EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162396 (Gene tree)
Gene ID: 25973
Gene Symbol: PARS2
Alias: DKFZp727A071
Full Name: prolyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 9,035 bases
Position: chr1:54,755,519-54,764,553
Accession: 30563
RBP type: canonical RBP
Summary: This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000360327	HGTP_anticodon	PF03129.20	0.00012	1	1
ENSP00000360327	tRNA-synt_2b	PF00587.25	3.3e-35	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371279	PARS2-201	2347	-	ENSP00000360327	475 (aa)	-	Q7L3T8

Gene Model

Click here to download ENSG00000162396's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000162396	Stroke	7.5204212E-005	19369658

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000162396	rs1180949	1	54762456	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162396's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162396	PARS2	92	64.692	ENSAPOG00000016537	pars2	89	64.516	Acanthochromis_polyacanthus
ENSG00000162396	PARS2	100	84.632	ENSAMEG00000019649	PARS2	100	84.632	Ailuropoda_melanoleuca
ENSG00000162396	PARS2	92	65.675	ENSACIG00000013596	pars2	90	65.509	Amphilophus_citrinellus
ENSG00000162396	PARS2	92	64.760	ENSAOCG00000023902	pars2	89	64.583	Amphiprion_ocellaris
ENSG00000162396	PARS2	86	65.441	ENSAPEG00000010009	pars2	89	66.005	Amphiprion_percula
ENSG00000162396	PARS2	99	61.392	ENSATEG00000019166	pars2	97	60.549	Anabas_testudineus
ENSG00000162396	PARS2	99	61.181	ENSATEG00000019329	-	97	60.338	Anabas_testudineus
ENSG00000162396	PARS2	100	64.780	ENSACAG00000000115	PARS2	100	64.780	Anolis_carolinensis
ENSG00000162396	PARS2	90	93.897	ENSANAG00000034319	PARS2	96	93.897	Aotus_nancymaae
ENSG00000162396	PARS2	93	64.430	ENSACLG00000009522	pars2	89	64.896	Astatotilapia_calliptera
ENSG00000162396	PARS2	94	60.217	ENSAMXG00000032578	pars2	95	60.000	Astyanax_mexicanus
ENSG00000162396	PARS2	94	55.902	ENSAMXG00000033563	-	93	56.481	Astyanax_mexicanus
ENSG00000162396	PARS2	100	86.737	ENSBTAG00000040313	PARS2	73	86.737	Bos_taurus
ENSG00000162396	PARS2	77	39.305	WBGene00004190	pars-2	79	39.305	Caenorhabditis_elegans
ENSG00000162396	PARS2	100	93.053	ENSCJAG00000015633	PARS2	100	93.053	Callithrix_jacchus
ENSG00000162396	PARS2	100	84.632	ENSCAFG00020012254	PARS2	100	84.632	Canis_lupus_dingo
ENSG00000162396	PARS2	100	88.000	ENSCHIG00000004850	PARS2	100	88.000	Capra_hircus
ENSG00000162396	PARS2	100	81.684	ENSCAPG00000007226	PARS2	100	81.684	Cavia_aperea
ENSG00000162396	PARS2	100	81.895	ENSCPOG00000025477	PARS2	100	81.895	Cavia_porcellus
ENSG00000162396	PARS2	100	83.368	ENSCLAG00000016176	PARS2	98	83.368	Chinchilla_lanigera
ENSG00000162396	PARS2	100	95.158	ENSCSAG00000000146	PARS2	100	95.158	Chlorocebus_sabaeus
ENSG00000162396	PARS2	97	68.365	ENSCPBG00000003691	PARS2	91	68.365	Chrysemys_picta_bellii
ENSG00000162396	PARS2	84	44.030	ENSCING00000000992	-	97	44.030	Ciona_intestinalis
ENSG00000162396	PARS2	85	44.118	ENSCSAVG00000004773	-	94	44.118	Ciona_savignyi
