EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000161980 (Gene tree)
Gene ID: 51728
Gene Symbol: POLR3K
Alias: RPC11
Full Name: RNA polymerase III subunit K
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,226 bases
Position: chr16:46,407-53,632
Accession: 14121
RBP type: canonical RBP
Summary: This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000293860	RNA_POL_M_15KD	PF02150.16	1e-07	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10079944	[Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III].	Bioorg Khim	1998 Nov	Spakovskii GV	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000293860	POLR3K-201	1392	-	ENSP00000293860	108 (aa)	-	Q9Y2Y1
ENST00000481810	POLR3K-202	907	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000161980's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa04623	Cytosolic DNA-sensing pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000161980	Platelet Function Tests	9.4000000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161980's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000161980	POLR3K	100	92.593	ENSAPOG00000023908	polr3k	100	92.593	Acanthochromis_polyacanthus
ENSG00000161980	POLR3K	100	98.148	ENSAMEG00000006776	POLR3K	100	98.148	Ailuropoda_melanoleuca
ENSG00000161980	POLR3K	100	92.593	ENSACIG00000023296	polr3k	100	92.593	Amphilophus_citrinellus
ENSG00000161980	POLR3K	100	92.593	ENSAOCG00000022121	polr3k	100	92.593	Amphiprion_ocellaris
ENSG00000161980	POLR3K	100	66.225	ENSAPEG00000011600	polr3k	100	66.225	Amphiprion_percula
ENSG00000161980	POLR3K	100	93.519	ENSATEG00000004474	polr3k	100	93.519	Anabas_testudineus
ENSG00000161980	POLR3K	100	99.074	ENSANAG00000024313	POLR3K	100	99.074	Aotus_nancymaae
ENSG00000161980	POLR3K	100	90.741	ENSAMXG00000039818	polr3k	100	90.741	Astyanax_mexicanus
ENSG00000161980	POLR3K	100	98.148	ENSBTAG00000019803	POLR3K	100	98.148	Bos_taurus
ENSG00000161980	POLR3K	100	99.074	ENSCJAG00000011568	POLR3K	100	99.074	Callithrix_jacchus
ENSG00000161980	POLR3K	100	100.000	ENSCAFG00000019715	POLR3K	100	100.000	Canis_familiaris
ENSG00000161980	POLR3K	100	100.000	ENSCAFG00020009353	POLR3K	100	100.000	Canis_lupus_dingo
ENSG00000161980	POLR3K	100	98.148	ENSCPOG00000038538	POLR3K	100	98.148	Cavia_porcellus
ENSG00000161980	POLR3K	100	99.074	ENSCCAG00000036420	POLR3K	100	99.074	Cebus_capucinus
ENSG00000161980	POLR3K	100	99.074	ENSCATG00000044779	POLR3K	100	99.074	Cercocebus_atys
ENSG00000161980	POLR3K	100	98.148	ENSCLAG00000015623	POLR3K	100	98.148	Chinchilla_lanigera
ENSG00000161980	POLR3K	100	99.074	ENSCSAG00000013189	POLR3K	100	99.074	Chlorocebus_sabaeus
ENSG00000161980	POLR3K	100	98.148	ENSCHOG00000011936	POLR3K	100	98.148	Choloepus_hoffmanni
ENSG00000161980	POLR3K	100	88.889	ENSCPBG00000026407	POLR3K	53	88.889	Chrysemys_picta_bellii
ENSG00000161980	POLR3K	100	76.852	ENSCING00000018769	polr3k	100	76.852	Ciona_intestinalis
