EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163312 (Gene tree)
Gene ID: 113510
Gene Symbol: HELQ
Alias: Hel308
Full Name: helicase, POLQ like
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 48,541 bases
Position: chr4:83,407,343-83,455,883
Accession: 18536
RBP type: canonical RBP
Summary: HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000295488	DEAD	PF00270.29	9.4e-15	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508591	HELQ-203	3429	-	ENSP00000424186	489 (aa)	-	E3W982
ENST00000515482	HELQ-206	574	-	-	- (aa)	-	-
ENST00000510985	HELQ-204	3315	XM_017007679	ENSP00000424539	1034 (aa)	XP_016863168	E3W980
ENST00000295488	HELQ-201	3579	XM_005262711	ENSP00000295488	1101 (aa)	XP_005262768	Q8TDG4
ENST00000440639	HELQ-202	744	-	-	- (aa)	-	-
ENST00000512539	HELQ-205	631	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000163312's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163312	Extraversion (Psychology)	3.601e-005	-
ENSG00000163312	Ankle Brachial Index	7.8328782E-005	-
ENSG00000163312	Head and Neck Neoplasms	1E-8	21437268
ENSG00000163312	Menopause	2E-19	22267201

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163312	rs4693089	4	83452469	A	Menarche (age at onset)	29773799	[0.091-0.197] year decrease	0.144	EFO_0004703
ENSG00000163312	rs7665103	4	83443598	G	Menopause (age at onset)	29773799	[0.091-0.209] year increase	0.15	EFO_0004704
ENSG00000163312	rs4693089	4	83452469	A	Menopause (age at onset)	26414677	[0.16-0.24] years decrease	0.2	EFO_0004704
ENSG00000163312	rs4693089	4	83452469	G	Menopause (age at onset)	22267201	[0.18-0.28] years increase	0.228	EFO_0004704
ENSG00000163312	rs1494961	4	83453327	C	Oral cavity and pharyngeal cancer	21437268	[1.08-1.17]	1.12	EFO_0004284

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163312's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163312	HELQ	75	44.624	ENSAPOG00000013379	-	88	44.624	Acanthochromis_polyacanthus
ENSG00000163312	HELQ	75	44.624	ENSAPOG00000012769	-	92	44.624	Acanthochromis_polyacanthus
ENSG00000163312	HELQ	92	92.527	ENSAMEG00000004921	HELQ	100	89.343	Ailuropoda_melanoleuca
ENSG00000163312	HELQ	89	60.362	ENSACIG00000020216	helq	93	60.362	Amphilophus_citrinellus
ENSG00000163312	HELQ	89	55.849	ENSAOCG00000014323	helq	96	55.849	Amphiprion_ocellaris
ENSG00000163312	HELQ	90	56.884	ENSAPEG00000022964	helq	98	56.884	Amphiprion_percula
ENSG00000163312	HELQ	75	56.643	ENSAPEG00000023153	-	87	56.691	Amphiprion_percula
ENSG00000163312	HELQ	90	56.770	ENSATEG00000023420	helq	94	56.583	Anabas_testudineus
ENSG00000163312	HELQ	90	73.734	ENSAPLG00000012292	HELQ	94	73.734	Anas_platyrhynchos
ENSG00000163312	HELQ	92	62.755	ENSACAG00000010842	HELQ	98	62.755	Anolis_carolinensis
ENSG00000163312	HELQ	100	96.417	ENSANAG00000033513	HELQ	100	94.914	Aotus_nancymaae
ENSG00000163312	HELQ	75	62.440	ENSACLG00000010558	helq	100	62.440	Astatotilapia_calliptera
ENSG00000163312	HELQ	88	62.875	ENSAMXG00000012252	helq	93	62.875	Astyanax_mexicanus
ENSG00000163312	HELQ	100	91.121	ENSBTAG00000018151	HELQ	94	91.121	Bos_taurus
ENSG00000163312	HELQ	70	39.186	WBGene00021905	helq-1	83	39.313	Caenorhabditis_elegans
ENSG00000163312	HELQ	100	96.729	ENSCJAG00000005247	HELQ	100	94.641	Callithrix_jacchus
