AZGP1-2022027-ENSP00000396093227 (aa)-C9JEV0
ENST00000495765AZGP1-206540--- (aa)--
ENST00000483612AZGP1-205679--- (aa)--
ENST00000477251AZGP1-204787--- (aa)--
ENST00000419575AZGP1-203719-ENSP0000038994285 (aa)-H7BZJ8
ENST00000292401AZGP1-2011307-ENSP00000292401298 (aa)-P25311
Gene Model
Click here to download ENSG00000160862's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000160862Lung Diseases, Interstitial5.8712920E-007-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000160862rs187130073799968131GRed blood cell count27863252[0.11-0.2] unit decrease0.1546703EFO_0004305
ENSG00000160862rs8192465799968384AEducational attainment (years of education)30038396[0.018-0.037] unit decrease0.0272EFO_0004784
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160862's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste24248522.IDAProcess
GO:0001895retina homeostasis23580065.HEPProcess
GO:0004540ribonuclease activity10462714.NASFunction
GO:0005515protein binding16237761.18930737.IPIFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005576extracellular region14718574.NASComponent
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space16502470.22664934.23580065.HDAComponent
GO:0005615extracellular space21873635.IBAComponent
GO:0005615extracellular space24248522.IDAComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0006955immune response21873635.IBAProcess
GO:0007155cell adhesion9813179.IDAProcess
GO:0008285negative regulation of cell proliferation10462714.NASProcess
GO:0008320protein transmembrane transporter activity6896906.NASFunction
GO:0009897external side of plasma membrane21873635.IBAComponent
GO:0055085transmembrane transport-TASProcess
GO:0062023collagen-containing extracellular matrix27559042.HDAComponent
GO:0070062extracellular exosome19199708.23533145.HDAComponent
GO:0071806protein transmembrane transport-IEAProcess
GO:0090501RNA phosphodiester bond hydrolysis-IEAProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23935945Decreased expression of AZGP1 is associated with poor prognosis in primary gastric cancer.PLoS One2013 Jul 23Huang CYdoi: 10.1371/journal.pone.0069155
27993894Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma.Carcinogenesis2017 Feb 1Tian Hdoi: 10.1093/carcin/bgw125.
25561225Zinc-α-2-glycoprotein: a candidate biomarker for colon cancer diagnosis in Chinese population.Int J Mol Sci2014 Dec 30Xue Ydoi: 10.3390/ijms16010691.
27473574Loss of AZGP1 as a Superior Predictor of Relapse in Margin-Positive Localized Prostate Cancer.Prostate2016 DecBruce HMdoi: 10.1002/pros.23233
20683033Zinc-alpha2-glycoprotein: a new biomarker of breast cancer?Anticancer Res2010 JulDubois V-
26383228Reduced AZGP1 expression is an independent predictor of early PSA recurrence and associated with ERG-fusion positive and PTEN deleted prostate cancers.Int J Cancer2016 Mar 1Burdelski Cdoi: 10.1002/ijc.29860
22935975Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer.Pathology2012 OctMills J-
24508823AZGP-1 immunohistochemical marker in prostate cancer: potential predictive marker of biochemical recurrence in post radical prostatectomy specimens.Appl Immunohistochem Mol Morphol2014 OctJung WYdoi: 10.1097/PAI.0000000000000015.
21245862Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients.Br J Cancer2011 Feb 1Mracek Tdoi: 10.1038/sj.bjc.6606083
16598739Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system.Prostate2006 Jul 1Descazeaud A-
23448999Zinc-α2-glycoprotein as a marker of fat catabolism in humans.Curr Opin Clin Nutr Metab Care2013 MayCabassi Adoi: 10.1097/MCO.0b013e32835f816c.
23634719Development of an online microbore hollow fiber enzyme reactor coupled with nanoflow liquid chromatography-tandem mass spectrometry for global proteomics.Anal Chem2013 Jun 4Kim JYdoi: 10.1021/ac400625k
27711093In the search of novel urine biomarkers for the early diagnosis of prostate cancer. Intracellular or secreted proteins as the target group? Where and how to search for possible biomarkers useful in the everyday clinical practice.Arch Ital Urol Androl2016 Oct 5Katafigioti Adoi: 10.4081/aiua.2016.3.195.
27325561Loss of Expression of AZGP1 Is Associated With Worse Clinical Outcomes in a Multi-Institutional Radical Prostatectomy Cohort.Prostate2016 NovBrooks JDdoi: 10.1002/pros.23225

