EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000162688 (Gene tree)
Gene ID: 178
Gene Symbol: AGL
Alias: N
Full Name: amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 73,947 bases
Position: chr1:99,850,077-99,924,023
Accession: 321
RBP type: non-canonical RBP
Summary: This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000294724	AGL-201	7446	-	ENSP00000294724	1532 (aa)	-	P35573
ENST00000637337	AGL-208	7179	-	-	- (aa)	-	-
ENST00000370163	AGL-205	7166	-	ENSP00000359182	1532 (aa)	-	P35573
ENST00000370161	AGL-204	6923	XM_017000501	ENSP00000359180	1516 (aa)	XP_016855990	P35573
ENST00000477753	AGL-207	682	-	-	- (aa)	-	-
ENST00000370165	AGL-206	7106	-	ENSP00000359184	1532 (aa)	-	P35573
ENST00000361915	AGL-203	7368	XM_005270557	ENSP00000355106	1532 (aa)	XP_005270614	P35573
ENST00000361302	AGL-202	7179	-	ENSP00000354971	68 (aa)	-	A0A1C7CYW1

Gene Model

Click here to download ENSG00000162688's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00500	Starch and sucrose metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000162688	Macular Degeneration	4.776E-05	20385819
ENSG00000162688	Carotid Arteries	4E-7	26343869
ENSG00000162688	Forced Expiratory Volume	7E-6	22424883

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000162688	rs2230307	1	99896369	?	Carotid intima media thickness	26343869			EFO_0007117
ENSG00000162688	rs17121403	1	99870421	?	Pulmonary function decline	22424883	[0.47-1.20] unit decrease	0.8328	EFO_0004314

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162688's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004133	glycogen debranching enzyme activity	1374391.	TAS	Function
GO:0004134	4-alpha-glucanotransferase activity	2961257.	EXP	Function
GO:0004134	4-alpha-glucanotransferase activity	21873635.	IBA	Function
GO:0004135	amylo-alpha-1,6-glucosidase activity	2961257.	EXP	Function
GO:0004135	amylo-alpha-1,6-glucosidase activity	21873635.	IBA	Function
GO:0005515	protein binding	17908927.24837458.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	17908927.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005978	glycogen biosynthetic process	-	IEA	Process
GO:0005980	glycogen catabolic process	21873635.	IBA	Process
GO:0005980	glycogen catabolic process	-	TAS	Process
GO:0007584	response to nutrient	-	IEA	Process
GO:0016234	inclusion body	-	IEA	Component
GO:0016529	sarcoplasmic reticulum	-	IEA	Component
GO:0030247	polysaccharide binding	-	IEA	Function
GO:0031593	polyubiquitin modification-dependent protein binding	-	IEA	Function
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0043033	isoamylase complex	1374391.	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0051384	response to glucocorticoid	-	IEA	Process
GO:0102500	beta-maltose 4-alpha-glucanotransferase activity	-	IEA	Function
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26975021	Metabolic phenotype of bladder cancer.	Cancer Treat Rev	2016 Apr	Massari F	doi: 10.1016/j.ctrv.2016.03.005
