EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162302 (Gene tree)
Gene ID: 8986
Gene Symbol: RPS6KA4
Alias: RSK-B|MSK2
Full Name: ribosomal protein S6 kinase A4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 13,068 bases
Position: chr11:64,359,148-64,372,215
Accession: 10433
RBP type: canonical RBP
Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000432945	RIO1	PF01163.22	8.9e-06	1	1
ENSP00000435580	RIO1	PF01163.22	1.1e-05	1	1
ENSP00000333896	RIO1	PF01163.22	1.2e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000531659	RPS6KA4-206	555	-	-	- (aa)	-	-
ENST00000528057	RPS6KA4-202	3121	-	ENSP00000435580	765 (aa)	-	E9PJN1
ENST00000528355	RPS6KA4-203	2532	-	ENSP00000435314	48 (aa)	-	E9PKU3
ENST00000532496	RPS6KA4-207	588	-	-	- (aa)	-	-
ENST00000530504	RPS6KA4-205	2114	-	ENSP00000432945	704 (aa)	-	A0A0A6YYC0
ENST00000532885	RPS6KA4-208	902	-	-	- (aa)	-	-
ENST00000334205	RPS6KA4-201	3119	XM_005274380	ENSP00000333896	772 (aa)	XP_005274437	O75676
ENST00000530383	RPS6KA4-204	521	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000162302's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG
hsa04668	TNF signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000162302	Leprosy	7E-6	22019778
ENSG00000162302	Liver Cirrhosis, Biliary	2E-10	21399635

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000162302	rs645078	11	64367826	A	Psoriasis	23143594		1.09	EFO_0000676
ENSG00000162302	rs538147	11	64362250	A	Leprosy	22019778	[1.09-1.25]	1.17	EFO_0001054
ENSG00000162302	rs538147	11	64362250	G	Primary biliary cholangitis	21399635	[1.15-1.31]	1.23	EFO_0004267
ENSG00000162302	rs645078	11	64367826	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000162302	rs61886926	11	64366080	T	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0067-0.0111] unit decrease	0.00891707	EFO_0006527
ENSG00000162302	rs61886926	11	64366080	T	Smoking initiation (ever regular vs never regular)	30643251	[0.013-0.023] unit decrease	0.017940067	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162302's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162302	RPS6KA4	100	71.831	ENSAPOG00000014961	rps6ka4	98	69.051	Acanthochromis_polyacanthus
ENSG00000162302	RPS6KA4	99	97.038	ENSAMEG00000017931	RPS6KA4	100	97.483	Ailuropoda_melanoleuca
ENSG00000162302	RPS6KA4	99	71.469	ENSACIG00000015277	rps6ka4	99	68.531	Amphilophus_citrinellus
ENSG00000162302	RPS6KA4	100	71.831	ENSAOCG00000022999	rps6ka4	98	69.051	Amphiprion_ocellaris
ENSG00000162302	RPS6KA4	100	67.697	ENSAPEG00000009598	rps6ka4	98	65.325	Amphiprion_percula
ENSG00000162302	RPS6KA4	100	72.535	ENSATEG00000007829	rps6ka4	98	69.701	Anabas_testudineus
ENSG00000162302	RPS6KA4	100	77.887	ENSACAG00000015587	RPS6KA4	99	75.690	Anolis_carolinensis
ENSG00000162302	RPS6KA4	99	98.588	ENSANAG00000038299	RPS6KA4	99	98.939	Aotus_nancymaae
ENSG00000162302	RPS6KA4	100	70.563	ENSACLG00000009762	rps6ka4	99	67.529	Astatotilapia_calliptera
ENSG00000162302	RPS6KA4	100	72.996	ENSAMXG00000009127	rps6ka4	96	70.696	Astyanax_mexicanus
