EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000161847 (Gene tree)
Gene ID: 125950
Gene Symbol: RAVER1
Alias: KIAA1978
Full Name: ribonucleoprotein, PTB binding 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 17,429 bases
Position: chr19:10,316,212-10,333,640
Accession: 30296
RBP type: canonical RBP
Summary: (Ribonucleoprotein, PTB Binding 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RAVER2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000479520	RRM_1	PF00076.22	1.9e-29	1	3
ENSP00000479520	RRM_1	PF00076.22	1.9e-29	2	3
ENSP00000479520	RRM_1	PF00076.22	1.9e-29	3	3
ENSP00000482277	RRM_1	PF00076.22	4.3e-29	1	2
ENSP00000482277	RRM_1	PF00076.22	4.3e-29	2	2
ENSP00000293677	RRM_1	PF00076.22	4.7e-29	1	2
ENSP00000293677	RRM_1	PF00076.22	4.7e-29	2	2
ENSP00000482486	RRM_1	PF00076.22	4.7e-29	1	2
ENSP00000482486	RRM_1	PF00076.22	4.7e-29	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21633983	Apo raver1 structure reveals distinct RRM domain orientations.	Protein Sci	2011 Aug	Rangarajan ES	doi: 10.1002/pro.664
19033374	Visualizing protein-RNA interactions inside cells by fluorescence resonance energy transfer.	RNA	2009 Jan	Lorenz M	doi: 10.1261/rna.1307809
22709580	The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA.	J Mol Biol	2012 Oct 5	Lee JH	doi: 10.1016/j.jmb.2012.06.015
19523901	Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions.	Structure	2009 Jun 10	Lee JH	doi: 10.1016/j.str.2009.04.010.
11724819	Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.	J Cell Biol	2001 Nov 26	Huttelmaier S	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000611074	RAVER1-206	3586	XM_011527671	ENSP00000482486	756 (aa)	XP_011525973	E9PAU2
ENST00000617231	RAVER1-208	3501	-	ENSP00000482277	739 (aa)	-	A0A087WZ13
ENST00000615032	RAVER1-207	1952	-	ENSP00000479520	606 (aa)	-	Q8IY67
ENST00000592208	RAVER1-204	4693	-	-	- (aa)	-	-
ENST00000591969	RAVER1-203	742	-	ENSP00000465753	96 (aa)	-	K7EKR9
ENST00000593136	RAVER1-205	500	-	ENSP00000468375	130 (aa)	-	K7ERR4
ENST00000293677	RAVER1-201	3595	-	ENSP00000293677	756 (aa)	-	E9PAU2
ENST00000585935	RAVER1-202	470	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000161847's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000161847	rs74956615	19	10317045	A	Plateletcrit	27863252	[0.048-0.079] unit decrease	0.06337232	EFO_0007985

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161847's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000161847	RAVER1	72	52.174	ENSG00000162437	RAVER2	84	42.857

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000161847	RAVER1	79	61.842	ENSAPOG00000017267	raver1	53	64.252	Acanthochromis_polyacanthus
ENSG00000161847	RAVER1	100	91.304	ENSAMEG00000011738	RAVER1	100	91.041	Ailuropoda_melanoleuca
