EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162613 (Gene tree)
Gene ID: 8880
Gene Symbol: FUBP1
Alias: FBP|FUBP
Full Name: far upstream element binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 35,151 bases
Position: chr1:77,944,055-77,979,205
Accession: 4004
RBP type: canonical RBP
Summary: The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359804	KH_1	PF00013.29	6e-69	1	4
ENSP00000359804	KH_1	PF00013.29	6e-69	2	4
ENSP00000359804	KH_1	PF00013.29	6e-69	3	4
ENSP00000359804	KH_1	PF00013.29	6e-69	4	4
ENSP00000359803	KH_1	PF00013.29	6.6e-69	1	4
ENSP00000359803	KH_1	PF00013.29	6.6e-69	2	4
ENSP00000359803	KH_1	PF00013.29	6.6e-69	3	4
ENSP00000359803	KH_1	PF00013.29	6.6e-69	4	4
ENSP00000402630	KH_1	PF00013.29	7.1e-27	1	2
ENSP00000402630	KH_1	PF00013.29	7.1e-27	2	2
ENSP00000359804	KH_2	PF07650.17	6.4e-22	1	2
ENSP00000359804	KH_2	PF07650.17	6.4e-22	2	2
ENSP00000359803	KH_2	PF07650.17	7e-22	1	2
ENSP00000359803	KH_2	PF07650.17	7e-22	2	2
ENSP00000359804	DUF1897	PF09005.10	3.8e-11	1	2
ENSP00000359804	DUF1897	PF09005.10	3.8e-11	2	2
ENSP00000359803	DUF1897	PF09005.10	4.1e-11	1	2
ENSP00000359803	DUF1897	PF09005.10	4.1e-11	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23818605	Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression.	Proc Natl Acad Sci U S A	2013 Jul 16	Li H	doi: 10.1073/pnas.1310607110
18698806	Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays.	J Proteome Res	2008 Sep	Amanchy R	doi: 10.1021/pr800198w
9092640	Identification of two proteins that bind to a pyrimidine-rich sequence in the 3'-untranslated region of GAP-43 mRNA.	Nucleic Acids Res	1997 Mar 15	Irwin N	-
25662218	FUBP1: a new protagonist in splicing regulation of the DMD gene.	Nucleic Acids Res	2015 Feb 27	Miro J	doi: 10.1093/nar/gkv086
30343319	The master regulator FUBP1: its emerging role in normal cell function and malignant development.	Cell Mol Life Sci	2019 Jan	Debaize L	doi: 10.1007/s00018-018-2933-6
29743362	Adenovirus 5 E1A-Mediated Suppression of p53 via FUBP1.	J Virol	2018 Jun 29	Frost JR	doi: 10.1128/JVI.00439-18
21367899	FUSE binding protein 1 interacts with untranslated regions of Japanese encephalitis virus RNA and negatively regulates viral replication.	J Virol	2011 May	Chien HL	doi: 10.1128/JVI.01950-10
10698944	Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression.	EMBO J	2000 Mar 1	He L	-
21285945	JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress.	EMBO J	2011 Mar 2	Liu J	doi: 10.1038/emboj.2011.11
20711187	Molecular basis of FIR-mediated c-myc transcriptional control.	Nat Struct Mol Biol	2010 Sep	Cukier CD	doi: 10.1038/nsmb.1883

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000488814	FUBP1-210	612	-	-	- (aa)	-	-
ENST00000370767	FUBP1-202	2524	XM_011542391	ENSP00000359803	655 (aa)	XP_011540693	E9PEB5
ENST00000470287	FUBP1-205	726	-	-	- (aa)	-	-
ENST00000294623	FUBP1-201	2201	-	ENSP00000294623	653 (aa)	-	Q96AE4
ENST00000474632	FUBP1-206	639	-	-	- (aa)	-	-
ENST00000370768	FUBP1-203	2378	XM_011542393	ENSP00000359804	644 (aa)	XP_011540695	Q96AE4
ENST00000492405	FUBP1-212	668	-	-	- (aa)	-	-
ENST00000487684	FUBP1-209	535	-	-	- (aa)	-	-
ENST00000492724	FUBP1-213	583	-	-	- (aa)	-	-
ENST00000421641	FUBP1-204	802	-	ENSP00000402630	232 (aa)	-	C9JSZ1
ENST00000480673	FUBP1-207	262	-	-	- (aa)	-	-
ENST00000483894	FUBP1-208	605	-	-	- (aa)	-	-
