EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162851 (Gene tree)
Gene ID: 64216
Gene Symbol: TFB2M
Alias: FLJ23182|FLJ22661|Hkp1
Full Name: transcription factor B2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 25,765 bases
Position: chr1:246,540,560-246,566,324
Accession: 18559
RBP type: canonical RBP
Summary: (Transcription Factor B2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Mitochondrial Gene Expression and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include rRNA methyltransferase activity. An important paralog of this gene is TFB1M.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000355471	RrnaAD	PF00398.20	3.1e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17557812	Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.	Nucleic Acids Res	2007	Cotney J	-
17337445	Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.	J Biol Chem	2007 Apr 27	Wang Z	-
25800739	A model for transcription initiation in human mitochondria.	Nucleic Acids Res	2015 Apr 20	Morozov YI	doi: 10.1093/nar/gkv235
30190598	Structural basis of mitochondrial transcription.	Nat Struct Mol Biol	2018 Sep	Hillen HS	doi: 10.1038/s41594-018-0122-9

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000366514	TFB2M-201	1848	XM_011544248	ENSP00000355471	396 (aa)	XP_011542550	Q9H5Q4

Gene Model

Click here to download ENSG00000162851's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162851's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162851	TFB2M	83	39.394	ENSAPOG00000020846	tfb2m	72	39.394	Acanthochromis_polyacanthus
ENSG00000162851	TFB2M	99	52.826	ENSAMEG00000006593	TFB2M	99	52.736	Ailuropoda_melanoleuca
ENSG00000162851	TFB2M	84	40.419	ENSACIG00000008758	tfb2m	74	40.419	Amphilophus_citrinellus
ENSG00000162851	TFB2M	75	41.472	ENSAOCG00000008467	tfb2m	65	41.806	Amphiprion_ocellaris
ENSG00000162851	TFB2M	75	41.472	ENSAPEG00000004298	tfb2m	65	41.806	Amphiprion_percula
ENSG00000162851	TFB2M	82	39.759	ENSATEG00000020372	tfb2m	71	39.759	Anabas_testudineus
ENSG00000162851	TFB2M	84	44.776	ENSACAG00000011940	TFB2M	98	44.776	Anolis_carolinensis
ENSG00000162851	TFB2M	100	67.758	ENSANAG00000038040	TFB2M	99	67.758	Aotus_nancymaae
ENSG00000162851	TFB2M	82	40.491	ENSACLG00000009801	tfb2m	71	40.491	Astatotilapia_calliptera
ENSG00000162851	TFB2M	82	41.104	ENSAMXG00000001243	tfb2m	80	41.104	Astyanax_mexicanus
ENSG00000162851	TFB2M	99	53.924	ENSBTAG00000000072	TFB2M	99	53.924	Bos_taurus
ENSG00000162851	TFB2M	100	67.003	ENSCJAG00000016845	TFB2M	100	67.003	Callithrix_jacchus
ENSG00000162851	TFB2M	99	52.381	ENSCAFG00000032694	TFB2M	99	52.381	Canis_familiaris
ENSG00000162851	TFB2M	99	52.381	ENSCAFG00020001084	TFB2M	99	52.381	Canis_lupus_dingo
