EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162623 (Gene tree)
Gene ID: 127253
Gene Symbol: TYW3
Alias: FLJ40918|C1orf171
Full Name: tRNA-yW synthesizing protein 3 homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 33,536 bases
Position: chr1:74,733,143-74,766,678
Accession: 24757
RBP type: canonical RBP
Summary: Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359904	TYW3	PF02676.14	7e-55	1	1
ENSP00000407025	TYW3	PF02676.14	1.1e-40	1	2
ENSP00000407025	TYW3	PF02676.14	1.1e-40	2	2
ENSP00000477469	TYW3	PF02676.14	1.1e-20	1	1
ENSP00000476365	TYW3	PF02676.14	7.1e-13	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000479111	TYW3-205	1130	-	ENSP00000477469	139 (aa)	-	V9GZ67
ENST00000486467	TYW3-208	551	-	-	- (aa)	-	-
ENST00000449696	TYW3-202	632	-	-	- (aa)	-	-
ENST00000370867	TYW3-201	3430	XM_006710347	ENSP00000359904	259 (aa)	XP_006710410	Q6IPR3
ENST00000467646	TYW3-204	653	-	-	- (aa)	-	-
ENST00000485401	TYW3-207	513	-	-	- (aa)	-	-
ENST00000457880	TYW3-203	3335	-	ENSP00000407025	226 (aa)	-	Q6IPR3
ENST00000483990	TYW3-206	708	-	ENSP00000476365	56 (aa)	-	V9GY40

Gene Model

Click here to download ENSG00000162623's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000162623	Tissue Plasminogen Activator	5.62533436855245E-5	17903294
ENSG00000162623	Albuminuria	6.36154736601955E-6	17903292
ENSG00000162623	Blood Pressure	2.0323153E-006	-
ENSG00000162623	Platelet Function Tests	7.0400000E-006	-
ENSG00000162623	Platelet Function Tests	5.6500000E-006	-
ENSG00000162623	Platelet Function Tests	3.8559100E-005	-
ENSG00000162623	Platelet Function Tests	3.7476900E-005	-
ENSG00000162623	Platelet Function Tests	3.7476900E-005	-
ENSG00000162623	Platelet Function Tests	1.8507300E-005	-
ENSG00000162623	Platelet Function Tests	2.3044900E-005	-
ENSG00000162623	Platelet Function Tests	2.1401400E-005	-
ENSG00000162623	Adipose Tissue	7E-6	22589738
ENSG00000162623	Resistin	6E-12	22843503

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000162623	rs28482086	1	74760568	A	Educational attainment (years of education)	30038396	[0.0057-0.0115] unit increase	0.0086	EFO_0004784
ENSG00000162623	rs28594379	1	74758876	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162623's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162623	TYW3	100	75.000	ENSAPOG00000009462	tyw3	91	54.132	Acanthochromis_polyacanthus
ENSG00000162623	TYW3	100	91.071	ENSAMEG00000003461	TYW3	100	82.375	Ailuropoda_melanoleuca
ENSG00000162623	TYW3	100	73.214	ENSACIG00000002242	tyw3	91	53.680	Amphilophus_citrinellus
ENSG00000162623	TYW3	100	73.214	ENSAOCG00000002161	tyw3	91	51.653	Amphiprion_ocellaris
ENSG00000162623	TYW3	100	75.000	ENSAPEG00000009395	tyw3	90	60.440	Amphiprion_percula
ENSG00000162623	TYW3	100	71.429	ENSATEG00000004411	-	90	54.709	Anabas_testudineus