ENST00000489495	FUBP1-211	2156	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000162613's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000162613	Body Mass Index	6E-10	25673413
ENSG00000162613	Body Mass Index	1E-10	25673413
ENSG00000162613	Body Mass Index	2E-10	25673413

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000162613	rs17382996	1	77947094	A	Lung cancer in never smokers	28604730	[1.266731374-1.793327236]	1.5072039	EFO_0006527\|EFO_0001071

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162613's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000162613	FUBP1	93	60.781	ENSG00000088247	KHSRP	100	73.276
ENSG00000162613	FUBP1	60	40.625	ENSG00000183570	PCBP3	88	31.613
ENSG00000162613	FUBP1	52	31.609	ENSG00000139910	NOVA1	68	38.667
ENSG00000162613	FUBP1	59	36.000	ENSG00000090097	PCBP4	91	37.037
ENSG00000162613	FUBP1	93	54.870	ENSG00000107164	FUBP3	82	65.268
ENSG00000162613	FUBP1	53	32.800	ENSG00000136231	IGF2BP3	61	32.800

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162613	FUBP1	100	69.592	ENSAPOG00000014845	fubp1	70	75.817	Acanthochromis_polyacanthus
ENSG00000162613	FUBP1	100	98.723	ENSAMEG00000007372	FUBP1	100	96.402	Ailuropoda_melanoleuca
ENSG00000162613	FUBP1	100	69.325	ENSACIG00000020024	fubp1	69	73.684	Amphilophus_citrinellus
ENSG00000162613	FUBP1	100	68.154	ENSAPEG00000012232	fubp1	72	77.024	Amphiprion_percula
ENSG00000162613	FUBP1	99	72.360	ENSATEG00000018619	fubp1	70	78.146	Anabas_testudineus
ENSG00000162613	FUBP1	93	97.181	ENSAPLG00000005965	FUBP1	100	97.342	Anas_platyrhynchos
ENSG00000162613	FUBP1	100	90.129	ENSACAG00000006310	FUBP1	98	86.167	Anolis_carolinensis
ENSG00000162613	FUBP1	99	71.166	ENSACLG00000006708	fubp1	72	77.925	Astatotilapia_calliptera
ENSG00000162613	FUBP1	88	77.799	ENSAMXG00000005525	fubp1	64	86.628	Astyanax_mexicanus
ENSG00000162613	FUBP1	100	99.689	ENSCJAG00000007062	FUBP1	100	99.689	Callithrix_jacchus
ENSG00000162613	FUBP1	100	99.845	ENSCAFG00000020361	FUBP1	100	99.845	Canis_familiaris
ENSG00000162613	FUBP1	94	99.187	ENSTSYG00000000148	FUBP1	100	99.187	Carlito_syrichta
ENSG00000162613	FUBP1	58	98.529	ENSCAPG00000011052	-	67	98.168	Cavia_aperea
ENSG00000162613	FUBP1	100	98.632	ENSCPOG00000002757	FUBP1	100	98.632	Cavia_porcellus
ENSG00000162613	FUBP1	100	90.558	ENSCCAG00000036537	FUBP1	100	84.682	Cebus_capucinus
ENSG00000162613	FUBP1	100	100.000	ENSCATG00000042126	FUBP1	100	100.000	Cercocebus_atys
ENSG00000162613	FUBP1	100	99.389	ENSCLAG00000005621	FUBP1	100	100.000	Chinchilla_lanigera
ENSG00000162613	FUBP1	100	100.000	ENSCSAG00000001402	FUBP1	100	100.000	Chlorocebus_sabaeus
ENSG00000162613	FUBP1	100	99.237	ENSCHOG00000008177	FUBP1	100	99.237	Choloepus_hoffmanni
ENSG00000162613	FUBP1	100	98.176	ENSCGRG00001007103	Fubp1	100	98.176	Cricetulus_griseus_chok1gshd
ENSG00000162613	FUBP1	94	98.867	ENSCGRG00000003372	Fubp1	100	98.867	Cricetulus_griseus_crigri
ENSG00000162613	FUBP1	100	70.661	ENSCSEG00000021412	fubp1	70	76.096	Cynoglossus_semilaevis
ENSG00000162613	FUBP1	99	69.231	ENSCVAG00000014487	fubp1	60	85.269	Cyprinodon_variegatus
ENSG00000162613	FUBP1	100	69.760	ENSDARG00000029248	fubp1	70	77.155	Danio_rerio
ENSG00000162613	FUBP1	100	46.121	ENSDNOG00000034565	-	83	74.699	Dasypus_novemcinctus
ENSG00000162613	FUBP1	100	99.389	ENSDORG00000016534	Fubp1	100	99.389	Dipodomys_ordii
ENSG00000162613	FUBP1	100	87.931	ENSETEG00000000948	-	62	97.695	Echinops_telfairi
ENSG00000162613	FUBP1	86	46.101	ENSEBUG00000016143	fubp1	64	65.152	Eptatretus_burgeri