ENSG00000162851	TFB2M	99	54.430	ENSCHIG00000017458	TFB2M	99	54.430	Capra_hircus
ENSG00000162851	TFB2M	99	69.873	ENSTSYG00000010006	TFB2M	99	69.873	Carlito_syrichta
ENSG00000162851	TFB2M	99	49.010	ENSCPOG00000013225	-	99	49.010	Cavia_porcellus
ENSG00000162851	TFB2M	100	66.499	ENSCCAG00000028811	TFB2M	99	66.499	Cebus_capucinus
ENSG00000162851	TFB2M	99	70.886	ENSCATG00000043081	-	99	71.646	Cercocebus_atys
ENSG00000162851	TFB2M	99	77.215	ENSCATG00000041118	TFB2M	99	77.215	Cercocebus_atys
ENSG00000162851	TFB2M	99	52.020	ENSCLAG00000008614	TFB2M	99	52.020	Chinchilla_lanigera
ENSG00000162851	TFB2M	99	85.823	ENSCSAG00000009135	TFB2M	99	85.823	Chlorocebus_sabaeus
ENSG00000162851	TFB2M	99	55.612	ENSCHOG00000001296	TFB2M	99	55.612	Choloepus_hoffmanni
ENSG00000162851	TFB2M	84	44.880	ENSCPBG00000016975	TFB2M	81	44.880	Chrysemys_picta_bellii
ENSG00000162851	TFB2M	99	71.465	ENSCANG00000023198	-	99	71.465	Colobus_angolensis_palliatus
ENSG00000162851	TFB2M	99	53.418	ENSCGRG00001000953	Tfb2m	99	53.418	Cricetulus_griseus_chok1gshd
ENSG00000162851	TFB2M	99	53.418	ENSCGRG00000013379	Tfb2m	99	53.418	Cricetulus_griseus_crigri
ENSG00000162851	TFB2M	79	33.439	ENSCSEG00000008303	TFB2M	69	35.197	Cynoglossus_semilaevis
ENSG00000162851	TFB2M	84	37.425	ENSCVAG00000010328	tfb2m	74	37.425	Cyprinodon_variegatus
ENSG00000162851	TFB2M	82	39.939	ENSDARG00000074756	tfb2m	74	39.939	Danio_rerio
ENSG00000162851	TFB2M	99	60.401	ENSDNOG00000035182	TFB2M	100	60.401	Dasypus_novemcinctus
ENSG00000162851	TFB2M	99	56.313	ENSDORG00000026012	Tfb2m	99	56.313	Dipodomys_ordii
ENSG00000162851	TFB2M	86	50.442	ENSETEG00000007294	-	100	50.442	Echinops_telfairi
ENSG00000162851	TFB2M	100	64.141	ENSEASG00005005729	TFB2M	99	64.141	Equus_asinus_asinus
ENSG00000162851	TFB2M	100	64.394	ENSECAG00000016462	TFB2M	99	64.394	Equus_caballus
ENSG00000162851	TFB2M	84	41.317	ENSELUG00000002046	tfb2m	92	39.701	Esox_lucius
ENSG00000162851	TFB2M	97	57.623	ENSFCAG00000021951	TFB2M	99	57.623	Felis_catus
ENSG00000162851	TFB2M	76	45.151	ENSFALG00000011573	TFB2M	89	45.151	Ficedula_albicollis
ENSG00000162851	TFB2M	99	50.886	ENSFDAG00000005822	TFB2M	99	50.886	Fukomys_damarensis
ENSG00000162851	TFB2M	84	39.118	ENSFHEG00000019185	tfb2m	74	39.118	Fundulus_heteroclitus
ENSG00000162851	TFB2M	58	33.188	ENSGMOG00000013664	tfb2m	97	33.188	Gadus_morhua
ENSG00000162851	TFB2M	87	42.693	ENSGALG00000010651	TFB2M	88	42.693	Gallus_gallus
ENSG00000162851	TFB2M	84	39.412	ENSGAFG00000008503	tfb2m	74	39.412	Gambusia_affinis
ENSG00000162851	TFB2M	58	38.261	ENSGACG00000016236	tfb2m	97	38.261	Gasterosteus_aculeatus
ENSG00000162851	TFB2M	76	44.186	ENSGAGG00000023556	TFB2M	72	44.186	Gopherus_agassizii
ENSG00000162851	TFB2M	100	98.232	ENSGGOG00000001095	TFB2M	100	98.232	Gorilla_gorilla