ENSG00000161847	RAVER1	89	57.647	ENSACIG00000008853	raver1	81	67.490	Amphilophus_citrinellus
ENSG00000161847	RAVER1	79	60.526	ENSAOCG00000005128	raver1	89	50.481	Amphiprion_ocellaris
ENSG00000161847	RAVER1	75	75.439	ENSAPEG00000010854	raver1	82	75.439	Amphiprion_percula
ENSG00000161847	RAVER1	100	50.861	ENSATEG00000021004	raver1	94	50.398	Anabas_testudineus
ENSG00000161847	RAVER1	87	59.750	ENSACAG00000008386	-	94	59.084	Anolis_carolinensis
ENSG00000161847	RAVER1	100	95.905	ENSANAG00000028226	RAVER1	100	95.905	Aotus_nancymaae
ENSG00000161847	RAVER1	96	51.099	ENSACLG00000018492	raver1	91	52.006	Astatotilapia_calliptera
ENSG00000161847	RAVER1	99	51.333	ENSAMXG00000005132	raver1	96	51.425	Astyanax_mexicanus
ENSG00000161847	RAVER1	100	90.079	ENSBTAG00000015721	RAVER1	100	95.204	Bos_taurus
ENSG00000161847	RAVER1	100	96.081	ENSCJAG00000005671	RAVER1	100	95.905	Callithrix_jacchus
ENSG00000161847	RAVER1	100	90.079	ENSCAFG00000017861	RAVER1	100	90.079	Canis_familiaris
ENSG00000161847	RAVER1	100	89.851	ENSCAFG00020024449	RAVER1	100	89.851	Canis_lupus_dingo
ENSG00000161847	RAVER1	100	90.759	ENSCHIG00000006718	RAVER1	100	90.759	Capra_hircus
ENSG00000161847	RAVER1	89	88.376	ENSTSYG00000027107	RAVER1	100	88.376	Carlito_syrichta
ENSG00000161847	RAVER1	90	88.473	ENSCAPG00000002269	RAVER1	100	87.874	Cavia_aperea
ENSG00000161847	RAVER1	100	89.609	ENSCPOG00000001008	RAVER1	100	89.744	Cavia_porcellus
ENSG00000161847	RAVER1	100	96.164	ENSCCAG00000031723	RAVER1	100	96.164	Cebus_capucinus
ENSG00000161847	RAVER1	100	98.810	ENSCATG00000043863	RAVER1	100	98.810	Cercocebus_atys
ENSG00000161847	RAVER1	100	91.117	ENSCLAG00000009336	RAVER1	100	90.713	Chinchilla_lanigera
ENSG00000161847	RAVER1	100	98.810	ENSCSAG00000007317	RAVER1	86	98.810	Chlorocebus_sabaeus
ENSG00000161847	RAVER1	95	68.607	ENSCPBG00000005349	-	96	62.065	Chrysemys_picta_bellii
ENSG00000161847	RAVER1	100	98.545	ENSCANG00000008337	RAVER1	100	98.545	Colobus_angolensis_palliatus
ENSG00000161847	RAVER1	100	88.949	ENSCGRG00001013260	-	100	89.488	Cricetulus_griseus_chok1gshd
ENSG00000161847	RAVER1	100	88.949	ENSCGRG00000015138	-	100	89.488	Cricetulus_griseus_crigri
ENSG00000161847	RAVER1	97	48.594	ENSCSEG00000021092	raver1	78	78.846	Cynoglossus_semilaevis
ENSG00000161847	RAVER1	97	50.273	ENSCVAG00000013971	raver1	92	49.932	Cyprinodon_variegatus
ENSG00000161847	RAVER1	69	65.152	ENSDARG00000052617	raver1	91	51.182	Danio_rerio
ENSG00000161847	RAVER1	93	93.258	ENSDNOG00000035742	-	85	91.946	Dasypus_novemcinctus
ENSG00000161847	RAVER1	93	94.382	ENSDORG00000010106	-	100	82.459	Dipodomys_ordii
ENSG00000161847	RAVER1	91	72.777	ENSETEG00000008201	-	87	88.325	Echinops_telfairi
