EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000161016 (Gene tree)
Gene ID: 6132
Gene Symbol: RPL8
Alias: L8
Full Name: ribosomal protein L8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 2,823 bases
Position: chr8:144,789,765-144,792,587
Accession: 10368
RBP type: canonical RBP
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262584	Ribosomal_L2_C	PF03947.18	6.6e-48	1	1
ENSP00000378378	Ribosomal_L2_C	PF03947.18	6.6e-48	1	1
ENSP00000433464	Ribosomal_L2_C	PF03947.18	6.6e-48	1	1
ENSP00000434535	Ribosomal_L2_C	PF03947.18	4e-39	1	1
ENSP00000435313	Ribosomal_L2_C	PF03947.18	2.4e-35	1	1
ENSP00000436460	Ribosomal_L2_C	PF03947.18	2.8e-21	1	1
ENSP00000434535	Ribosomal_L2	PF00181.23	9.6e-19	1	1
ENSP00000262584	Ribosomal_L2	PF00181.23	1.3e-18	1	1
ENSP00000378378	Ribosomal_L2	PF00181.23	1.3e-18	1	1
ENSP00000433464	Ribosomal_L2	PF00181.23	1.3e-18	1	1
ENSP00000435313	Ribosomal_L2	PF00181.23	1.7e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17288598	Appropriate 'housekeeping' genes for use in expression profiling the effects of environmental estrogens in fish.	BMC Mol Biol	2007 Feb 8	Filby AL	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000526668	RPL8-204	717	-	-	- (aa)	-	-
ENST00000262584	RPL8-201	1041	-	ENSP00000262584	257 (aa)	-	P62917
ENST00000394920	RPL8-202	965	-	ENSP00000378378	257 (aa)	-	P62917
ENST00000534781	RPL8-214	716	-	-	- (aa)	-	-
ENST00000531767	RPL8-210	570	-	-	- (aa)	-	-
ENST00000527914	RPL8-205	551	-	ENSP00000436460	148 (aa)	-	E9PP36
ENST00000529920	RPL8-209	876	-	ENSP00000433703	167 (aa)	-	G3V1A1
ENST00000529163	RPL8-208	556	-	-	- (aa)	-	-
ENST00000528957	RPL8-207	1015	-	ENSP00000433464	257 (aa)	-	P62917
ENST00000531975	RPL8-211	698	-	ENSP00000437062	110 (aa)	-	H0YF23
ENST00000532702	RPL8-212	745	-	ENSP00000434535	205 (aa)	-	E9PKZ0
ENST00000525232	RPL8-203	1007	-	-	- (aa)	-	-
ENST00000528296	RPL8-206	540	-	-	- (aa)	-	-
ENST00000533397	RPL8-213	730	-	ENSP00000435313	235 (aa)	-	E9PKU4

Gene Model

Click here to download ENSG00000161016's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161016's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000161016	RPL8	100	100.000	ENSAPOG00000018383	-	100	98.054	Acanthochromis_polyacanthus
ENSG00000161016	RPL8	100	100.000	ENSAPOG00000003954	rpl8	100	98.054	Acanthochromis_polyacanthus
ENSG00000161016	RPL8	100	100.000	ENSAMEG00000005395	RPL8	100	100.000	Ailuropoda_melanoleuca
ENSG00000161016	RPL8	100	100.000	ENSACIG00000020232	rpl8	100	97.665	Amphilophus_citrinellus
ENSG00000161016	RPL8	86	30.682	ENSACIG00000012738	-	77	32.044	Amphilophus_citrinellus
ENSG00000161016	RPL8	100	100.000	ENSAOCG00000019406	rpl8	100	97.665	Amphiprion_ocellaris
ENSG00000161016	RPL8	100	100.000	ENSAPEG00000002868	rpl8	100	97.665	Amphiprion_percula
ENSG00000161016	RPL8	100	100.000	ENSATEG00000005320	rpl8	100	96.498	Anabas_testudineus
ENSG00000161016	RPL8	95	99.029	ENSAPLG00000014582	RPL8	97	95.618	Anas_platyrhynchos
ENSG00000161016	RPL8	100	97.087	ENSACAG00000009145	-	100	96.887	Anolis_carolinensis
ENSG00000161016	RPL8	100	99.401	ENSACAG00000017933	-	100	99.222	Anolis_carolinensis