ENSG00000163312	HELQ	100	83.453	ENSCAFG00000009108	HELQ	100	83.845	Canis_familiaris
ENSG00000163312	HELQ	90	87.751	ENSCAFG00020010495	HELQ	100	87.751	Canis_lupus_dingo
ENSG00000163312	HELQ	100	92.368	ENSCHIG00000020128	HELQ	94	92.368	Capra_hircus
ENSG00000163312	HELQ	99	76.735	ENSTSYG00000012900	HELQ	99	76.075	Carlito_syrichta
ENSG00000163312	HELQ	99	83.931	ENSCPOG00000009180	HELQ	93	83.931	Cavia_porcellus
ENSG00000163312	HELQ	100	96.417	ENSCCAG00000036773	HELQ	100	94.278	Cebus_capucinus
ENSG00000163312	HELQ	100	96.730	ENSCATG00000034442	HELQ	100	96.730	Cercocebus_atys
ENSG00000163312	HELQ	99	84.243	ENSCLAG00000004733	HELQ	94	84.243	Chinchilla_lanigera
ENSG00000163312	HELQ	100	97.196	ENSCSAG00000004405	HELQ	100	96.912	Chlorocebus_sabaeus
ENSG00000163312	HELQ	91	70.748	ENSCPBG00000007787	HELQ	96	71.040	Chrysemys_picta_bellii
ENSG00000163312	HELQ	68	59.574	ENSCING00000006332	-	89	59.574	Ciona_intestinalis
ENSG00000163312	HELQ	100	97.352	ENSCANG00000002407	HELQ	100	96.458	Colobus_angolensis_palliatus
ENSG00000163312	HELQ	87	83.054	ENSCGRG00001024451	Helq	99	83.054	Cricetulus_griseus_chok1gshd
ENSG00000163312	HELQ	91	82.687	ENSCGRG00000000309	Helq	99	82.687	Cricetulus_griseus_crigri
ENSG00000163312	HELQ	89	59.277	ENSCVAG00000020159	helq	99	54.363	Cyprinodon_variegatus
ENSG00000163312	HELQ	89	66.023	ENSDARG00000079818	helq	99	65.737	Danio_rerio
ENSG00000163312	HELQ	68	65.882	FBgn0002899	mus301	70	65.882	Drosophila_melanogaster
ENSG00000163312	HELQ	85	86.667	ENSETEG00000012220	HELQ	85	86.667	Echinops_telfairi
ENSG00000163312	HELQ	100	89.564	ENSEASG00005013248	HELQ	100	85.041	Equus_asinus_asinus
ENSG00000163312	HELQ	99	88.974	ENSECAG00000020717	HELQ	99	84.111	Equus_caballus
ENSG00000163312	HELQ	72	90.909	ENSEEUG00000008373	-	73	88.571	Erinaceus_europaeus
ENSG00000163312	HELQ	91	58.110	ENSELUG00000002083	helq	99	53.458	Esox_lucius
ENSG00000163312	HELQ	100	92.523	ENSFCAG00000009921	HELQ	100	87.024	Felis_catus
ENSG00000163312	HELQ	82	71.064	ENSFALG00000005255	HELQ	94	71.064	Ficedula_albicollis
ENSG00000163312	HELQ	89	88.365	ENSFDAG00000018169	HELQ	100	85.945	Fukomys_damarensis
ENSG00000163312	HELQ	90	56.583	ENSFHEG00000015542	helq	93	56.583	Fundulus_heteroclitus
ENSG00000163312	HELQ	76	60.215	ENSGMOG00000000020	helq	99	60.215	Gadus_morhua
ENSG00000163312	HELQ	91	73.892	ENSGALG00000011208	HELQ	92	73.892	Gallus_gallus
ENSG00000163312	HELQ	93	55.253	ENSGAFG00000008037	helq	95	55.243	Gambusia_affinis
ENSG00000163312	HELQ	76	60.664	ENSGACG00000001186	helq	99	63.373	Gasterosteus_aculeatus
ENSG00000163312	HELQ	90	77.460	ENSGAGG00000015134	HELQ	90	77.460	Gopherus_agassizii
ENSG00000163312	HELQ	100	99.092	ENSGGOG00000008598	HELQ	100	99.092	Gorilla_gorilla
ENSG00000163312	HELQ	89	61.599	ENSHBUG00000001997	helq	92	61.599	Haplochromis_burtoni
ENSG00000163312	HELQ	90	87.421	ENSHGLG00000019137	HELQ	94	87.421	Heterocephalus_glaber_female
ENSG00000163312	HELQ	90	87.421	ENSHGLG00100015489	HELQ	94	87.421	Heterocephalus_glaber_male
ENSG00000163312	HELQ	91	63.880	ENSIPUG00000003800	helq	90	63.880	Ictalurus_punctatus
ENSG00000163312	HELQ	96	78.132	ENSSTOG00000025285	HELQ	98	78.163	Ictidomys_tridecemlineatus