ENSG00000162623	TYW3	100	71.429	ENSATEG00000004518	tyw3	90	54.709	Anabas_testudineus
ENSG00000162623	TYW3	100	73.214	ENSACAG00000011380	TYW3	91	58.436	Anolis_carolinensis
ENSG00000162623	TYW3	100	98.214	ENSANAG00000034485	TYW3	100	93.436	Aotus_nancymaae
ENSG00000162623	TYW3	100	71.429	ENSACLG00000022833	tyw3	89	55.111	Astatotilapia_calliptera
ENSG00000162623	TYW3	98	67.273	ENSAMXG00000039965	tyw3	87	57.658	Astyanax_mexicanus
ENSG00000162623	TYW3	100	91.071	ENSBTAG00000005196	TYW3	100	80.309	Bos_taurus
ENSG00000162623	TYW3	100	96.429	ENSCJAG00000006550	TYW3	100	91.120	Callithrix_jacchus
ENSG00000162623	TYW3	100	94.643	ENSCAFG00000032209	TYW3	100	83.410	Canis_familiaris
ENSG00000162623	TYW3	100	94.643	ENSCAFG00020017095	TYW3	92	82.308	Canis_lupus_dingo
ENSG00000162623	TYW3	100	89.286	ENSCHIG00000009333	TYW3	100	80.385	Capra_hircus
ENSG00000162623	TYW3	98	92.727	ENSTSYG00000006369	TYW3	99	76.587	Carlito_syrichta
ENSG00000162623	TYW3	100	98.214	ENSCCAG00000034210	TYW3	100	93.822	Cebus_capucinus
ENSG00000162623	TYW3	100	96.429	ENSCATG00000044397	TYW3	100	90.347	Cercocebus_atys
ENSG00000162623	TYW3	100	91.071	ENSCLAG00000004370	TYW3	95	80.695	Chinchilla_lanigera
ENSG00000162623	TYW3	100	96.429	ENSCSAG00000001387	TYW3	100	90.347	Chlorocebus_sabaeus
ENSG00000162623	TYW3	73	89.831	ENSCHOG00000005179	TYW3	73	89.831	Choloepus_hoffmanni
ENSG00000162623	TYW3	100	80.357	ENSCPBG00000017047	TYW3	91	65.236	Chrysemys_picta_bellii
ENSG00000162623	TYW3	100	96.429	ENSCANG00000036108	TYW3	100	89.189	Colobus_angolensis_palliatus
ENSG00000162623	TYW3	98	89.091	ENSCGRG00001022820	Tyw3	100	72.917	Cricetulus_griseus_chok1gshd
ENSG00000162623	TYW3	98	89.091	ENSCGRG00000003132	Tyw3	93	76.250	Cricetulus_griseus_crigri
ENSG00000162623	TYW3	100	69.643	ENSCSEG00000021219	tyw3	88	53.659	Cynoglossus_semilaevis
ENSG00000162623	TYW3	98	67.273	ENSCVAG00000003270	tyw3	80	58.586	Cyprinodon_variegatus
ENSG00000162623	TYW3	100	69.643	ENSDARG00000038222	tyw3	86	58.636	Danio_rerio
ENSG00000162623	TYW3	100	94.643	ENSDNOG00000033863	TYW3	100	82.625	Dasypus_novemcinctus
ENSG00000162623	TYW3	100	91.071	ENSDORG00000002718	-	100	78.571	Dipodomys_ordii
ENSG00000162623	TYW3	100	94.643	ENSETEG00000012572	TYW3	99	77.889	Echinops_telfairi
ENSG00000162623	TYW3	100	57.143	ENSEBUG00000014020	tyw3	56	52.143	Eptatretus_burgeri
ENSG00000162623	TYW3	100	92.857	ENSEASG00005007776	TYW3	100	84.674	Equus_asinus_asinus
ENSG00000162623	TYW3	100	92.857	ENSECAG00000007888	TYW3	100	85.441	Equus_caballus
ENSG00000162623	TYW3	100	91.071	ENSEEUG00000009289	TYW3	99	70.930	Erinaceus_europaeus
ENSG00000162623	TYW3	100	73.214	ENSELUG00000023000	tyw3	77	65.445	Esox_lucius
ENSG00000162623	TYW3	100	92.857	ENSFCAG00000035340	TYW3	100	82.759	Felis_catus
