EuRBPDB

Description

Ensembl ID: ENSG00000163125 (Gene tree)
Gene ID: 23248
Gene Symbol: RPRD2
Alias: FLJ32145|HSPC099|KIAA0460
Full Name: regulation of nuclear pre-mRNA domain containing 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 113,476 bases
Position: chr1:150,363,091-150,476,566
Accession: 29039
RBP type: non-canonical RBP
Summary: (Regulation Of Nuclear Pre-MRNA Domain Containing 2) is a Protein Coding gene. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Gene Expression. An important paralog of this gene is RPRD1A.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000401000	RPRD2-203	7605	XM_017000763	ENSP00000383785	1435 (aa)	XP_016856252	Q5VT52
ENST00000369067	RPRD2-201	1043	-	ENSP00000358063	152 (aa)	-	Q5VT52
ENST00000492220	RPRD2-204	4780	-	-	- (aa)	-	-
ENST00000369068	RPRD2-202	4612	XM_005245033	ENSP00000358064	1461 (aa)	XP_005245090	Q5VT52

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163125	Echocardiography	9.0030247551276E-5	17903301
ENSG00000163125	Neuroblastoma	3.23e-005	23222812
ENSG00000163125	Circadian Rhythm	3E-10	26835600

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163125	rs1694369	1	150378625	A	Blood protein levels	30072576	[NR] unit decrease	0.20090714	EFO_0007937
ENSG00000163125	rs1694369	1	150378625	A	Blood protein levels	30072576	[NR] unit decrease	0.1508924	EFO_0007937
ENSG00000163125	rs1694369	1	150378625	A	Blood protein levels	30072576	[NR] unit decrease	0.15838285	EFO_0007937
ENSG00000163125	rs1694369	1	150378625	A	Blood protein levels	30072576	[0.32-0.41] unit increase	0.366	EFO_0007937
ENSG00000163125	rs16836940	1	150444437	A	Broad depression or bipolar disorder	30626913			EFO_0003761\|EFO_0000289
ENSG00000163125	rs187799739	1	150452900	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000163125	rs12040949	1	150474986	C	Osteoarthritis (hip)	30664745	[1.04-1.09]	1.07	EFO_1000786

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163125	RPRD2	96	97.945	ENSMUSG00000028106	Rprd2	99	90.258	Mus_musculus
ENSG00000163125	RPRD2	78	40.984	ENSMUSG00000027651	Rprd1b	61	38.686	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000993	RNA polymerase II complex binding	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0016591	RNA polymerase II, holoenzyme	21873635.	IBA	Component
GO:0016591	RNA polymerase II, holoenzyme	22231121.	IDA	Component
GO:0031124	mRNA 3'-end processing	21873635.	IBA	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process