ENSG00000161980	POLR3K	100	79.630	ENSCSAVG00000008256	-	100	79.630	Ciona_savignyi
ENSG00000161980	POLR3K	100	99.074	ENSCANG00000014572	POLR3K	100	99.074	Colobus_angolensis_palliatus
ENSG00000161980	POLR3K	100	98.148	ENSCGRG00001000491	Polr3k	100	98.148	Cricetulus_griseus_chok1gshd
ENSG00000161980	POLR3K	100	98.148	ENSCGRG00000008002	Polr3k	100	98.148	Cricetulus_griseus_crigri
ENSG00000161980	POLR3K	100	93.519	ENSCSEG00000010369	polr3k	100	93.519	Cynoglossus_semilaevis
ENSG00000161980	POLR3K	100	93.519	ENSCVAG00000015750	polr3k	100	93.519	Cyprinodon_variegatus
ENSG00000161980	POLR3K	100	92.593	ENSDARG00000037835	polr3k	100	92.593	Danio_rerio
ENSG00000161980	POLR3K	100	70.370	FBgn0061362	CG33785	100	70.370	Drosophila_melanogaster
ENSG00000161980	POLR3K	100	98.148	ENSETEG00000009989	POLR3K	100	98.148	Echinops_telfairi
ENSG00000161980	POLR3K	100	83.333	ENSEBUG00000014194	polr3k	100	83.333	Eptatretus_burgeri
ENSG00000161980	POLR3K	100	98.148	ENSEASG00005017858	POLR3K	100	98.148	Equus_asinus_asinus
ENSG00000161980	POLR3K	100	98.148	ENSECAG00000024929	POLR3K	100	98.148	Equus_caballus
ENSG00000161980	POLR3K	100	90.741	ENSELUG00000021625	polr3k	100	90.741	Esox_lucius
ENSG00000161980	POLR3K	100	100.000	ENSFCAG00000038431	POLR3K	100	100.000	Felis_catus
ENSG00000161980	POLR3K	99	86.916	ENSFALG00000004058	POLR3K	96	86.916	Ficedula_albicollis
ENSG00000161980	POLR3K	100	97.222	ENSFDAG00000001608	POLR3K	100	97.222	Fukomys_damarensis
ENSG00000161980	POLR3K	100	93.519	ENSFHEG00000000757	polr3k	100	93.519	Fundulus_heteroclitus
ENSG00000161980	POLR3K	100	87.037	ENSGMOG00000004334	polr3k	100	87.037	Gadus_morhua
ENSG00000161980	POLR3K	100	87.963	ENSGALG00000017681	POLR3K	100	87.963	Gallus_gallus
ENSG00000161980	POLR3K	100	93.519	ENSGAFG00000017933	polr3k	100	93.519	Gambusia_affinis
ENSG00000161980	POLR3K	100	89.815	ENSGACG00000013978	polr3k	100	89.815	Gasterosteus_aculeatus
ENSG00000161980	POLR3K	100	88.889	ENSGAGG00000024229	POLR3K	53	88.889	Gopherus_agassizii
ENSG00000161980	POLR3K	100	99.074	ENSGGOG00000008500	POLR3K	100	99.074	Gorilla_gorilla
ENSG00000161980	POLR3K	100	92.593	ENSHBUG00000000079	polr3k	100	92.593	Haplochromis_burtoni
ENSG00000161980	POLR3K	100	98.148	ENSHGLG00000002434	POLR3K	100	98.148	Heterocephalus_glaber_female
ENSG00000161980	POLR3K	100	98.148	ENSHGLG00100004679	POLR3K	100	98.148	Heterocephalus_glaber_male
ENSG00000161980	POLR3K	100	90.741	ENSHCOG00000007116	polr3k	100	90.741	Hippocampus_comes
ENSG00000161980	POLR3K	100	90.741	ENSIPUG00000011366	polr3k	100	90.741	Ictalurus_punctatus
ENSG00000161980	POLR3K	100	98.148	ENSSTOG00000022940	POLR3K	100	98.148	Ictidomys_tridecemlineatus
ENSG00000161980	POLR3K	100	98.148	ENSJJAG00000022791	Polr3k	100	98.148	Jaculus_jaculus
ENSG00000161980	POLR3K	100	92.593	ENSKMAG00000018692	polr3k	100	92.593	Kryptolebias_marmoratus
