EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162676 (Gene tree)
Gene ID: 2672
Gene Symbol: GFI1
Alias: GFI1A|GFI-1|ZNF163
Full Name: growth factor independent 1 transcriptional repressor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,834 bases
Position: chr1:92,473,043-92,486,876
Accession: 4237
RBP type: canonical RBP
Summary: This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000294702	zf-C2H2	PF00096.26	1.3e-27	1	6
ENSP00000294702	zf-C2H2	PF00096.26	1.3e-27	2	6
ENSP00000294702	zf-C2H2	PF00096.26	1.3e-27	3	6
ENSP00000294702	zf-C2H2	PF00096.26	1.3e-27	4	6
ENSP00000294702	zf-C2H2	PF00096.26	1.3e-27	5	6
ENSP00000294702	zf-C2H2	PF00096.26	1.3e-27	6	6
ENSP00000359357	zf-C2H2	PF00096.26	1.3e-27	1	6
ENSP00000359357	zf-C2H2	PF00096.26	1.3e-27	2	6
ENSP00000359357	zf-C2H2	PF00096.26	1.3e-27	3	6
ENSP00000359357	zf-C2H2	PF00096.26	1.3e-27	4	6
ENSP00000359357	zf-C2H2	PF00096.26	1.3e-27	5	6
ENSP00000359357	zf-C2H2	PF00096.26	1.3e-27	6	6
ENSP00000399719	zf-C2H2	PF00096.26	1.3e-27	1	6
ENSP00000399719	zf-C2H2	PF00096.26	1.3e-27	2	6
ENSP00000399719	zf-C2H2	PF00096.26	1.3e-27	3	6
ENSP00000399719	zf-C2H2	PF00096.26	1.3e-27	4	6
ENSP00000399719	zf-C2H2	PF00096.26	1.3e-27	5	6
ENSP00000399719	zf-C2H2	PF00096.26	1.3e-27	6	6
ENSP00000294702	zf-met	PF12874.7	5.7e-07	1	1
ENSP00000359357	zf-met	PF12874.7	5.7e-07	1	1
ENSP00000399719	zf-met	PF12874.7	5.7e-07	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24121275	The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1.	Oncogene	2014 Aug 28	Zhao L	doi: 10.1038/onc.2013.419

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000483490	GFI1-204	508	-	-	- (aa)	-	-
ENST00000370332	GFI1-202	2855	XM_005270749	ENSP00000359357	422 (aa)	XP_005270806	Q99684
ENST00000427103	GFI1-203	2693	-	ENSP00000399719	422 (aa)	-	Q99684
ENST00000294702	GFI1-201	2784	-	ENSP00000294702	422 (aa)	-	Q99684

Gene Model

Click here to download ENSG00000162676's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000162676	Cholesterol, LDL	2E-8	25961943
ENSG00000162676	Cholesterol	1E-9	25961943

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162676's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162676	GFI1	100	63.529	ENSAPOG00000015189	gfi1ab	100	63.529	Acanthochromis_polyacanthus
ENSG00000162676	GFI1	100	63.679	ENSACIG00000016354	gfi1ab	100	63.403	Amphilophus_citrinellus
ENSG00000162676	GFI1	100	42.576	ENSAOCG00000008339	gfi1ab	100	43.213	Amphiprion_ocellaris
ENSG00000162676	GFI1	100	64.186	ENSAPEG00000023870	gfi1ab	100	64.000	Amphiprion_percula
ENSG00000162676	GFI1	100	60.880	ENSATEG00000009167	gfi1ab	89	60.369	Anabas_testudineus
ENSG00000162676	GFI1	87	75.472	ENSAPLG00000015700	GFI1	99	75.472	Anas_platyrhynchos
ENSG00000162676	GFI1	100	71.594	ENSACAG00000004498	GFI1	100	71.363	Anolis_carolinensis
ENSG00000162676	GFI1	100	97.156	ENSANAG00000019656	GFI1	100	97.156	Aotus_nancymaae
ENSG00000162676	GFI1	100	63.341	ENSACLG00000026458	gfi1ab	93	63.170	Astatotilapia_calliptera