ENSG00000162623	TYW3	100	78.571	ENSFALG00000001161	TYW3	98	76.699	Ficedula_albicollis
ENSG00000162623	TYW3	100	89.286	ENSFDAG00000003816	TYW3	100	78.764	Fukomys_damarensis
ENSG00000162623	TYW3	98	67.273	ENSFHEG00000001347	tyw3	88	56.561	Fundulus_heteroclitus
ENSG00000162623	TYW3	100	75.000	ENSGALG00000032549	TYW3	88	53.478	Gallus_gallus
ENSG00000162623	TYW3	100	69.643	ENSGAFG00000012457	tyw3	83	55.405	Gambusia_affinis
ENSG00000162623	TYW3	100	69.643	ENSGACG00000014630	tyw3	98	55.157	Gasterosteus_aculeatus
ENSG00000162623	TYW3	100	100.000	ENSGGOG00000013676	TYW3	100	99.228	Gorilla_gorilla
ENSG00000162623	TYW3	100	89.286	ENSHGLG00000004440	TYW3	100	81.467	Heterocephalus_glaber_female
ENSG00000162623	TYW3	100	89.286	ENSHGLG00100018315	TYW3	100	77.606	Heterocephalus_glaber_male
ENSG00000162623	TYW3	98	61.818	ENSHCOG00000016590	TYW3	92	55.263	Hippocampus_comes
ENSG00000162623	TYW3	98	72.727	ENSIPUG00000012907	tyw3	74	58.559	Ictalurus_punctatus
ENSG00000162623	TYW3	100	76.448	ENSSTOG00000028816	TYW3	95	76.448	Ictidomys_tridecemlineatus
ENSG00000162623	TYW3	56	77.083	ENSJJAG00000005103	-	100	77.083	Jaculus_jaculus
ENSG00000162623	TYW3	100	71.429	ENSKMAG00000020761	tyw3	81	56.250	Kryptolebias_marmoratus
ENSG00000162623	TYW3	100	67.857	ENSLBEG00000021318	tyw3	88	55.000	Labrus_bergylta
ENSG00000162623	TYW3	98	72.727	ENSLACG00000012636	TYW3	89	59.031	Latimeria_chalumnae
ENSG00000162623	TYW3	100	75.000	ENSLOCG00000003437	tyw3	89	57.456	Lepisosteus_oculatus
ENSG00000162623	TYW3	98	90.909	ENSLAFG00000011373	TYW3	100	82.625	Loxodonta_africana
ENSG00000162623	TYW3	100	96.429	ENSMFAG00000003496	TYW3	100	89.575	Macaca_fascicularis
ENSG00000162623	TYW3	100	96.429	ENSMMUG00000014595	TYW3	100	89.381	Macaca_mulatta
ENSG00000162623	TYW3	100	96.429	ENSMNEG00000028346	TYW3	100	89.189	Macaca_nemestrina
ENSG00000162623	TYW3	100	96.429	ENSMLEG00000041647	TYW3	100	89.961	Mandrillus_leucophaeus
ENSG00000162623	TYW3	100	71.429	ENSMAMG00000010987	tyw3	92	54.694	Mastacembelus_armatus
ENSG00000162623	TYW3	100	71.429	ENSMZEG00005023808	tyw3	75	60.697	Maylandia_zebra
ENSG00000162623	TYW3	100	73.214	ENSMGAG00000012152	TYW3	79	58.696	Meleagris_gallopavo
ENSG00000162623	TYW3	99	58.222	ENSMAUG00000000522	Tyw3	100	64.368	Mesocricetus_auratus
ENSG00000162623	TYW3	100	96.429	ENSMICG00000015883	TYW3	100	85.841	Microcebus_murinus
ENSG00000162623	TYW3	100	92.857	ENSMOCG00000021348	Tyw3	83	81.818	Microtus_ochrogaster
ENSG00000162623	TYW3	100	71.429	ENSMMOG00000021442	tyw3	89	55.804	Mola_mola
ENSG00000162623	TYW3	100	91.071	ENSMODG00000019082	TYW3	93	67.954	Monodelphis_domestica
ENSG00000162623	TYW3	100	69.643	ENSMALG00000014442	tyw3	76	60.784	Monopterus_albus
ENSG00000162623	TYW3	100	91.071	MGP_CAROLIEiJ_G0025755	Tyw3	100	77.083	Mus_caroli
ENSG00000162623	TYW3	100	89.286	ENSMUSG00000047583	Tyw3	100	77.083	Mus_musculus