ENSG00000161980	POLR3K	100	89.815	ENSLACG00000014660	POLR3K	100	89.815	Latimeria_chalumnae
ENSG00000161980	POLR3K	100	91.667	ENSLOCG00000007584	polr3k	100	91.667	Lepisosteus_oculatus
ENSG00000161980	POLR3K	100	98.148	ENSLAFG00000026907	POLR3K	100	98.148	Loxodonta_africana
ENSG00000161980	POLR3K	100	99.074	ENSMFAG00000041536	POLR3K	100	99.074	Macaca_fascicularis
ENSG00000161980	POLR3K	100	99.074	ENSMMUG00000000586	POLR3K	100	99.074	Macaca_mulatta
ENSG00000161980	POLR3K	100	98.148	ENSMLEG00000040084	POLR3K	100	98.148	Mandrillus_leucophaeus
ENSG00000161980	POLR3K	100	93.519	ENSMAMG00000002908	polr3k	100	93.519	Mastacembelus_armatus
ENSG00000161980	POLR3K	100	92.593	ENSMZEG00005022452	polr3k	100	92.593	Maylandia_zebra
ENSG00000161980	POLR3K	100	98.148	ENSMAUG00000010035	-	100	98.148	Mesocricetus_auratus
ENSG00000161980	POLR3K	100	96.296	ENSMICG00000031366	-	100	96.296	Microcebus_murinus
ENSG00000161980	POLR3K	100	87.963	ENSMICG00000027063	-	100	87.963	Microcebus_murinus
ENSG00000161980	POLR3K	100	98.148	ENSMOCG00000014307	Polr3k	100	98.148	Microtus_ochrogaster
ENSG00000161980	POLR3K	100	92.593	ENSMMOG00000014830	polr3k	100	92.593	Mola_mola
ENSG00000161980	POLR3K	100	93.519	ENSMALG00000020770	polr3k	100	93.519	Monopterus_albus
ENSG00000161980	POLR3K	100	99.074	MGP_CAROLIEiJ_G0024823	Polr3k	100	99.074	Mus_caroli
ENSG00000161980	POLR3K	100	99.074	ENSMUSG00000038628	Polr3k	100	99.074	Mus_musculus
ENSG00000161980	POLR3K	100	99.074	MGP_PahariEiJ_G0026271	Polr3k	100	99.074	Mus_pahari
ENSG00000161980	POLR3K	100	99.074	MGP_SPRETEiJ_G0025750	Polr3k	100	99.074	Mus_spretus
ENSG00000161980	POLR3K	100	99.074	ENSMLUG00000015593	POLR3K	100	99.074	Myotis_lucifugus
ENSG00000161980	POLR3K	100	98.148	ENSNGAG00000016438	Polr3k	100	98.148	Nannospalax_galili
ENSG00000161980	POLR3K	100	99.074	ENSNLEG00000007943	POLR3K	100	99.074	Nomascus_leucogenys
ENSG00000161980	POLR3K	100	92.593	ENSOPRG00000005506	POLR3K	100	92.593	Ochotona_princeps
ENSG00000161980	POLR3K	100	97.222	ENSODEG00000015558	POLR3K	100	97.222	Octodon_degus
ENSG00000161980	POLR3K	100	92.593	ENSONIG00000001424	polr3k	100	92.593	Oreochromis_niloticus
ENSG00000161980	POLR3K	100	97.222	ENSOCUG00000013608	POLR3K	100	97.222	Oryctolagus_cuniculus
ENSG00000161980	POLR3K	100	89.815	ENSOCUG00000022824	-	100	89.815	Oryctolagus_cuniculus
ENSG00000161980	POLR3K	100	90.741	ENSORLG00000026165	polr3k	100	90.741	Oryzias_latipes
ENSG00000161980	POLR3K	100	91.667	ENSORLG00020005190	polr3k	100	91.667	Oryzias_latipes_hni
ENSG00000161980	POLR3K	100	91.667	ENSORLG00015018330	polr3k	100	91.667	Oryzias_latipes_hsok
ENSG00000161980	POLR3K	100	91.667	ENSOMEG00000023979	polr3k	100	91.667	Oryzias_melastigma
ENSG00000161980	POLR3K	100	98.148	ENSOGAG00000002526	-	100	98.148	Otolemur_garnettii
ENSG00000161980	POLR3K	99	96.262	ENSOARG00000010407	POLR3K	95	96.262	Ovis_aries
ENSG00000161980	POLR3K	100	99.074	ENSPPAG00000038313	POLR3K	100	99.074	Pan_paniscus