ENSG00000162302	RPS6KA4	100	95.915	ENSBTAG00000039153	RPS6KA4	100	95.725	Bos_taurus
ENSG00000162302	RPS6KA4	100	98.575	ENSCJAG00000017957	RPS6KA4	100	98.575	Callithrix_jacchus
ENSG00000162302	RPS6KA4	100	96.906	ENSCAFG00000031793	RPS6KA4	100	96.636	Canis_familiaris
ENSG00000162302	RPS6KA4	100	96.906	ENSCAFG00020014242	RPS6KA4	100	96.636	Canis_lupus_dingo
ENSG00000162302	RPS6KA4	100	87.060	ENSCHIG00000002656	RPS6KA4	97	84.404	Capra_hircus
ENSG00000162302	RPS6KA4	91	96.232	ENSCAPG00000018010	RPS6KA4	95	96.631	Cavia_aperea
ENSG00000162302	RPS6KA4	100	98.316	ENSCCAG00000029039	RPS6KA4	100	98.316	Cebus_capucinus
ENSG00000162302	RPS6KA4	100	97.283	ENSCATG00000032072	RPS6KA4	100	97.283	Cercocebus_atys
ENSG00000162302	RPS6KA4	100	98.575	ENSCSAG00000007216	RPS6KA4	100	98.575	Chlorocebus_sabaeus
ENSG00000162302	RPS6KA4	100	80.197	ENSCPBG00000023443	RPS6KA4	99	77.500	Chrysemys_picta_bellii
ENSG00000162302	RPS6KA4	100	98.592	ENSCANG00000043367	RPS6KA4	99	97.742	Colobus_angolensis_palliatus
ENSG00000162302	RPS6KA4	100	96.761	ENSCGRG00001006171	Rps6ka4	100	95.990	Cricetulus_griseus_chok1gshd
ENSG00000162302	RPS6KA4	100	71.549	ENSCSEG00000015452	rps6ka4	97	69.201	Cynoglossus_semilaevis
ENSG00000162302	RPS6KA4	100	70.423	ENSCVAG00000018631	rps6ka4	97	68.248	Cyprinodon_variegatus
ENSG00000162302	RPS6KA4	98	73.066	ENSDARG00000044436	rps6ka4	98	71.781	Danio_rerio
ENSG00000162302	RPS6KA4	100	97.183	ENSECAG00000018402	RPS6KA4	100	96.891	Equus_caballus
ENSG00000162302	RPS6KA4	100	97.183	ENSFCAG00000000512	RPS6KA4	100	97.150	Felis_catus
ENSG00000162302	RPS6KA4	100	95.211	ENSFDAG00000008757	RPS6KA4	100	91.710	Fukomys_damarensis
ENSG00000162302	RPS6KA4	58	67.965	ENSFHEG00000020924	-	82	67.965	Fundulus_heteroclitus
ENSG00000162302	RPS6KA4	100	70.986	ENSGAFG00000013515	rps6ka4	96	68.874	Gambusia_affinis
ENSG00000162302	RPS6KA4	99	71.368	ENSGACG00000020273	rps6ka4	99	68.497	Gasterosteus_aculeatus
ENSG00000162302	RPS6KA4	98	80.057	ENSGAGG00000022791	RPS6KA4	99	77.793	Gopherus_agassizii
ENSG00000162302	RPS6KA4	100	70.845	ENSHBUG00000021438	rps6ka4	98	68.270	Haplochromis_burtoni
ENSG00000162302	RPS6KA4	100	96.761	ENSHGLG00000011748	RPS6KA4	100	95.984	Heterocephalus_glaber_female
ENSG00000162302	RPS6KA4	98	96.264	ENSHGLG00100016032	RPS6KA4	96	96.264	Heterocephalus_glaber_male
ENSG00000162302	RPS6KA4	100	71.972	ENSHCOG00000010506	rps6ka4	99	68.921	Hippocampus_comes
ENSG00000162302	RPS6KA4	100	72.958	ENSIPUG00000014676	Rps6ka4	97	70.921	Ictalurus_punctatus
ENSG00000162302	RPS6KA4	100	97.280	ENSSTOG00000026269	RPS6KA4	100	97.280	Ictidomys_tridecemlineatus
ENSG00000162302	RPS6KA4	100	71.268	ENSKMAG00000011683	rps6ka4	95	69.180	Kryptolebias_marmoratus
ENSG00000162302	RPS6KA4	100	71.972	ENSLBEG00000002940	rps6ka4	96	69.554	Labrus_bergylta
ENSG00000162302	RPS6KA4	100	96.373	ENSLAFG00000008921	RPS6KA4	100	96.373	Loxodonta_africana
ENSG00000162302	RPS6KA4	100	98.705	ENSMFAG00000036152	RPS6KA4	100	98.705	Macaca_fascicularis
ENSG00000162302	RPS6KA4	100	99.006	ENSMMUG00000007610	RPS6KA4	100	98.693	Macaca_mulatta