ENSG00000162851	TFB2M	84	39.820	ENSHBUG00000000565	tfb2m	73	39.820	Haplochromis_burtoni
ENSG00000162851	TFB2M	99	50.000	ENSHGLG00000015476	-	99	50.000	Heterocephalus_glaber_female
ENSG00000162851	TFB2M	99	50.000	ENSHGLG00100004104	-	99	50.000	Heterocephalus_glaber_male
ENSG00000162851	TFB2M	82	39.091	ENSHCOG00000018851	tfb2m	70	39.091	Hippocampus_comes
ENSG00000162851	TFB2M	82	44.343	ENSIPUG00000015951	TFB2M	75	44.343	Ictalurus_punctatus
ENSG00000162851	TFB2M	99	56.345	ENSSTOG00000034162	TFB2M	100	56.345	Ictidomys_tridecemlineatus
ENSG00000162851	TFB2M	99	58.481	ENSJJAG00000019285	Tfb2m	99	58.481	Jaculus_jaculus
ENSG00000162851	TFB2M	84	38.922	ENSKMAG00000019736	tfb2m	74	38.922	Kryptolebias_marmoratus
ENSG00000162851	TFB2M	84	39.157	ENSLBEG00000003846	tfb2m	72	39.157	Labrus_bergylta
ENSG00000162851	TFB2M	61	41.736	ENSLACG00000016461	tfb2m	95	40.828	Latimeria_chalumnae
ENSG00000162851	TFB2M	84	44.910	ENSLOCG00000016646	tfb2m	79	44.910	Lepisosteus_oculatus
ENSG00000162851	TFB2M	98	63.104	ENSLAFG00000015061	TFB2M	97	63.104	Loxodonta_africana
ENSG00000162851	TFB2M	99	85.316	ENSMFAG00000000959	TFB2M	99	85.316	Macaca_fascicularis
ENSG00000162851	TFB2M	99	85.316	ENSMMUG00000022915	TFB2M	99	85.316	Macaca_mulatta
ENSG00000162851	TFB2M	99	71.139	ENSMMUG00000041253	-	99	71.899	Macaca_mulatta
ENSG00000162851	TFB2M	99	85.316	ENSMNEG00000034600	TFB2M	99	85.316	Macaca_nemestrina
ENSG00000162851	TFB2M	99	66.582	ENSMNEG00000045067	-	99	67.342	Macaca_nemestrina
ENSG00000162851	TFB2M	99	85.570	ENSMLEG00000031716	TFB2M	99	85.570	Mandrillus_leucophaeus
ENSG00000162851	TFB2M	84	39.521	ENSMAMG00000020525	tfb2m	66	39.521	Mastacembelus_armatus
ENSG00000162851	TFB2M	82	40.491	ENSMZEG00005010491	tfb2m	71	40.491	Maylandia_zebra
ENSG00000162851	TFB2M	73	44.674	ENSMGAG00000011408	TFB2M	98	44.674	Meleagris_gallopavo
ENSG00000162851	TFB2M	99	54.523	ENSMAUG00000015170	Tfb2m	99	54.523	Mesocricetus_auratus
ENSG00000162851	TFB2M	99	68.354	ENSMICG00000016790	TFB2M	99	68.354	Microcebus_murinus
ENSG00000162851	TFB2M	99	55.919	ENSMOCG00000016864	Tfb2m	99	55.919	Microtus_ochrogaster
ENSG00000162851	TFB2M	84	39.820	ENSMMOG00000001118	tfb2m	74	39.820	Mola_mola
ENSG00000162851	TFB2M	73	46.528	ENSMODG00000029299	-	98	46.528	Monodelphis_domestica
ENSG00000162851	TFB2M	91	39.410	ENSMALG00000007148	tfb2m	81	39.410	Monopterus_albus
ENSG00000162851	TFB2M	58	45.041	ENSMALG00000020355	-	63	45.041	Monopterus_albus
ENSG00000162851	TFB2M	58	44.856	ENSMALG00000015323	-	82	44.856	Monopterus_albus
ENSG00000162851	TFB2M	99	54.337	MGP_CAROLIEiJ_G0014966	-	98	54.337	Mus_caroli
ENSG00000162851	TFB2M	99	54.337	MGP_CAROLIEiJ_G0014967	-	98	54.337	Mus_caroli
ENSG00000162851	TFB2M	99	53.061	ENSMUSG00000026492	Tfb2m	98	53.061	Mus_musculus