ENSG00000162676	GFI1	75	58.750	ENSAMXG00000006669	GFI1	59	87.568	Astyanax_mexicanus
ENSG00000162676	GFI1	100	59.953	ENSAMXG00000039600	gfi1ab	100	59.485	Astyanax_mexicanus
ENSG00000162676	GFI1	100	92.180	ENSBTAG00000016723	GFI1	100	92.180	Bos_taurus
ENSG00000162676	GFI1	100	96.682	ENSCJAG00000017609	GFI1	100	96.682	Callithrix_jacchus
ENSG00000162676	GFI1	100	93.365	ENSCAFG00000020155	GFI1	100	93.365	Canis_familiaris
ENSG00000162676	GFI1	100	93.365	ENSCAFG00020013371	GFI1	88	93.365	Canis_lupus_dingo
ENSG00000162676	GFI1	100	91.943	ENSCHIG00000016135	GFI1	100	91.943	Capra_hircus
ENSG00000162676	GFI1	100	92.417	ENSCPOG00000011727	GFI1	100	91.706	Cavia_porcellus
ENSG00000162676	GFI1	100	97.393	ENSCCAG00000036072	GFI1	100	97.393	Cebus_capucinus
ENSG00000162676	GFI1	100	99.526	ENSCATG00000037873	GFI1	100	99.526	Cercocebus_atys
ENSG00000162676	GFI1	100	86.493	ENSCLAG00000005915	GFI1	100	85.023	Chinchilla_lanigera
ENSG00000162676	GFI1	86	99.176	ENSCSAG00000001469	GFI1	100	99.176	Chlorocebus_sabaeus
ENSG00000162676	GFI1	100	99.289	ENSCANG00000034077	GFI1	100	99.289	Colobus_angolensis_palliatus
ENSG00000162676	GFI1	100	86.493	ENSCGRG00001015432	Gfi1	100	86.493	Cricetulus_griseus_chok1gshd
ENSG00000162676	GFI1	100	57.339	ENSCSEG00000017729	GFI1	100	57.014	Cynoglossus_semilaevis
ENSG00000162676	GFI1	100	58.508	ENSCVAG00000004930	GFI1	100	58.974	Cyprinodon_variegatus
ENSG00000162676	GFI1	100	62.295	ENSCVAG00000011828	gfi1ab	100	61.124	Cyprinodon_variegatus
ENSG00000162676	GFI1	100	64.019	ENSDARG00000044457	gfi1ab	100	64.019	Danio_rerio
ENSG00000162676	GFI1	100	89.835	ENSDNOG00000000782	GFI1	97	91.253	Dasypus_novemcinctus
ENSG00000162676	GFI1	100	90.780	ENSEASG00005015509	GFI1	86	90.780	Equus_asinus_asinus
ENSG00000162676	GFI1	92	85.090	ENSECAG00000006647	GFI1	92	85.090	Equus_caballus
ENSG00000162676	GFI1	100	85.545	ENSEEUG00000000198	GFI1	100	85.545	Erinaceus_europaeus
ENSG00000162676	GFI1	100	59.624	ENSELUG00000019033	GFI1	100	59.390	Esox_lucius
ENSG00000162676	GFI1	100	63.341	ENSELUG00000003015	gfi1ab	99	63.109	Esox_lucius
ENSG00000162676	GFI1	100	93.602	ENSFCAG00000005914	GFI1	100	93.602	Felis_catus
ENSG00000162676	GFI1	100	58.469	ENSFHEG00000000341	GFI1	100	60.046	Fundulus_heteroclitus
ENSG00000162676	GFI1	100	62.791	ENSFHEG00000010997	gfi1ab	100	61.647	Fundulus_heteroclitus
ENSG00000162676	GFI1	100	60.698	ENSGMOG00000007737	gfi1ab	100	60.465	Gadus_morhua
ENSG00000162676	GFI1	100	73.782	ENSGALG00000043650	GFI1	100	73.782	Gallus_gallus
ENSG00000162676	GFI1	100	63.170	ENSGAFG00000016637	gfi1ab	100	62.937	Gambusia_affinis
ENSG00000162676	GFI1	100	60.373	ENSGAFG00000018063	GFI1	100	60.789	Gambusia_affinis
ENSG00000162676	GFI1	100	63.593	ENSGACG00000004257	gfi1ab	97	62.824	Gasterosteus_aculeatus
ENSG00000162676	GFI1	100	100.000	ENSGGOG00000005320	GFI1	100	100.000	Gorilla_gorilla
ENSG00000162676	GFI1	100	64.235	ENSHBUG00000011969	gfi1ab	100	62.529	Haplochromis_burtoni
