EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163239 (Gene tree)
Gene ID: 126668
Gene Symbol: TDRD10
Alias: DKFZp434M202
Full Name: tudor domain containing 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 45,929 bases
Position: chr1:154,502,219-154,548,147
Accession: 25316
RBP type: canonical RBP
Summary: (Tudor Domain Containing 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TDRD1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000357467	TUDOR	PF00567.24	1.6e-09	1	1
ENSP00000357465	TUDOR	PF00567.24	1.7e-09	1	1
ENSP00000357467	RRM_1	PF00076.22	3e-08	1	1
ENSP00000357465	RRM_1	PF00076.22	3.3e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368480	TDRD10-201	1776	XM_011509152	ENSP00000357465	366 (aa)	XP_011507454	Q5VZ19
ENST00000368482	TDRD10-202	2331	XM_011509155	ENSP00000357467	351 (aa)	XP_011507457	Q5VZ19
ENST00000462871	TDRD10-203	489	-	-	- (aa)	-	-
ENST00000479937	TDRD10-205	1327	-	-	- (aa)	-	-
ENST00000468714	TDRD10-204	572	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000163239's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163239	Platelet Function Tests	1.7800600E-005	-
ENSG00000163239	Receptors, Interleukin-6	1.4490000E-008	-
ENSG00000163239	Receptors, Interleukin-6	1.8800000E-010	-
ENSG00000163239	Receptors, Interleukin-6	1.4490000E-008	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163239's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163239	TDRD10	100	91.738	ENSANAG00000027928	TDRD10	100	91.738	Aotus_nancymaae
ENSG00000163239	TDRD10	99	74.499	ENSBTAG00000011881	TDRD10	99	74.499	Bos_taurus
ENSG00000163239	TDRD10	100	91.168	ENSCJAG00000009543	TDRD10	100	91.168	Callithrix_jacchus
ENSG00000163239	TDRD10	100	74.929	ENSCHIG00000022402	TDRD10	100	74.929	Capra_hircus
ENSG00000163239	TDRD10	97	80.059	ENSTSYG00000011904	TDRD10	97	80.059	Carlito_syrichta
ENSG00000163239	TDRD10	100	92.593	ENSCCAG00000021454	TDRD10	100	92.593	Cebus_capucinus
ENSG00000163239	TDRD10	100	91.738	ENSCATG00000039790	TDRD10	100	91.738	Cercocebus_atys
ENSG00000163239	TDRD10	99	94.521	ENSCSAG00000001953	TDRD10	99	94.521	Chlorocebus_sabaeus
ENSG00000163239	TDRD10	91	48.287	ENSCPBG00000024650	TDRD10	91	48.287	Chrysemys_picta_bellii
ENSG00000163239	TDRD10	100	96.011	ENSCANG00000034127	TDRD10	100	96.011	Colobus_angolensis_palliatus
ENSG00000163239	TDRD10	100	79.202	ENSEASG00005000310	TDRD10	100	79.202	Equus_asinus_asinus
ENSG00000163239	TDRD10	100	78.917	ENSECAG00000023297	TDRD10	93	78.917	Equus_caballus
ENSG00000163239	TDRD10	85	46.795	ENSGAGG00000009787	TDRD10	91	46.795	Gopherus_agassizii
ENSG00000163239	TDRD10	100	98.907	ENSGGOG00000040815	TDRD10	100	98.907	Gorilla_gorilla
ENSG00000163239	TDRD10	95	42.941	ENSLACG00000014771	TDRD10	94	43.529	Latimeria_chalumnae
ENSG00000163239	TDRD10	54	76.119	ENSLAFG00000014490	-	100	76.119	Loxodonta_africana
ENSG00000163239	TDRD10	100	96.581	ENSMFAG00000037009	TDRD10	100	96.581	Macaca_fascicularis
ENSG00000163239	TDRD10	100	96.581	ENSMMUG00000019545	TDRD10	100	96.581	Macaca_mulatta
ENSG00000163239	TDRD10	100	96.581	ENSMNEG00000044137	TDRD10	100	96.581	Macaca_nemestrina