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr799967109Missense_MutationnovelS264F0.05
BLCAchr799971930SilentnovelG51G0.12
BLCAchr7999808455'Flanknovel0.08
BLCAchr799967155Missense_MutationnovelE249Q0.35
BLCAchr799968375Silentrs777569319S131S0.24
BRCAchr799968235Missense_MutationNAA178V0.47
CESCchr7999669933'UTRnovel0.12
CESCchr799967027SilentnovelL291L0.65
COADchr799971747Splice_Regionrs200393898N112N0.35
COADchr799968375Silentrs777569319S131S0.38
COADchr799971756Silentrs141506204N109N0.29
COADchr799968220Missense_MutationNAE183G0.09
GBMchr799967026Missense_MutationNAV292L0.18
GBMchr799967197Frame_Shift_DelNAI235Lfs*1010.24
GBMchr799971952Missense_MutationNAV44D0.05
GBMchr799972003Missense_MutationNAR27H0.2
GBMchr799968197Missense_Mutationrs370476332R191W0.24
HNSCchr799968186SilentnovelL194L0.45
HNSCchr799967006Missense_MutationnovelS298R0.39
HNSCchr799968307Nonsense_Mutationrs145427176W154*0.15
HNSCchr799967122Missense_MutationnovelG260C0.29
KIRCchr799976000SilentNAV7V0.22
KIRPchr799976012Missense_MutationnovelR3S0.07
KIRPchr799968199Missense_MutationnovelL190Q0.3
LGGchr7999669893'UTRnovel0.15
LGGchr799968162SilentnovelD202D0.11
LIHCchr799971904Missense_MutationNAR60I0.22
LUADchr799967023Missense_MutationnovelV293L0.24
LUADchr7999807945'Flanknovel0.29
LUADchr7999808065'Flanknovel0.22
LUADchr7999808075'Flanknovel0.22
LUADchr7999807935'FlankNA0.41
LUADchr799967279SilentNAP207P0.2
LUADchr799968396Missense_MutationnovelE124D0.05
LUADchr799971765Missense_MutationnovelE106D0.3
LUADchr799967100Missense_MutationnovelV267A0.13
LUADchr799971915SilentnovelL56L0.08
LUADchr799968374Nonsense_MutationNAG132*0.26
LUSCchr7999668793'UTRnovel0.26
LUSCchr799968333SilentnovelI145I0.42
LUSCchr799967122Missense_MutationnovelG260S0.26
LUSCchr799968410Frame_Shift_InsnovelR120Ffs*160.24
LUSCchr799971993SilentnovelL30L0.47
LUSCchr799971746Missense_Mutationrs377632165G113R0.2
LUSCchr7999669823'UTRnovel0.38
LUSCchr799971827Missense_MutationnovelD86H0.48
OVchr799968307Missense_MutationNAW154S0.17
OVchr799967110Missense_MutationNAS264A0.44
OVchr799971946Missense_Mutationrs142669146A46V0.14
PAADchr799967203Missense_MutationnovelG233W0.14
PAADchr799967176Missense_MutationnovelA242T0.36
PRADchr7999807945'Flanknovel0.1
PRADchr799968246Silentrs746576320Y174Y0.56
PRADchr799971909Missense_MutationnovelF58L0.45
READchr799968382Missense_MutationNAR129K0.42
READchr7999760275'UTRnovel0.35
READchr799968371Missense_MutationnovelA133P0.41
SARCchr799971757Missense_MutationnovelN109S0.35
SARCchr7999669333'UTRnovel0.6
SKCMchr799971800Missense_MutationNAD95N0.34
SKCMchr799968186SilentNAL194L0.37