ENSG00000162676	GFI1	100	91.469	ENSHGLG00000008020	GFI1	100	90.521	Heterocephalus_glaber_female
ENSG00000162676	GFI1	100	91.469	ENSHGLG00100000610	GFI1	100	90.521	Heterocephalus_glaber_male
ENSG00000162676	GFI1	100	52.655	ENSHCOG00000008590	gfi1ab	100	51.002	Hippocampus_comes
ENSG00000162676	GFI1	100	57.377	ENSHCOG00000019555	GFI1	100	56.909	Hippocampus_comes
ENSG00000162676	GFI1	100	56.613	ENSIPUG00000013414	GFI1	100	57.309	Ictalurus_punctatus
ENSG00000162676	GFI1	100	62.588	ENSIPUG00000010071	gfi1ab	87	62.118	Ictalurus_punctatus
ENSG00000162676	GFI1	100	92.654	ENSSTOG00000014583	GFI1	100	92.654	Ictidomys_tridecemlineatus
ENSG00000162676	GFI1	100	63.380	ENSKMAG00000003810	gfi1ab	100	63.380	Kryptolebias_marmoratus
ENSG00000162676	GFI1	100	63.869	ENSLBEG00000027776	gfi1ab	100	63.636	Labrus_bergylta
ENSG00000162676	GFI1	99	77.222	ENSLACG00000017590	-	99	77.222	Latimeria_chalumnae
ENSG00000162676	GFI1	100	69.767	ENSLACG00000013362	GFI1	98	69.767	Latimeria_chalumnae
ENSG00000162676	GFI1	100	66.513	ENSLOCG00000004711	gfi1ab	100	66.513	Lepisosteus_oculatus
ENSG00000162676	GFI1	100	85.545	ENSLAFG00000018346	GFI1	100	85.782	Loxodonta_africana
ENSG00000162676	GFI1	100	99.526	ENSMFAG00000045801	GFI1	100	99.526	Macaca_fascicularis
ENSG00000162676	GFI1	100	99.526	ENSMNEG00000036338	GFI1	100	99.526	Macaca_nemestrina
ENSG00000162676	GFI1	100	99.526	ENSMLEG00000036181	GFI1	100	99.526	Mandrillus_leucophaeus
ENSG00000162676	GFI1	100	64.720	ENSMAMG00000008125	gfi1ab	100	64.252	Mastacembelus_armatus
ENSG00000162676	GFI1	100	63.573	ENSMZEG00005009895	gfi1ab	100	63.109	Maylandia_zebra
ENSG00000162676	GFI1	87	76.216	ENSMGAG00000008187	GFI1	99	76.216	Meleagris_gallopavo
ENSG00000162676	GFI1	100	94.313	ENSMICG00000047208	GFI1	100	94.313	Microcebus_murinus
ENSG00000162676	GFI1	100	59.198	ENSMMOG00000005556	gfi1ab	100	58.451	Mola_mola
ENSG00000162676	GFI1	100	79.634	ENSMODG00000011802	GFI1	100	79.634	Monodelphis_domestica
ENSG00000162676	GFI1	100	62.500	ENSMALG00000014672	gfi1ab	100	60.798	Monopterus_albus
ENSG00000162676	GFI1	100	87.943	MGP_CAROLIEiJ_G0027508	Gfi1	100	100.000	Mus_caroli
ENSG00000162676	GFI1	100	87.470	ENSMUSG00000029275	Gfi1	100	87.470	Mus_musculus
ENSG00000162676	GFI1	100	86.998	MGP_PahariEiJ_G0017280	Gfi1	100	100.000	Mus_pahari
ENSG00000162676	GFI1	100	87.234	MGP_SPRETEiJ_G0028507	Gfi1	100	87.234	Mus_spretus
ENSG00000162676	GFI1	100	83.412	ENSMPUG00000004178	GFI1	97	83.412	Mustela_putorius_furo
ENSG00000162676	GFI1	100	89.151	ENSMLUG00000015191	GFI1	97	88.915	Myotis_lucifugus
ENSG00000162676	GFI1	100	62.299	ENSNBRG00000015774	gfi1ab	100	61.839	Neolamprologus_brichardi
ENSG00000162676	GFI1	93	98.721	ENSNLEG00000010470	GFI1	97	98.721	Nomascus_leucogenys
ENSG00000162676	GFI1	100	91.232	ENSOPRG00000001473	GFI1	100	91.232	Ochotona_princeps
ENSG00000162676	GFI1	100	63.256	ENSONIG00000019246	gfi1ab	100	62.791	Oreochromis_niloticus
ENSG00000162676	GFI1	86	87.978	ENSOCUG00000023553	GFI1	93	89.891	Oryctolagus_cuniculus