ENSG00000162851	TFB2M	99	54.337	MGP_PahariEiJ_G0028197	-	98	54.337	Mus_pahari
ENSG00000162851	TFB2M	99	53.827	MGP_SPRETEiJ_G0015765	-	98	53.827	Mus_spretus
ENSG00000162851	TFB2M	99	54.135	ENSMPUG00000015810	TFB2M	99	54.135	Mustela_putorius_furo
ENSG00000162851	TFB2M	99	52.405	ENSMLUG00000003923	TFB2M	99	52.405	Myotis_lucifugus
ENSG00000162851	TFB2M	99	58.186	ENSNGAG00000018240	Tfb2m	99	58.186	Nannospalax_galili
ENSG00000162851	TFB2M	59	38.356	ENSNBRG00000003110	-	61	38.356	Neolamprologus_brichardi
ENSG00000162851	TFB2M	60	44.813	ENSNBRG00000000213	tfb2m	97	44.813	Neolamprologus_brichardi
ENSG00000162851	TFB2M	100	93.687	ENSNLEG00000004146	TFB2M	100	93.687	Nomascus_leucogenys
ENSG00000162851	TFB2M	99	48.500	ENSODEG00000013735	-	99	48.500	Octodon_degus
ENSG00000162851	TFB2M	84	40.719	ENSONIG00000017120	tfb2m	73	40.719	Oreochromis_niloticus
ENSG00000162851	TFB2M	75	47.826	ENSOANG00000010246	-	98	47.945	Ornithorhynchus_anatinus
ENSG00000162851	TFB2M	99	65.063	ENSOCUG00000013727	-	99	65.063	Oryctolagus_cuniculus
ENSG00000162851	TFB2M	99	63.544	ENSOCUG00000022792	-	99	63.544	Oryctolagus_cuniculus
ENSG00000162851	TFB2M	84	38.922	ENSORLG00000011263	tfb2m	59	38.922	Oryzias_latipes
ENSG00000162851	TFB2M	84	38.623	ENSORLG00020003041	tfb2m	72	38.623	Oryzias_latipes_hni
ENSG00000162851	TFB2M	82	39.385	ENSORLG00015001311	tfb2m	70	39.385	Oryzias_latipes_hsok
ENSG00000162851	TFB2M	82	39.692	ENSOMEG00000010814	tfb2m	70	39.692	Oryzias_melastigma
ENSG00000162851	TFB2M	99	65.063	ENSOGAG00000007823	TFB2M	99	65.063	Otolemur_garnettii
ENSG00000162851	TFB2M	99	53.924	ENSOARG00000004242	-	99	53.924	Ovis_aries
ENSG00000162851	TFB2M	76	56.173	ENSOARG00000020149	-	99	56.173	Ovis_aries
ENSG00000162851	TFB2M	100	98.737	ENSPPAG00000036577	TFB2M	100	98.737	Pan_paniscus
ENSG00000162851	TFB2M	97	57.364	ENSPPRG00000007350	TFB2M	98	57.364	Panthera_pardus
ENSG00000162851	TFB2M	97	56.555	ENSPTIG00000007649	TFB2M	98	56.555	Panthera_tigris_altaica
ENSG00000162851	TFB2M	100	98.737	ENSPTRG00000002188	TFB2M	100	98.737	Pan_troglodytes
ENSG00000162851	TFB2M	99	71.139	ENSPANG00000033033	-	99	71.139	Papio_anubis
ENSG00000162851	TFB2M	93	84.824	ENSPANG00000024989	TFB2M	86	84.824	Papio_anubis
ENSG00000162851	TFB2M	96	38.579	ENSPKIG00000007071	tfb2m	88	38.579	Paramormyrops_kingsleyae
ENSG00000162851	TFB2M	71	47.222	ENSPSIG00000005507	TFB2M	98	47.222	Pelodiscus_sinensis
ENSG00000162851	TFB2M	75	41.472	ENSPMGG00000002042	tfb2m	66	41.472	Periophthalmus_magnuspinnatus
ENSG00000162851	TFB2M	99	52.645	ENSPEMG00000018713	Tfb2m	99	52.645	Peromyscus_maniculatus_bairdii
ENSG00000162851	TFB2M	81	34.154	ENSPMAG00000007459	tfb2m	96	34.154	Petromyzon_marinus
ENSG00000162851	TFB2M	99	46.482	ENSPCIG00000003268	-	97	46.482	Phascolarctos_cinereus