SKCMchr799968303SilentNAV155V0.33
SKCMchr799967063SilentNAS279S0.26
SKCMchr799968409Missense_MutationNAR120K0.09
SKCMchr799967203Missense_MutationNAG233R0.16
SKCMchr799967086Missense_MutationNAP272S0.2
SKCMchr799967267SilentnovelV211V0.47
SKCMchr799968320Missense_MutationnovelE150K0.18
SKCMchr799967108SilentNAS264S0.29
SKCMchr799967109Missense_MutationnovelS264F0.3
SKCMchr799975957Missense_MutationNAE22K0.23
SKCMchr799968350Missense_MutationNAD140N0.64
SKCMchr7999807605'Flanknovel0.35
SKCMchr799971788Missense_MutationNAE99K0.34
SKCMchr799971869Missense_MutationNAG72R0.26
SKCMchr799967280Missense_MutationnovelP207L0.56
SKCMchr799971847Missense_MutationnovelG79E0.15
SKCMchr799967145Missense_MutationNAG252E0.17
SKCMchr799967179Missense_Mutationrs772831043R241W0.35
STADchr799971746Missense_Mutationrs377632165G113R0.34
STADchr7999668783'UTRnovel0.33
STADchr799971823Missense_MutationNAS87N0.08
STADchr799968154Splice_Siters112067579X205_splice0.45
THCAchr799971795Missense_MutationNAI96M0.04
UCECchr799971746Missense_Mutationrs377632165G113R0.41
UCECchr799971786Missense_MutationNAE99D0.63
UCECchr799968422Missense_Mutationrs770260118V116I0.42
UCECchr799967121Missense_MutationNAG260D0.23
UCECchr799967143Missense_MutationNAD253Y0.51
UCECchr799968245Missense_Mutationrs779480370V175M0.34
UCECchr799971755Missense_Mutationrs375716148D110N0.39
UCECchr799968296Missense_MutationnovelD158N0.52
UCECchr799967149Missense_Mutationrs199572012R251W0.35
UCECchr799967143Missense_MutationNAD253Y0.24
UCECchr799971920Missense_MutationNAD55Y0.44
UCECchr7999668913'UTRnovel0.23
UCECchr799971776Missense_MutationnovelD103Y0.2
UCECchr799971765Missense_MutationnovelE106D0.48
UCECchr799967245Nonsense_MutationnovelE219*0.51
UCECchr799967046Missense_MutationnovelS285I0.28
UCECchr7999669743'UTRrs7790591490.63
UCECchr799967170Missense_Mutationrs758931128E244K0.43
UCECchr7999760285'UTRnovel0.38
UCSchr799967237Missense_MutationnovelK221N0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.05560.12261
DLBCAMP0.29170.13215
PAADDEL0.0380.049388
PRADAMP0.14230.012709
STADAMP0.37648.0319e-14
TGCTAMP0.63330.035574
THCADEL0.0020.27619

Survival Analysis
CancerP-value Q-value
KIRC0.0016

Kaplan-Meier Survival Analysis

SARC0.02

Kaplan-Meier Survival Analysis

MESO0.033

Kaplan-Meier Survival Analysis

LUSC0.0075

Kaplan-Meier Survival Analysis

KIRP0.0033

Kaplan-Meier Survival Analysis

PAAD0.014

Kaplan-Meier Survival Analysis

BLCA0.0036

Kaplan-Meier Survival Analysis

UCEC0.0065

Kaplan-Meier Survival Analysis

LIHC0.015

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us