ENSG00000161980	POLR3K	100	100.000	ENSPPRG00000014063	POLR3K	100	100.000	Panthera_pardus
ENSG00000161980	POLR3K	100	98.148	ENSPTIG00000013600	POLR3K	100	98.148	Panthera_tigris_altaica
ENSG00000161980	POLR3K	100	99.074	ENSPTRG00000007525	POLR3K	100	99.074	Pan_troglodytes
ENSG00000161980	POLR3K	100	99.074	ENSPANG00000006340	POLR3K	100	99.074	Papio_anubis
ENSG00000161980	POLR3K	100	92.593	ENSPKIG00000020663	polr3k	100	92.593	Paramormyrops_kingsleyae
ENSG00000161980	POLR3K	100	93.519	ENSPMGG00000004235	polr3k	100	93.519	Periophthalmus_magnuspinnatus
ENSG00000161980	POLR3K	100	99.074	ENSPCIG00000026349	POLR3K	100	99.074	Phascolarctos_cinereus
ENSG00000161980	POLR3K	100	94.444	ENSPFOG00000010720	polr3k	100	94.444	Poecilia_formosa
ENSG00000161980	POLR3K	100	94.444	ENSPLAG00000002402	polr3k	100	94.444	Poecilia_latipinna
ENSG00000161980	POLR3K	100	94.444	ENSPMEG00000019096	polr3k	100	94.444	Poecilia_mexicana
ENSG00000161980	POLR3K	100	94.444	ENSPREG00000007842	polr3k	100	94.444	Poecilia_reticulata
ENSG00000161980	POLR3K	100	71.296	ENSPPYG00000006893	-	100	71.296	Pongo_abelii
ENSG00000161980	POLR3K	100	70.370	ENSPCAG00000009454	POLR3K	100	70.370	Procavia_capensis
ENSG00000161980	POLR3K	100	99.074	ENSPCOG00000018678	POLR3K	100	99.074	Propithecus_coquereli
ENSG00000161980	POLR3K	100	99.074	ENSPVAG00000000530	POLR3K	100	99.074	Pteropus_vampyrus
ENSG00000161980	POLR3K	100	92.593	ENSPNYG00000007973	polr3k	100	92.593	Pundamilia_nyererei
ENSG00000161980	POLR3K	100	92.593	ENSPNAG00000012135	polr3k	100	92.593	Pygocentrus_nattereri
ENSG00000161980	POLR3K	100	99.074	ENSRNOG00000017843	Polr3k	100	99.074	Rattus_norvegicus
ENSG00000161980	POLR3K	100	99.074	ENSRBIG00000044310	POLR3K	100	99.074	Rhinopithecus_bieti
ENSG00000161980	POLR3K	100	99.074	ENSRROG00000039773	POLR3K	100	99.074	Rhinopithecus_roxellana
ENSG00000161980	POLR3K	100	52.212	YDR045C	RPC11	99	52.212	Saccharomyces_cerevisiae
ENSG00000161980	POLR3K	100	74.074	ENSSBOG00000013108	POLR3K	100	74.074	Saimiri_boliviensis_boliviensis
ENSG00000161980	POLR3K	100	93.519	ENSSFOG00015014586	polr3k	100	93.519	Scleropages_formosus
ENSG00000161980	POLR3K	100	88.889	ENSSMAG00000005016	polr3k	100	88.889	Scophthalmus_maximus
ENSG00000161980	POLR3K	100	93.519	ENSSDUG00000019184	polr3k	100	93.519	Seriola_dumerili
ENSG00000161980	POLR3K	100	91.667	ENSSLDG00000010911	polr3k	100	91.667	Seriola_lalandi_dorsalis
ENSG00000161980	POLR3K	100	89.815	ENSSPUG00000019095	POLR3K	100	89.815	Sphenodon_punctatus
ENSG00000161980	POLR3K	100	93.519	ENSSPAG00000013884	polr3k	100	93.519	Stegastes_partitus
ENSG00000161980	POLR3K	100	99.074	ENSSSCG00000007970	POLR3K	100	99.074	Sus_scrofa
ENSG00000161980	POLR3K	100	92.593	ENSTRUG00000011844	polr3k	100	92.593	Takifugu_rubripes
ENSG00000161980	POLR3K	100	93.519	ENSTNIG00000018584	polr3k	100	93.519	Tetraodon_nigroviridis