ENSG00000163312	HELQ	94	62.816	ENSKMAG00000016486	helq	94	62.816	Kryptolebias_marmoratus
ENSG00000163312	HELQ	90	54.900	ENSLBEG00000021886	helq	95	54.826	Labrus_bergylta
ENSG00000163312	HELQ	90	67.496	ENSLACG00000010835	HELQ	86	67.496	Latimeria_chalumnae
ENSG00000163312	HELQ	89	67.299	ENSLOCG00000012099	helq	88	67.405	Lepisosteus_oculatus
ENSG00000163312	HELQ	99	90.665	ENSLAFG00000001056	HELQ	94	90.665	Loxodonta_africana
ENSG00000163312	HELQ	100	97.003	ENSMFAG00000040731	HELQ	100	97.003	Macaca_fascicularis
ENSG00000163312	HELQ	100	96.912	ENSMMUG00000015350	HELQ	100	96.912	Macaca_mulatta
ENSG00000163312	HELQ	100	97.094	ENSMNEG00000038829	HELQ	100	97.094	Macaca_nemestrina
ENSG00000163312	HELQ	100	95.980	ENSMLEG00000035125	HELQ	100	93.460	Mandrillus_leucophaeus
ENSG00000163312	HELQ	94	63.766	ENSMAMG00000012364	helq	93	63.766	Mastacembelus_armatus
ENSG00000163312	HELQ	89	61.392	ENSMZEG00005023270	helq	94	56.526	Maylandia_zebra
ENSG00000163312	HELQ	89	74.367	ENSMGAG00000008112	HELQ	100	68.924	Meleagris_gallopavo
ENSG00000163312	HELQ	85	80.220	ENSMAUG00000000249	Helq	99	80.220	Mesocricetus_auratus
ENSG00000163312	HELQ	99	77.455	ENSMOCG00000014354	Helq	99	77.455	Microtus_ochrogaster
ENSG00000163312	HELQ	84	57.384	ENSMMOG00000011313	helq	97	57.384	Mola_mola
ENSG00000163312	HELQ	97	72.787	ENSMODG00000020774	HELQ	99	72.091	Monodelphis_domestica
ENSG00000163312	HELQ	100	83.956	MGP_CAROLIEiJ_G0027457	Helq	93	83.956	Mus_caroli
ENSG00000163312	HELQ	100	75.181	ENSMUSG00000035266	Helq	99	77.381	Mus_musculus
ENSG00000163312	HELQ	100	75.408	MGP_PahariEiJ_G0017235	Helq	99	78.571	Mus_pahari
ENSG00000163312	HELQ	100	84.268	MGP_SPRETEiJ_G0028454	Helq	93	84.268	Mus_spretus
ENSG00000163312	HELQ	87	89.408	ENSMPUG00000014683	HELQ	94	89.408	Mustela_putorius_furo
ENSG00000163312	HELQ	97	83.380	ENSMLUG00000017053	HELQ	100	83.303	Myotis_lucifugus
ENSG00000163312	HELQ	100	98.274	ENSNLEG00000009088	HELQ	100	98.274	Nomascus_leucogenys
ENSG00000163312	HELQ	75	63.385	ENSONIG00000012532	helq	99	63.385	Oreochromis_niloticus
ENSG00000163312	HELQ	65	74.826	ENSOANG00000002113	-	99	74.826	Ornithorhynchus_anatinus
ENSG00000163312	HELQ	100	89.564	ENSOCUG00000013294	HELQ	94	89.564	Oryctolagus_cuniculus
ENSG00000163312	HELQ	77	58.941	ENSORLG00000022717	helq	97	52.772	Oryzias_latipes
ENSG00000163312	HELQ	77	58.920	ENSORLG00015006855	helq	88	59.001	Oryzias_latipes_hsok
ENSG00000163312	HELQ	93	52.229	ENSOMEG00000004983	helq	97	52.326	Oryzias_melastigma
ENSG00000163312	HELQ	100	75.090	ENSOGAG00000014188	HELQ	100	75.090	Otolemur_garnettii
ENSG00000163312	HELQ	100	92.212	ENSOARG00000002630	HELQ	94	92.212	Ovis_aries
ENSG00000163312	HELQ	100	99.183	ENSPPAG00000004520	HELQ	100	99.183	Pan_paniscus
ENSG00000163312	HELQ	100	92.523	ENSPPRG00000010520	HELQ	100	86.673	Panthera_pardus
ENSG00000163312	HELQ	100	92.835	ENSPTIG00000021394	HELQ	100	87.035	Panthera_tigris_altaica
ENSG00000163312	HELQ	100	99.092	ENSPTRG00000016232	HELQ	100	99.092	Pan_troglodytes
ENSG00000163312	HELQ	100	96.912	ENSPANG00000005130	HELQ	100	96.912	Papio_anubis
ENSG00000163312	HELQ	89	60.455	ENSPKIG00000021702	helq	90	60.455	Paramormyrops_kingsleyae
ENSG00000163312	HELQ	89	70.529	ENSPSIG00000015865	HELQ	99	70.629	Pelodiscus_sinensis