ENSG00000161016	RPL8	100	100.000	ENSANAG00000007844	-	100	100.000	Aotus_nancymaae
ENSG00000161016	RPL8	99	84.337	ENSANAG00000018683	-	98	84.337	Aotus_nancymaae
ENSG00000161016	RPL8	100	99.029	ENSACLG00000025654	rpl8	93	96.109	Astatotilapia_calliptera
ENSG00000161016	RPL8	100	96.117	ENSAMXG00000043706	rpl8	100	93.774	Astyanax_mexicanus
ENSG00000161016	RPL8	100	100.000	ENSBTAG00000026327	RPL8	100	100.000	Bos_taurus
ENSG00000161016	RPL8	100	96.407	ENSBTAG00000003560	-	100	96.109	Bos_taurus
ENSG00000161016	RPL8	100	78.095	WBGene00004413	rpl-2	99	72.973	Caenorhabditis_elegans
ENSG00000161016	RPL8	100	100.000	ENSCJAG00000021388	RPL8	100	100.000	Callithrix_jacchus
ENSG00000161016	RPL8	100	100.000	ENSCAFG00000001677	RPL8	100	100.000	Canis_familiaris
ENSG00000161016	RPL8	100	100.000	ENSCAFG00020021034	RPL8	100	100.000	Canis_lupus_dingo
ENSG00000161016	RPL8	100	100.000	ENSCHIG00000025056	RPL8	100	100.000	Capra_hircus
ENSG00000161016	RPL8	100	100.000	ENSTSYG00000009157	-	100	100.000	Carlito_syrichta
ENSG00000161016	RPL8	99	81.481	ENSTSYG00000033452	-	86	75.391	Carlito_syrichta
ENSG00000161016	RPL8	95	94.048	ENSTSYG00000035678	-	100	84.047	Carlito_syrichta
ENSG00000161016	RPL8	100	95.146	ENSCAPG00000006217	-	100	83.658	Cavia_aperea
ENSG00000161016	RPL8	100	95.146	ENSCPOG00000036122	-	100	87.549	Cavia_porcellus
ENSG00000161016	RPL8	100	100.000	ENSCPOG00000003854	RPL8	100	100.000	Cavia_porcellus
ENSG00000161016	RPL8	99	81.928	ENSCCAG00000026470	-	99	81.928	Cebus_capucinus
ENSG00000161016	RPL8	100	100.000	ENSCCAG00000032759	-	100	100.000	Cebus_capucinus
ENSG00000161016	RPL8	98	79.141	ENSCCAG00000001410	-	91	80.769	Cebus_capucinus
ENSG00000161016	RPL8	95	95.597	ENSCCAG00000035850	-	94	95.597	Cebus_capucinus
ENSG00000161016	RPL8	100	92.233	ENSCCAG00000023421	-	99	85.169	Cebus_capucinus
ENSG00000161016	RPL8	100	78.814	ENSCCAG00000023546	-	99	78.814	Cebus_capucinus
ENSG00000161016	RPL8	100	78.641	ENSCATG00000035333	-	100	77.043	Cercocebus_atys
ENSG00000161016	RPL8	100	100.000	ENSCATG00000029003	RPL8	100	100.000	Cercocebus_atys
ENSG00000161016	RPL8	100	100.000	ENSCLAG00000010832	-	100	100.000	Chinchilla_lanigera
ENSG00000161016	RPL8	100	100.000	ENSCSAG00000008214	RPL8	100	100.000	Chlorocebus_sabaeus
ENSG00000161016	RPL8	100	98.537	ENSCSAG00000019435	-	100	97.665	Chlorocebus_sabaeus
ENSG00000161016	RPL8	80	98.507	ENSCSAG00000007461	-	100	100.000	Chlorocebus_sabaeus
ENSG00000161016	RPL8	100	99.029	ENSCPBG00000019912	RPL8	100	99.029	Chrysemys_picta_bellii
ENSG00000161016	RPL8	99	83.333	ENSCING00000023083	-	100	78.125	Ciona_intestinalis
ENSG00000161016	RPL8	99	83.333	ENSCSAVG00000003127	-	100	77.344	Ciona_savignyi
ENSG00000161016	RPL8	100	83.902	ENSCANG00000043762	-	100	78.599	Colobus_angolensis_palliatus
ENSG00000161016	RPL8	100	98.058	ENSCANG00000017925	-	100	91.440	Colobus_angolensis_palliatus
ENSG00000161016	RPL8	70	100.000	ENSCANG00000031094	-	96	100.000	Colobus_angolensis_palliatus
ENSG00000161016	RPL8	93	72.385	ENSCGRG00001017476	-	92	74.895	Cricetulus_griseus_chok1gshd
ENSG00000161016	RPL8	100	100.000	ENSCGRG00001002982	-	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000161016	RPL8	100	91.707	ENSCGRG00001005314	-	96	92.946	Cricetulus_griseus_chok1gshd
