EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162910 (Gene tree)
Gene ID: 128308
Gene Symbol: MRPL55
Alias: N
Full Name: mitochondrial ribosomal protein L55
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 4,275 bases
Position: chr1:228,106,679-228,110,953
Accession: 16686
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000295008	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000337342	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000337361	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000338189	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355694	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355695	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355696	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355697	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355700	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355701	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355702	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355703	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355705	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355707	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355708	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000375740	Mitoc_L55	PF09776.9	8.4e-56	1	1
ENSP00000355699	Mitoc_L55	PF09776.9	1.9e-55	1	1
ENSP00000403614	Mitoc_L55	PF09776.9	1.9e-55	1	1
ENSP00000409966	Mitoc_L55	PF09776.9	2.7e-30	1	1
ENSP00000355692	Mitoc_L55	PF09776.9	2.7e-20	1	1
ENSP00000355693	Mitoc_L55	PF09776.9	2.7e-20	1	1
ENSP00000482290	Mitoc_L55	PF09776.9	2.7e-20	1	1
ENSP00000401737	Mitoc_L55	PF09776.9	5.4e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497758	MRPL55-234	470	-	-	- (aa)	-	-
ENST00000430433	MRPL55-221	864	-	ENSP00000403614	164 (aa)	-	Q7Z7F7
ENST00000295008	MRPL55-201	632	XM_005273062	ENSP00000295008	128 (aa)	XP_005273119	Q7Z7F7
ENST00000464148	MRPL55-224	636	-	ENSP00000484813	24 (aa)	-	A0A087X2A2
ENST00000391867	MRPL55-219	685	XM_005273063	ENSP00000375740	128 (aa)	XP_005273120	Q7Z7F7
ENST00000336520	MRPL55-203	744	XM_005273059	ENSP00000337342	128 (aa)	XP_005273116	Q7Z7F7
ENST00000476267	MRPL55-228	169	-	-	- (aa)	-	-
ENST00000495434	MRPL55-232	224	-	ENSP00000479463	8 (aa)	-	A0A0G2JMK5
ENST00000492170	MRPL55-231	241	-	-	- (aa)	-	-
ENST00000483159	MRPL55-229	790	-	ENSP00000479251	4 (aa)	-	UPI00053BD59C
ENST00000465268	MRPL55-225	848	-	-	- (aa)	-	-
ENST00000336300	MRPL55-202	722	-	ENSP00000337361	128 (aa)	-	Q7Z7F7
ENST00000459783	MRPL55-223	694	-	ENSP00000482290	55 (aa)	-	X6R631
ENST00000366741	MRPL55-214	603	-	ENSP00000355702	128 (aa)	-	Q7Z7F7
ENST00000366740	MRPL55-213	644	-	ENSP00000355701	128 (aa)	-	Q7Z7F7
ENST00000348259	MRPL55-204	661	-	ENSP00000338189	128 (aa)	-	Q7Z7F7