26490312	Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis.	Clin Cancer Res	2016 Mar 1	Guin S	doi: 10.1158/1078-0432.CCR-15-1706

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	99910736	Missense_Mutation	novel	D1242A	0.71
BLCA	chr1	99850892	5'UTR	novel		0.22
BLCA	chr1	99892481	Frame_Shift_Del	novel	*Q1046Efs2**	0.1
BLCA	chr1	99877826	Missense_Mutation	novel	E537K	0.17
BLCA	chr1	99876565	Missense_Mutation	novel	G464A	0.26
BLCA	chr1	99880655	Missense_Mutation	rs139488862	H587Y	0.41
BLCA	chr1	99916427	Missense_Mutation	novel	G1426V	0.33
BLCA	chr1	99876580	Missense_Mutation	rs759535258	R469Q	0.51
BLCA	chr1	99921628	Missense_Mutation	novel	L1526I	0.57
BLCA	chr1	99913532	Missense_Mutation	NA	A1319P	0.31
BLCA	chr1	99875360	Splice_Region	novel	A396A	0.3
BLCA	chr1	99921631	Missense_Mutation	NA	E1527Q	0.18
BLCA	chr1	99892491	Missense_Mutation	NA	C1048F	0.28
BLCA	chr1	99902787	Nonsense_Mutation	novel	K1231_D1232ins*	0.09
BLCA	chr1	99902789	Frame_Shift_Ins	novel	*D1232Efs11**	0.09
BLCA	chr1	99851111	Missense_Mutation	novel	F23L	0.21
BLCA	chr1	99874743	Missense_Mutation	novel	P339T	0.41
BLCA	chr1	99870533	Silent	novel	Y266Y	0.12
BLCA	chr1	99892441	Missense_Mutation	NA	Q1031H	0.17
BLCA	chr1	99900798	Silent	novel	L1175L	0.18
BLCA	chr1	99892439	Missense_Mutation	novel	Q1031E	0.14
BLCA	chr1	99921721	3'UTR	novel		0.14
BLCA	chr1	99884158	Missense_Mutation	NA	E783Q	0.53
BLCA	chr1	99875404	Missense_Mutation	novel	G411D	0.1
BLCA	chr1	99864482	Nonsense_Mutation	novel	S186*	0.25
BLCA	chr1	99861683	Missense_Mutation	NA	S88Y	0.18
BRCA	chr1	99874710	Missense_Mutation	novel	D328N	0.1
BRCA	chr1	99910805	Frame_Shift_Del	NA	*S1266Vfs24**	0.49
BRCA	chr1	99864451	Missense_Mutation	NA	A176P	0.41
BRCA	chr1	99876565	Missense_Mutation	novel	G464E	0.06
BRCA	chr1	99900806	Missense_Mutation	novel	P1178L	0.46
BRCA	chr1	99884453	Splice_Site	NA	X849_splice	0.4
BRCA	chr1	99861492	Intron	NA		0.23
BRCA	chr1	99875415	Missense_Mutation	NA	K415Q	0.16
BRCA	chr1	99884612	Nonsense_Mutation	rs113994130	R864*	0.12
BRCA	chr1	99900823	Missense_Mutation	novel	P1184S	0.26
CESC	chr1	99861556	Missense_Mutation	rs762935611	V46M	0.4
CESC	chr1	99902787	Nonsense_Mutation	novel	D1232*	0.17
CESC	chr1	99892594	Silent	novel	V1082V	0.21
CESC	chr1	99921615	Frame_Shift_Ins	novel	*I1522Gfs29**	0.15
CESC	chr1	99921616	Missense_Mutation	novel	I1522F	0.15
CESC	chr1	99881636	Silent	NA	F751F	0.55
CESC	chr1	99861466	Intron	novel		0.1
CESC	chr1	99870501	Missense_Mutation	rs757347826	R256C	0.33
COAD	chr1	99861415	Intron	novel		0.26
COAD	chr1	99862279	Missense_Mutation	NA	Y106N	0.27
COAD	chr1	99915441	Missense_Mutation	rs28730708	E1405G	0.26
COAD	chr1	99881379	Missense_Mutation	rs771211030	G697S	0.38
COAD	chr1	99921661	3'UTR	NA		0.45
COAD	chr1	99862417	Nonsense_Mutation	novel	E152*	0.28
COAD	chr1	99850899	Splice_Site	novel		0.81