ENSG00000162676	GFI1	100	59.059	ENSORLG00000005060	GFI1	100	59.112	Oryzias_latipes
ENSG00000162676	GFI1	100	61.395	ENSORLG00000013806	gfi1ab	100	60.930	Oryzias_latipes
ENSG00000162676	GFI1	100	60.829	ENSORLG00020001602	gfi1ab	100	60.890	Oryzias_latipes_hni
ENSG00000162676	GFI1	100	53.647	ENSORLG00020002817	GFI1	90	61.468	Oryzias_latipes_hni
ENSG00000162676	GFI1	100	60.047	ENSORLG00015006070	GFI1	100	59.346	Oryzias_latipes_hsok
ENSG00000162676	GFI1	100	59.535	ENSOMEG00000016722	GFI1	100	60.140	Oryzias_melastigma
ENSG00000162676	GFI1	100	77.488	ENSOGAG00000027913	GFI1	100	79.858	Otolemur_garnettii
ENSG00000162676	GFI1	98	97.143	ENSOARG00000016329	GFI1	94	97.143	Ovis_aries
ENSG00000162676	GFI1	100	81.043	ENSPPAG00000042186	GFI1	100	82.701	Pan_paniscus
ENSG00000162676	GFI1	100	93.602	ENSPPRG00000007521	GFI1	100	93.602	Panthera_pardus
ENSG00000162676	GFI1	100	99.763	ENSPTRG00000043053	GFI1	100	99.763	Pan_troglodytes
ENSG00000162676	GFI1	100	99.526	ENSPANG00000016433	GFI1	100	99.526	Papio_anubis
ENSG00000162676	GFI1	100	64.516	ENSPKIG00000004263	GFI1	100	64.055	Paramormyrops_kingsleyae
ENSG00000162676	GFI1	88	75.067	ENSPSIG00000008734	GFI1	97	75.067	Pelodiscus_sinensis
ENSG00000162676	GFI1	100	60.427	ENSPMGG00000012546	gfi1ab	100	59.811	Periophthalmus_magnuspinnatus
ENSG00000162676	GFI1	100	80.000	ENSPCIG00000013728	GFI1	100	80.930	Phascolarctos_cinereus
ENSG00000162676	GFI1	100	62.824	ENSPFOG00000023214	gfi1ab	100	62.588	Poecilia_formosa
ENSG00000162676	GFI1	100	61.215	ENSPLAG00000005376	GFI1	91	60.930	Poecilia_latipinna
ENSG00000162676	GFI1	100	62.824	ENSPLAG00000010879	gfi1ab	100	62.588	Poecilia_latipinna
ENSG00000162676	GFI1	100	60.981	ENSPMEG00000019299	GFI1	100	60.698	Poecilia_mexicana
ENSG00000162676	GFI1	100	63.294	ENSPMEG00000013694	gfi1ab	100	63.059	Poecilia_mexicana
ENSG00000162676	GFI1	100	63.294	ENSPREG00000014097	gfi1ab	100	62.588	Poecilia_reticulata
ENSG00000162676	GFI1	100	53.394	ENSPREG00000007997	GFI1	100	53.153	Poecilia_reticulata
ENSG00000162676	GFI1	100	78.824	ENSPCAG00000011020	GFI1	100	79.529	Procavia_capensis
ENSG00000162676	GFI1	100	93.602	ENSPCOG00000020540	GFI1	100	93.602	Propithecus_coquereli
ENSG00000162676	GFI1	100	87.441	ENSPVAG00000006928	GFI1	100	87.441	Pteropus_vampyrus
ENSG00000162676	GFI1	100	63.341	ENSPNYG00000021183	gfi1ab	100	62.877	Pundamilia_nyererei
ENSG00000162676	GFI1	100	61.412	ENSPNAG00000027258	gfi1ab	100	60.706	Pygocentrus_nattereri
ENSG00000162676	GFI1	100	55.093	ENSPNAG00000028014	GFI1	100	54.630	Pygocentrus_nattereri
ENSG00000162676	GFI1	100	87.470	ENSRNOG00000002042	Gfi1	100	87.470	Rattus_norvegicus
ENSG00000162676	GFI1	100	99.526	ENSRBIG00000036467	GFI1	100	99.526	Rhinopithecus_bieti
ENSG00000162676	GFI1	100	99.526	ENSRROG00000031687	GFI1	100	99.526	Rhinopithecus_roxellana
ENSG00000162676	GFI1	100	97.156	ENSSBOG00000031300	GFI1	100	97.156	Saimiri_boliviensis_boliviensis
ENSG00000162676	GFI1	100	66.512	ENSSFOG00015020295	gfi1	100	64.651	Scleropages_formosus