ENST00000366742	MRPL55-215	630	-	ENSP00000355703	128 (aa)	-	Q7Z7F7
ENST00000366744	MRPL55-216	726	-	ENSP00000355705	128 (aa)	-	Q7Z7F7
ENST00000366747	MRPL55-218	603	-	ENSP00000355708	128 (aa)	-	Q7Z7F7
ENST00000366746	MRPL55-217	565	-	ENSP00000355707	128 (aa)	-	Q7Z7F7
ENST00000495899	MRPL55-233	790	-	-	- (aa)	-	-
ENST00000473066	MRPL55-226	820	-	-	- (aa)	-	-
ENST00000411464	MRPL55-220	767	-	ENSP00000401737	43 (aa)	-	A0A0A0MST4
ENST00000475832	MRPL55-227	858	-	-	- (aa)	-	-
ENST00000457264	MRPL55-222	544	-	ENSP00000409966	76 (aa)	-	X6RIW1
ENST00000489430	MRPL55-230	847	-	-	- (aa)	-	-
ENST00000366738	MRPL55-211	705	-	ENSP00000355699	164 (aa)	-	Q7Z7F7
ENST00000366739	MRPL55-212	641	-	ENSP00000355700	128 (aa)	-	Q7Z7F7
ENST00000366731	MRPL55-205	1423	-	ENSP00000355692	55 (aa)	-	X6R631
ENST00000366732	MRPL55-206	722	-	ENSP00000355693	55 (aa)	-	X6R631
ENST00000366733	MRPL55-207	834	-	ENSP00000355694	128 (aa)	-	Q7Z7F7
ENST00000366734	MRPL55-208	990	-	ENSP00000355695	128 (aa)	-	Q7Z7F7
ENST00000366735	MRPL55-209	1212	-	ENSP00000355696	128 (aa)	-	Q7Z7F7
ENST00000366736	MRPL55-210	660	-	ENSP00000355697	128 (aa)	-	Q7Z7F7

Gene Model

Click here to download ENSG00000162910's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162910's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162910	MRPL55	93	73.239	ENSAMEG00000016292	MRPL55	95	70.000	Ailuropoda_melanoleuca
ENSG00000162910	MRPL55	100	84.211	ENSANAG00000036592	MRPL55	100	83.594	Aotus_nancymaae
ENSG00000162910	MRPL55	99	69.737	ENSBTAG00000020721	MRPL55	89	69.048	Bos_taurus
ENSG00000162910	MRPL55	100	88.158	ENSCJAG00000016730	MRPL55	100	85.938	Callithrix_jacchus
ENSG00000162910	MRPL55	99	77.333	ENSCAFG00000001176	MRPL55	99	74.400	Canis_familiaris
ENSG00000162910	MRPL55	99	77.333	ENSCAFG00020005742	MRPL55	99	74.400	Canis_lupus_dingo
ENSG00000162910	MRPL55	99	71.053	ENSCHIG00000024153	MRPL55	99	68.254	Capra_hircus
ENSG00000162910	MRPL55	100	78.947	ENSTSYG00000002932	MRPL55	100	77.344	Carlito_syrichta
ENSG00000162910	MRPL55	100	76.364	ENSCAPG00000005899	MRPL55	100	74.016	Cavia_aperea
ENSG00000162910	MRPL55	100	76.364	ENSCPOG00000014241	MRPL55	100	75.781	Cavia_porcellus
ENSG00000162910	MRPL55	99	89.333	ENSCCAG00000031724	MRPL55	100	86.719	Cebus_capucinus
ENSG00000162910	MRPL55	100	93.421	ENSCATG00000001114	MRPL55	100	92.188	Cercocebus_atys
ENSG00000162910	MRPL55	100	80.263	ENSCLAG00000000917	MRPL55	100	78.125	Chinchilla_lanigera
ENSG00000162910	MRPL55	100	93.421	ENSCSAG00000016477	MRPL55	100	91.406	Chlorocebus_sabaeus
ENSG00000162910	MRPL55	100	93.421	ENSCANG00000034934	MRPL55	100	92.188	Colobus_angolensis_palliatus
ENSG00000162910	MRPL55	93	80.282	ENSCGRG00001020506	Mrpl55	97	75.610	Cricetulus_griseus_chok1gshd