ENSG00000161847	RAVER1	93	96.629	ENSEASG00005010544	-	100	81.878	Equus_asinus_asinus
ENSG00000161847	RAVER1	100	92.754	ENSECAG00000024966	RAVER1	100	93.149	Equus_caballus
ENSG00000161847	RAVER1	98	51.226	ENSELUG00000023287	raver1	93	51.604	Esox_lucius
ENSG00000161847	RAVER1	100	92.622	ENSFCAG00000009435	RAVER1	100	92.358	Felis_catus
ENSG00000161847	RAVER1	100	89.906	ENSFDAG00000015113	RAVER1	100	89.637	Fukomys_damarensis
ENSG00000161847	RAVER1	76	65.753	ENSFHEG00000001653	raver1	81	68.571	Fundulus_heteroclitus
ENSG00000161847	RAVER1	82	60.327	ENSGMOG00000003649	raver1	80	60.327	Gadus_morhua
ENSG00000161847	RAVER1	69	56.061	ENSGALG00000050608	-	53	45.117	Gallus_gallus
ENSG00000161847	RAVER1	100	50.798	ENSGAFG00000015944	raver1	96	50.330	Gambusia_affinis
ENSG00000161847	RAVER1	89	60.227	ENSGACG00000013818	raver1	99	51.129	Gasterosteus_aculeatus
ENSG00000161847	RAVER1	96	63.685	ENSGAGG00000011748	-	96	76.344	Gopherus_agassizii
ENSG00000161847	RAVER1	100	99.735	ENSGGOG00000006015	RAVER1	100	99.735	Gorilla_gorilla
ENSG00000161847	RAVER1	96	50.761	ENSHBUG00000021210	raver1	91	51.715	Haplochromis_burtoni
ENSG00000161847	RAVER1	100	90.040	ENSHGLG00000015460	RAVER1	100	89.637	Heterocephalus_glaber_female
ENSG00000161847	RAVER1	100	90.040	ENSHGLG00100000812	RAVER1	100	89.637	Heterocephalus_glaber_male
ENSG00000161847	RAVER1	98	49.932	ENSHCOG00000000449	raver1	91	50.543	Hippocampus_comes
ENSG00000161847	RAVER1	97	52.603	ENSIPUG00000013153	raver1	99	50.384	Ictalurus_punctatus
ENSG00000161847	RAVER1	100	92.308	ENSSTOG00000003241	RAVER1	100	92.173	Ictidomys_tridecemlineatus
ENSG00000161847	RAVER1	100	90.201	ENSJJAG00000018219	-	100	90.201	Jaculus_jaculus
ENSG00000161847	RAVER1	98	51.425	ENSKMAG00000017355	raver1	93	50.606	Kryptolebias_marmoratus
ENSG00000161847	RAVER1	80	57.143	ENSLBEG00000008268	raver1	71	58.824	Labrus_bergylta
ENSG00000161847	RAVER1	90	61.341	ENSLACG00000005809	-	99	62.108	Latimeria_chalumnae
ENSG00000161847	RAVER1	96	56.410	ENSLOCG00000007500	raver1	93	55.733	Lepisosteus_oculatus
ENSG00000161847	RAVER1	100	91.790	ENSLAFG00000003664	-	100	92.059	Loxodonta_africana
ENSG00000161847	RAVER1	100	98.545	ENSMFAG00000037977	RAVER1	100	98.545	Macaca_fascicularis
ENSG00000161847	RAVER1	100	98.545	ENSMMUG00000014897	RAVER1	100	98.545	Macaca_mulatta
ENSG00000161847	RAVER1	100	98.545	ENSMNEG00000028390	RAVER1	100	98.545	Macaca_nemestrina
ENSG00000161847	RAVER1	100	98.545	ENSMLEG00000041959	RAVER1	100	98.545	Mandrillus_leucophaeus
ENSG00000161847	RAVER1	98	50.607	ENSMAMG00000012059	raver1	93	51.012	Mastacembelus_armatus
ENSG00000161847	RAVER1	72	85.417	ENSMZEG00005019002	raver1	91	52.427	Maylandia_zebra
ENSG00000161847	RAVER1	100	88.306	ENSMAUG00000017948	-	100	88.441	Mesocricetus_auratus
