EuRBPDB

Description

Ensembl ID: ENSG00000161956 (Gene tree)
Gene ID: 26168
Gene Symbol: SENP3
Alias: DKFZP586K0919|SSP3|DKFZp762A152|SMT3IP1|Ulp1
Full Name: SUMO specific peptidase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 10,095 bases
Position: chr17:7,561,875-7,571,969
Accession: 17862
RBP type: non-canonical RBP
Summary: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000610454	SENP3-209	606	-	ENSP00000479187	177 (aa)	-	A0A087WV50
ENST00000619785	SENP3-210	634	-	ENSP00000482398	63 (aa)	-	A0A087WZ63
ENST00000581093	SENP3-206	493	-	ENSP00000462461	82 (aa)	-	J3KSF5
ENST00000580997	SENP3-204	679	-	-	- (aa)	-	-
ENST00000582789	SENP3-207	536	-	ENSP00000464172	110 (aa)	-	J3QRE4
ENST00000321337	SENP3-201	2611	-	ENSP00000314029	574 (aa)	-	Q9H4L4
ENST00000583277	SENP3-208	1578	-	-	- (aa)	-	-
ENST00000581010	SENP3-205	527	-	-	- (aa)	-	-
ENST00000429205	SENP3-202	2222	-	ENSP00000403712	574 (aa)	-	Q9H4L4
ENST00000580231	SENP3-203	901	-	ENSP00000463358	237 (aa)	-	J3QL36

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000161956	Immunoglobulin M	4E-7	23118916

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000161956	rs11078697	17	7565912	C	IgM levels	23118916			EFO_0004993

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000161956	SENP3	100	94.599	ENSMUSG00000005204	Senp3	99	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	18259216.19680224.21326211.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006364	rRNA processing	-	TAS	Process
GO:0008234	cysteine-type peptidase activity	-	IEA	Function
GO:0016926	protein desumoylation	21873635.	IBA	Process
GO:0071339	MLL1 complex	15960975.	IDA	Component