ENSG00000162613	FUBP1	98	100.000	ENSEEUG00000001287	FUBP1	89	97.917	Erinaceus_europaeus
ENSG00000162613	FUBP1	100	68.835	ENSELUG00000007990	fubp1	70	74.892	Esox_lucius
ENSG00000162613	FUBP1	100	85.345	ENSFALG00000005768	FUBP1	69	97.351	Ficedula_albicollis
ENSG00000162613	FUBP1	100	99.084	ENSFDAG00000014210	FUBP1	100	100.000	Fukomys_damarensis
ENSG00000162613	FUBP1	100	71.233	ENSFHEG00000005230	fubp1	70	78.587	Fundulus_heteroclitus
ENSG00000162613	FUBP1	100	66.667	ENSGMOG00000003370	fubp1	70	70.175	Gadus_morhua
ENSG00000162613	FUBP1	100	96.440	ENSGALG00000008939	FUBP1	100	96.440	Gallus_gallus
ENSG00000162613	FUBP1	100	69.910	ENSGAFG00000020972	fubp1	91	77.727	Gambusia_affinis
ENSG00000162613	FUBP1	100	70.489	ENSGACG00000016563	fubp1	70	76.096	Gasterosteus_aculeatus
ENSG00000162613	FUBP1	100	70.074	ENSHBUG00000009835	fubp1	85	76.703	Haplochromis_burtoni
ENSG00000162613	FUBP1	100	84.188	ENSHGLG00000002808	-	72	91.209	Heterocephalus_glaber_female
ENSG00000162613	FUBP1	100	98.784	ENSHGLG00000008415	-	100	100.000	Heterocephalus_glaber_female
ENSG00000162613	FUBP1	100	98.784	ENSHGLG00100003417	-	100	98.784	Heterocephalus_glaber_male
ENSG00000162613	FUBP1	100	84.188	ENSHGLG00100001414	-	72	91.868	Heterocephalus_glaber_male
ENSG00000162613	FUBP1	100	68.256	ENSHCOG00000000910	fubp1	70	74.893	Hippocampus_comes
ENSG00000162613	FUBP1	100	74.164	ENSIPUG00000009896	fubp1	70	77.632	Ictalurus_punctatus
ENSG00000162613	FUBP1	100	99.845	ENSSTOG00000014312	FUBP1	100	99.845	Ictidomys_tridecemlineatus
ENSG00000162613	FUBP1	100	98.145	ENSJJAG00000020069	Fubp1	100	100.000	Jaculus_jaculus
ENSG00000162613	FUBP1	100	70.399	ENSKMAG00000018897	fubp1	69	77.042	Kryptolebias_marmoratus
ENSG00000162613	FUBP1	100	67.216	ENSLBEG00000012700	fubp1	72	74.947	Labrus_bergylta
ENSG00000162613	FUBP1	100	71.795	ENSLOCG00000003745	fubp1	92	74.385	Lepisosteus_oculatus
ENSG00000162613	FUBP1	100	98.712	ENSLAFG00000003273	FUBP1	100	98.018	Loxodonta_africana
ENSG00000162613	FUBP1	100	99.847	ENSMFAG00000031825	FUBP1	100	99.847	Macaca_fascicularis
ENSG00000162613	FUBP1	100	100.000	ENSMMUG00000002899	FUBP1	100	100.000	Macaca_mulatta
ENSG00000162613	FUBP1	100	100.000	ENSMNEG00000045212	FUBP1	100	100.000	Macaca_nemestrina
ENSG00000162613	FUBP1	99	69.298	ENSMAMG00000007489	fubp1	60	67.241	Mastacembelus_armatus
ENSG00000162613	FUBP1	100	71.429	ENSMZEG00005024298	fubp1	70	78.337	Maylandia_zebra
ENSG00000162613	FUBP1	94	96.700	ENSMGAG00000009424	FUBP1	100	96.700	Meleagris_gallopavo
ENSG00000162613	FUBP1	100	98.784	ENSMAUG00000016428	Fubp1	100	98.784	Mesocricetus_auratus
ENSG00000162613	FUBP1	100	98.632	ENSMOCG00000014751	Fubp1	100	98.658	Microtus_ochrogaster
ENSG00000162613	FUBP1	89	73.866	ENSMMOG00000019463	fubp1	64	82.535	Mola_mola
ENSG00000162613	FUBP1	96	90.723	ENSMODG00000020804	FUBP1	100	90.866	Monodelphis_domestica
ENSG00000162613	FUBP1	100	70.534	ENSMALG00000015173	fubp1	70	77.042	Monopterus_albus
ENSG00000162613	FUBP1	100	98.321	MGP_CAROLIEiJ_G0025740	Fubp1	100	98.321	Mus_caroli
ENSG00000162613	FUBP1	100	98.015	ENSMUSG00000028034	Fubp1	100	98.015	Mus_musculus
ENSG00000162613	FUBP1	100	98.779	MGP_PahariEiJ_G0027191	Fubp1	100	99.291	Mus_pahari
ENSG00000162613	FUBP1	100	98.168	MGP_SPRETEiJ_G0026693	Fubp1	100	98.168	Mus_spretus
ENSG00000162613	FUBP1	100	98.723	ENSMLUG00000014802	FUBP1	100	95.224	Myotis_lucifugus
ENSG00000162613	FUBP1	100	94.833	ENSNGAG00000014302	Fubp1	98	100.000	Nannospalax_galili