ENSG00000162623	TYW3	100	89.286	MGP_PahariEiJ_G0027206	Tyw3	100	76.389	Mus_pahari
ENSG00000162623	TYW3	100	89.286	MGP_SPRETEiJ_G0026708	Tyw3	100	76.389	Mus_spretus
ENSG00000162623	TYW3	100	92.857	ENSMPUG00000010967	TYW3	100	83.525	Mustela_putorius_furo
ENSG00000162623	TYW3	100	94.643	ENSMLUG00000005999	TYW3	100	83.846	Myotis_lucifugus
ENSG00000162623	TYW3	56	80.690	ENSNGAG00000000586	-	100	80.690	Nannospalax_galili
ENSG00000162623	TYW3	100	98.214	ENSNLEG00000009556	TYW3	100	93.050	Nomascus_leucogenys
ENSG00000162623	TYW3	100	62.934	ENSOPRG00000014182	TYW3	100	62.934	Ochotona_princeps
ENSG00000162623	TYW3	100	91.071	ENSODEG00000005361	TYW3	100	82.069	Octodon_degus
ENSG00000162623	TYW3	100	67.857	ENSONIG00000019965	tyw3	100	60.804	Oreochromis_niloticus
ENSG00000162623	TYW3	100	78.571	ENSOANG00000002172	-	83	68.675	Ornithorhynchus_anatinus
ENSG00000162623	TYW3	100	89.286	ENSOCUG00000003043	TYW3	100	80.309	Oryctolagus_cuniculus
ENSG00000162623	TYW3	100	67.857	ENSORLG00000004470	tyw3	91	52.381	Oryzias_latipes
ENSG00000162623	TYW3	100	67.857	ENSORLG00020003793	tyw3	91	51.515	Oryzias_latipes_hni
ENSG00000162623	TYW3	100	66.071	ENSORLG00015006950	tyw3	91	51.515	Oryzias_latipes_hsok
ENSG00000162623	TYW3	100	69.643	ENSOMEG00000016176	tyw3	90	52.609	Oryzias_melastigma
ENSG00000162623	TYW3	100	87.500	ENSOGAG00000025029	-	99	76.448	Otolemur_garnettii
ENSG00000162623	TYW3	100	92.857	ENSOGAG00000011590	-	99	81.783	Otolemur_garnettii
ENSG00000162623	TYW3	100	87.500	ENSOARG00000012508	TYW3	99	80.309	Ovis_aries
ENSG00000162623	TYW3	100	100.000	ENSPPAG00000043438	TYW3	100	99.228	Pan_paniscus
ENSG00000162623	TYW3	100	92.857	ENSPPRG00000023209	TYW3	100	83.398	Panthera_pardus
ENSG00000162623	TYW3	100	92.857	ENSPTIG00000017448	TYW3	100	82.375	Panthera_tigris_altaica
ENSG00000162623	TYW3	100	100.000	ENSPTRG00000000867	TYW3	100	99.228	Pan_troglodytes
ENSG00000162623	TYW3	100	96.429	ENSPANG00000013397	TYW3	100	89.961	Papio_anubis
ENSG00000162623	TYW3	100	62.500	ENSPKIG00000009802	tyw3	86	50.417	Paramormyrops_kingsleyae
ENSG00000162623	TYW3	100	82.143	ENSPSIG00000008432	TYW3	84	69.014	Pelodiscus_sinensis
ENSG00000162623	TYW3	100	66.071	ENSPMGG00000005290	tyw3	90	50.649	Periophthalmus_magnuspinnatus
ENSG00000162623	TYW3	100	87.500	ENSPEMG00000013100	Tyw3	100	75.694	Peromyscus_maniculatus_bairdii
ENSG00000162623	TYW3	100	87.500	ENSPCIG00000024204	TYW3	76	77.056	Phascolarctos_cinereus
ENSG00000162623	TYW3	100	69.643	ENSPFOG00000000927	tyw3	83	56.696	Poecilia_formosa
ENSG00000162623	TYW3	100	69.643	ENSPLAG00000009891	tyw3	83	56.696	Poecilia_latipinna
ENSG00000162623	TYW3	100	69.643	ENSPMEG00000002006	tyw3	83	56.696	Poecilia_mexicana
ENSG00000162623	TYW3	100	69.643	ENSPREG00000012341	tyw3	83	56.250	Poecilia_reticulata