ENSG00000162396	PARS2	100	95.579	ENSCANG00000018730	PARS2	100	95.579	Colobus_angolensis_palliatus
ENSG00000162396	PARS2	100	84.211	ENSCGRG00001013821	Pars2	100	84.211	Cricetulus_griseus_chok1gshd
ENSG00000162396	PARS2	100	83.789	ENSCGRG00000012554	Pars2	100	83.789	Cricetulus_griseus_crigri
ENSG00000162396	PARS2	97	61.064	ENSCSEG00000017559	pars2	89	63.426	Cynoglossus_semilaevis
ENSG00000162396	PARS2	92	65.079	ENSCVAG00000011283	pars2	89	64.908	Cyprinodon_variegatus
ENSG00000162396	PARS2	92	62.844	ENSDARG00000044404	pars2	89	62.731	Danio_rerio
ENSG00000162396	PARS2	100	84.454	ENSDORG00000013567	Pars2	100	84.454	Dipodomys_ordii
ENSG00000162396	PARS2	86	45.122	FBgn0027082	ProRS-m	85	46.292	Drosophila_melanogaster
ENSG00000162396	PARS2	100	79.412	ENSETEG00000017674	PARS2	100	79.412	Echinops_telfairi
ENSG00000162396	PARS2	84	44.717	ENSEBUG00000012814	pars2	80	44.717	Eptatretus_burgeri
ENSG00000162396	PARS2	100	86.947	ENSEASG00005014595	PARS2	100	86.947	Equus_asinus_asinus
ENSG00000162396	PARS2	100	83.579	ENSFCAG00000022858	PARS2	98	83.579	Felis_catus
ENSG00000162396	PARS2	100	63.190	ENSFALG00000012136	PARS2	80	69.853	Ficedula_albicollis
ENSG00000162396	PARS2	100	84.000	ENSFDAG00000013750	PARS2	100	84.000	Fukomys_damarensis
ENSG00000162396	PARS2	94	63.111	ENSFHEG00000011032	pars2	89	63.678	Fundulus_heteroclitus
ENSG00000162396	PARS2	69	68.056	ENSGMOG00000015469	pars2	73	67.626	Gadus_morhua
ENSG00000162396	PARS2	92	66.667	ENSGALG00000010789	PARS2	71	66.434	Gallus_gallus
ENSG00000162396	PARS2	99	62.236	ENSGACG00000007240	pars2	89	65.127	Gasterosteus_aculeatus
ENSG00000162396	PARS2	88	70.476	ENSGAGG00000014148	PARS2	98	70.476	Gopherus_agassizii
ENSG00000162396	PARS2	100	99.579	ENSGGOG00000005426	PARS2	100	99.579	Gorilla_gorilla
ENSG00000162396	PARS2	93	64.206	ENSHBUG00000013678	pars2	89	64.665	Haplochromis_burtoni
ENSG00000162396	PARS2	100	84.211	ENSHGLG00000003221	PARS2	100	84.211	Heterocephalus_glaber_female
ENSG00000162396	PARS2	100	84.211	ENSHGLG00100002370	PARS2	100	84.211	Heterocephalus_glaber_male
ENSG00000162396	PARS2	92	63.844	ENSHCOG00000006282	pars2	89	63.657	Hippocampus_comes
ENSG00000162396	PARS2	100	59.221	ENSIPUG00000007836	pars2	100	58.402	Ictalurus_punctatus
ENSG00000162396	PARS2	100	87.579	ENSSTOG00000012213	PARS2	100	87.579	Ictidomys_tridecemlineatus
ENSG00000162396	PARS2	92	65.217	ENSKMAG00000012222	pars2	89	65.046	Kryptolebias_marmoratus
ENSG00000162396	PARS2	92	62.557	ENSLBEG00000005842	pars2	93	62.356	Labrus_bergylta
ENSG00000162396	PARS2	79	66.489	ENSLBEG00000006420	-	96	66.489	Labrus_bergylta
ENSG00000162396	PARS2	94	70.444	ENSLACG00000004845	PARS2	91	70.930	Latimeria_chalumnae
ENSG00000162396	PARS2	92	65.618	ENSLOCG00000008678	pars2	89	66.590	Lepisosteus_oculatus
ENSG00000162396	PARS2	99	86.498	ENSLAFG00000008727	PARS2	99	86.498	Loxodonta_africana
ENSG00000162396	PARS2	100	94.526	ENSMMUG00000032084	PARS2	100	94.526	Macaca_mulatta
ENSG00000162396	PARS2	100	94.737	ENSMLEG00000027947	PARS2	100	94.737	Mandrillus_leucophaeus
ENSG00000162396	PARS2	92	64.073	ENSMAMG00000008843	pars2	89	63.889	Mastacembelus_armatus