ENSG00000163312	HELQ	89	57.013	ENSPMGG00000002986	helq	99	57.013	Periophthalmus_magnuspinnatus
ENSG00000163312	HELQ	97	78.785	ENSPEMG00000007325	Helq	99	78.040	Peromyscus_maniculatus_bairdii
ENSG00000163312	HELQ	76	60.870	ENSPMAG00000004427	helq	100	60.836	Petromyzon_marinus
ENSG00000163312	HELQ	93	73.659	ENSPCIG00000019746	HELQ	99	74.308	Phascolarctos_cinereus
ENSG00000163312	HELQ	90	55.114	ENSPFOG00000002091	helq	96	55.114	Poecilia_formosa
ENSG00000163312	HELQ	92	55.577	ENSPLAG00000015199	helq	96	55.642	Poecilia_latipinna
ENSG00000163312	HELQ	90	56.212	ENSPMEG00000014496	helq	91	56.212	Poecilia_mexicana
ENSG00000163312	HELQ	91	56.139	ENSPREG00000012605	helq	94	56.139	Poecilia_reticulata
ENSG00000163312	HELQ	100	97.911	ENSPPYG00000014897	HELQ	100	97.911	Pongo_abelii
ENSG00000163312	HELQ	87	83.815	ENSPCAG00000004842	HELQ	88	82.629	Procavia_capensis
ENSG00000163312	HELQ	99	80.204	ENSPVAG00000006438	HELQ	100	77.063	Pteropus_vampyrus
ENSG00000163312	HELQ	83	53.738	ENSPNYG00000010575	helq	93	53.738	Pundamilia_nyererei
ENSG00000163312	HELQ	89	62.776	ENSPNAG00000009397	helq	94	62.776	Pygocentrus_nattereri
ENSG00000163312	HELQ	100	84.112	ENSRNOG00000002181	Helq	93	84.112	Rattus_norvegicus
ENSG00000163312	HELQ	100	97.040	ENSRBIG00000041497	HELQ	100	96.549	Rhinopithecus_bieti
ENSG00000163312	HELQ	100	96.885	ENSRROG00000045128	HELQ	100	96.549	Rhinopithecus_roxellana
ENSG00000163312	HELQ	100	96.262	ENSSBOG00000034314	HELQ	100	91.281	Saimiri_boliviensis_boliviensis
ENSG00000163312	HELQ	99	71.351	ENSSHAG00000006446	HELQ	99	71.623	Sarcophilus_harrisii
ENSG00000163312	HELQ	75	62.724	ENSSFOG00015019460	helq	93	62.754	Scleropages_formosus
ENSG00000163312	HELQ	92	62.342	ENSSDUG00000015665	helq	92	62.342	Seriola_dumerili
ENSG00000163312	HELQ	80	47.619	ENSSLDG00000009263	-	82	47.619	Seriola_lalandi_dorsalis
ENSG00000163312	HELQ	84	84.466	ENSSARG00000013932	HELQ	100	84.466	Sorex_araneus
ENSG00000163312	HELQ	77	55.958	ENSSPAG00000008705	helq	86	56.192	Stegastes_partitus
ENSG00000163312	HELQ	100	87.003	ENSSSCG00000009236	HELQ	100	86.543	Sus_scrofa
ENSG00000163312	HELQ	90	67.200	ENSTGUG00000002154	HELQ	100	67.200	Taeniopygia_guttata
ENSG00000163312	HELQ	89	62.184	ENSTRUG00000018644	helq	89	62.184	Takifugu_rubripes
ENSG00000163312	HELQ	76	61.950	ENSTNIG00000005673	helq	99	61.950	Tetraodon_nigroviridis
ENSG00000163312	HELQ	98	91.900	ENSTTRG00000004895	HELQ	100	87.228	Tursiops_truncatus
ENSG00000163312	HELQ	100	92.523	ENSUAMG00000012816	HELQ	94	92.523	Ursus_americanus
ENSG00000163312	HELQ	100	92.523	ENSUMAG00000008823	HELQ	94	92.523	Ursus_maritimus
ENSG00000163312	HELQ	100	83.031	ENSVPAG00000011357	HELQ	100	83.031	Vicugna_pacos
ENSG00000163312	HELQ	100	83.424	ENSVVUG00000015676	HELQ	100	83.424	Vulpes_vulpes
ENSG00000163312	HELQ	76	69.332	ENSXETG00000001831	helq	100	69.332	Xenopus_tropicalis
ENSG00000163312	HELQ	75	61.198	ENSXCOG00000016210	helq	99	61.916	Xiphophorus_couchianus
ENSG00000163312	HELQ	75	61.198	ENSXMAG00000012563	helq	99	61.916	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	19995904.	IMP	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	24005329.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function