ENSG00000161847	RAVER1	93	98.876	ENSMICG00000010326	RAVER1	99	92.053	Microcebus_murinus
ENSG00000161847	RAVER1	100	89.757	ENSMOCG00000015553	-	100	90.027	Microtus_ochrogaster
ENSG00000161847	RAVER1	97	51.163	ENSMMOG00000012093	raver1	93	50.404	Mola_mola
ENSG00000161847	RAVER1	93	85.393	ENSMODG00000005584	-	91	77.402	Monodelphis_domestica
ENSG00000161847	RAVER1	99	50.602	ENSMALG00000016569	raver1	56	64.988	Monopterus_albus
ENSG00000161847	RAVER1	100	87.567	MGP_CAROLIEiJ_G0031860	-	100	88.102	Mus_caroli
ENSG00000161847	RAVER1	100	87.433	ENSMUSG00000010205	Raver1	100	87.968	Mus_musculus
ENSG00000161847	RAVER1	100	86.303	MGP_PahariEiJ_G0014726	-	100	87.633	Mus_pahari
ENSG00000161847	RAVER1	100	87.299	MGP_SPRETEiJ_G0032984	-	100	87.834	Mus_spretus
ENSG00000161847	RAVER1	100	92.885	ENSMPUG00000006712	RAVER1	100	92.885	Mustela_putorius_furo
ENSG00000161847	RAVER1	100	89.581	ENSMLUG00000012328	RAVER1	100	89.986	Myotis_lucifugus
ENSG00000161847	RAVER1	100	89.189	ENSNGAG00000001260	-	100	89.189	Nannospalax_galili
ENSG00000161847	RAVER1	96	44.766	ENSNBRG00000010139	raver1	78	55.556	Neolamprologus_brichardi
ENSG00000161847	RAVER1	100	98.241	ENSNLEG00000012181	RAVER1	100	98.148	Nomascus_leucogenys
ENSG00000161847	RAVER1	90	75.522	ENSMEUG00000003281	-	100	75.373	Notamacropus_eugenii
ENSG00000161847	RAVER1	70	82.090	ENSOPRG00000005855	-	51	89.844	Ochotona_princeps
ENSG00000161847	RAVER1	100	90.848	ENSODEG00000016260	RAVER1	100	90.310	Octodon_degus
ENSG00000161847	RAVER1	96	51.469	ENSONIG00000001559	raver1	99	51.796	Oreochromis_niloticus
ENSG00000161847	RAVER1	93	95.506	ENSOCUG00000020918	RAVER1	100	85.450	Oryctolagus_cuniculus
ENSG00000161847	RAVER1	76	63.014	ENSORLG00000005458	raver1	67	66.584	Oryzias_latipes
ENSG00000161847	RAVER1	76	63.014	ENSORLG00020004392	raver1	67	66.832	Oryzias_latipes_hni
ENSG00000161847	RAVER1	76	63.014	ENSORLG00015017222	raver1	67	66.584	Oryzias_latipes_hsok
ENSG00000161847	RAVER1	61	81.633	ENSOMEG00000023956	raver1	67	81.633	Oryzias_melastigma
ENSG00000161847	RAVER1	100	92.460	ENSOGAG00000011071	RAVER1	100	92.328	Otolemur_garnettii
ENSG00000161847	RAVER1	100	88.538	ENSOARG00000015886	RAVER1	100	89.065	Ovis_aries
ENSG00000161847	RAVER1	100	100.000	ENSPPAG00000002611	RAVER1	100	100.000	Pan_paniscus
ENSG00000161847	RAVER1	100	93.017	ENSPPRG00000009912	RAVER1	100	92.754	Panthera_pardus
ENSG00000161847	RAVER1	100	100.000	ENSPTRG00000010466	RAVER1	100	100.000	Pan_troglodytes
ENSG00000161847	RAVER1	100	98.677	ENSPANG00000004122	RAVER1	100	98.677	Papio_anubis
ENSG00000161847	RAVER1	69	71.212	ENSPKIG00000015863	raver1	70	72.321	Paramormyrops_kingsleyae
ENSG00000161847	RAVER1	76	64.384	ENSPMGG00000001451	raver1	75	70.870	Periophthalmus_magnuspinnatus