ENSG00000161016	RPL8	100	94.175	ENSCGRG00001020900	-	100	90.272	Cricetulus_griseus_chok1gshd
ENSG00000161016	RPL8	100	91.707	ENSCGRG00000006443	-	96	92.946	Cricetulus_griseus_crigri
ENSG00000161016	RPL8	100	94.175	ENSCGRG00000011524	-	100	90.272	Cricetulus_griseus_crigri
ENSG00000161016	RPL8	93	72.803	ENSCGRG00000008422	-	92	75.314	Cricetulus_griseus_crigri
ENSG00000161016	RPL8	99	100.000	ENSCGRG00000007961	-	100	97.348	Cricetulus_griseus_crigri
ENSG00000161016	RPL8	53	92.135	ENSCSEG00000006542	-	83	90.526	Cynoglossus_semilaevis
ENSG00000161016	RPL8	100	99.029	ENSCSEG00000005223	rpl8	100	94.942	Cynoglossus_semilaevis
ENSG00000161016	RPL8	100	100.000	ENSCVAG00000015806	rpl8	100	97.276	Cyprinodon_variegatus
ENSG00000161016	RPL8	100	99.029	ENSDARG00000014867	rpl8	100	96.887	Danio_rerio
ENSG00000161016	RPL8	100	100.000	ENSDNOG00000009300	RPL8	100	99.611	Dasypus_novemcinctus
ENSG00000161016	RPL8	100	100.000	ENSDORG00000003352	-	100	100.000	Dipodomys_ordii
ENSG00000161016	RPL8	100	80.976	FBgn0261602	RpL8	98	80.800	Drosophila_melanogaster
ENSG00000161016	RPL8	100	100.000	ENSETEG00000007104	RPL8	100	99.222	Echinops_telfairi
ENSG00000161016	RPL8	100	87.838	ENSEBUG00000010495	rpl8	100	93.137	Eptatretus_burgeri
ENSG00000161016	RPL8	100	100.000	ENSEASG00005010978	RPL8	100	99.611	Equus_asinus_asinus
ENSG00000161016	RPL8	100	100.000	ENSECAG00000008403	RPL8	100	100.000	Equus_caballus
ENSG00000161016	RPL8	100	99.029	ENSELUG00000023566	rpl8	100	96.498	Esox_lucius
ENSG00000161016	RPL8	100	100.000	ENSFCAG00000026288	RPL8	100	100.000	Felis_catus
ENSG00000161016	RPL8	100	99.029	ENSFALG00000001533	RPL8	100	98.054	Ficedula_albicollis
ENSG00000161016	RPL8	100	100.000	ENSFDAG00000001217	RPL8	100	100.000	Fukomys_damarensis
ENSG00000161016	RPL8	100	100.000	ENSFHEG00000009770	rpl8	100	97.276	Fundulus_heteroclitus
ENSG00000161016	RPL8	100	99.029	ENSGMOG00000012966	rpl8	100	95.720	Gadus_morhua
ENSG00000161016	RPL8	100	99.029	ENSGALG00000016232	RPL8	100	98.054	Gallus_gallus
ENSG00000161016	RPL8	100	99.029	ENSGAFG00000021160	rpl8	98	96.887	Gambusia_affinis
ENSG00000161016	RPL8	100	99.029	ENSGACG00000002035	rpl8	100	96.109	Gasterosteus_aculeatus
ENSG00000161016	RPL8	100	99.029	ENSGAGG00000004064	RPL8	100	98.054	Gopherus_agassizii
ENSG00000161016	RPL8	100	100.000	ENSGGOG00000008164	RPL8	100	100.000	Gorilla_gorilla
ENSG00000161016	RPL8	100	99.029	ENSHBUG00000010765	rpl8	100	96.109	Haplochromis_burtoni
ENSG00000161016	RPL8	100	83.495	ENSHGLG00000017791	-	99	73.541	Heterocephalus_glaber_female
ENSG00000161016	RPL8	100	86.486	ENSHGLG00000010381	-	100	88.636	Heterocephalus_glaber_female
ENSG00000161016	RPL8	100	100.000	ENSHGLG00000016268	-	100	100.000	Heterocephalus_glaber_female
ENSG00000161016	RPL8	100	88.293	ENSHGLG00100007134	-	100	86.381	Heterocephalus_glaber_male
ENSG00000161016	RPL8	91	91.111	ENSHGLG00100005983	-	99	74.590	Heterocephalus_glaber_male
ENSG00000161016	RPL8	100	100.000	ENSHGLG00100007653	-	100	100.000	Heterocephalus_glaber_male
ENSG00000161016	RPL8	100	100.000	ENSHCOG00000014263	rpl8	100	96.887	Hippocampus_comes