ENSG00000162910	MRPL55	100	70.909	ENSCGRG00000002872	Mrpl55	97	73.984	Cricetulus_griseus_crigri
ENSG00000162910	MRPL55	99	74.667	ENSDNOG00000024342	MRPL55	99	69.600	Dasypus_novemcinctus
ENSG00000162910	MRPL55	100	78.947	ENSEASG00005017538	MRPL55	99	75.200	Equus_asinus_asinus
ENSG00000162910	MRPL55	100	78.947	ENSECAG00000019642	MRPL55	99	75.200	Equus_caballus
ENSG00000162910	MRPL55	99	76.000	ENSFCAG00000015199	MRPL55	99	72.800	Felis_catus
ENSG00000162910	MRPL55	100	78.182	ENSFDAG00000006749	MRPL55	100	74.803	Fukomys_damarensis
ENSG00000162910	MRPL55	100	100.000	ENSGGOG00000015709	MRPL55	100	98.438	Gorilla_gorilla
ENSG00000162910	MRPL55	100	76.316	ENSHGLG00000000165	MRPL55	100	74.219	Heterocephalus_glaber_female
ENSG00000162910	MRPL55	100	76.316	ENSHGLG00100007233	MRPL55	100	74.219	Heterocephalus_glaber_male
ENSG00000162910	MRPL55	100	76.316	ENSHGLG00100018781	MRPL55	100	74.219	Heterocephalus_glaber_male
ENSG00000162910	MRPL55	96	78.082	ENSJJAG00000021164	Mrpl55	99	73.810	Jaculus_jaculus
ENSG00000162910	MRPL55	98	66.667	ENSLAFG00000003008	-	93	69.492	Loxodonta_africana
ENSG00000162910	MRPL55	100	93.421	ENSMFAG00000003524	MRPL55	100	91.406	Macaca_fascicularis
ENSG00000162910	MRPL55	100	87.273	ENSMMUG00000002790	MRPL55	100	87.273	Macaca_mulatta
ENSG00000162910	MRPL55	100	93.421	ENSMNEG00000036387	MRPL55	100	91.406	Macaca_nemestrina
ENSG00000162910	MRPL55	100	93.421	ENSMLEG00000043407	MRPL55	100	92.188	Mandrillus_leucophaeus
ENSG00000162910	MRPL55	92	80.000	ENSMAUG00000000347	Mrpl55	97	73.984	Mesocricetus_auratus
ENSG00000162910	MRPL55	100	87.273	ENSMICG00000031760	MRPL55	100	85.938	Microcebus_murinus
ENSG00000162910	MRPL55	96	79.452	ENSMOCG00000022355	Mrpl55	98	73.600	Microtus_ochrogaster
ENSG00000162910	MRPL55	90	59.130	ENSMODG00000013793	-	100	59.130	Monodelphis_domestica
ENSG00000162910	MRPL55	100	72.368	MGP_CAROLIEiJ_G0016428	Mrpl55	98	72.000	Mus_caroli
ENSG00000162910	MRPL55	100	72.368	ENSMUSG00000036860	Mrpl55	98	72.800	Mus_musculus
ENSG00000162910	MRPL55	100	70.909	MGP_PahariEiJ_G0017559	Mrpl55	98	71.200	Mus_pahari
ENSG00000162910	MRPL55	99	72.000	MGP_SPRETEiJ_G0017265	Mrpl55	98	72.000	Mus_spretus
ENSG00000162910	MRPL55	99	78.667	ENSMPUG00000001004	MRPL55	99	73.600	Mustela_putorius_furo
ENSG00000162910	MRPL55	100	77.632	ENSMLUG00000007037	MRPL55	99	73.600	Myotis_lucifugus
ENSG00000162910	MRPL55	95	76.389	ENSNGAG00000023889	Mrpl55	98	69.841	Nannospalax_galili
ENSG00000162910	MRPL55	100	98.182	ENSNLEG00000014215	MRPL55	100	96.875	Nomascus_leucogenys
ENSG00000162910	MRPL55	95	61.538	ENSOPRG00000015086	-	99	55.901	Ochotona_princeps
ENSG00000162910	MRPL55	100	80.000	ENSODEG00000001067	MRPL55	99	77.966	Octodon_degus