ENSG00000162302	RPS6KA4	100	98.834	ENSMLEG00000030486	RPS6KA4	100	98.834	Mandrillus_leucophaeus
ENSG00000162302	RPS6KA4	100	72.394	ENSMAMG00000008349	rps6ka4	98	69.311	Mastacembelus_armatus
ENSG00000162302	RPS6KA4	100	70.563	ENSMZEG00005013541	rps6ka4	99	67.529	Maylandia_zebra
ENSG00000162302	RPS6KA4	100	96.479	ENSMAUG00000014157	Rps6ka4	100	95.731	Mesocricetus_auratus
ENSG00000162302	RPS6KA4	100	96.197	ENSMOCG00000017820	Rps6ka4	100	95.472	Microtus_ochrogaster
ENSG00000162302	RPS6KA4	100	71.549	ENSMMOG00000006536	rps6ka4	97	69.020	Mola_mola
ENSG00000162302	RPS6KA4	95	88.140	ENSMODG00000021146	RPS6KA4	100	88.393	Monodelphis_domestica
ENSG00000162302	RPS6KA4	100	71.549	ENSMALG00000014600	rps6ka4	98	68.750	Monopterus_albus
ENSG00000162302	RPS6KA4	100	70.986	ENSNBRG00000012404	rps6ka4	99	67.917	Neolamprologus_brichardi
ENSG00000162302	RPS6KA4	100	93.005	ENSNLEG00000005042	RPS6KA4	100	98.995	Nomascus_leucogenys
ENSG00000162302	RPS6KA4	97	91.608	ENSMEUG00000008722	RPS6KA4	100	90.453	Notamacropus_eugenii
ENSG00000162302	RPS6KA4	100	89.014	ENSOPRG00000015562	-	100	87.953	Ochotona_princeps
ENSG00000162302	RPS6KA4	100	71.127	ENSONIG00000001731	rps6ka4	97	69.180	Oreochromis_niloticus
ENSG00000162302	RPS6KA4	100	70.986	ENSORLG00000029603	rps6ka4	97	68.481	Oryzias_latipes
ENSG00000162302	RPS6KA4	100	70.845	ENSORLG00020019751	rps6ka4	95	68.742	Oryzias_latipes_hni
ENSG00000162302	RPS6KA4	100	70.704	ENSORLG00015002430	rps6ka4	95	68.609	Oryzias_latipes_hsok
ENSG00000162302	RPS6KA4	100	71.268	ENSOMEG00000008409	rps6ka4	97	68.270	Oryzias_melastigma
ENSG00000162302	RPS6KA4	100	97.465	ENSOGAG00000007168	RPS6KA4	100	96.244	Otolemur_garnettii
ENSG00000162302	RPS6KA4	100	99.741	ENSPPAG00000029347	RPS6KA4	100	99.741	Pan_paniscus
ENSG00000162302	RPS6KA4	100	99.741	ENSPTRG00000003839	RPS6KA4	100	99.741	Pan_troglodytes
ENSG00000162302	RPS6KA4	100	99.741	ENSPTRG00000050834	-	100	99.741	Pan_troglodytes
ENSG00000162302	RPS6KA4	100	98.575	ENSPANG00000003107	RPS6KA4	100	98.575	Papio_anubis
ENSG00000162302	RPS6KA4	99	69.014	ENSPMGG00000017943	rps6ka4	98	67.152	Periophthalmus_magnuspinnatus
ENSG00000162302	RPS6KA4	100	96.197	ENSPEMG00000014867	Rps6ka4	100	95.343	Peromyscus_maniculatus_bairdii
ENSG00000162302	RPS6KA4	100	92.676	ENSPCIG00000008010	RPS6KA4	99	92.938	Phascolarctos_cinereus
ENSG00000162302	RPS6KA4	100	71.268	ENSPFOG00000018888	rps6ka4	96	70.461	Poecilia_formosa
ENSG00000162302	RPS6KA4	100	71.268	ENSPLAG00000022311	rps6ka4	99	68.458	Poecilia_latipinna
ENSG00000162302	RPS6KA4	100	71.408	ENSPMEG00000008075	rps6ka4	96	69.272	Poecilia_mexicana
ENSG00000162302	RPS6KA4	97	68.091	ENSPREG00000005629	rps6ka4	96	66.894	Poecilia_reticulata
ENSG00000162302	RPS6KA4	88	96.991	ENSPPYG00000029624	-	90	96.991	Pongo_abelii
ENSG00000162302	RPS6KA4	82	100.000	ENSPCAG00000011052	RPS6KA4	72	95.238	Procavia_capensis
ENSG00000162302	RPS6KA4	100	70.704	ENSPNYG00000023083	rps6ka4	98	68.140	Pundamilia_nyererei
ENSG00000162302	RPS6KA4	100	72.855	ENSPNAG00000022780	rps6ka4	98	69.725	Pygocentrus_nattereri