COAD	chr1	99915441	Frame_Shift_Del	novel	*K1407Nfs8**	0.39
COAD	chr1	99877811	Missense_Mutation	novel	P532A	0.45
COAD	chr1	99881540	Splice_Site	NA	X720_splice	0.14
COAD	chr1	99864434	Missense_Mutation	novel	R170K	0.36
COAD	chr1	99892564	Missense_Mutation	novel	E1072D	0.05
COAD	chr1	99877770	Missense_Mutation	novel	T518N	0.07
COAD	chr1	99861695	Missense_Mutation	novel	Q92R	0.2
COAD	chr1	99880036	Silent	NA	S575S	0.3
COAD	chr1	99884184	Missense_Mutation	NA	K791N	0.14
COAD	chr1	99861555	Silent	rs752964406	T45T	0.15
COAD	chr1	99880770	Missense_Mutation	rs147569805	T625M	0.27
COAD	chr1	99912471	Frame_Shift_Ins	rs772172553	*N1304Kfs7**	0.38
COAD	chr1	99884576	Missense_Mutation	NA	L852I	0.3
COAD	chr1	99875201	Missense_Mutation	NA	R377I	0.32
COAD	chr1	99892517	Missense_Mutation	NA	P1057S	0.43
COAD	chr1	99912472	Frame_Shift_Del	rs745757264	*N1304Ifs10**	0.38
DLBC	chr1	99861608	Missense_Mutation	rs199958942	R63H	0.43
ESCA	chr1	99912471	Frame_Shift_Ins	rs772172553	*N1304Kfs7**	0.58
ESCA	chr1	99916663	Silent	NA	P1471P	0.29
ESCA	chr1	99896349	Missense_Mutation	novel	R1108T	0.06
ESCA	chr1	99870423	Missense_Mutation	NA	E230K	0.24
GBM	chr1	99874753	Missense_Mutation	novel	R342I	0.24
GBM	chr1	99877695	Missense_Mutation	novel	L493S	0.52
GBM	chr1	99884349	Missense_Mutation	novel	S815T	0.18
GBM	chr1	99892512	Missense_Mutation	novel	S1055F	0.21
GBM	chr1	99916629	Missense_Mutation	rs546855663	R1460H	0.33
GBM	chr1	99902776	Nonsense_Mutation	rs113994131	R1228*	0.23
GBM	chr1	99900753	Frame_Shift_Del	novel	C1160*	0.18
HNSC	chr1	99881334	Missense_Mutation	novel	P682S	0.23
HNSC	chr1	99900688	Missense_Mutation	novel	L1139V	0.2
HNSC	chr1	99877666	Silent	rs750093972	E483E	0.23
HNSC	chr1	99861505	Missense_Mutation	novel	Y29H	0.54
HNSC	chr1	99852621	Intron	novel		0.5
HNSC	chr1	99892502	Missense_Mutation	novel	K1052E	0.5
HNSC	chr1	99861528	Frame_Shift_Del	novel	*P37Qfs71**	0.15
HNSC	chr1	99921674	3'UTR	novel		0.25
HNSC	chr1	99864528	Silent	novel	V201V	0.3
HNSC	chr1	99888094	Missense_Mutation	novel	Y933C	0.3
HNSC	chr1	99891635	Silent	novel	F993F	0.13
HNSC	chr1	99850987	5'UTR	novel		0.21
HNSC	chr1	99892549	Silent	novel	P1067P	0.19
KICH	chr1	99888038	Silent	novel	E914E	0.09
KIRC	chr1	99870838	Silent	rs181804327	A309A	0.28
KIRC	chr1	99884350	Frame_Shift_Ins	novel	*I817Nfs3**	0.24
KIRC	chr1	99921625	Frame_Shift_Del	novel	*I1525Rfs20**	0.11
KIRC	chr1	99870529	Missense_Mutation	NA	K265I	0.16
KIRP	chr1	99874771	Missense_Mutation	novel	V348E	0.18
KIRP	chr1	99881119	Missense_Mutation	NA	S648C	0.46
LAML	chr1	99875156	Frame_Shift_Ins	novel	*K362Nfs7**	0.09
LAML	chr1	99850896	Splice_Region	novel		1
LAML	chr1	99892452	Missense_Mutation	novel	T1035S	0.05
LAML	chr1	99912506	Frame_Shift_Ins	novel	*K1314Rfs13**	0.04
LAML	chr1	99921582	Silent	novel	Y1510Y	0.12
LGG	chr1	99891277	Missense_Mutation	novel	C957Y	0.39
LGG	chr1	99896315	Missense_Mutation	rs768133891	R1097C	0.41
LGG	chr1	99888003	Missense_Mutation	NA	E903K	0.1