ENSG00000162851	TFB2M	84	40.120	ENSPFOG00000010834	tfb2m	85	40.120	Poecilia_formosa
ENSG00000162851	TFB2M	84	38.323	ENSPLAG00000000382	tfb2m	73	38.323	Poecilia_latipinna
ENSG00000162851	TFB2M	84	40.120	ENSPMEG00000011437	tfb2m	74	40.120	Poecilia_mexicana
ENSG00000162851	TFB2M	84	39.820	ENSPREG00000010841	tfb2m	74	39.820	Poecilia_reticulata
ENSG00000162851	TFB2M	100	94.192	ENSPPYG00000000046	TFB2M	100	94.192	Pongo_abelii
ENSG00000162851	TFB2M	85	62.130	ENSPCAG00000014525	TFB2M	100	62.130	Procavia_capensis
ENSG00000162851	TFB2M	99	66.835	ENSPCOG00000017595	TFB2M	98	66.835	Propithecus_coquereli
ENSG00000162851	TFB2M	100	62.121	ENSPVAG00000000353	TFB2M	99	62.121	Pteropus_vampyrus
ENSG00000162851	TFB2M	84	39.521	ENSPNYG00000017560	tfb2m	73	39.521	Pundamilia_nyererei
ENSG00000162851	TFB2M	82	45.706	ENSPNAG00000006270	tfb2m	62	45.706	Pygocentrus_nattereri
ENSG00000162851	TFB2M	98	54.639	ENSRNOG00000002695	Tfb2m	97	54.639	Rattus_norvegicus
ENSG00000162851	TFB2M	99	87.342	ENSRBIG00000007430	TFB2M	99	87.342	Rhinopithecus_bieti
ENSG00000162851	TFB2M	99	69.697	ENSRBIG00000032518	-	99	69.697	Rhinopithecus_bieti
ENSG00000162851	TFB2M	99	87.089	ENSRROG00000011991	TFB2M	99	87.089	Rhinopithecus_roxellana
ENSG00000162851	TFB2M	100	64.232	ENSSBOG00000033950	TFB2M	99	64.232	Saimiri_boliviensis_boliviensis
ENSG00000162851	TFB2M	99	43.325	ENSSHAG00000010044	-	98	43.325	Sarcophilus_harrisii
ENSG00000162851	TFB2M	83	42.378	ENSSFOG00015019107	tfb2m	74	42.378	Scleropages_formosus
ENSG00000162851	TFB2M	83	44.207	ENSSFOG00015019121	tfb2m	73	44.207	Scleropages_formosus
ENSG00000162851	TFB2M	84	40.597	ENSSMAG00000005476	tfb2m	73	40.597	Scophthalmus_maximus
ENSG00000162851	TFB2M	84	39.759	ENSSDUG00000001650	tfb2m	74	39.759	Seriola_dumerili
ENSG00000162851	TFB2M	84	40.240	ENSSLDG00000024489	tfb2m	74	40.240	Seriola_lalandi_dorsalis
ENSG00000162851	TFB2M	86	57.602	ENSSARG00000003285	TFB2M	86	57.602	Sorex_araneus
ENSG00000162851	TFB2M	84	45.833	ENSSPUG00000011591	TFB2M	83	45.833	Sphenodon_punctatus
ENSG00000162851	TFB2M	83	39.697	ENSSPAG00000010535	tfb2m	72	39.697	Stegastes_partitus
ENSG00000162851	TFB2M	99	53.418	ENSSSCG00000023775	TFB2M	100	53.529	Sus_scrofa
ENSG00000162851	TFB2M	81	43.034	ENSTGUG00000008396	TFB2M	98	43.034	Taeniopygia_guttata
ENSG00000162851	TFB2M	86	39.474	ENSTRUG00000010411	tfb2m	75	39.474	Takifugu_rubripes
ENSG00000162851	TFB2M	82	42.025	ENSTNIG00000017700	tfb2m	99	42.025	Tetraodon_nigroviridis
ENSG00000162851	TFB2M	99	59.241	ENSTBEG00000008705	TFB2M	100	59.241	Tupaia_belangeri
ENSG00000162851	TFB2M	99	51.646	ENSTTRG00000005299	TFB2M	99	51.646	Tursiops_truncatus
ENSG00000162851	TFB2M	67	55.472	ENSUAMG00000009323	-	91	55.472	Ursus_americanus