ENSG00000162676	GFI1	100	64.085	ENSSMAG00000002782	gfi1ab	100	63.551	Scophthalmus_maximus
ENSG00000162676	GFI1	100	62.676	ENSSDUG00000022410	gfi1ab	100	62.118	Seriola_dumerili
ENSG00000162676	GFI1	100	62.441	ENSSLDG00000020163	gfi1ab	100	61.882	Seriola_lalandi_dorsalis
ENSG00000162676	GFI1	81	78.125	ENSSPAG00000009140	gfi1ab	99	78.125	Stegastes_partitus
ENSG00000162676	GFI1	100	91.469	ENSSSCG00000006902	GFI1	100	91.943	Sus_scrofa
ENSG00000162676	GFI1	88	75.472	ENSTGUG00000006060	GFI1	100	75.472	Taeniopygia_guttata
ENSG00000162676	GFI1	100	61.033	ENSTRUG00000000415	gfi1ab	100	60.329	Takifugu_rubripes
ENSG00000162676	GFI1	100	60.377	ENSTNIG00000000651	gfi1ab	97	61.557	Tetraodon_nigroviridis
ENSG00000162676	GFI1	100	91.469	ENSTTRG00000000082	GFI1	100	91.469	Tursiops_truncatus
ENSG00000162676	GFI1	100	88.416	ENSUAMG00000021124	GFI1	91	88.416	Ursus_americanus
ENSG00000162676	GFI1	100	66.981	ENSXETG00000023006	gfi1	98	66.667	Xenopus_tropicalis
ENSG00000162676	GFI1	100	62.588	ENSXMAG00000010523	gfi1ab	100	62.353	Xiphophorus_maculatus
ENSG00000162676	GFI1	87	54.424	ENSXMAG00000009274	GFI1	70	54.933	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	8441411.	TAS	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	15947108.19506020.	IDA	Process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	19506020.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0005515	protein binding	11060035.12874834.16287849.17197705.17636019.17909014.18805794.19506020.20190815.20547752.21570500.	IPI	Function
GO:0005634	nucleus	12874834.20547752.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	15947108.	IDA	Process
GO:0010957	negative regulation of vitamin D biosynthetic process	15947108.	IC	Process
GO:0010977	negative regulation of neuron projection development	19026687.	IDA	Process
GO:0016032	viral process	8441411.	TAS	Process
GO:0016363	nuclear matrix	12874834.	IDA	Component
GO:0016604	nuclear body	11060035.	IDA	Component
GO:0017053	transcriptional repressor complex	12874834.19506020.	IDA	Component
GO:0030097	hemopoiesis	-	IEA	Process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	ISS	Process
GO:0034121	regulation of toll-like receptor signaling pathway	20547752.	IDA	Process
GO:0044212	transcription regulatory region DNA binding	21873635.	IBA	Function
GO:0044212	transcription regulatory region DNA binding	15947108.	IDA	Function
GO:0045892	negative regulation of transcription, DNA-templated	12874834.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051569	regulation of histone H3-K4 methylation	-	IEA	Process
GO:0070105	positive regulation of interleukin-6-mediated signaling pathway	11060035.	IDA	Process
GO:0071222	cellular response to lipopolysaccharide	20547752.	IEP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27840243	Simvastatin attenuates macrophage-mediated gemcitabine resistance of pancreatic ductal adenocarcinoma by regulating the TGF-β1/Gfi-1 axis.	Cancer Lett	2017 Jan 28	Xian G	doi: 10.1016/j.canlet.2016.11.006