ENSG00000161016	RPL8	100	98.058	ENSIPUG00000023148	rpl8	100	95.331	Ictalurus_punctatus
ENSG00000161016	RPL8	100	100.000	ENSSTOG00000013016	RPL8	100	100.000	Ictidomys_tridecemlineatus
ENSG00000161016	RPL8	100	70.946	ENSJJAG00000001121	-	86	70.946	Jaculus_jaculus
ENSG00000161016	RPL8	100	100.000	ENSJJAG00000008974	Rpl8	100	100.000	Jaculus_jaculus
ENSG00000161016	RPL8	100	100.000	ENSKMAG00000005087	rpl8	96	97.665	Kryptolebias_marmoratus
ENSG00000161016	RPL8	100	99.029	ENSLBEG00000020852	rpl8	100	96.109	Labrus_bergylta
ENSG00000161016	RPL8	99	59.091	ENSLACG00000005788	-	99	55.472	Latimeria_chalumnae
ENSG00000161016	RPL8	100	98.058	ENSLACG00000006824	RPL8	100	96.109	Latimeria_chalumnae
ENSG00000161016	RPL8	100	98.058	ENSLOCG00000002206	rpl8	100	96.109	Lepisosteus_oculatus
ENSG00000161016	RPL8	100	100.000	ENSLAFG00000031938	-	100	100.000	Loxodonta_africana
ENSG00000161016	RPL8	100	100.000	ENSMFAG00000043225	RPL8	100	100.000	Macaca_fascicularis
ENSG00000161016	RPL8	97	85.859	ENSMFAG00000032554	-	100	82.101	Macaca_fascicularis
ENSG00000161016	RPL8	88	84.141	ENSMMUG00000023683	-	99	84.141	Macaca_mulatta
ENSG00000161016	RPL8	100	100.000	ENSMMUG00000013379	RPL8	100	100.000	Macaca_mulatta
ENSG00000161016	RPL8	100	100.000	ENSMNEG00000032084	RPL8	100	100.000	Macaca_nemestrina
ENSG00000161016	RPL8	100	79.641	ENSMNEG00000034097	-	100	77.432	Macaca_nemestrina
ENSG00000161016	RPL8	82	100.000	ENSMLEG00000030289	-	100	100.000	Mandrillus_leucophaeus
ENSG00000161016	RPL8	88	83.700	ENSMLEG00000039316	-	99	83.700	Mandrillus_leucophaeus
ENSG00000161016	RPL8	100	100.000	ENSMAMG00000018769	rpl8	100	97.665	Mastacembelus_armatus
ENSG00000161016	RPL8	100	99.029	ENSMZEG00005021486	rpl8	100	96.109	Maylandia_zebra
ENSG00000161016	RPL8	100	99.029	ENSMGAG00000014610	RPL8	100	98.054	Meleagris_gallopavo
ENSG00000161016	RPL8	84	30.612	ENSMGAG00000003797	MRPL2	65	30.612	Meleagris_gallopavo
ENSG00000161016	RPL8	100	100.000	ENSMICG00000001569	-	100	100.000	Microcebus_murinus
ENSG00000161016	RPL8	99	78.767	ENSMOCG00000002638	-	96	78.767	Microtus_ochrogaster
ENSG00000161016	RPL8	100	82.432	ENSMOCG00000003289	-	83	82.432	Microtus_ochrogaster
ENSG00000161016	RPL8	100	85.437	ENSMOCG00000015706	-	97	75.875	Microtus_ochrogaster
ENSG00000161016	RPL8	100	100.000	ENSMOCG00000001074	Rpl8	100	100.000	Microtus_ochrogaster
ENSG00000161016	RPL8	100	100.000	ENSMMOG00000019733	rpl8	100	96.498	Mola_mola
ENSG00000161016	RPL8	100	99.029	ENSMODG00000004283	-	100	98.833	Monodelphis_domestica
ENSG00000161016	RPL8	70	86.408	ENSMODG00000024900	-	100	88.742	Monodelphis_domestica
ENSG00000161016	RPL8	100	98.058	ENSMALG00000002030	rpl8	96	95.720	Monopterus_albus
ENSG00000161016	RPL8	100	100.000	MGP_CAROLIEiJ_G0019952	-	100	100.000	Mus_caroli
ENSG00000161016	RPL8	100	100.000	ENSMUSG00000003970	Rpl8	100	100.000	Mus_musculus
ENSG00000161016	RPL8	100	100.000	MGP_PahariEiJ_G0019962	Rpl8	100	100.000	Mus_pahari
ENSG00000161016	RPL8	77	64.925	ENSMPUG00000015865	-	100	64.925	Mustela_putorius_furo
ENSG00000161016	RPL8	100	100.000	ENSMPUG00000006022	-	100	100.000	Mustela_putorius_furo
ENSG00000161016	RPL8	100	100.000	ENSMLUG00000016519	RPL8	100	100.000	Myotis_lucifugus