LGG	chr1	99881086	Missense_Mutation	NA	A637V	0.2
LGG	chr1	99902758	Frame_Shift_Ins	novel	*A1222Vfs11**	0.12
LIHC	chr1	99874693	Missense_Mutation	NA	R322K	0.14
LIHC	chr1	99861260	Intron	novel		0.41
LIHC	chr1	99850888	5'UTR	novel		0.47
LIHC	chr1	99900843	Silent	novel	P1190P	0.19
LIHC	chr1	99884602	Silent	NA	V860V	0.37
LIHC	chr1	99916443	Frame_Shift_Del	novel	*L1432Rfs3**	0.33
LUAD	chr1	99851092	Missense_Mutation	NA	K17I	0.4
LUAD	chr1	99874739	Missense_Mutation	novel	Q337H	0.18
LUAD	chr1	99864546	Frame_Shift_Ins	novel	*W208Rfs10**	0.07
LUAD	chr1	99850988	5'UTR	novel		0.24
LUAD	chr1	99875235	Silent	NA	L388L	0.23
LUAD	chr1	99861562	Missense_Mutation	NA	T48A	0.22
LUAD	chr1	99916484	Missense_Mutation	novel	Y1445F	0.18
LUAD	chr1	99913554	Missense_Mutation	novel	E1326G	0.27
LUAD	chr1	99861485	Intron	novel		0.15
LUAD	chr1	99902710	Missense_Mutation	NA	E1206K	0.23
LUAD	chr1	99916658	Missense_Mutation	novel	G1470C	0.36
LUAD	chr1	99862304	Missense_Mutation	novel	R114L	0.25
LUAD	chr1	99870525	Missense_Mutation	NA	G264W	0.17
LUAD	chr1	99915388	Splice_Site	novel	X1388_splice	0.14
LUAD	chr1	99875394	Nonsense_Mutation	rs113994128	R408*	0.28
LUAD	chr1	99862417	Missense_Mutation	novel	E152K	0.14
LUAD	chr1	99861652	Missense_Mutation	NA	D78N	0.16
LUAD	chr1	99892598	Missense_Mutation	NA	L1084V	0.17
LUAD	chr1	99891254	Missense_Mutation	NA	K949N	0.24
LUAD	chr1	99916654	Missense_Mutation	NA	L1468F	0.23
LUAD	chr1	99921730	3'UTR	novel		0.31
LUAD	chr1	99902787	Nonsense_Mutation	novel	K1231_D1232ins*	0.08
LUAD	chr1	99881390	Silent	NA	A700A	0.22
LUAD	chr1	99864440	Missense_Mutation	novel	C172F	0.18
LUAD	chr1	99884702	Missense_Mutation	NA	S894A	0.25
LUAD	chr1	99912488	Missense_Mutation	novel	P1307L	0.11
LUSC	chr1	99884449	Splice_Region	novel	F848F	0.29
LUSC	chr1	99910738	Missense_Mutation	rs778230759	E1243K	0.23
LUSC	chr1	99884162	Missense_Mutation	novel	R784K	0.35
LUSC	chr1	99891700	Missense_Mutation	rs750686172	Y1015C	0.12
LUSC	chr1	99892555	Missense_Mutation	novel	R1069S	0.23
LUSC	chr1	99862315	Missense_Mutation	novel	D118H	0.12
LUSC	chr1	99862322	Missense_Mutation	rs758162985	H120R	0.37
LUSC	chr1	99881692	Splice_Site	novel	X770_splice	0.39
LUSC	chr1	99913668	Missense_Mutation	novel	D1364G	0.17
LUSC	chr1	99913708	Silent	rs751505814	L1377L	0.21
LUSC	chr1	99876543	Missense_Mutation	novel	A457P	0.37
LUSC	chr1	99862332	Silent	novel	P123P	0.18
LUSC	chr1	99880712	Missense_Mutation	novel	Q606K	0.21
LUSC	chr1	99861538	Nonsense_Mutation	rs771961377	Q40*	0.17
LUSC	chr1	99887976	Splice_Site	novel	X894_splice	0.31
LUSC	chr1	99880665	Missense_Mutation	NA	G590A	0.21
LUSC	chr1	99884634	Missense_Mutation	NA	S871I	0.08
OV	chr1	99884128	Missense_Mutation	NA	E773K	0.38
OV	chr1	99875436	Frame_Shift_Ins	novel	*K422Tfs12**	0.04
OV	chr1	99880763	Missense_Mutation	novel	D623H	0.06
OV	chr1	99870510	Missense_Mutation	novel	C259S	0.06
OV	chr1	99915473	Missense_Mutation	novel	T1416P	0.04