ENSG00000162851	TFB2M	99	53.133	ENSUMAG00000013324	TFB2M	99	53.133	Ursus_maritimus
ENSG00000162851	TFB2M	99	58.376	ENSVPAG00000009586	TFB2M	99	58.376	Vicugna_pacos
ENSG00000162851	TFB2M	73	55.593	ENSVVUG00000000650	-	78	54.730	Vulpes_vulpes
ENSG00000162851	TFB2M	86	42.899	ENSXETG00000033343	TFB2M	93	42.899	Xenopus_tropicalis
ENSG00000162851	TFB2M	84	39.222	ENSXCOG00000012233	tfb2m	75	39.222	Xiphophorus_couchianus
ENSG00000162851	TFB2M	84	39.820	ENSXMAG00000017710	tfb2m	74	39.820	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	21873635.	IBA	Function
GO:0003712	transcription coregulator activity	12068295.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	12068295.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006390	mitochondrial transcription	21873635.	IBA	Process
GO:0006390	mitochondrial transcription	12068295.	IDA	Process
GO:0006391	transcription initiation from mitochondrial promoter	20410300.	IDA	Process
GO:0006391	transcription initiation from mitochondrial promoter	-	TAS	Process
GO:0007005	mitochondrion organization	-	TAS	Process
GO:0031167	rRNA methylation	21873635.	IBA	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0045893	positive regulation of transcription, DNA-templated	20410300.	IDA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	246540946	3'UTR	novel		0.39
BLCA	chr1	246548549	Missense_Mutation	rs746323608	R285H	0.31	RrnaAD
BLCA	chr1	246564384	Missense_Mutation	novel	A122T	0.89	RrnaAD
BLCA	chr1	246566005	Missense_Mutation	NA	S45F	0.19
BLCA	chr1	246541181	Silent	rs369141918	A347A	0.33
BRCA	chr1	246551224	Missense_Mutation	NA	V262I	0.36	RrnaAD
BRCA	chr1	246557527	Missense_Mutation	novel	G137E	0.04	RrnaAD
BRCA	chr1	246540915	3'UTR	novel		0.09
BRCA	chr1	246566041	Missense_Mutation	novel	R33P	0.08
BRCA	chr1	246540918	3'UTR	novel		0.21
BRCA	chr1	246565895	Missense_Mutation	NA	E82K	0.11
BRCA	chr1	246566227	5'UTR	novel		0.33
CESC	chr1	246541007	3'UTR	novel		0.1
CESC	chr1	246540946	3'UTR	novel		0.5
CESC	chr1	246544619	Silent	novel	L307L	0.38
CESC	chr1	246541120	Missense_Mutation	rs778994953	Q368E	0.07	RrnaAD
CESC	chr1	246551249	Missense_Mutation	novel	I253M	0.29	RrnaAD
COAD	chr1	246544543	Missense_Mutation	rs776314909	A333T	0.12	RrnaAD
COAD	chr1	246557386	Missense_Mutation	novel	T184I	0.05	RrnaAD
COAD	chr1	246556619	Missense_Mutation	NA	F220C	0.17	RrnaAD
COAD	chr1	246548567	Missense_Mutation	rs373807670	P279L	0.32	RrnaAD
COAD	chr1	246541018	3'UTR	rs780302034		0.39
COAD	chr1	246556604	Missense_Mutation	NA	V225E	0.1	RrnaAD
COAD	chr1	246541181	Silent	rs369141918	A347A	0.9
COAD	chr1	246556591	Silent	NA	I229I	0.34
COAD	chr1	246541193	Silent	NA	T343T	0.23
COAD	chr1	246541012	3'UTR	novel		0.46
COAD	chr1	246566069	Frame_Shift_Del	novel	*C24Afs3**	0.19