ENSG00000161016	RPL8	100	100.000	ENSNGAG00000002558	Rpl8	100	100.000	Nannospalax_galili
ENSG00000161016	RPL8	100	99.029	ENSNBRG00000019585	rpl8	100	96.498	Neolamprologus_brichardi
ENSG00000161016	RPL8	77	84.177	ENSNLEG00000035106	-	98	78.095	Nomascus_leucogenys
ENSG00000161016	RPL8	100	100.000	ENSNLEG00000010952	RPL8	100	100.000	Nomascus_leucogenys
ENSG00000161016	RPL8	100	100.000	ENSMEUG00000013824	RPL8	100	99.222	Notamacropus_eugenii
ENSG00000161016	RPL8	100	100.000	ENSOPRG00000010237	RPL8	100	97.561	Ochotona_princeps
ENSG00000161016	RPL8	100	89.756	ENSODEG00000019300	-	100	90.086	Octodon_degus
ENSG00000161016	RPL8	100	71.711	ENSODEG00000006851	-	100	81.982	Octodon_degus
ENSG00000161016	RPL8	100	89.320	ENSODEG00000013958	-	100	80.545	Octodon_degus
ENSG00000161016	RPL8	100	100.000	ENSODEG00000000033	-	100	100.000	Octodon_degus
ENSG00000161016	RPL8	100	99.029	ENSODEG00000020011	-	100	98.833	Octodon_degus
ENSG00000161016	RPL8	100	99.029	ENSONIG00000006857	rpl8	100	96.109	Oreochromis_niloticus
ENSG00000161016	RPL8	87	99.554	ENSOANG00000002646	RPL8	99	99.554	Ornithorhynchus_anatinus
ENSG00000161016	RPL8	100	100.000	ENSOCUG00000003706	-	100	98.444	Oryctolagus_cuniculus
ENSG00000161016	RPL8	100	100.000	ENSOCUG00000024716	-	100	100.000	Oryctolagus_cuniculus
ENSG00000161016	RPL8	100	99.029	ENSORLG00000010680	rpl8	100	96.109	Oryzias_latipes
ENSG00000161016	RPL8	100	99.029	ENSORLG00020014864	rpl8	100	96.109	Oryzias_latipes_hni
ENSG00000161016	RPL8	100	99.029	ENSORLG00015017791	rpl8	100	95.720	Oryzias_latipes_hsok
ENSG00000161016	RPL8	100	99.029	ENSOMEG00000015010	rpl8	100	95.720	Oryzias_melastigma
ENSG00000161016	RPL8	100	100.000	ENSOGAG00000016563	RPL8	100	100.000	Otolemur_garnettii
ENSG00000161016	RPL8	100	100.000	ENSOARG00000012645	RPL8	100	100.000	Ovis_aries
ENSG00000161016	RPL8	100	76.159	ENSPPAG00000042448	-	100	82.857	Pan_paniscus
ENSG00000161016	RPL8	100	100.000	ENSPPAG00000041407	RPL8	100	100.000	Pan_paniscus
ENSG00000161016	RPL8	100	100.000	ENSPPRG00000009150	-	100	100.000	Panthera_pardus
ENSG00000161016	RPL8	97	100.000	ENSPTIG00000017713	RPL8	100	100.000	Panthera_tigris_altaica
ENSG00000161016	RPL8	100	78.808	ENSPTRG00000045205	-	100	86.667	Pan_troglodytes
ENSG00000161016	RPL8	100	100.000	ENSPTRG00000020716	RPL8	100	100.000	Pan_troglodytes
ENSG00000161016	RPL8	100	100.000	ENSPANG00000029411	RPL8	100	100.000	Papio_anubis
ENSG00000161016	RPL8	82	87.050	ENSPANG00000030980	-	95	87.050	Papio_anubis
ENSG00000161016	RPL8	100	97.087	ENSPKIG00000003798	-	100	94.942	Paramormyrops_kingsleyae
ENSG00000161016	RPL8	100	100.000	ENSPKIG00000004287	RPL8	100	96.498	Paramormyrops_kingsleyae
ENSG00000161016	RPL8	100	99.029	ENSPSIG00000010752	RPL8	100	98.054	Pelodiscus_sinensis
ENSG00000161016	RPL8	100	99.029	ENSPMGG00000012679	rpl8	100	96.109	Periophthalmus_magnuspinnatus
ENSG00000161016	RPL8	100	100.000	ENSPEMG00000010123	-	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000161016	RPL8	76	92.857	ENSPMAG00000008745	rpl8	100	92.857	Petromyzon_marinus
ENSG00000161016	RPL8	100	84.459	ENSPCIG00000015010	-	100	90.476	Phascolarctos_cinereus