ENSG00000163239	TDRD10	100	96.296	ENSMLEG00000035989	TDRD10	100	96.296	Mandrillus_leucophaeus
ENSG00000163239	TDRD10	99	79.656	ENSMICG00000001419	TDRD10	99	79.656	Microcebus_murinus
ENSG00000163239	TDRD10	95	59.654	ENSMODG00000017190	TDRD10	96	59.654	Monodelphis_domestica
ENSG00000163239	TDRD10	96	68.639	ENSMLUG00000017676	TDRD10	94	68.605	Myotis_lucifugus
ENSG00000163239	TDRD10	92	90.237	ENSNLEG00000011370	TDRD10	100	90.237	Nomascus_leucogenys
ENSG00000163239	TDRD10	56	66.162	ENSMEUG00000003705	-	58	65.672	Notamacropus_eugenii
ENSG00000163239	TDRD10	58	62.212	ENSOCUG00000023677	-	93	62.212	Oryctolagus_cuniculus
ENSG00000163239	TDRD10	99	74.571	ENSOARG00000002772	TDRD10	99	74.571	Ovis_aries
ENSG00000163239	TDRD10	100	98.634	ENSPPAG00000025622	TDRD10	100	98.824	Pan_paniscus
ENSG00000163239	TDRD10	100	98.907	ENSPTRG00000001386	TDRD10	100	98.907	Pan_troglodytes
ENSG00000163239	TDRD10	100	96.581	ENSPANG00000023014	TDRD10	100	96.581	Papio_anubis
ENSG00000163239	TDRD10	95	60.519	ENSPCIG00000021750	TDRD10	96	60.519	Phascolarctos_cinereus
ENSG00000163239	TDRD10	68	96.203	ENSPPYG00000000779	-	100	96.203	Pongo_abelii
ENSG00000163239	TDRD10	99	79.885	ENSPCOG00000027913	TDRD10	99	79.885	Propithecus_coquereli
ENSG00000163239	TDRD10	100	95.442	ENSRBIG00000028016	TDRD10	100	95.442	Rhinopithecus_bieti
ENSG00000163239	TDRD10	92	95.975	ENSRROG00000041498	TDRD10	100	95.975	Rhinopithecus_roxellana
ENSG00000163239	TDRD10	100	88.604	ENSSBOG00000016823	TDRD10	100	88.604	Saimiri_boliviensis_boliviensis
ENSG00000163239	TDRD10	95	59.654	ENSSHAG00000014322	TDRD10	96	59.654	Sarcophilus_harrisii
ENSG00000163239	TDRD10	94	78.248	ENSSSCG00000006546	TDRD10	100	78.248	Sus_scrofa
ENSG00000163239	TDRD10	95	75.931	ENSTTRG00000013996	TDRD10	100	75.931	Tursiops_truncatus
ENSG00000163239	TDRD10	87	40.694	ENSXETG00000022972	tdrd10	100	40.625	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	154521362	Silent	NA	T84T	0.26
BLCA	chr1	154544021	Missense_Mutation	novel	L188F	0.33
BRCA	chr1	154544407	Silent	NA	T229T	0.49
BRCA	chr1	154547931	3'UTR	novel		0.35
BRCA	chr1	154544506	Silent	rs768018563	H262H	0.21
BRCA	chr1	154544033	Missense_Mutation	rs143192137	V192I	0.07
BRCA	chr1	154521414	Missense_Mutation	rs543994368	V102M	0.16
BRCA	chr1	154544108	Missense_Mutation	NA	E217K	0.24
BRCA	chr1	154547585	3'UTR	novel		0.21
BRCA	chr1	154544000	Nonsense_Mutation	rs759988293	R181*	0.4
BRCA	chr1	154544931	Missense_Mutation	novel	P312T	0.05
CESC	chr1	154544423	Missense_Mutation	NA	E235K	0.24
CESC	chr1	154544071	Silent	NA	V204V	0.38
CESC	chr1	154544506	Silent	rs768018563	H262H	0.18
CESC	chr1	154547649	3'UTR	novel		0.2
COAD	chr1	154547764	3'UTR	novel		0.06
COAD	chr1	154544461	Silent	rs151222618	R247R	0.36
COAD	chr1	154542753	Silent	NA	K145K	0.32
COAD	chr1	154542780	Missense_Mutation	NA	E154D	0.25
COAD	chr1	154544032	Silent	rs201832003	S191S	0.26
COAD	chr1	154543986	Missense_Mutation	novel	L176P	0.09
COAD	chr1	154521431	Missense_Mutation	NA	R107S	0.4
ESCA	chr1	154542809	Missense_Mutation	novel	P164L	0.23
ESCA	chr1	154520358	Nonsense_Mutation	novel	Q66*	0.23	TUDOR
GBM	chr1	154507280	Silent	NA	L14L	0.31