COAD	chr1	246566147	5'UTR	novel		0.31
COAD	chr1	246548608	Splice_Site	NA	X266_splice	0.22
GBM	chr1	246556652	Missense_Mutation	novel	Y209F	0.09	RrnaAD
GBM	chr1	246544630	Missense_Mutation	rs780893269	R304C	0.42	RrnaAD
GBM	chr1	246557403	Missense_Mutation	novel	I178M	0.42	RrnaAD
GBM	chr1	246541004	3'UTR	rs371554842		0.34
GBM	chr1	246557504	Nonsense_Mutation	rs763735264	R145*	0.41	RrnaAD
HNSC	chr1	246564378	Missense_Mutation	NA	E124K	0.16	RrnaAD
HNSC	chr1	246541139	Silent	novel	K361K	0.07
HNSC	chr1	246541142	Silent	novel	E360E	0.09
HNSC	chr1	246566151	5'UTR	novel		0.21
HNSC	chr1	246566093	Missense_Mutation	rs143392079	A16S	0.52
HNSC	chr1	246541000	3'UTR	novel		0.29
KIRC	chr1	246544535	Silent	NA	V335V	0.21
LGG	chr1	246566126	Missense_Mutation	novel	V5L	0.43
LIHC	chr1	246566167	5'UTR	novel		0.23
LUAD	chr1	246566083	Missense_Mutation	novel	G19V	0.11
LUAD	chr1	246551275	Missense_Mutation	NA	D245H	0.09	RrnaAD
LUAD	chr1	246541147	Missense_Mutation	novel	D359Y	0.28	RrnaAD
LUAD	chr1	246551268	Missense_Mutation	NA	Y247C	0.24	RrnaAD
LUAD	chr1	246544616	Silent	novel	F308F	0.34
LUAD	chr1	246556635	Missense_Mutation	rs770593847	T215A	0.06	RrnaAD
LUSC	chr1	246565910	Missense_Mutation	novel	D77H	0.2
LUSC	chr1	246566093	Missense_Mutation	rs143392079	A16S	0.48
LUSC	chr1	246556629	Missense_Mutation	NA	I217V	0.14	RrnaAD
LUSC	chr1	246566114	Missense_Mutation	novel	P9S	0.33
LUSC	chr1	246544576	Missense_Mutation	novel	H322Y	0.07	RrnaAD
LUSC	chr1	246556685	Missense_Mutation	novel	R198T	0.51	RrnaAD
LUSC	chr1	246541186	Missense_Mutation	novel	D346N	0.19	RrnaAD
LUSC	chr1	246541147	Missense_Mutation	NA	D359N	0.35	RrnaAD
OV	chr1	246541165	Missense_Mutation	NA	Q353E	0.76	RrnaAD
OV	chr1	246541062	Missense_Mutation	NA	W387S	0.09
OV	chr1	246540978	3'UTR	novel		0.14
OV	chr1	246551266	Frame_Shift_Ins	novel	*H248Efs18**	0.04	RrnaAD
OV	chr1	246557429	Frame_Shift_Del	novel	*R170Efs9**	0.15	RrnaAD
OV	chr1	246544589	Nonsense_Mutation	novel	Y317*	0.38	RrnaAD
OV	chr1	246566021	Missense_Mutation	novel	N40Y	0.11
PAAD	chr1	246541004	3'UTR	rs371554842		0.27
PAAD	chr1	246544522	Missense_Mutation	rs778528523	R340C	0.14	RrnaAD
PAAD	chr1	246541059	Missense_Mutation	novel	L388Q	0.11
READ	chr1	246565878	Silent	NA	I87I	0.4
READ	chr1	246557411	Missense_Mutation	novel	L176V	0.05	RrnaAD
SKCM	chr1	246548597	Missense_Mutation	novel	S269L	0.46	RrnaAD
SKCM	chr1	246551287	Missense_Mutation	NA	P241S	0.34	RrnaAD
SKCM	chr1	246541095	Missense_Mutation	novel	T376S	0.21	RrnaAD
SKCM	chr1	246544576	Missense_Mutation	novel	H322Y	0.46	RrnaAD
STAD	chr1	246544606	Missense_Mutation	NA	L312I	0.22	RrnaAD
STAD	chr1	246566029	Missense_Mutation	NA	P37L	0.22
STAD	chr1	246565898	Missense_Mutation	NA	A81T	0.27
