EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000161057 (Gene tree)
Gene ID: 5701
Gene Symbol: PSMC2
Alias: MSS1|S7|Nbla10058
Full Name: proteasome 26S subunit, ATPase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 25,142 bases
Position: chr7:103,344,254-103,369,395
Accession: 9548
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000457587	PSMC2-204	682	-	ENSP00000401724	130 (aa)	-	C9JLS9
ENST00000292644	PSMC2-201	2637	-	ENSP00000292644	433 (aa)	-	P35998
ENST00000435765	PSMC2-203	3054	-	ENSP00000391211	433 (aa)	-	P35998
ENST00000425206	PSMC2-202	656	-	ENSP00000393027	130 (aa)	-	C9JLS9
ENST00000640277	PSMC2-206	1357	-	ENSP00000491883	400 (aa)	-	A0A1W2PQS1
ENST00000460021	PSMC2-205	733	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000161057's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000161057	rs117430989	7	103366166	?	Morning person	30595370			EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161057's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000161057	PSMC2	99	87.657	WBGene00004501	rpt-1	100	85.287	Caenorhabditis_elegans
ENSG00000161057	PSMC2	84	45.833	WBGene00004502	rpt-2	74	45.833	Caenorhabditis_elegans
ENSG00000161057	PSMC2	67	51.880	WBGene00004503	rpt-3	64	51.880	Caenorhabditis_elegans
ENSG00000161057	PSMC2	77	56.311	ENSG00000087191	PSMC5	97	51.449	Homo_sapiens
ENSG00000161057	PSMC2	78	50.323	ENSG00000100519	PSMC6	99	53.030	Homo_sapiens
ENSG00000161057	PSMC2	84	47.321	ENSG00000100764	PSMC1	95	60.000	Homo_sapiens
ENSG00000161057	PSMC2	76	49.013	ENSG00000165916	PSMC3	75	49.013	Homo_sapiens
ENSG00000161057	PSMC2	99	72.365	YKL145W	RPT1	96	72.197	Saccharomyces_cerevisiae
ENSG00000161057	PSMC2	84	51.045	YGL048C	RPT6	82	51.045	Saccharomyces_cerevisiae
ENSG00000161057	PSMC2	82	45.289	YDL007W	RPT2	74	45.427	Saccharomyces_cerevisiae
ENSG00000161057	PSMC2	71	48.944	YDR394W	RPT3	66	48.944	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	9295362.17323924.	IDA	Component
GO:0000932	P-body	-	ISS	Component
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005515	protein binding	16189514.16763564.19490896.21516116.22078707.22901813.25416956.26496610.27107012.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	9295362.	IDA	Process
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	16210410.19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	9295362.	IDA	Function
GO:0017025	TBP-class protein binding	21873635.	IBA	Function
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0036402	proteasome-activating ATPase activity	-	IEA	Function
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043197	dendritic spine	21873635.	IBA	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	21873635.	IBA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901800	positive regulation of proteasomal protein catabolic process	-	IEA	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component