ENSG00000161847	RAVER1	100	89.098	ENSPEMG00000016411	-	100	89.637	Peromyscus_maniculatus_bairdii
ENSG00000161847	RAVER1	93	85.393	ENSPCIG00000018695	-	100	78.016	Phascolarctos_cinereus
ENSG00000161847	RAVER1	97	51.556	ENSPFOG00000007016	raver1	92	50.538	Poecilia_formosa
ENSG00000161847	RAVER1	73	80.000	ENSPLAG00000020793	raver1	76	80.000	Poecilia_latipinna
ENSG00000161847	RAVER1	97	52.660	ENSPMEG00000011220	raver1	92	51.565	Poecilia_mexicana
ENSG00000161847	RAVER1	72	88.372	ENSPREG00000006864	raver1	77	88.372	Poecilia_reticulata
ENSG00000161847	RAVER1	100	98.148	ENSPPYG00000010514	RAVER1	85	98.148	Pongo_abelii
ENSG00000161847	RAVER1	100	92.773	ENSPCOG00000026605	RAVER1	100	93.167	Propithecus_coquereli
ENSG00000161847	RAVER1	100	92.558	ENSPVAG00000003689	RAVER1	100	92.558	Pteropus_vampyrus
ENSG00000161847	RAVER1	61	82.353	ENSPNYG00000013284	raver1	64	82.353	Pundamilia_nyererei
ENSG00000161847	RAVER1	97	51.436	ENSPNAG00000015476	raver1	92	51.786	Pygocentrus_nattereri
ENSG00000161847	RAVER1	100	87.968	ENSRNOG00000020710	Raver1	100	87.968	Rattus_norvegicus
ENSG00000161847	RAVER1	100	98.942	ENSRBIG00000034702	RAVER1	100	98.942	Rhinopithecus_bieti
ENSG00000161847	RAVER1	100	95.899	ENSRROG00000031186	RAVER1	100	95.899	Rhinopithecus_roxellana
ENSG00000161847	RAVER1	100	92.857	ENSSBOG00000023423	RAVER1	100	92.857	Saimiri_boliviensis_boliviensis
ENSG00000161847	RAVER1	90	77.219	ENSSHAG00000008181	-	90	76.775	Sarcophilus_harrisii
ENSG00000161847	RAVER1	73	68.571	ENSSFOG00015023666	raver1	79	72.368	Scleropages_formosus
ENSG00000161847	RAVER1	81	58.974	ENSSMAG00000004546	raver1	93	49.802	Scophthalmus_maximus
ENSG00000161847	RAVER1	97	52.044	ENSSDUG00000021063	raver1	92	52.239	Seriola_dumerili
ENSG00000161847	RAVER1	79	61.842	ENSSLDG00000014505	raver1	92	51.967	Seriola_lalandi_dorsalis
ENSG00000161847	RAVER1	79	61.842	ENSSPAG00000000688	raver1	92	52.531	Stegastes_partitus
ENSG00000161847	RAVER1	100	92.602	ENSSSCG00000013650	-	100	92.999	Sus_scrofa
ENSG00000161847	RAVER1	96	50.964	ENSTRUG00000025641	raver1	91	50.685	Takifugu_rubripes
ENSG00000161847	RAVER1	81	59.259	ENSTNIG00000018570	raver1	91	62.500	Tetraodon_nigroviridis
ENSG00000161847	RAVER1	100	91.475	ENSTTRG00000009552	RAVER1	100	91.881	Tursiops_truncatus
ENSG00000161847	RAVER1	100	93.017	ENSUAMG00000020385	RAVER1	100	92.754	Ursus_americanus
ENSG00000161847	RAVER1	100	90.079	ENSVVUG00000028976	RAVER1	100	90.079	Vulpes_vulpes
ENSG00000161847	RAVER1	100	56.454	ENSXETG00000011622	raver1	100	55.932	Xenopus_tropicalis
ENSG00000161847	RAVER1	99	51.206	ENSXCOG00000016368	raver1	94	50.870	Xiphophorus_couchianus
ENSG00000161847	RAVER1	99	51.007	ENSXMAG00000000217	raver1	94	50.606	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	-	IEA	Component