ENSG00000162613	FUBP1	100	69.350	ENSNBRG00000015099	fubp1	72	77.925	Neolamprologus_brichardi
ENSG00000162613	FUBP1	100	96.043	ENSNLEG00000009772	FUBP1	100	96.043	Nomascus_leucogenys
ENSG00000162613	FUBP1	90	100.000	ENSMEUG00000007917	-	79	100.000	Notamacropus_eugenii
ENSG00000162613	FUBP1	91	99.315	ENSOPRG00000001175	FUBP1	91	99.315	Ochotona_princeps
ENSG00000162613	FUBP1	100	99.237	ENSODEG00000002600	-	100	100.000	Octodon_degus
ENSG00000162613	FUBP1	99	66.978	ENSODEG00000003657	-	100	66.199	Octodon_degus
ENSG00000162613	FUBP1	99	69.985	ENSONIG00000018381	fubp1	69	78.337	Oreochromis_niloticus
ENSG00000162613	FUBP1	89	92.574	ENSOANG00000009777	FUBP1	99	92.881	Ornithorhynchus_anatinus
ENSG00000162613	FUBP1	99	68.896	ENSORLG00000003540	fubp1	71	77.704	Oryzias_latipes
ENSG00000162613	FUBP1	100	68.047	ENSORLG00020005908	fubp1	70	77.042	Oryzias_latipes_hni
ENSG00000162613	FUBP1	99	70.607	ENSORLG00015008779	fubp1	70	77.042	Oryzias_latipes_hsok
ENSG00000162613	FUBP1	100	70.388	ENSOMEG00000021943	fubp1	70	75.991	Oryzias_melastigma
ENSG00000162613	FUBP1	100	97.890	ENSOGAG00000014233	FUBP1	100	95.827	Otolemur_garnettii
ENSG00000162613	FUBP1	100	98.723	ENSOARG00000013259	FUBP1	100	96.386	Ovis_aries
ENSG00000162613	FUBP1	100	99.847	ENSPPRG00000000413	FUBP1	100	99.847	Panthera_pardus
ENSG00000162613	FUBP1	100	99.847	ENSPTIG00000019450	FUBP1	100	99.847	Panthera_tigris_altaica
ENSG00000162613	FUBP1	95	95.915	ENSPSIG00000012965	FUBP1	100	96.627	Pelodiscus_sinensis
ENSG00000162613	FUBP1	99	71.296	ENSPMGG00000009060	fubp1	71	76.688	Periophthalmus_magnuspinnatus
ENSG00000162613	FUBP1	100	97.872	ENSPEMG00000021802	Fubp1	100	99.315	Peromyscus_maniculatus_bairdii
ENSG00000162613	FUBP1	94	54.054	ENSPMAG00000001644	-	90	63.514	Petromyzon_marinus
ENSG00000162613	FUBP1	100	69.469	ENSPFOG00000000238	fubp1	60	67.672	Poecilia_formosa
ENSG00000162613	FUBP1	100	68.049	ENSPLAG00000021170	fubp1	72	78.587	Poecilia_latipinna
ENSG00000162613	FUBP1	99	72.558	ENSPMEG00000004747	fubp1	73	78.587	Poecilia_mexicana
ENSG00000162613	FUBP1	99	71.298	ENSPREG00000017911	fubp1	70	78.587	Poecilia_reticulata
ENSG00000162613	FUBP1	100	90.948	ENSPPYG00000001219	-	70	100.000	Pongo_abelii
ENSG00000162613	FUBP1	100	98.931	ENSPCAG00000012617	FUBP1	100	98.931	Procavia_capensis
ENSG00000162613	FUBP1	100	99.847	ENSPCOG00000024974	FUBP1	100	99.847	Propithecus_coquereli
ENSG00000162613	FUBP1	100	95.420	ENSPVAG00000014637	FUBP1	100	95.420	Pteropus_vampyrus
ENSG00000162613	FUBP1	100	71.254	ENSPNYG00000004552	fubp1	73	78.194	Pundamilia_nyererei
ENSG00000162613	FUBP1	100	72.100	ENSPNAG00000016207	fubp1	87	77.440	Pygocentrus_nattereri
ENSG00000162613	FUBP1	100	98.145	ENSRNOG00000043370	Fubp1	100	98.145	Rattus_norvegicus
ENSG00000162613	FUBP1	100	100.000	ENSRBIG00000042950	FUBP1	100	100.000	Rhinopithecus_bieti
ENSG00000162613	FUBP1	100	100.000	ENSRROG00000043534	FUBP1	100	100.000	Rhinopithecus_roxellana
ENSG00000162613	FUBP1	100	99.845	ENSSBOG00000027299	FUBP1	100	99.845	Saimiri_boliviensis_boliviensis
ENSG00000162613	FUBP1	94	97.694	ENSSHAG00000005367	FUBP1	100	98.373	Sarcophilus_harrisii
ENSG00000162613	FUBP1	100	73.025	ENSSFOG00015010213	fubp1	70	79.560	Scleropages_formosus
ENSG00000162613	FUBP1	100	66.667	ENSSMAG00000012029	fubp1	57	63.362	Scophthalmus_maximus
ENSG00000162613	FUBP1	99	69.774	ENSSDUG00000007383	fubp1	68	76.509	Seriola_dumerili