ENSG00000161016	RPL8	100	100.000	ENSPCIG00000018928	-	100	99.222	Phascolarctos_cinereus
ENSG00000161016	RPL8	100	87.317	ENSPCIG00000020262	-	100	87.500	Phascolarctos_cinereus
ENSG00000161016	RPL8	100	100.000	ENSPFOG00000014562	rpl8	100	97.276	Poecilia_formosa
ENSG00000161016	RPL8	100	100.000	ENSPLAG00000018241	rpl8	92	97.276	Poecilia_latipinna
ENSG00000161016	RPL8	100	100.000	ENSPMEG00000012679	rpl8	100	97.276	Poecilia_mexicana
ENSG00000161016	RPL8	100	100.000	ENSPREG00000004710	rpl8	100	97.276	Poecilia_reticulata
ENSG00000161016	RPL8	100	100.000	ENSPPYG00000018991	RPL8	100	100.000	Pongo_abelii
ENSG00000161016	RPL8	100	100.000	ENSPCAG00000007056	RPL8	100	100.000	Procavia_capensis
ENSG00000161016	RPL8	97	79.565	ENSPCOG00000015481	-	99	79.565	Propithecus_coquereli
ENSG00000161016	RPL8	100	100.000	ENSPCOG00000015651	RPL8	100	100.000	Propithecus_coquereli
ENSG00000161016	RPL8	97	100.000	ENSPVAG00000004292	RPL8	100	87.549	Pteropus_vampyrus
ENSG00000161016	RPL8	100	99.029	ENSPNYG00000010707	rpl8	100	96.109	Pundamilia_nyererei
ENSG00000161016	RPL8	100	97.087	ENSPNAG00000020229	rpl8	100	94.942	Pygocentrus_nattereri
ENSG00000161016	RPL8	100	100.000	ENSRNOG00000032635	LOC100360117	100	100.000	Rattus_norvegicus
ENSG00000161016	RPL8	100	100.000	ENSRNOG00000048456	Rpl8	100	100.000	Rattus_norvegicus
ENSG00000161016	RPL8	100	100.000	ENSRNOG00000048523	LOC108348142	100	100.000	Rattus_norvegicus
ENSG00000161016	RPL8	100	98.204	ENSRNOG00000031381	AC129049.1	100	98.054	Rattus_norvegicus
ENSG00000161016	RPL8	100	85.437	ENSRBIG00000037275	-	100	82.879	Rhinopithecus_bieti
ENSG00000161016	RPL8	65	99.074	ENSRBIG00000035018	-	95	99.074	Rhinopithecus_bieti
ENSG00000161016	RPL8	100	100.000	ENSRBIG00000029613	-	100	100.000	Rhinopithecus_bieti
ENSG00000161016	RPL8	100	100.000	ENSRROG00000040580	-	95	99.187	Rhinopithecus_roxellana
ENSG00000161016	RPL8	98	96.933	ENSRROG00000015309	-	99	96.933	Rhinopithecus_roxellana
ENSG00000161016	RPL8	100	100.000	ENSRROG00000027288	-	100	100.000	Rhinopithecus_roxellana
ENSG00000161016	RPL8	82	87.050	ENSRROG00000043588	-	95	87.050	Rhinopithecus_roxellana
ENSG00000161016	RPL8	100	72.195	YIL018W	RPL2B	100	71.654	Saccharomyces_cerevisiae
ENSG00000161016	RPL8	82	30.769	YEL050C	-	57	30.769	Saccharomyces_cerevisiae
ENSG00000161016	RPL8	100	72.195	YFR031C-A	RPL2A	100	71.654	Saccharomyces_cerevisiae
ENSG00000161016	RPL8	99	83.735	ENSSBOG00000022771	-	99	83.735	Saimiri_boliviensis_boliviensis
ENSG00000161016	RPL8	100	72.024	ENSSBOG00000020538	-	90	73.224	Saimiri_boliviensis_boliviensis
ENSG00000161016	RPL8	100	100.000	ENSSHAG00000013568	RPL8	100	99.222	Sarcophilus_harrisii
ENSG00000161016	RPL8	100	100.000	ENSSFOG00015022286	rpl8	93	97.665	Scleropages_formosus
ENSG00000161016	RPL8	100	99.029	ENSSMAG00000004617	rpl8	100	96.109	Scophthalmus_maximus
ENSG00000161016	RPL8	100	100.000	ENSSDUG00000010473	rpl8	100	97.665	Seriola_dumerili
ENSG00000161016	RPL8	99	74.257	ENSSLDG00000011567	-	100	67.059	Seriola_lalandi_dorsalis
ENSG00000161016	RPL8	100	99.029	ENSSLDG00000023024	rpl8	100	96.498	Seriola_lalandi_dorsalis
ENSG00000161016	RPL8	91	100.000	ENSSARG00000008430	-	99	80.400	Sorex_araneus