ENSG00000162396	PARS2	93	64.430	ENSMZEG00005018397	pars2	89	64.896	Maylandia_zebra
ENSG00000162396	PARS2	92	67.586	ENSMGAG00000011416	PARS2	91	67.366	Meleagris_gallopavo
ENSG00000162396	PARS2	100	82.526	ENSMAUG00000022043	Pars2	100	82.526	Mesocricetus_auratus
ENSG00000162396	PARS2	100	81.684	ENSMOCG00000018351	Pars2	100	81.684	Microtus_ochrogaster
ENSG00000162396	PARS2	94	64.588	ENSMMOG00000006550	pars2	92	63.697	Mola_mola
ENSG00000162396	PARS2	100	74.105	ENSMODG00000025123	PARS2	99	74.105	Monodelphis_domestica
ENSG00000162396	PARS2	93	64.108	ENSMALG00000018954	pars2	89	64.352	Monopterus_albus
ENSG00000162396	PARS2	100	81.895	MGP_CAROLIEiJ_G0026236	Pars2	100	81.895	Mus_caroli
ENSG00000162396	PARS2	100	81.895	ENSMUSG00000043572	Pars2	100	81.895	Mus_musculus
ENSG00000162396	PARS2	100	81.761	MGP_PahariEiJ_G0028570	Pars2	100	81.761	Mus_pahari
ENSG00000162396	PARS2	100	82.105	MGP_SPRETEiJ_G0027205	Pars2	100	82.105	Mus_spretus
ENSG00000162396	PARS2	100	81.053	ENSMPUG00000020180	PARS2	100	81.053	Mustela_putorius_furo
ENSG00000162396	PARS2	100	86.947	ENSMLUG00000016899	PARS2	93	86.947	Myotis_lucifugus
ENSG00000162396	PARS2	100	86.526	ENSNGAG00000015140	Pars2	100	86.526	Nannospalax_galili
ENSG00000162396	PARS2	93	65.022	ENSNBRG00000020304	pars2	89	65.509	Neolamprologus_brichardi
ENSG00000162396	PARS2	100	98.105	ENSNLEG00000003040	PARS2	100	98.105	Nomascus_leucogenys
ENSG00000162396	PARS2	100	82.526	ENSOPRG00000016102	PARS2	100	82.526	Ochotona_princeps
ENSG00000162396	PARS2	100	81.263	ENSODEG00000020020	PARS2	100	81.263	Octodon_degus
ENSG00000162396	PARS2	93	65.247	ENSONIG00000009984	pars2	89	65.509	Oreochromis_niloticus
ENSG00000162396	PARS2	91	62.212	ENSOANG00000007752	PARS2	91	62.181	Ornithorhynchus_anatinus
ENSG00000162396	PARS2	100	81.799	ENSOCUG00000001045	PARS2	81	81.799	Oryctolagus_cuniculus
ENSG00000162396	PARS2	93	65.306	ENSORLG00000025001	pars2	92	65.278	Oryzias_latipes
ENSG00000162396	PARS2	93	64.626	ENSORLG00020011316	pars2	90	64.583	Oryzias_latipes_hni
ENSG00000162396	PARS2	94	63.920	ENSORLG00015007461	pars2	98	62.806	Oryzias_latipes_hsok
ENSG00000162396	PARS2	92	65.753	ENSOMEG00000007136	pars2	90	65.509	Oryzias_melastigma
ENSG00000162396	PARS2	100	88.421	ENSOGAG00000031493	PARS2	100	88.421	Otolemur_garnettii
ENSG00000162396	PARS2	100	88.211	ENSOARG00000009941	PARS2	99	88.211	Ovis_aries
ENSG00000162396	PARS2	100	99.579	ENSPPAG00000001589	PARS2	96	99.579	Pan_paniscus
ENSG00000162396	PARS2	100	82.737	ENSPPRG00000020447	PARS2	100	82.737	Panthera_pardus
ENSG00000162396	PARS2	100	82.947	ENSPTIG00000004031	PARS2	100	82.947	Panthera_tigris_altaica
ENSG00000162396	PARS2	100	99.579	ENSPTRG00000000776	PARS2	100	99.579	Pan_troglodytes
ENSG00000162396	PARS2	92	65.297	ENSPKIG00000001336	pars2	82	65.046	Paramormyrops_kingsleyae
ENSG00000162396	PARS2	90	64.802	ENSPMGG00000021953	pars2	91	64.802	Periophthalmus_magnuspinnatus
ENSG00000162396	PARS2	100	82.105	ENSPEMG00000004864	Pars2	100	82.105	Peromyscus_maniculatus_bairdii