GBM	chr1	154542063	Missense_Mutation	rs559839407	A137T	0.48
GBM	chr1	154544033	Missense_Mutation	rs143192137	V192I	0.31
GBM	chr1	154544461	Silent	rs151222618	R247R	0.44
GBM	chr1	154521476	Silent	novel	P122P	0.46
GBM	chr1	154547502	Nonsense_Mutation	novel	L349*	0.25
HNSC	chr1	154542745	Missense_Mutation	rs779845457	A143T	0.09
HNSC	chr1	154520333	Missense_Mutation	novel	F57L	0.16	TUDOR
HNSC	chr1	154544061	Missense_Mutation	rs546615227	T201M	0.36
HNSC	chr1	154544519	Splice_Site	novel	X266_splice	0.33
HNSC	chr1	154520333	Silent	novel	F57F	0.09
KIRC	chr1	154521403	Missense_Mutation	rs768196430	R98Q	0.24	TUDOR
KIRP	chr1	154521359	Silent	novel	V83V	0.09
KIRP	chr1	154547691	3'UTR	novel		0.39
LAML	chr1	154547830	3'UTR	novel		0.17
LAML	chr1	154544037	Missense_Mutation	rs751439221	R193H	0.5
LAML	chr1	154547829	3'UTR	novel		0.15
LGG	chr1	154544033	Missense_Mutation	rs143192137	V192I	0.27
LGG	chr1	154521475	Missense_Mutation	rs202037343	P122L	0.45
LGG	chr1	154547800	3'UTR	novel		0.33
LIHC	chr1	154544443	Silent	novel	E241E	0.13
LIHC	chr1	154544923	Missense_Mutation	novel	L309Q	0.12
LIHC	chr1	154547452	Silent	novel	G332G	0.22
LUAD	chr1	154544864	Silent	NA	T289T	0.25
LUAD	chr1	154544037	Missense_Mutation	NA	R193L	0.38
LUAD	chr1	154508479	Nonsense_Mutation	NA	K47*	0.2	TUDOR
LUAD	chr1	154547408	Splice_Site	NA	X318_splice	0.11
LUAD	chr1	154508427	Missense_Mutation	novel	F29L	0.08
LUAD	chr1	154521385	Missense_Mutation	NA	G92A	0.04	TUDOR
LUAD	chr1	154543965	Missense_Mutation	NA	G169V	0.36
LUSC	chr1	154544016	Missense_Mutation	novel	L186Q	0.32
LUSC	chr1	154542788	Missense_Mutation	novel	R157M	0.23
LUSC	chr1	154542809	Missense_Mutation	novel	P164R	0.27
LUSC	chr1	154520335	Missense_Mutation	rs370275136	N58S	0.31	TUDOR
OV	chr1	154544495	Missense_Mutation	novel	D259Y	0.09
OV	chr1	154543975	Silent	novel	L172L	0.03
OV	chr1	154544029	Missense_Mutation	NA	H190Q	0.16
PAAD	chr1	154547592	3'UTR	novel		0.26
PAAD	chr1	154542818	Missense_Mutation	novel	M167T	0.48
PRAD	chr1	154520338	Missense_Mutation	novel	P59H	0.14	TUDOR
READ	chr1	154544859	Missense_Mutation	NA	A288T	0.35
READ	chr1	154542063	Missense_Mutation	rs559839407	A137T	0.42
SKCM	chr1	154547649	3'UTR	novel		0.23
SKCM	chr1	154543968	Missense_Mutation	novel	S170F	0.13
SKCM	chr1	154520307	Missense_Mutation	NA	E49K	0.34	TUDOR
SKCM	chr1	154544434	Silent	NA	P238P	0.2
SKCM	chr1	154544072	Missense_Mutation	NA	P205S	0.35
SKCM	chr1	154544035	Silent	NA	V192V	0.32
SKCM	chr1	154521473	Silent	novel	A121A	0.51
SKCM	chr1	154521474	Missense_Mutation	novel	P122S	0.51
SKCM	chr1	154544039	Missense_Mutation	novel	G194R	0.06
SKCM	chr1	154508469	Silent	novel	L43L	0.33
SKCM	chr1	154508464	Missense_Mutation	NA	P42S	0.37	TUDOR
SKCM	chr1	154520327	Silent	novel	K55K	0.43
SKCM	chr1	154520328	Missense_Mutation	NA	D56N	0.44	TUDOR
SKCM	chr1	154544080	Silent	rs746297703	T207T	0.57
SKCM	chr1	154547818	3'UTR	novel		0.2
SKCM	chr1	154547452	Silent	NA	G332G	0.32
SKCM	chr1	154544808	Missense_Mutation	novel	D271N	0.22
SKCM	chr1	154544850	Missense_Mutation	NA	G285R	0.29
SKCM	chr1	154507289	Silent	novel	K17K	0.44
SKCM	chr1	154544041	Silent	NA	G194G	0.11