STAD	chr1	246544548	Missense_Mutation	rs770122933	R331H	0.26	RrnaAD
STAD	chr1	246564362	Missense_Mutation	NA	F129C	0.33	RrnaAD
STAD	chr1	246564378	Missense_Mutation	NA	E124K	0.17	RrnaAD
STAD	chr1	246566132	Missense_Mutation	NA	I3F	0.17
STAD	chr1	246548576	Missense_Mutation	rs545105645	R276Q	0.07	RrnaAD
UCEC	chr1	246548549	Missense_Mutation	rs746323608	R285H	0.17	RrnaAD
UCEC	chr1	246540898	3'UTR	novel		0.22
UCEC	chr1	246566165	5'UTR	novel		0.1
UCEC	chr1	246548550	Missense_Mutation	rs772712500	R285C	0.42	RrnaAD
UCEC	chr1	246565907	Silent	novel	R78R	0.14
UCEC	chr1	246541099	Nonsense_Mutation	novel	E375*	0.47	RrnaAD
UCEC	chr1	246540597	3'UTR	novel		0.74
UCEC	chr1	246556618	Missense_Mutation	novel	F220L	0.38	RrnaAD
UCEC	chr1	246557484	Missense_Mutation	novel	F151L	0.19	RrnaAD
UCEC	chr1	246544581	Missense_Mutation	novel	F320S	0.39	RrnaAD
UCEC	chr1	246566091	Frame_Shift_Del	NA	*L17Wfs10**	0.42
UCEC	chr1	246544570	Silent	rs373909454	L324L	0.49
UCEC	chr1	246544549	Missense_Mutation	rs200729611	R331C	0.2	RrnaAD
UCEC	chr1	246544621	Missense_Mutation	novel	L307V	0.48	RrnaAD
UCEC	chr1	246540974	3'UTR	novel		0.24
UCEC	chr1	246541182	Missense_Mutation	rs754216735	A347V	0.3	RrnaAD
UCEC	chr1	246541004	3'UTR	rs371554842		0.17
UCEC	chr1	246540703	3'UTR	novel		0.31
UCEC	chr1	246548566	Silent	rs146116264	P279P	0.13
UCEC	chr1	246551212	Splice_Site	novel	X265_splice	0.31
UCEC	chr1	246565842	Silent	novel	L99L	0.33
UCEC	chr1	246540927	3'UTR	novel		0.25
UCEC	chr1	246541117	Missense_Mutation	rs757317881	D369Y	0.56	RrnaAD
UCEC	chr1	246556657	Silent	rs373504632	L207L	0.55
UCEC	chr1	246566156	5'UTR	novel		0.4
UCEC	chr1	246548570	Missense_Mutation	novel	G278V	0.09	RrnaAD
UCEC	chr1	246565988	Silent	NA	L51L	0.34
UCEC	chr1	246541018	3'UTR	rs780302034		0.28
UCEC	chr1	246544621	Missense_Mutation	novel	L307V	0.38	RrnaAD
UCEC	chr1	246557429	Nonsense_Mutation	rs745408018	R170*	0.38	RrnaAD
UCEC	chr1	246540981	3'UTR	novel		0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	AMP	0.6935	1.4246e-20
DLBC	DEL	0.1458	0.0017831
ESCA	DEL	0.0543	0.0006282
GBM	DEL	0.0537	0.0061479
HNSC	DEL	0.0479	0.038263
KIRC	DEL	0.0682	0.018371
LGG	DEL	0.0409	0.11599
LIHC	AMP	0.6568	4.3428e-09
PCPG	DEL	0.0988	0.12617
READ	AMP	0.2667	0.14328
SARC	DEL	0.2685	2.6086e-08
SKCM	AMP	0.5041	9.5039e-09
STAD	DEL	0.0363	0.0018105
TGCT	DEL	0.02	0.16985
THYM	AMP	0.187	0.24554
UCEC	AMP	0.3785	2.3921e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.012	Kaplan-Meier Survival Analysis
MESO	0.041	Kaplan-Meier Survival Analysis
BRCA	0.015	Kaplan-Meier Survival Analysis
KIRP	0.046	Kaplan-Meier Survival Analysis
READ	0.0041	Kaplan-Meier Survival Analysis
KICH	0.0079	Kaplan-Meier Survival Analysis
LGG	0.00073	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742