ENSG00000162396	PARS2	86	59.069	ENSPMAG00000009138	pars2	97	59.360	Petromyzon_marinus
ENSG00000162396	PARS2	100	75.158	ENSPCIG00000018193	PARS2	100	75.158	Phascolarctos_cinereus
ENSG00000162396	PARS2	92	64.531	ENSPFOG00000010522	pars2	89	64.352	Poecilia_formosa
ENSG00000162396	PARS2	92	64.760	ENSPLAG00000022589	pars2	87	64.583	Poecilia_latipinna
ENSG00000162396	PARS2	92	64.531	ENSPMEG00000007151	pars2	87	64.352	Poecilia_mexicana
ENSG00000162396	PARS2	92	64.302	ENSPREG00000009788	pars2	89	64.120	Poecilia_reticulata
ENSG00000162396	PARS2	56	98.502	ENSPPYG00000001311	-	100	98.502	Pongo_abelii
ENSG00000162396	PARS2	63	85.714	ENSPCAG00000012707	PARS2	100	85.714	Procavia_capensis
ENSG00000162396	PARS2	93	64.206	ENSPNYG00000012698	pars2	89	64.665	Pundamilia_nyererei
ENSG00000162396	PARS2	94	60.870	ENSPNAG00000003869	pars2	95	60.652	Pygocentrus_nattereri
ENSG00000162396	PARS2	100	81.895	ENSRNOG00000007327	Pars2	100	81.895	Rattus_norvegicus
ENSG00000162396	PARS2	100	94.958	ENSRBIG00000030034	PARS2	100	94.958	Rhinopithecus_bieti
ENSG00000162396	PARS2	100	95.158	ENSRROG00000000487	PARS2	100	95.158	Rhinopithecus_roxellana
ENSG00000162396	PARS2	83	40.244	YER087W	-	66	40.244	Saccharomyces_cerevisiae
ENSG00000162396	PARS2	100	72.537	ENSSHAG00000004206	PARS2	99	72.537	Sarcophilus_harrisii
ENSG00000162396	PARS2	92	65.227	ENSSFOG00015000170	pars2	89	65.057	Scleropages_formosus
ENSG00000162396	PARS2	100	61.826	ENSSMAG00000020710	pars2	91	60.669	Scophthalmus_maximus
ENSG00000162396	PARS2	92	65.217	ENSSDUG00000012630	pars2	96	65.046	Seriola_dumerili
ENSG00000162396	PARS2	65	61.828	ENSSLDG00000003353	pars2	62	61.828	Seriola_lalandi_dorsalis
ENSG00000162396	PARS2	50	77.731	ENSSARG00000006071	-	99	77.731	Sorex_araneus
ENSG00000162396	PARS2	99	65.895	ENSSPUG00000014688	PARS2	99	65.895	Sphenodon_punctatus
ENSG00000162396	PARS2	92	64.465	ENSSPAG00000023092	pars2	89	64.286	Stegastes_partitus
ENSG00000162396	PARS2	95	83.592	ENSSSCG00000003843	PARS2	91	88.038	Sus_scrofa
ENSG00000162396	PARS2	93	66.516	ENSTGUG00000009489	PARS2	97	66.589	Taeniopygia_guttata
ENSG00000162396	PARS2	92	65.525	ENSTRUG00000018560	pars2	89	65.358	Takifugu_rubripes
ENSG00000162396	PARS2	92	64.545	ENSTNIG00000018113	pars2	89	64.368	Tetraodon_nigroviridis
ENSG00000162396	PARS2	83	86.239	ENSTTRG00000000716	PARS2	82	86.239	Tursiops_truncatus
ENSG00000162396	PARS2	100	84.842	ENSUAMG00000010990	-	96	84.842	Ursus_americanus
ENSG00000162396	PARS2	100	84.842	ENSUAMG00000003814	-	96	84.842	Ursus_americanus
ENSG00000162396	PARS2	100	80.842	ENSUMAG00000022250	PARS2	95	80.842	Ursus_maritimus
ENSG00000162396	PARS2	97	85.217	ENSVVUG00000026785	PARS2	97	85.217	Vulpes_vulpes
ENSG00000162396	PARS2	92	64.989	ENSXCOG00000008574	pars2	92	64.815	Xiphophorus_couchianus
ENSG00000162396	PARS2	92	65.217	ENSXMAG00000002269	pars2	89	65.046	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004827	proline-tRNA ligase activity	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0006433	prolyl-tRNA aminoacylation	21873635.	IBA	Process