OV	chr1	99880760	Missense_Mutation	novel	M622V	0.41
OV	chr1	99881600	Missense_Mutation	novel	I739M	0.04
OV	chr1	99881178	Splice_Site	NA	X667_splice	0.13
OV	chr1	99870764	Nonsense_Mutation	rs755747010	R285*	0.15
PAAD	chr1	99916663	Silent	NA	P1471P	0.05
PAAD	chr1	99870827	Missense_Mutation	rs764208593	V306I	0.34
PAAD	chr1	99884168	Missense_Mutation	rs147586981	T786M	0.08
PAAD	chr1	99891337	Missense_Mutation	rs147977213	R977Q	0.21
PRAD	chr1	99881412	In_Frame_Del	novel	L708del	0.12
PRAD	chr1	99916481	Missense_Mutation	rs143815159	N1444S	0.2
PRAD	chr1	99861691	Missense_Mutation	NA	F91L	0.26
PRAD	chr1	99880679	Nonsense_Mutation	rs765367405	R595*	0.36
PRAD	chr1	99881124	Missense_Mutation	novel	A650T	0.37
READ	chr1	99913603	Silent	rs764186886	S1342S	0.41
READ	chr1	99916710	Missense_Mutation	rs185681971	R1487Q	0.36
READ	chr1	99864396	Missense_Mutation	novel	M157I	0.29
SKCM	chr1	99880678	Silent	novel	Y594Y	0.38
SKCM	chr1	99861652	Missense_Mutation	NA	D78N	0.12
SKCM	chr1	99916668	Missense_Mutation	NA	T1473I	0.19
SKCM	chr1	99861577	Missense_Mutation	NA	P53S	0.22
SKCM	chr1	99900841	Missense_Mutation	NA	P1190S	0.44
SKCM	chr1	99851034	5'UTR	novel		0.42
SKCM	chr1	99881600	Silent	novel	I739I	0.32
SKCM	chr1	99888105	Missense_Mutation	novel	Q937E	0.35
SKCM	chr1	99916647	Missense_Mutation	NA	S1466F	0.26
SKCM	chr1	99864477	Silent	novel	D184D	0.18
SKCM	chr1	99864478	Missense_Mutation	novel	F185L	0.19
SKCM	chr1	99902787	Nonsense_Mutation	novel	D1232*	0.11
SKCM	chr1	99902788	Frame_Shift_Ins	novel	*D1232Vfs10**	0.09
SKCM	chr1	99902764	Missense_Mutation	NA	P1224S	0.48
SKCM	chr1	99921646	Missense_Mutation	novel	L1532I	0.45
SKCM	chr1	99881440	Missense_Mutation	NA	F717Y	0.15
SKCM	chr1	99861500	Splice_Region	novel		0.18
SKCM	chr1	99900682	Missense_Mutation	NA	P1137S	0.16
SKCM	chr1	99876494	Silent	rs267597890	S440S	0.11
SKCM	chr1	99921705	3'UTR	novel		0.14
SKCM	chr1	99881301	Missense_Mutation	NA	V671I	0.22
SKCM	chr1	99852674	Intron	novel		0.67
SKCM	chr1	99887983	Missense_Mutation	rs777099171	A896V	0.49
SKCM	chr1	99887984	Silent	novel	A896A	0.49
SKCM	chr1	99874737	Nonsense_Mutation	NA	Q337*	0.08
SKCM	chr1	99891708	Missense_Mutation	NA	L1018F	0.11
SKCM	chr1	99880035	Missense_Mutation	NA	S575F	0.18
SKCM	chr1	99900796	Missense_Mutation	NA	L1175F	0.07
SKCM	chr1	99892452	Missense_Mutation	novel	T1035I	0.35
SKCM	chr1	99884693	Missense_Mutation	NA	P891S	0.9
SKCM	chr1	99896314	Silent	NA	F1096F	0.35
SKCM	chr1	99881097	Missense_Mutation	NA	L641F	0.22
SKCM	chr1	99880663	Silent	novel	E589E	0.33
SKCM	chr1	99851118	Missense_Mutation	NA	E26K	0.18
SKCM	chr1	99912487	Missense_Mutation	novel	P1307S	0.56
SKCM	chr1	99884582	Missense_Mutation	novel	P854S	0.3
SKCM	chr1	99900765	Silent	rs370202718	Y1164Y	0.6
STAD	chr1	99874792	Missense_Mutation	rs557516658	T355M	0.27
STAD	chr1	99864502	Missense_Mutation	NA	T193A	0.42
STAD	chr1	99913680	Missense_Mutation	rs769401330	A1368V	0.36
STAD	chr1	99870764	Nonsense_Mutation	rs755747010	R285*	0.13
