EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163412 (Gene tree)
Gene ID: 317649
Gene Symbol: EIF4E3
Alias: MGC39820
Full Name: eukaryotic translation initiation factor 4E family member 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 79,358 bases
Position: chr3:71,675,416-71,754,773
Accession: 31837
RBP type: canonical RBP
Summary: EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000393324	IF4E	PF01652.18	5.8e-39	1	1
ENSP00000418211	IF4E	PF01652.18	2.4e-20	1	1
ENSP00000295612	IF4E	PF01652.18	2.5e-20	1	1
ENSP00000374476	IF4E	PF01652.18	2.5e-20	1	1
ENSP00000410350	IF4E	PF01652.18	2.5e-20	1	1
ENSP00000411762	IF4E	PF01652.18	2.5e-20	1	1
ENSP00000417889	IF4E	PF01652.18	5.8e-11	1	1
ENSP00000419421	IF4E	PF01652.18	1.4e-09	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496214	EIF4E3-209	613	-	ENSP00000417889	51 (aa)	-	C9J6E5
ENST00000448225	EIF4E3-205	6209	XM_017006282	ENSP00000410350	118 (aa)	XP_016861771	Q8N5X7
ENST00000468147	EIF4E3-206	567	-	-	- (aa)	-	-
ENST00000389826	EIF4E3-202	6083	-	ENSP00000374476	118 (aa)	-	Q8N5X7
ENST00000421769	EIF4E3-203	777	-	ENSP00000411762	118 (aa)	-	Q8N5X7
ENST00000469524	EIF4E3-207	519	-	ENSP00000419421	44 (aa)	-	C9JUY2
ENST00000481525	EIF4E3-208	531	-	-	- (aa)	-	-
ENST00000425534	EIF4E3-204	9949	XM_011533651	ENSP00000393324	224 (aa)	XP_011531953	Q8N5X7
ENST00000295612	EIF4E3-201	2764	-	ENSP00000295612	118 (aa)	-	Q8N5X7
ENST00000497838	EIF4E3-210	693	-	ENSP00000418211	93 (aa)	-	C9J7Z6

Gene Model

Click here to download ENSG00000163412's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163412	Vascular Diseases	1.5540000E-005	-
ENSG00000163412	Hypertension	3.2335514E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163412	rs34778241	3	71722065	TG	Granulocyte percentage of myeloid white cells	27863252	[0.019-0.035] unit increase	0.02692521	EFO_0007997
ENSG00000163412	rs34778241	3	71722065	TG	Monocyte percentage of white cells	27863252	[0.023-0.038] unit decrease	0.03031825	EFO_0007989
ENSG00000163412	rs12487980	3	71710890	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163412's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000163412	EIF4E3	89	41.026	ENSG00000135930	EIF4E2	81	32.597
ENSG00000163412	EIF4E3	90	31.818	ENSG00000151247	EIF4E	65	31.068