ENSG00000162613	FUBP1	100	69.865	ENSSLDG00000022863	fubp1	72	76.535	Seriola_lalandi_dorsalis
ENSG00000162613	FUBP1	100	97.491	ENSSARG00000011730	FUBP1	57	100.000	Sorex_araneus
ENSG00000162613	FUBP1	100	93.534	ENSSPUG00000008389	FUBP1	100	85.839	Sphenodon_punctatus
ENSG00000162613	FUBP1	99	72.136	ENSSPAG00000010161	fubp1	69	77.704	Stegastes_partitus
ENSG00000162613	FUBP1	93	96.059	ENSTGUG00000006841	FUBP1	100	96.217	Taeniopygia_guttata
ENSG00000162613	FUBP1	93	72.139	ENSTRUG00000004615	fubp1	65	77.511	Takifugu_rubripes
ENSG00000162613	FUBP1	50	84.459	ENSTNIG00000019815	-	88	84.459	Tetraodon_nigroviridis
ENSG00000162613	FUBP1	82	100.000	ENSTBEG00000017333	FUBP1	67	100.000	Tupaia_belangeri
ENSG00000162613	FUBP1	100	99.695	ENSTTRG00000000096	FUBP1	100	99.695	Tursiops_truncatus
ENSG00000162613	FUBP1	99	99.692	ENSVPAG00000004709	FUBP1	100	99.692	Vicugna_pacos
ENSG00000162613	FUBP1	100	68.664	ENSXCOG00000019354	fubp1	72	77.042	Xiphophorus_couchianus
ENSG00000162613	FUBP1	97	71.677	ENSXMAG00000007168	fubp1	73	78.366	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003697	single-stranded DNA binding	8125259.	TAS	Function
GO:0003700	DNA-binding transcription factor activity	8125259.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	21285945.21779003.21988832.	IPI	Function
GO:0005634	nucleus	19087307.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	-	IEA	Process
GO:0006366	transcription by RNA polymerase II	8125259.	TAS	Process
GO:0010628	positive regulation of gene expression	19087307.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19585652	Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells.	Hepatology	2009 Oct	Malz M	doi: 10.1002/hep.23051.
19637194	Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth.	Hepatology	2009 Oct	Rabenhorst U	doi: 10.1002/hep.23098.
19087307	The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer.	BMC Cancer	2008 Dec 16	Weber A	doi: 10.1186/1471-2407-8-369.
26177862	Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells.	J Pathol	2015 Nov	M??ller B	doi: 10.1002/path.4588
28667493	MiR-16-1 Targeted Silences Far Upstream Element Binding Protein 1 to Advance the Chemosensitivity to Adriamycin in Gastric Cancer.	Pathol Oncol Res	2018 Jul	Zhao D	doi: 10.1007/s12253-017-0263-x

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	77948658	3'UTR	novel		0.38
BLCA	chr1	77964902	Missense_Mutation	novel	L235V	0.18
BLCA	chr1	77963681	Missense_Mutation	rs762636934	R359Q	0.36
BLCA	chr1	77978885	Splice_Region	NA	Q40Q	0.1
BLCA	chr1	77965182	Missense_Mutation	NA	P175S	0.16
BLCA	chr1	77963693	Missense_Mutation	novel	G355V	0.17
BRCA	chr1	77949179	Missense_Mutation	NA	M634I	0.85
BRCA	chr1	77949233	Silent	NA	A616A	0.38
BRCA	chr1	77964106	Missense_Mutation	novel	Q333E	0.16
BRCA	chr1	77978973	Missense_Mutation	NA	S11Y	0.18
BRCA	chr1	77949232	Missense_Mutation	NA	E617Q	0.15	KH_1
BRCA	chr1	77948638	3'UTR	novel		0.44
BRCA	chr1	77965215	Silent	novel	L164L	0.12
BRCA	chr1	77970014	Splice_Site	novel	X41_splice	0.06
BRCA	chr1	77955294	Missense_Mutation	novel	D581N	0.08
CESC	chr1	77962826	Missense_Mutation	NA	R430C	0.25
CESC	chr1	77964340	Missense_Mutation	novel	F285S	0.28
CESC	chr1	77965135	Silent	novel	I190I	0.37
CESC	chr1	77962776	Missense_Mutation	novel	K446N	0.23
CESC	chr1	77964682	Missense_Mutation	novel	E267D	0.11
CESC	chr1	77979196	5'Flank	NA		0.45
COAD	chr1	77965156	Silent	rs758508471	P183P	0.57
COAD	chr1	77967644	Silent	rs375397592	P91P	0.75