STAD	chr1	99864536	Frame_Shift_Ins	NA	*E207Gfs9**	0.22
STAD	chr1	99881617	Missense_Mutation	NA	A745D	0.27
STAD	chr1	99912453	Silent	NA	R1295R	0.28
STAD	chr1	99921632	Missense_Mutation	NA	E1527G	0.23
STAD	chr1	99916663	Silent	NA	P1471P	0.45
STAD	chr1	99850848	5'UTR	novel		0.41
STAD	chr1	99864436	Missense_Mutation	novel	S171P	0.4
STAD	chr1	99874695	Nonsense_Mutation	rs757987101	R323*	0.33
STAD	chr1	99876599	Splice_Site	NA	X475_splice	0.35
STAD	chr1	99915441	Frame_Shift_Del	novel	*K1407Nfs8**	0.23
STAD	chr1	99888061	Missense_Mutation	NA	C922Y	0.2
STAD	chr1	99851030	5'UTR	novel		0.04
STAD	chr1	99884613	Missense_Mutation	rs776599112	R864Q	0.11
STAD	chr1	99879989	Missense_Mutation	NA	S560R	0.13
STAD	chr1	99874695	Nonsense_Mutation	rs757987101	R323*	0.13
THCA	chr1	99862402	Missense_Mutation	NA	L147F	0.51
UCEC	chr1	99913669	Silent	NA	D1364D	0.32
UCEC	chr1	99876501	Nonsense_Mutation	NA	E443*	0.24
UCEC	chr1	99896372	Missense_Mutation	rs773625464	R1116C	0.32
UCEC	chr1	99870855	Missense_Mutation	novel	R315K	0.19
UCEC	chr1	99852642	Intron	novel		0.34
UCEC	chr1	99870583	Splice_Site	NA	X282_splice	0.34
UCEC	chr1	99870812	Missense_Mutation	novel	F301L	0.36
UCEC	chr1	99884703	Missense_Mutation	NA	S894F	0.42
UCEC	chr1	99921575	Missense_Mutation	novel	A1508V	0.46
UCEC	chr1	99864529	Missense_Mutation	rs528260114	E202K	0.28
UCEC	chr1	99879920	Splice_Region	novel		0.12
UCEC	chr1	99870502	Missense_Mutation	rs200180652	R256H	0.5
UCEC	chr1	99874695	Nonsense_Mutation	rs757987101	R323*	0.24
UCEC	chr1	99910837	Missense_Mutation	NA	A1276S	0.19
UCEC	chr1	99864419	Missense_Mutation	NA	T165I	0.11
UCEC	chr1	99891275	Missense_Mutation	NA	F956L	0.13
UCEC	chr1	99881087	Silent	rs778511499	A637A	0.29
UCEC	chr1	99851060	Missense_Mutation	NA	Q6H	0.38
UCEC	chr1	99864530	Frame_Shift_Del	novel	*K203Nfs2**	0.24
UCEC	chr1	99891254	Missense_Mutation	NA	K949N	0.36
UCEC	chr1	99861420	Intron	novel		0.1
UCEC	chr1	99884690	Missense_Mutation	novel	I890L	0.13
UCEC	chr1	99900773	Missense_Mutation	novel	M1167T	0.09
UCEC	chr1	99880770	Missense_Mutation	NA	T625K	0.25
UCEC	chr1	99861366	Intron	novel		0.41
UCEC	chr1	99891702	Missense_Mutation	novel	T1016A	0.38
UCEC	chr1	99864421	Missense_Mutation	novel	L166F	0.29
UCEC	chr1	99891727	Missense_Mutation	rs755500845	K1024R	0.22
UCEC	chr1	99861608	Missense_Mutation	rs199958942	R63H	0.31
UCEC	chr1	99916465	Missense_Mutation	novel	L1439I	0.43
UCEC	chr1	99884190	Missense_Mutation	novel	E793D	0.38
UCEC	chr1	99875234	Missense_Mutation	novel	L388R	0.42
UCEC	chr1	99875425	Missense_Mutation	novel	P418H	0.42
UCEC	chr1	99916466	Missense_Mutation	NA	L1439P	0.42
UCEC	chr1	99880680	Missense_Mutation	rs753015481	R595Q	0.48
UCEC	chr1	99884190	Missense_Mutation	novel	E793D	0.4
UCEC	chr1	99870485	Frame_Shift_Del	rs748789700	*D251Efs23**	0.24
UCEC	chr1	99864428	Missense_Mutation	NA	L168P	0.43
UCEC	chr1	99862417	Nonsense_Mutation	novel	E152*	0.43