ENSG00000161016	RPL8	100	100.000	ENSSPUG00000005349	RPL8	100	100.000	Sphenodon_punctatus
ENSG00000161016	RPL8	100	100.000	ENSSPAG00000008593	rpl8	99	94.894	Stegastes_partitus
ENSG00000161016	RPL8	100	100.000	ENSSSCG00000029830	RPL8	100	100.000	Sus_scrofa
ENSG00000161016	RPL8	98	67.194	ENSSSCG00000009838	-	99	67.194	Sus_scrofa
ENSG00000161016	RPL8	97	55.245	ENSSSCG00000034644	-	95	55.245	Sus_scrofa
ENSG00000161016	RPL8	78	97.500	ENSTGUG00000013958	-	100	97.500	Taeniopygia_guttata
ENSG00000161016	RPL8	100	99.029	ENSTGUG00000006502	-	97	98.054	Taeniopygia_guttata
ENSG00000161016	RPL8	100	95.610	ENSTRUG00000013973	rpl8	83	92.887	Takifugu_rubripes
ENSG00000161016	RPL8	100	99.029	ENSTNIG00000005285	rpl8	100	96.498	Tetraodon_nigroviridis
ENSG00000161016	RPL8	100	97.605	ENSTBEG00000010363	RPL8	100	92.760	Tupaia_belangeri
ENSG00000161016	RPL8	100	100.000	ENSTTRG00000013858	RPL8	100	100.000	Tursiops_truncatus
ENSG00000161016	RPL8	100	100.000	ENSUAMG00000007856	RPL8	100	100.000	Ursus_americanus
ENSG00000161016	RPL8	77	100.000	ENSUMAG00000019359	RPL8	84	100.000	Ursus_maritimus
ENSG00000161016	RPL8	100	100.000	ENSVVUG00000005507	-	100	100.000	Vulpes_vulpes
ENSG00000161016	RPL8	100	99.029	ENSXETG00000015483	rpl8	100	97.665	Xenopus_tropicalis
ENSG00000161016	RPL8	100	100.000	ENSXCOG00000018568	rpl8	100	97.276	Xiphophorus_couchianus
ENSG00000161016	RPL8	100	100.000	ENSXMAG00000017781	rpl8	100	97.276	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0002181	cytoplasmic translation	21873635.	IBA	Process
GO:0002181	cytoplasmic translation	25957688.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	12962325.	NAS	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006412	translation	12962325.	NAS	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	TAS	Process
GO:0014069	postsynaptic density	21170055.	EXP	Component
GO:0014069	postsynaptic density	21170055.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0019083	viral transcription	-	TAS	Process
GO:0019843	rRNA binding	-	IEA	Function
GO:0022625	cytosolic large ribosomal subunit	12962325.	HDA	Component
GO:0022625	cytosolic large ribosomal subunit	21873635.	IBA	Component
GO:0022625	cytosolic large ribosomal subunit	25957688.	IDA	Component
GO:0042788	polysomal ribosome	25957688.	IDA	Component
GO:0098794	postsynapse	23071613.	EXP	Component
GO:0098794	postsynapse	23071613.	IDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	144791236	Intron	novel		0.69
BLCA	chr8	144789910	Missense_Mutation	novel	S223Y	0.23
BLCA	chr8	144789799	3'UTR	novel		0.11
BLCA	chr8	144791363	Missense_Mutation	novel	S138F	0.35
BLCA	chr8	144791242	Intron	novel		0.3
BRCA	chr8	144791215	Intron	novel		0.13
BRCA	chr8	144791443	Frame_Shift_Ins	NA	*I112Qfs38**	0.2
CESC	chr8	144791682	Intron	novel		0.42
CESC	chr8	144789921	Silent	rs746835373	I219I	0.43
CESC	chr8	144791280	Missense_Mutation	NA	V166F	0.3
COAD	chr8	144789914	Missense_Mutation	NA	P222S	0.57
COAD	chr8	144791755	Intron	novel		0.17
COAD	chr8	144790471	Splice_Site	NA	X167_splice	0.2
COAD	chr8	144791738	Intron	novel		0.2
COAD	chr8	144789797	3'UTR	novel		0.5
DLBC	chr8	144791490	Missense_Mutation	rs11539889	L96F	0.21