SKCM	chr1	154521403	Missense_Mutation	rs768196430	R98Q	0.34	TUDOR
SKCM	chr1	154508423	Missense_Mutation	novel	G28E	0.42
SKCM	chr1	154542774	Silent	rs141912752	E152E	0.43
SKCM	chr1	154506877	Splice_Region	NA		0.13
SKCM	chr1	154520330	Silent	novel	D56D	0.25
SKCM	chr1	154544072	Missense_Mutation	NA	P205S	0.65
SKCM	chr1	154547790	3'UTR	novel		0.23
STAD	chr1	154544884	Missense_Mutation	rs199739020	R296H	0.23
STAD	chr1	154547592	3'UTR	novel		0.29
STAD	chr1	154507280	Silent	NA	L14L	0.17
STAD	chr1	154544060	Missense_Mutation	NA	T201A	0.13
STAD	chr1	154521475	Missense_Mutation	rs202037343	P122L	0.18
STAD	chr1	154544901	Missense_Mutation	rs774000552	D302N	0.16
STAD	chr1	154544860	Missense_Mutation	novel	A288V	0.42
STAD	chr1	154521432	Missense_Mutation	novel	P108S	0.29
STAD	chr1	154543990	Silent	novel	R177R	0.17
STAD	chr1	154542036	Missense_Mutation	NA	A128T	0.5
STAD	chr1	154547812	3'UTR	novel		0.34
STAD	chr1	154521342	Missense_Mutation	NA	G78S	0.1	TUDOR
STAD	chr1	154543978	Silent	NA	V173V	0.14
STAD	chr1	154521362	Silent	NA	T84T	0.27
UCEC	chr1	154544884	Missense_Mutation	rs199739020	R296H	0.23
UCEC	chr1	154508447	Missense_Mutation	novel	V36A	0.55	TUDOR
UCEC	chr1	154547585	3'UTR	novel		0.4
UCEC	chr1	154542758	Missense_Mutation	novel	P147H	0.46
UCEC	chr1	154508482	Splice_Site	NA	X47_splice	0.23
UCEC	chr1	154547531	Missense_Mutation	novel	G359R	0.15
UCEC	chr1	154508461	Missense_Mutation	novel	L41I	0.33	TUDOR
UCEC	chr1	154507260	Missense_Mutation	NA	P8S	0.23
UCEC	chr1	154547901	3'UTR	novel		0.45
UCEC	chr1	154547839	3'UTR	novel		0.4
UCEC	chr1	154544069	Missense_Mutation	rs753287462	V204I	0.46
UCEC	chr1	154544469	Missense_Mutation	rs369618965	R250H	0.18
UCEC	chr1	154544453	Missense_Mutation	rs781605784	V245I	0.2
UCEC	chr1	154521481	Splice_Site	novel	X123_splice	0.36
UCEC	chr1	154521472	Missense_Mutation	NA	A121V	0.17
UCEC	chr1	154521402	Nonsense_Mutation	rs141785787	R98*	0.25	TUDOR
UCEC	chr1	154544110	Splice_Region	NA	E217E	0.4
UCEC	chr1	154507293	Nonsense_Mutation	novel	G19*	0.2
UCEC	chr1	154544914	Missense_Mutation	novel	I306T	0.04
UCEC	chr1	154544844	Missense_Mutation	NA	D283Y	0.13
UCEC	chr1	154544069	Missense_Mutation	rs753287462	V204I	0.24
UCEC	chr1	154506902	5'UTR	novel		0.07
UCEC	chr1	154542745	Missense_Mutation	rs779845457	A143T	0.44
UCS	chr1	154521476	Silent	novel	P122P	0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1444	0.11282
CESC	AMP	0.4847	3.2002e-05
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3913	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2283	0.085665
PCPG	AMP	0.1481	0.00029562
PRAD	AMP	0.0772	0.00077815
READ	AMP	0.2667	0.025154
SKCM	AMP	0.4986	9.6912e-06
TGCT	AMP	0.3467	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.02	Kaplan-Meier Survival Analysis
STAD	0.04	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.022	Kaplan-Meier Survival Analysis
HNSC	0.0062	Kaplan-Meier Survival Analysis
PAAD	0.0025	Kaplan-Meier Survival Analysis
UCEC	0.027	Kaplan-Meier Survival Analysis
GBM	0.044	Kaplan-Meier Survival Analysis
LUAD	0.001	Kaplan-Meier Survival Analysis
UVM	0.00017	Kaplan-Meier Survival Analysis