ENSG00000162910	MRPL55	99	64.000	ENSOCUG00000027013	-	99	59.200	Oryctolagus_cuniculus
ENSG00000162910	MRPL55	99	73.333	ENSOCUG00000015380	-	96	71.774	Oryctolagus_cuniculus
ENSG00000162910	MRPL55	95	84.615	ENSOGAG00000010981	MRPL55	91	86.087	Otolemur_garnettii
ENSG00000162910	MRPL55	99	72.368	ENSOARG00000006369	MRPL55	99	69.841	Ovis_aries
ENSG00000162910	MRPL55	100	100.000	ENSPPAG00000030545	MRPL55	100	99.219	Pan_paniscus
ENSG00000162910	MRPL55	99	77.333	ENSPPRG00000004595	MRPL55	99	73.600	Panthera_pardus
ENSG00000162910	MRPL55	99	77.333	ENSPTIG00000008780	MRPL55	93	73.600	Panthera_tigris_altaica
ENSG00000162910	MRPL55	100	100.000	ENSPTRG00000002068	MRPL55	100	98.438	Pan_troglodytes
ENSG00000162910	MRPL55	100	92.105	ENSPANG00000017717	MRPL55	100	91.406	Papio_anubis
ENSG00000162910	MRPL55	96	80.822	ENSPEMG00000010381	Mrpl55	98	74.400	Peromyscus_maniculatus_bairdii
ENSG00000162910	MRPL55	100	100.000	ENSPPYG00000000146	-	100	96.875	Pongo_abelii
ENSG00000162910	MRPL55	95	71.154	ENSPCAG00000010591	MRPL55	71	69.565	Procavia_capensis
ENSG00000162910	MRPL55	100	85.526	ENSPCOG00000013827	MRPL55	100	83.594	Propithecus_coquereli
ENSG00000162910	MRPL55	96	79.452	ENSRNOG00000002943	Mrpl55	98	74.400	Rattus_norvegicus
ENSG00000162910	MRPL55	100	93.421	ENSRBIG00000038180	MRPL55	100	92.188	Rhinopithecus_bieti
ENSG00000162910	MRPL55	100	93.421	ENSRROG00000033833	MRPL55	100	92.188	Rhinopithecus_roxellana
ENSG00000162910	MRPL55	99	90.667	ENSSBOG00000035388	MRPL55	100	84.375	Saimiri_boliviensis_boliviensis
ENSG00000162910	MRPL55	99	65.333	ENSSHAG00000014746	-	100	59.524	Sarcophilus_harrisii
ENSG00000162910	MRPL55	99	73.684	ENSSSCG00000029050	MRPL55	99	70.635	Sus_scrofa
ENSG00000162910	MRPL55	99	76.000	ENSUAMG00000016465	-	99	70.400	Ursus_americanus
ENSG00000162910	MRPL55	57	72.093	ENSUAMG00000022827	-	60	50.538	Ursus_americanus
ENSG00000162910	MRPL55	99	74.667	ENSUMAG00000000905	MRPL55	99	69.600	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	-	ISS	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	28892042.	IDA	Component
GO:0005762	mitochondrial large ribosomal subunit	-	ISS	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0006412	translation	-	ISS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	228107825	Missense_Mutation	rs775022732	R24H	0.3	Mitoc_L55
BLCA	chr1	228106788	Missense_Mutation	rs765181332	R120Q	0.12
BRCA	chr1	228108075	Intron	NA		0.17
BRCA	chr1	228107841	Missense_Mutation	NA	T19A	0.12	Mitoc_L55
BRCA	chr1	228108002	Intron	novel		0.16
BRCA	chr1	228107865	Silent	novel	L11L	0.1
COAD	chr1	228107817	Missense_Mutation	NA	H27Y	0.41	Mitoc_L55
COAD	chr1	228108344	Intron	novel		0.25
COAD	chr1	228107755	Silent	novel	A47A	0.34
COAD	chr1	228106907	Silent	NA	D80D	0.2