COAD	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.15
COAD	chr1	77949161	Silent	novel	A640A	0.3
COAD	chr1	77948737	3'UTR	novel		0.25
COAD	chr1	77966914	Missense_Mutation	novel	E129K	0.06
COAD	chr1	77964293	Frame_Shift_Del	NA	*I301Yfs22**	0.14
COAD	chr1	77964096	Missense_Mutation	NA	A336V	0.27
COAD	chr1	77960364	Silent	NA	G492G	0.29
COAD	chr1	77955257	Missense_Mutation	NA	M593T	0.36
COAD	chr1	77978991	Missense_Mutation	NA	S5L	0.11
COAD	chr1	77949207	Missense_Mutation	rs762248194	Y625C	0.14
COAD	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.31
COAD	chr1	77978962	Missense_Mutation	NA	A15T	0.24
COAD	chr1	77964293	Frame_Shift_Del	NA	*I301Yfs22**	0.39
COAD	chr1	77965124	Missense_Mutation	NA	A194V	0.11
ESCA	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.4
GBM	chr1	77964707	Missense_Mutation	novel	G259D	0.38
GBM	chr1	77969945	Missense_Mutation	novel	K64R	0.48
HNSC	chr1	77968174	Nonsense_Mutation	novel	Q81*	0.14
HNSC	chr1	77962875	Missense_Mutation	novel	Q413H	0.12
HNSC	chr1	77964689	Missense_Mutation	novel	R265Q	0.21
HNSC	chr1	77949249	Missense_Mutation	novel	Y611C	0.33	KH_1
HNSC	chr1	77964145	Nonsense_Mutation	novel	E320*	0.3
KICH	chr1	77962795	Missense_Mutation	rs569795654	R440Q	0.29
KIRP	chr1	77967055	Nonsense_Mutation	novel	G113*	0.47
KIRP	chr1	77960365	Missense_Mutation	novel	G492A	0.42
KIRP	chr1	77960177	Splice_Site	novel	X520_splice	0.14
KIRP	chr1	77949284	Silent	NA	A599A	0.21
LGG	chr1	77960221	Frame_Shift_Del	novel	*A513Vfs11**	0.72
LGG	chr1	77964350	Frame_Shift_Ins	novel	*I282Hfs23**	0.39
LGG	chr1	77966914	Nonsense_Mutation	novel	E129*	0.83
LGG	chr1	77960184	Missense_Mutation	NA	A526P	0.48
LGG	chr1	77964252	Splice_Site	NA	X314_splice	0.58
LGG	chr1	77955277	Nonsense_Mutation	NA	W586*	0.31
LGG	chr1	77964109	Frame_Shift_Ins	novel	*C332Pfs20**	0.75
LGG	chr1	77966752	Splice_Site	NA	X139_splice	0.38
LGG	chr1	77968164	Splice_Site	NA	X83_splice	0.22
LGG	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.45
LGG	chr1	77956645	Frame_Shift_Del	novel	*Y544Lfs22**	0.33
LGG	chr1	77962785	Frame_Shift_Del	novel	*I443Rfs47**	0.78
LGG	chr1	77962806	Frame_Shift_Del	novel	*I436Mfs8**	0.92
LGG	chr1	77960373	Nonsense_Mutation	novel	Y489*	0.74
LGG	chr1	77960225	Frame_Shift_Del	novel	*N512Mfs153**	0.66
LGG	chr1	77964958	Frame_Shift_Del	novel	*G216Efs6**	0.66
LGG	chr1	77962814	Nonsense_Mutation	novel	Q434*	0.1
LGG	chr1	77964969	Splice_Site	novel	X213_splice	0.8
LGG	chr1	77964748	Splice_Site	novel	X246_splice	0.15
LGG	chr1	77965221	Frame_Shift_Ins	novel	*R162Tfs8**	0.12
LGG	chr1	77956583	Frame_Shift_Ins	novel	*T565Nfs2**	0.6
LGG	chr1	77968164	Splice_Site	NA	X83_splice	0.39
LGG	chr1	77966885	Frame_Shift_Ins	novel	D139*	0.45
LGG	chr1	77964112	Nonsense_Mutation	NA	R331*	0.73
LGG	chr1	77965204	Frame_Shift_Del	novel	*I167Mfs25**	0.94
LGG	chr1	77964163	Splice_Site	NA	X314_splice	0.88
LGG	chr1	77964701	Frame_Shift_Del	novel	*F261Sfs12**	0.19
LGG	chr1	77956583	Frame_Shift_Del	novel	*Q564Lfs100**	0.56
LGG	chr1	77964703	Frame_Shift_Ins	novel	*R262Sfs12**	0.33
LGG	chr1	77962775	Frame_Shift_Del	novel	*E445Dfs44**	0.56
LGG	chr1	77978913	Frame_Shift_Del	novel	*F31Sfs23**	0.58
LGG	chr1	77965161	Nonsense_Mutation	NA	G182*	0.07
LGG	chr1	77964107	Nonsense_Mutation	NA	C332*	0.24
LGG	chr1	77965070	Missense_Mutation	novel	Q212P	0.04
LGG	chr1	77968166	Splice_Region	novel	D83D	0.54
LGG	chr1	77962785	Frame_Shift_Del	novel	*I443Rfs47**	0.74