UCEC	chr1	99875239	Missense_Mutation	novel	N390H	0.41
UCEC	chr1	99876580	Missense_Mutation	rs759535258	R469Q	0.41
UCEC	chr1	99880796	Splice_Site	novel	X633_splice	0.36
UCEC	chr1	99921613	Missense_Mutation	novel	S1521A	0.22
UCEC	chr1	99884586	Missense_Mutation	rs754642543	H855R	0.31
UCEC	chr1	99861369	Intron	novel		0.33
UCEC	chr1	99884352	Missense_Mutation	novel	K816R	0.1
UCEC	chr1	99884353	Frame_Shift_Ins	novel	I817*	0.1
UCEC	chr1	99891336	Nonsense_Mutation	rs531425980	R977*	0.36
UCEC	chr1	99861443	Intron	novel		0.38
UCEC	chr1	99912483	Missense_Mutation	novel	I1305M	0.07
UCEC	chr1	99875167	Missense_Mutation	novel	A366S	0.24
UCEC	chr1	99881545	Missense_Mutation	novel	Y721C	0.39
UCEC	chr1	99910768	Missense_Mutation	rs375531470	R1253C	0.45
UCEC	chr1	99888025	Missense_Mutation	rs369044372	R910Q	0.46
UCEC	chr1	99881648	Missense_Mutation	novel	K755N	0.17
UCEC	chr1	99900745	Silent	novel	L1158L	0.18
UCEC	chr1	99900731	Missense_Mutation	novel	A1153D	0.14
UCEC	chr1	99861555	Silent	rs752964406	T45T	0.13
UCEC	chr1	99900759	Silent	novel	Q1162Q	0.11
UCEC	chr1	99875425	Missense_Mutation	novel	P418H	0.21
UCEC	chr1	99888108	Missense_Mutation	novel	G938C	0.26
UCEC	chr1	99921609	Silent	novel	A1519A	0.24
UCEC	chr1	99870797	Missense_Mutation	NA	L296F	0.35
UCEC	chr1	99850857	5'UTR	novel		0.29
UCEC	chr1	99884411	Nonsense_Mutation	NA	E836*	0.15
UCEC	chr1	99881293	Frame_Shift_Ins	novel	*S669Ffs5**	0.06
UCEC	chr1	99851043	Translation_Start_Site	novel	M1?	0.3
UCEC	chr1	99880732	Missense_Mutation	NA	L612F	0.31
UCEC	chr1	99861583	Nonsense_Mutation	novel	E55*	0.35
UCEC	chr1	99884613	Missense_Mutation	rs776599112	R864Q	0.33
UCEC	chr1	99884233	Nonsense_Mutation	novel	E808*	0.53
UCEC	chr1	99913603	Silent	rs764186886	S1342S	0.51
UCEC	chr1	99910713	Splice_Region	novel	G1234G	0.48
UCEC	chr1	99881438	Silent	novel	G716G	0.38
UCEC	chr1	99915441	Frame_Shift_Del	novel	*K1407Nfs8**	0.51
UCEC	chr1	99900862	Splice_Site	NA	X1196_splice	0.33
UCEC	chr1	99851018	5'UTR	rs373822240		0.26
UCEC	chr1	99877686	Missense_Mutation	novel	S490N	0.48
UCEC	chr1	99921691	3'UTR	novel		0.25
UCEC	chr1	99880649	Missense_Mutation	novel	N585D	0.15

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2694	5.7821e-10
CESC	DEL	0.0881	0.01281
COAD	DEL	0.2328	0.00038973
DLBC	DEL	0.1042	0.0017831
LUAD	DEL	0.2248	2.5961e-13
MESO	DEL	0.4138	5.9874e-12
PRAD	DEL	0.0894	0.0061054
SKCM	DEL	0.2044	9.7877e-07
STAD	DEL	0.161	0.0040659
TGCT	AMP	0.1733	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.045	Kaplan-Meier Survival Analysis
SKCM	0.0026	Kaplan-Meier Survival Analysis
LUSC	0.0066	Kaplan-Meier Survival Analysis
KIRP	0.017	Kaplan-Meier Survival Analysis
COAD	0.0091	Kaplan-Meier Survival Analysis
PAAD	0.037	Kaplan-Meier Survival Analysis
CESC	0.017	Kaplan-Meier Survival Analysis
READ	0.027	Kaplan-Meier Survival Analysis
UCEC	0.024	Kaplan-Meier Survival Analysis
GBM	0.0045	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742