25043047	Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.	Nature	2014 Jul 24	Northcott PA	doi: 10.1038/nature13379
15947108	Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells.	Endocr Relat Cancer	2005 Jun	Dwivedi PP	-
17207994	Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells.	J Steroid Biochem Mol Biol	2007 Mar	Dwivedi PP	-
28387757	GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer.	Cell Death Differ	2017 May	Xing W	doi: 10.1038/cdd.2017.50
30296465	MiR-650 regulates the proliferation, migration and invasion of human oral cancer by targeting growth factor independent 1 (Gfi1).	Biochimie	2019 Jan	Ningning S	doi: 10.1016/j.biochi.2018.10.001

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	92480613	Silent	novel	I258I	0.4
BLCA	chr1	92478598	Missense_Mutation	rs373356460	F360L	0.14
BLCA	chr1	92476149	Silent	NA	L383L	0.38
BRCA	chr1	92474838	3'UTR	novel		0.38
BRCA	chr1	92483015	Silent	NA	A49A	0.26
BRCA	chr1	92480412	Missense_Mutation	NA	E287A	0.25
BRCA	chr1	92475953	3'UTR	novel		0.16
CESC	chr1	92474796	3'UTR	novel		0.34
COAD	chr1	92482873	Missense_Mutation	rs771344042	A97T	0.44
COAD	chr1	92476047	Silent	rs757855720	T417T	0.14
COAD	chr1	92475835	3'UTR	novel		0.38
COAD	chr1	92476201	Missense_Mutation	novel	K366M	0.1
COAD	chr1	92478689	Missense_Mutation	novel	H330P	0.13	zf-C2H2
COAD	chr1	92483427	Missense_Mutation	novel	P21T	0.15
COAD	chr1	92476048	Missense_Mutation	rs777241871	T417M	0.32
ESCA	chr1	92475959	3'UTR	novel		0.25
GBM	chr1	92476063	Missense_Mutation	NA	R412Q	0.48
GBM	chr1	92476078	Missense_Mutation	novel	R407M	0.18
GBM	chr1	92480981	Missense_Mutation	novel	V136L	0.62
HNSC	chr1	92480666	Missense_Mutation	novel	S241P	0.21
HNSC	chr1	92483016	Missense_Mutation	novel	A49V	0.18
KIRP	chr1	92483044	Missense_Mutation	NA	S40G	0.4
LGG	chr1	92476135	Missense_Mutation	rs758869486	R388H	0.49
LIHC	chr1	92478614	Missense_Mutation	novel	M355T	0.05
LIHC	chr1	92481025	Missense_Mutation	NA	P121L	0.19
LUAD	chr1	92476104	Silent	novel	C398C	0.74
LUAD	chr1	92478674	Missense_Mutation	novel	S335L	0.14
LUAD	chr1	92480807	Missense_Mutation	novel	G194S	0.44
LUAD	chr1	92476146	Silent	NA	I384I	0.22
LUAD	chr1	92482936	Missense_Mutation	NA	E76K	0.24
LUSC	chr1	92481072	Missense_Mutation	novel	M105I	0.4
LUSC	chr1	92476015	3'UTR	novel		0.23
LUSC	chr1	92480647	Missense_Mutation	NA	R247L	0.53
LUSC	chr1	92476152	Silent	novel	N382N	0.54
LUSC	chr1	92476153	Missense_Mutation	novel	N382I	0.54
LUSC	chr1	92482936	Frame_Shift_Del	novel	*E76Kfs122**	0.39
LUSC	chr1	92478729	Missense_Mutation	novel	C317S	0.24	zf-C2H2
LUSC	chr1	92476055	Missense_Mutation	rs781101695	R415W	0.3
LUSC	chr1	92482934	Missense_Mutation	novel	E76D	0.44
LUSC	chr1	92480755	Missense_Mutation	novel	Y211F	0.3
LUSC	chr1	92481015	Nonsense_Mutation	novel	W124*	0.2
LUSC	chr1	92476110	Missense_Mutation	NA	F396L	0.38
LUSC	chr1	92480719	Missense_Mutation	novel	P223H	0.26
OV	chr1	92483021	Silent	NA	A47A	0.62
OV	chr1	92482917	Missense_Mutation	rs776862077	R82Q	0.33