COAD	chr1	228108051	Intron	rs763406280		0.22
COAD	chr1	228106795	Missense_Mutation	rs758299560	R118C	0.61
COAD	chr1	228108357	Intron	novel		0.05
ESCA	chr1	228106828	Missense_Mutation	rs375373877	E107K	0.51
GBM	chr1	228106700	3'UTR	novel		0.3
GBM	chr1	228106794	Missense_Mutation	rs145809265	R118H	0.36
LGG	chr1	228106876	Missense_Mutation	novel	A91T	0.45
LIHC	chr1	228108009	Intron	novel		0.45
LUAD	chr1	228106857	Missense_Mutation	novel	E97G	0.08
LUSC	chr1	228107829	Missense_Mutation	novel	L23V	0.26	Mitoc_L55
LUSC	chr1	228106680	3'UTR	novel		0.25
LUSC	chr1	228107802	Nonsense_Mutation	rs745358216	R32*	0.19	Mitoc_L55
STAD	chr1	228106789	Nonsense_Mutation	NA	R120*	0.19
STAD	chr1	228106700	3'UTR	novel		0.38
STAD	chr1	228106748	3'UTR	novel		0.23
STAD	chr1	228107995	Intron	NA		0.43
STAD	chr1	228107820	Missense_Mutation	novel	L26M	0.22	Mitoc_L55
STAD	chr1	228106842	Missense_Mutation	rs765396403	S102L	0.46
UCEC	chr1	228106804	Missense_Mutation	novel	H115Y	0.08
UCEC	chr1	228107767	Silent	novel	V43V	0.27
UCEC	chr1	228108013	Intron	NA		0.48
UCEC	chr1	228108284	5'UTR	novel		0.24
UCEC	chr1	228106697	3'UTR	novel		0.35
UCEC	chr1	228106800	Missense_Mutation	novel	V116A	0.29
UCEC	chr1	228107692	Silent	NA	Y68Y	0.21
UCEC	chr1	228108255	Silent	rs767859474	A2A	0.24
UCEC	chr1	228106861	Missense_Mutation	rs751426782	R96C	0.31
UCEC	chr1	228107838	Missense_Mutation	rs766879446	G20R	0.56	Mitoc_L55
UCEC	chr1	228108374	Intron	novel		0.32
UCEC	chr1	228108427	Intron	novel		0.38
UCEC	chr1	228108389	Intron	novel		0.22
UCEC	chr1	228106890	Missense_Mutation	novel	P86H	0.19
UCEC	chr1	228108043	Intron	novel		0.23
UCEC	chr1	228106700	3'UTR	novel		0.22
UCEC	chr1	228106789	Nonsense_Mutation	NA	R120*	0.27
UCEC	chr1	228106878	Missense_Mutation	rs376021962	R90Q	0.65
UCEC	chr1	228108301	5'UTR	novel		0.12
UCEC	chr1	228106680	3'UTR	novel		0.23
UCEC	chr1	228108048	Intron	novel		0.3
UCEC	chr1	228106829	Silent	novel	Y106Y	0.54

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0809	0.033566
DLBC	DEL	0.125	0.0017831
KIRC	DEL	0.0644	0.018371
LGG	DEL	0.0331	0.11599
PCPG	DEL	0.0864	0.12617
PRAD	DEL	0.0772	0.00015401
READ	AMP	0.2545	0.14328
SARC	DEL	0.2957	2.6086e-08
TGCT	DEL	0.0333	0.16985
THYM	AMP	0.187	0.24554
UCEC	AMP	0.3785	2.3921e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.016	Kaplan-Meier Survival Analysis
ACC	0.00025	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PRAD	0.021	Kaplan-Meier Survival Analysis
LUSC	0.047	Kaplan-Meier Survival Analysis
PAAD	0.0016	Kaplan-Meier Survival Analysis
READ	0.022	Kaplan-Meier Survival Analysis
LAML	0.0094	Kaplan-Meier Survival Analysis
CHOL	0.046	Kaplan-Meier Survival Analysis
UVM	0.0071	Kaplan-Meier Survival Analysis
OV	0.00054	Kaplan-Meier Survival Analysis