ENSG00000162302	RPS6KA4	100	98.592	ENSRBIG00000040205	RPS6KA4	99	99.073	Rhinopithecus_bieti
ENSG00000162302	RPS6KA4	100	98.964	ENSRROG00000040388	RPS6KA4	100	98.964	Rhinopithecus_roxellana
ENSG00000162302	RPS6KA4	100	98.446	ENSSBOG00000031882	RPS6KA4	100	98.446	Saimiri_boliviensis_boliviensis
ENSG00000162302	RPS6KA4	96	92.544	ENSSHAG00000003415	RPS6KA4	100	90.984	Sarcophilus_harrisii
ENSG00000162302	RPS6KA4	99	74.153	ENSSFOG00015005989	rps6ka4	99	71.768	Scleropages_formosus
ENSG00000162302	RPS6KA4	100	71.831	ENSSMAG00000019757	rps6ka4	98	68.742	Scophthalmus_maximus
ENSG00000162302	RPS6KA4	100	72.254	ENSSDUG00000016262	rps6ka4	98	68.952	Seriola_dumerili
ENSG00000162302	RPS6KA4	100	72.113	ENSSLDG00000018728	rps6ka4	98	68.903	Seriola_lalandi_dorsalis
ENSG00000162302	RPS6KA4	97	75.419	ENSSPUG00000007950	RPS6KA4	86	73.785	Sphenodon_punctatus
ENSG00000162302	RPS6KA4	100	71.972	ENSSPAG00000023434	rps6ka4	98	69.181	Stegastes_partitus
ENSG00000162302	RPS6KA4	100	97.465	ENSSSCG00000028806	RPS6KA4	100	97.409	Sus_scrofa
ENSG00000162302	RPS6KA4	99	71.875	ENSTNIG00000016170	rps6ka4	99	71.784	Tetraodon_nigroviridis
ENSG00000162302	RPS6KA4	100	97.260	ENSTTRG00000010308	RPS6KA4	91	96.082	Tursiops_truncatus
ENSG00000162302	RPS6KA4	100	97.328	ENSUAMG00000023341	RPS6KA4	100	97.283	Ursus_americanus
ENSG00000162302	RPS6KA4	93	97.139	ENSVVUG00000029755	RPS6KA4	100	97.042	Vulpes_vulpes
ENSG00000162302	RPS6KA4	100	70.704	ENSXCOG00000005797	rps6ka4	95	68.609	Xiphophorus_couchianus
ENSG00000162302	RPS6KA4	100	70.986	ENSXMAG00000005217	rps6ka4	96	68.874	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	IEA	Function
GO:0001818	negative regulation of cytokine production	18508628.	TAS	Process
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	9792677.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	12773393.	IMP	Function
GO:0004711	ribosomal protein S6 kinase activity	11035004.	NAS	Function
GO:0005515	protein binding	9792677.23602568.25852190.	IPI	Function
GO:0005524	ATP binding	9792677.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9792677.11035004.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	9792677.	IDA	Process
GO:0006468	protein phosphorylation	21873635.	IBA	Process
GO:0006468	protein phosphorylation	9792677.	IDA	Process
GO:0006954	inflammatory response	-	IEA	Process
GO:0016572	histone phosphorylation	20018936.	TAS	Process
GO:0032793	positive regulation of CREB transcription factor activity	18508628.	TAS	Process
GO:0033129	positive regulation of histone phosphorylation	20018936.	IMP	Process
GO:0035066	positive regulation of histone acetylation	20018936.	IMP	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0035556	intracellular signal transduction	9792677.	IDA	Process
GO:0043987	histone H3-S10 phosphorylation	12773393.	IMP	Process
GO:0043988	histone H3-S28 phosphorylation	12773393.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20018936.	IMP	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	18508628.	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	20018936.	IMP	Process