ESCA	chr8	144789932	Missense_Mutation	novel	H216Y	0.33
HNSC	chr8	144790381	Missense_Mutation	rs767157998	P197S	0.06
HNSC	chr8	144791502	Splice_Region	novel		0.13
HNSC	chr8	144791861	Silent	novel	R64R	0.17
HNSC	chr8	144791725	Intron	novel		0.1
KICH	chr8	144789892	Missense_Mutation	novel	A229V	0.28
LIHC	chr8	144791684	Intron	novel		0.36
LIHC	chr8	144791304	Missense_Mutation	novel	I158F	0.19
LUAD	chr8	144792078	Missense_Mutation	novel	A18T	0.11	Ribosomal_L2_C
LUAD	chr8	144791885	Silent	novel	A56A	0.48
LUAD	chr8	144791815	Missense_Mutation	NA	E80K	0.06	Ribosomal_L2_C
LUAD	chr8	144789820	Missense_Mutation	novel	Q253L	0.23
LUAD	chr8	144791315	Missense_Mutation	novel	S154Y	0.3
LUAD	chr8	144792016	Silent	rs201586885	H38H	0.25
LUSC	chr8	144791915	Splice_Site	novel	X47_splice	0.23
LUSC	chr8	144791835	Missense_Mutation	rs376660224	T73M	0.16	Ribosomal_L2_C
LUSC	chr8	144789809	Missense_Mutation	NA	N257D	0.14
LUSC	chr8	144789816	Silent	NA	E254E	0.16
LUSC	chr8	144791781	Frame_Shift_Del	novel	*G91Afs58**	0.18
LUSC	chr8	144791383	Silent	rs770588390	G131G	0.06
OV	chr8	144789821	Missense_Mutation	NA	Q253E	0.1
OV	chr8	144791975	Intron	novel		0.08
READ	chr8	144789810	Missense_Mutation	NA	E256D	0.28
SKCM	chr8	144792046	Silent	NA	R28R	0.71
SKCM	chr8	144791557	Intron	novel		0.5
SKCM	chr8	144791849	Silent	novel	R68R	0.29
SKCM	chr8	144790463	Silent	NA	V169V	0.13
SKCM	chr8	144791440	Silent	NA	I112I	0.11
SKCM	chr8	144791804	Silent	rs368194465	H83H	0.64
SKCM	chr8	144791874	Missense_Mutation	NA	K60T	0.09	Ribosomal_L2_C
STAD	chr8	144792078	Missense_Mutation	novel	A18P	0.1	Ribosomal_L2_C
STAD	chr8	144791291	Missense_Mutation	NA	N162S	0.06
STAD	chr8	144791788	Missense_Mutation	NA	Y89H	0.07	Ribosomal_L2_C
STAD	chr8	144791378	Frame_Shift_Ins	novel	*Y133Lfs10**	0.33
STAD	chr8	144791381	In_Frame_Del	novel	G131_N132del	0.32
STAD	chr8	144789882	Silent	NA	G232G	0.26
STAD	chr8	144790415	Silent	rs188677090	A185A	0.07
TGCT	chr8	144791729	Intron	novel		0.18
UCEC	chr8	144789893	Missense_Mutation	novel	A229T	0.33
UCEC	chr8	144790443	Missense_Mutation	NA	D176G	0.21
UCEC	chr8	144791229	Intron	novel		0.21
UCEC	chr8	144791380	Silent	novel	N132N	0.25
UCEC	chr8	144791354	Missense_Mutation	novel	P141L	0.26
UCEC	chr8	144791774	Missense_Mutation	novel	K93N	0.59
UCEC	chr8	144791684	Intron	novel		0.33
UCEC	chr8	144790415	Silent	rs188677090	A185A	0.45
UCEC	chr8	144791121	Intron	novel		0.44
UCEC	chr8	144789810	Missense_Mutation	NA	E256D	0.37
UCEC	chr8	144790416	Missense_Mutation	novel	A185V	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1174	0.15559
LGG	DEL	0.0487	0.014004
SARC	AMP	0.249	0.18425
SKCM	AMP	0.4469	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0031	Kaplan-Meier Survival Analysis
STAD	0.047	Kaplan-Meier Survival Analysis
SARC	0.0031	Kaplan-Meier Survival Analysis
ACC	0.0028	Kaplan-Meier Survival Analysis
UCS	0.035	Kaplan-Meier Survival Analysis
KIRP	0.014	Kaplan-Meier Survival Analysis
PCPG	0.02	Kaplan-Meier Survival Analysis
CESC	0.036	Kaplan-Meier Survival Analysis
LAML	0.045	Kaplan-Meier Survival Analysis
LIHC	0.0048	Kaplan-Meier Survival Analysis
LGG	0.021	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742