ENSG00000162623	TYW3	100	96.525	ENSPPYG00000001234	TYW3	100	96.525	Pongo_abelii
ENSG00000162623	TYW3	98	94.545	ENSPCAG00000000524	TYW3	100	82.625	Procavia_capensis
ENSG00000162623	TYW3	100	98.214	ENSPCOG00000023207	TYW3	97	86.873	Propithecus_coquereli
ENSG00000162623	TYW3	100	89.286	ENSPVAG00000002356	TYW3	100	77.992	Pteropus_vampyrus
ENSG00000162623	TYW3	100	71.429	ENSPNYG00000017982	tyw3	60	61.780	Pundamilia_nyererei
ENSG00000162623	TYW3	98	72.727	ENSPNAG00000028431	tyw3	87	59.459	Pygocentrus_nattereri
ENSG00000162623	TYW3	100	87.500	ENSRNOG00000028328	Tyw3	76	77.477	Rattus_norvegicus
ENSG00000162623	TYW3	100	96.429	ENSRBIG00000040137	-	100	85.612	Rhinopithecus_bieti
ENSG00000162623	TYW3	100	96.429	ENSRROG00000034171	TYW3	100	88.803	Rhinopithecus_roxellana
ENSG00000162623	TYW3	100	98.214	ENSSBOG00000022917	TYW3	100	90.347	Saimiri_boliviensis_boliviensis
ENSG00000162623	TYW3	100	71.429	ENSSFOG00015021842	tyw3	89	57.895	Scleropages_formosus
ENSG00000162623	TYW3	98	72.727	ENSSMAG00000019609	tyw3	90	53.414	Scophthalmus_maximus
ENSG00000162623	TYW3	100	71.429	ENSSDUG00000003674	tyw3	91	54.132	Seriola_dumerili
ENSG00000162623	TYW3	100	71.429	ENSSLDG00000010425	tyw3	91	54.132	Seriola_lalandi_dorsalis
ENSG00000162623	TYW3	100	85.714	ENSSARG00000001097	TYW3	100	76.733	Sorex_araneus
ENSG00000162623	TYW3	100	71.429	ENSSPUG00000007880	TYW3	93	58.996	Sphenodon_punctatus
ENSG00000162623	TYW3	100	71.429	ENSSPAG00000013786	tyw3	91	50.996	Stegastes_partitus
ENSG00000162623	TYW3	100	92.857	ENSSSCG00000003779	TYW3	100	81.679	Sus_scrofa
ENSG00000162623	TYW3	100	78.571	ENSTGUG00000010408	TYW3	99	78.125	Taeniopygia_guttata
ENSG00000162623	TYW3	100	69.643	ENSTRUG00000023563	tyw3	76	62.927	Takifugu_rubripes
ENSG00000162623	TYW3	100	67.857	ENSTNIG00000003368	tyw3	97	60.209	Tetraodon_nigroviridis
ENSG00000162623	TYW3	100	94.643	ENSTBEG00000017002	TYW3	100	84.170	Tupaia_belangeri
ENSG00000162623	TYW3	100	89.286	ENSTTRG00000010464	TYW3	100	84.351	Tursiops_truncatus
ENSG00000162623	TYW3	100	92.857	ENSUAMG00000010803	TYW3	93	84.322	Ursus_americanus
ENSG00000162623	TYW3	100	92.857	ENSUMAG00000006460	TYW3	92	84.322	Ursus_maritimus
ENSG00000162623	TYW3	100	92.857	ENSVPAG00000006900	TYW3	100	90.860	Vicugna_pacos
ENSG00000162623	TYW3	100	96.429	ENSVVUG00000006902	TYW3	92	83.077	Vulpes_vulpes
ENSG00000162623	TYW3	100	67.857	ENSXETG00000002996	tyw3	92	54.113	Xenopus_tropicalis
ENSG00000162623	TYW3	100	69.643	ENSXCOG00000000715	tyw3	83	51.770	Xiphophorus_couchianus
ENSG00000162623	TYW3	100	69.643	ENSXMAG00000006464	tyw3	76	60.847	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0008175	tRNA methyltransferase activity	21873635.	IBA	Function
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0031591	wybutosine biosynthetic process	21873635.	IBA	Process