PRAD	chr1	92478711	Silent	NA	R323R	0.21
READ	chr1	92481056	Missense_Mutation	NA	E111K	0.22
READ	chr1	92483047	Splice_Site	NA	X39_splice	0.36
SKCM	chr1	92480626	Missense_Mutation	NA	S254F	0.46
SKCM	chr1	92483406	Missense_Mutation	NA	R28C	0.11
SKCM	chr1	92476030	Silent	novel	*423*	0.21
SKCM	chr1	92476167	Silent	NA	F377F	0.11
SKCM	chr1	92481084	Silent	NA	S101S	0.39
STAD	chr1	92481012	Silent	rs754401447	S125S	0.15
STAD	chr1	92483434	Silent	NA	P18P	0.43
STAD	chr1	92476002	3'UTR	novel		0.36
STAD	chr1	92482872	Missense_Mutation	novel	A97V	0.07
STAD	chr1	92483469	Missense_Mutation	NA	V7I	0.32
STAD	chr1	92476054	Missense_Mutation	rs770564130	R415Q	0.1
STAD	chr1	92476048	Missense_Mutation	rs777241871	T417M	0.46
STAD	chr1	92478715	Silent	NA	F321F	0.31
STAD	chr1	92481056	Missense_Mutation	NA	E111K	0.39
THCA	chr1	92475989	3'UTR	rs766808857		0.15
THCA	chr1	92476207	Missense_Mutation	NA	G364D	0.15
THYM	chr1	92475982	3'UTR	rs41296169		0.47
UCEC	chr1	92474773	3'UTR	rs550067131		0.31
UCEC	chr1	92482944	Missense_Mutation	novel	D73G	0.08
UCEC	chr1	92476055	Missense_Mutation	rs781101695	R415W	0.51
UCEC	chr1	92476055	Missense_Mutation	rs781101695	R415W	0.37
UCEC	chr1	92476126	Missense_Mutation	NA	T391I	0.29
UCEC	chr1	92476135	Missense_Mutation	rs758869486	R388H	0.24
UCEC	chr1	92480414	Nonsense_Mutation	novel	C286*	0.4
UCEC	chr1	92478702	Missense_Mutation	NA	T326A	0.46	zf-C2H2
UCEC	chr1	92483043	Missense_Mutation	novel	S40I	0.36
UCEC	chr1	92474881	3'UTR	novel		0.25
UCEC	chr1	92476103	Missense_Mutation	rs766451911	D399N	0.29
UCEC	chr1	92476109	Missense_Mutation	rs747009263	G397S	0.33
UCEC	chr1	92480482	Missense_Mutation	novel	F264L	0.38
UCEC	chr1	92482898	Silent	novel	D88D	0.31
UCEC	chr1	92476103	Missense_Mutation	rs766451911	D399N	0.12
UCEC	chr1	92483398	Missense_Mutation	novel	E30D	0.15
UCEC	chr1	92475899	3'UTR	novel		0.29
UCEC	chr1	92482950	Missense_Mutation	rs763578383	S71F	0.09
UCEC	chr1	92475906	3'UTR	novel		0.28
UCEC	chr1	92476110	Silent	rs374783582	F396F	0.48
UCEC	chr1	92480990	Missense_Mutation	NA	R133W	0.14
UCEC	chr1	92476063	Missense_Mutation	NA	R412Q	0.19
UCEC	chr1	92478712	Missense_Mutation	novel	K322N	0.37	zf-C2H2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.275	5.7821e-10
CESC	DEL	0.078	0.01281
COAD	DEL	0.2306	0.00038973
GBM	DEL	0.0641	6.3283e-06
MESO	DEL	0.4138	5.9874e-12
PRAD	DEL	0.1016	0.0061054
SKCM	DEL	0.2262	9.7877e-07
STAD	DEL	0.1746	0.0040659
TGCT	AMP	0.18	0.088103

Survival Analysis

Cancer	P-value	Q-value
THYM	0.00079	Kaplan-Meier Survival Analysis
HNSC	0.035	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.0011	Kaplan-Meier Survival Analysis
KIRP	0.024	Kaplan-Meier Survival Analysis
CESC	0.018	Kaplan-Meier Survival Analysis
LAML	0.033	Kaplan-Meier Survival Analysis
UCEC	0.033	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
LUAD	0.012	Kaplan-Meier Survival Analysis
UVM	0.0019	Kaplan-Meier Survival Analysis
OV	0.014	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742