LGG	chr1	77978882	Splice_Region	novel		0.87
LGG	chr1	77962785	Frame_Shift_Del	novel	*I443Rfs47**	0.53
LGG	chr1	77978993	Frame_Shift_Del	novel	*Y4Ffs24**	0.67
LGG	chr1	77956667	Nonsense_Mutation	NA	W537*	0.81
LGG	chr1	77964145	Nonsense_Mutation	novel	E320*	0.08
LGG	chr1	77964959	Nonsense_Mutation	novel	G216*	0.62
LGG	chr1	77965089	Nonsense_Mutation	NA	E206*	0.76
LGG	chr1	77966718	Frame_Shift_Del	novel	*M149Kfs42**	0.42
LGG	chr1	77968164	Splice_Site	NA	X83_splice	0.13
LGG	chr1	77968164	Splice_Site	NA	X83_splice	0.59
LGG	chr1	77966893	Missense_Mutation	NA	I136V	0.44
LGG	chr1	77964868	Splice_Site	NA	X245_splice	0.09
LGG	chr1	77968164	Splice_Site	NA	X83_splice	0.72
LIHC	chr1	77979082	5'UTR	novel		0.4
LIHC	chr1	77956610	Frame_Shift_Del	novel	*P556Lfs109**	0.46
LIHC	chr1	77963625	Nonsense_Mutation	novel	E378*	0.4
LIHC	chr1	77978910	Missense_Mutation	novel	K32R	0.54
LUAD	chr1	77962816	Missense_Mutation	novel	P433L	0.1
LUAD	chr1	77948703	3'UTR	novel		0.16
LUAD	chr1	77964927	Silent	novel	P226P	0.07
LUAD	chr1	77956666	Missense_Mutation	NA	W537C	0.14
LUAD	chr1	77968189	Missense_Mutation	novel	K76E	0.3
LUAD	chr1	77960495	Missense_Mutation	novel	G449S	0.09
LUAD	chr1	77960240	Missense_Mutation	NA	P507L	0.08
LUAD	chr1	77969989	Silent	novel	A49A	0.2
LUAD	chr1	77967641	Missense_Mutation	NA	M92I	0.34
LUAD	chr1	77960238	Nonsense_Mutation	NA	Q508*	0.14
LUAD	chr1	77964269	Missense_Mutation	novel	I309F	0.26
LUAD	chr1	77978944	Missense_Mutation	rs773565597	G21R	0.49
LUSC	chr1	77966712	Missense_Mutation	NA	G152V	0.19
LUSC	chr1	77966713	Nonsense_Mutation	NA	G152*	0.19
LUSC	chr1	77978923	Frame_Shift_Del	novel	*V27Tfs26**	0.1
LUSC	chr1	77979000	Missense_Mutation	novel	A2V	0.19
LUSC	chr1	77969994	Missense_Mutation	NA	D48H	0.6
LUSC	chr1	77960183	Splice_Site	novel	X526_splice	0.18
LUSC	chr1	77956623	Frame_Shift_Del	novel	*Q546Hfs15**	0.51
LUSC	chr1	77962822	Missense_Mutation	novel	G431V	0.71
OV	chr1	77978887	Missense_Mutation	novel	Q40K	0.1
OV	chr1	77967096	Missense_Mutation	novel	S99Y	0.07
OV	chr1	77960392	In_Frame_Del	novel	P475_P483del	0.3
PAAD	chr1	77964965	Silent	novel	R214R	0.05
PAAD	chr1	77948726	3'UTR	novel		0.45
PRAD	chr1	77960354	Missense_Mutation	novel	P496S	0.28
READ	chr1	77948641	3'UTR	novel		0.36
READ	chr1	77970016	Splice_Site	rs181446878	X41_splice	0.27
READ	chr1	77967644	Silent	rs375397592	P91P	0.37
READ	chr1	77956661	Missense_Mutation	NA	A539V	0.2
READ	chr1	77966704	Nonsense_Mutation	NA	E155*	0.32
SKCM	chr1	77966741	Silent	NA	G142G	0.3
SKCM	chr1	77965174	Silent	NA	F177F	0.22
SKCM	chr1	77965196	Frame_Shift_Ins	novel	*K170Ifs31**	0.05
SKCM	chr1	77964674	Missense_Mutation	NA	S270L	0.38
SKCM	chr1	77960443	Missense_Mutation	novel	P466L	0.17
SKCM	chr1	77963639	Missense_Mutation	novel	P373L	0.36
SKCM	chr1	77963640	Missense_Mutation	novel	P373S	0.36
SKCM	chr1	77964690	Missense_Mutation	rs569612114	R265W	0.07
SKCM	chr1	77964690	Missense_Mutation	rs569612114	R265W	0.22
SKCM	chr1	77962909	Missense_Mutation	novel	I402T	0.29
SKCM	chr1	77956611	Missense_Mutation	NA	P556S	0.63
SKCM	chr1	77964872	Nonsense_Mutation	novel	Q245*	0.62
SKCM	chr1	77968201	Nonsense_Mutation	NA	Q72*	0.15
STAD	chr1	77949174	Missense_Mutation	NA	Q636P	0.26
STAD	chr1	77964927	Silent	NA	P226P	0.26
STAD	chr1	77956668	Missense_Mutation	NA	W537R	0.24
STAD	chr1	77962826	Missense_Mutation	NA	R430C	0.4
STAD	chr1	77960470	Missense_Mutation	NA	P457H	0.35
STAD	chr1	77960218	Nonsense_Mutation	NA	Y514*	0.1