ENSG00000161980	POLR3K	100	98.148	ENSTTRG00000012043	POLR3K	100	98.148	Tursiops_truncatus
ENSG00000161980	POLR3K	100	99.074	ENSUAMG00000013850	POLR3K	100	99.074	Ursus_americanus
ENSG00000161980	POLR3K	100	98.148	ENSVPAG00000003438	POLR3K	100	98.148	Vicugna_pacos
ENSG00000161980	POLR3K	100	89.815	ENSXETG00000001142	polr3k	100	89.815	Xenopus_tropicalis
ENSG00000161980	POLR3K	100	94.444	ENSXCOG00000011122	polr3k	100	94.444	Xiphophorus_couchianus
ENSG00000161980	POLR3K	100	94.444	ENSXMAG00000025654	polr3k	100	94.444	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001056	RNA polymerase III activity	21873635.	IBA	Function
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005666	RNA polymerase III complex	21873635.	IBA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006383	transcription by RNA polymerase III	9869639.	TAS	Process
GO:0006386	termination of RNA polymerase III transcription	21873635.	IBA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0042779	tRNA 3'-trailer cleavage	-	IEA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0051607	defense response to virus	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr16	47531	Missense_Mutation	rs144406744	R76C	0.07
BRCA	chr16	53518	Silent	NA	F23F	0.2
CESC	chr16	47463	Silent	novel	C98C	0.36
COAD	chr16	47539	Missense_Mutation	novel	E73G	0.16
COAD	chr16	47443	Missense_Mutation	rs182344447	R105H	0.31
GBM	chr16	47346	3'UTR	novel		0.13
LAML	chr16	47327	3'UTR	novel		0.09
LGG	chr16	47470	Missense_Mutation	NA	K96R	0.42
LUAD	chr16	51609	Missense_Mutation	NA	D50H	0.08
LUAD	chr16	53541	Missense_Mutation	novel	E16K	0.17	RNA_POL_M_15KD
LUSC	chr16	51625	Silent	novel	P44P	0.39
LUSC	chr16	47419	3'UTR	novel		0.3
LUSC	chr16	47420	3'UTR	novel		0.3
LUSC	chr16	53535	Nonsense_Mutation	novel	Q18*	0.21	RNA_POL_M_15KD
OV	chr16	51600	Missense_Mutation	novel	L53I	0.11
READ	chr16	47554	Missense_Mutation	NA	S68L	0.46
SKCM	chr16	47479	Missense_Mutation	NA	T93I	0.15
SKCM	chr16	51619	Silent	NA	L46L	0.33
STAD	chr16	47531	Missense_Mutation	rs144406744	R76C	0.18
THYM	chr16	47504	Missense_Mutation	rs770284903	R85C	0.24
UCEC	chr16	47530	Missense_Mutation	rs763310172	R76H	0.32
UCEC	chr16	47503	Missense_Mutation	rs745993040	R85H	0.28
UCEC	chr16	47478	Silent	novel	T93T	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5222	0.22898
CHOL	DEL	0.1111	0.23475
ESCA	DEL	0.288	0.012791
LUAD	DEL	0.1318	0.1886
UCS	DEL	0.5	0.13407

Survival Analysis

Cancer	P-value	Q-value
THYM	0.033	Kaplan-Meier Survival Analysis
KIRC	0.0015	Kaplan-Meier Survival Analysis
STAD	0.037	Kaplan-Meier Survival Analysis
LUSC	0.032	Kaplan-Meier Survival Analysis
ESCA	0.036	Kaplan-Meier Survival Analysis
COAD	0.036	Kaplan-Meier Survival Analysis
CESC	0.0025	Kaplan-Meier Survival Analysis
LAML	0.015	Kaplan-Meier Survival Analysis
LIHC	0.0063	Kaplan-Meier Survival Analysis
CHOL	0.032	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742