STAD	chr1	77964258	Silent	NA	K312K	0.08
STAD	chr1	77968170	Frame_Shift_Del	novel	*N82Mfs19**	0.21
STAD	chr1	77965157	Missense_Mutation	rs556028059	P183L	0.37
STAD	chr1	77962844	Missense_Mutation	NA	M424V	0.2
THYM	chr1	77948271	3'Flank	novel		0.23
UCEC	chr1	77956687	Silent	rs375876626	T530T	0.43
UCEC	chr1	77962922	Frame_Shift_Del	NA	*T398Pfs2**	0.24
UCEC	chr1	77964073	Nonsense_Mutation	NA	R344*	0.38
UCEC	chr1	77962826	Missense_Mutation	NA	R430C	0.26
UCEC	chr1	77960482	Missense_Mutation	NA	P453H	0.27
UCEC	chr1	77968191	Missense_Mutation	NA	A75G	0.3
UCEC	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.24
UCEC	chr1	77965160	Missense_Mutation	novel	G182E	0.08
UCEC	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.4
UCEC	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.17
UCEC	chr1	77960417	Missense_Mutation	novel	P475S	0.1
UCEC	chr1	77979009	5'UTR	novel		0.12
UCEC	chr1	77967079	Frame_Shift_Del	novel	*Y105Tfs11**	0.39
UCEC	chr1	77965221	Frame_Shift_Ins	novel	*R162Tfs8**	0.36
UCEC	chr1	77964059	Splice_Region	novel		0.22
UCEC	chr1	77968179	Missense_Mutation	novel	A79V	0.21
UCEC	chr1	77962826	Missense_Mutation	NA	R430C	0.44
UCEC	chr1	77979068	5'UTR	novel		0.35
UCEC	chr1	77966726	Silent	NA	S147S	0.45
UCEC	chr1	77949270	Missense_Mutation	NA	P604H	0.22	KH_1
UCEC	chr1	77962826	Missense_Mutation	NA	R430C	0.16
UCEC	chr1	77963715	Missense_Mutation	novel	A348T	0.22
UCEC	chr1	77948683	3'UTR	novel		0.29
UCEC	chr1	77948271	3'Flank	novel		0.83
UCEC	chr1	77962826	Missense_Mutation	NA	R430C	0.37
UCEC	chr1	77960400	Silent	NA	P480P	0.32
UCEC	chr1	77963581	Missense_Mutation	novel	I392M	0.28
UCEC	chr1	77970003	Frame_Shift_Del	novel	*I45Lfs9**	0.52
UCEC	chr1	77967645	Missense_Mutation	rs537242451	P91L	0.46
UCEC	chr1	77969977	Silent	novel	L53L	0.34
UCEC	chr1	77964292	Frame_Shift_Ins	novel	*I301Nfs4**	0.34
UCEC	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.33
UCEC	chr1	77962826	Missense_Mutation	NA	R430C	0.31
UCEC	chr1	77964690	Missense_Mutation	rs569612114	R265W	0.46
UCEC	chr1	77979256	5'Flank	novel		0.3
UCEC	chr1	77978908	Missense_Mutation	novel	D33Y	0.35
UCEC	chr1	77969030	Intron	novel		0.28
UCEC	chr1	77963628	Nonsense_Mutation	novel	Q377*	0.32
UCEC	chr1	77964292	Frame_Shift_Del	novel	*I301Nfs22**	0.43
UCEC	chr1	77960185	Splice_Region	NA	P525P	0.35
UCEC	chr1	77948749	3'UTR	novel		0.5
UCEC	chr1	77964749	Splice_Site	novel	X246_splice	0.36
UCEC	chr1	77962826	Missense_Mutation	NA	R430C	0.48
UCEC	chr1	77948644	3'UTR	novel		0.29
UCEC	chr1	77955268	Silent	novel	Y589Y	0.45
UCEC	chr1	77978945	Silent	rs146004096	G20G	0.28
UCEC	chr1	77978975	Frame_Shift_Del	NA	*S11Lfs43**	0.51

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.2439	0.00038973
STAD	DEL	0.1565	0.0040659
TGCT	AMP	0.16	0.088103

Survival Analysis

Cancer	P-value	Q-value
THYM	0.042	Kaplan-Meier Survival Analysis
SARC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0093	Kaplan-Meier Survival Analysis
UCS	0.016	Kaplan-Meier Survival Analysis
SKCM	0.0018	Kaplan-Meier Survival Analysis
BRCA	0.036	Kaplan-Meier Survival Analysis
KIRP	0.042	Kaplan-Meier Survival Analysis
COAD	0.016	Kaplan-Meier Survival Analysis
PAAD	0.0088	Kaplan-Meier Survival Analysis
READ	0.009	Kaplan-Meier Survival Analysis
KICH	0.033	Kaplan-Meier Survival Analysis
UCEC	0.01	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.022	Kaplan-Meier Survival Analysis
LUAD	0.011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742