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163412	EIF4E3	100	90.909	ENSAPOG00000016094	eif4e3	81	82.584	Acanthochromis_polyacanthus
ENSG00000163412	EIF4E3	100	93.182	ENSAPOG00000014276	EIF4E3	78	84.270	Acanthochromis_polyacanthus
ENSG00000163412	EIF4E3	100	96.875	ENSAMEG00000015115	EIF4E3	100	97.633	Ailuropoda_melanoleuca
ENSG00000163412	EIF4E3	100	90.909	ENSACIG00000000059	eif4e3	81	82.022	Amphilophus_citrinellus
ENSG00000163412	EIF4E3	100	88.636	ENSACIG00000021312	-	78	82.584	Amphilophus_citrinellus
ENSG00000163412	EIF4E3	100	90.909	ENSAOCG00000024717	-	78	83.708	Amphiprion_ocellaris
ENSG00000163412	EIF4E3	100	90.909	ENSAOCG00000022785	eif4e3	81	82.584	Amphiprion_ocellaris
ENSG00000163412	EIF4E3	100	90.909	ENSAPEG00000021766	-	78	83.708	Amphiprion_percula
ENSG00000163412	EIF4E3	100	90.909	ENSAPEG00000018566	EIF4E3	84	80.435	Amphiprion_percula
ENSG00000163412	EIF4E3	100	95.455	ENSATEG00000008530	EIF4E3	81	80.978	Anabas_testudineus
ENSG00000163412	EIF4E3	100	90.909	ENSATEG00000020241	eif4e3	84	79.891	Anabas_testudineus
ENSG00000163412	EIF4E3	100	90.909	ENSACAG00000013899	EIF4E3	96	81.043	Anolis_carolinensis
ENSG00000163412	EIF4E3	100	100.000	ENSANAG00000031727	EIF4E3	99	97.129	Aotus_nancymaae
ENSG00000163412	EIF4E3	100	90.909	ENSACLG00000022985	EIF4E3	81	80.978	Astatotilapia_calliptera
ENSG00000163412	EIF4E3	100	93.182	ENSAMXG00000036675	eif4e3	85	79.058	Astyanax_mexicanus
ENSG00000163412	EIF4E3	100	100.000	ENSBTAG00000018862	EIF4E3	88	97.436	Bos_taurus
ENSG00000163412	EIF4E3	100	100.000	ENSCJAG00000044237	EIF4E3	100	97.321	Callithrix_jacchus
ENSG00000163412	EIF4E3	100	100.000	ENSCAFG00000006445	EIF4E3	84	91.192	Canis_familiaris
ENSG00000163412	EIF4E3	100	100.000	ENSCAFG00020016724	EIF4E3	100	99.153	Canis_lupus_dingo
ENSG00000163412	EIF4E3	100	100.000	ENSCHIG00000024333	EIF4E3	88	96.923	Capra_hircus
ENSG00000163412	EIF4E3	100	100.000	ENSTSYG00000011259	EIF4E3	100	100.000	Carlito_syrichta
ENSG00000163412	EIF4E3	96	94.690	ENSCAPG00000013651	EIF4E3	85	94.690	Cavia_aperea
ENSG00000163412	EIF4E3	100	100.000	ENSCPOG00000000391	EIF4E3	90	96.277	Cavia_porcellus
ENSG00000163412	EIF4E3	100	100.000	ENSCCAG00000002248	EIF4E3	100	96.875	Cebus_capucinus
ENSG00000163412	EIF4E3	100	92.473	ENSCATG00000031817	-	95	86.802	Cercocebus_atys
ENSG00000163412	EIF4E3	100	100.000	ENSCATG00000042150	-	100	100.000	Cercocebus_atys
ENSG00000163412	EIF4E3	100	100.000	ENSCLAG00000003818	EIF4E3	100	98.305	Chinchilla_lanigera
ENSG00000163412	EIF4E3	100	100.000	ENSCSAG00000011556	-	100	98.214	Chlorocebus_sabaeus
ENSG00000163412	EIF4E3	100	95.763	ENSCSAG00000000894	-	100	95.763	Chlorocebus_sabaeus
ENSG00000163412	EIF4E3	100	100.000	ENSCHOG00000009047	EIF4E3	100	98.182	Choloepus_hoffmanni
ENSG00000163412	EIF4E3	100	93.548	ENSCPBG00000006415	EIF4E3	87	88.144	Chrysemys_picta_bellii
ENSG00000163412	EIF4E3	100	56.818	ENSCING00000000308	-	82	54.404	Ciona_intestinalis
ENSG00000163412	EIF4E3	100	54.839	ENSCSAVG00000001252	-	84	54.404	Ciona_savignyi
ENSG00000163412	EIF4E3	100	95.455	ENSCANG00000034117	-	86	87.245	Colobus_angolensis_palliatus
ENSG00000163412	EIF4E3	100	100.000	ENSCANG00000036517	-	100	100.000	Colobus_angolensis_palliatus
ENSG00000163412	EIF4E3	100	100.000	ENSCGRG00001016500	Eif4e3	93	93.299	Cricetulus_griseus_chok1gshd
ENSG00000163412	EIF4E3	100	100.000	ENSCGRG00000007847	Eif4e3	93	92.398	Cricetulus_griseus_crigri
ENSG00000163412	EIF4E3	100	88.636	ENSCSEG00000007779	-	85	77.487	Cynoglossus_semilaevis
ENSG00000163412	EIF4E3	100	90.909	ENSCSEG00000018457	eif4e3	81	80.337	Cynoglossus_semilaevis
ENSG00000163412	EIF4E3	91	82.500	ENSCVAG00000023205	eif4e3	69	79.279	Cyprinodon_variegatus
ENSG00000163412	EIF4E3	100	90.909	ENSCVAG00000020000	-	79	81.461	Cyprinodon_variegatus
ENSG00000163412	EIF4E3	100	93.182	ENSDARG00000005078	eif4e3	85	79.058	Danio_rerio
ENSG00000163412	EIF4E3	100	100.000	ENSDNOG00000039475	EIF4E3	63	98.214	Dasypus_novemcinctus
ENSG00000163412	EIF4E3	100	95.455	ENSDORG00000006531	Eif4e3	100	91.515	Dipodomys_ordii
ENSG00000163412	EIF4E3	100	77.273	ENSEBUG00000005603	eif4e3	69	70.073	Eptatretus_burgeri
ENSG00000163412	EIF4E3	100	100.000	ENSEASG00005002204	EIF4E3	87	97.949	Equus_asinus_asinus
ENSG00000163412	EIF4E3	100	100.000	ENSECAG00000004471	EIF4E3	100	95.536	Equus_caballus
ENSG00000163412	EIF4E3	100	98.039	ENSEEUG00000008916	EIF4E3	100	96.454	Erinaceus_europaeus
ENSG00000163412	EIF4E3	100	88.636	ENSELUG00000003543	-	88	77.487	Esox_lucius
ENSG00000163412	EIF4E3	100	95.455	ENSELUG00000019727	eif4e3	71	85.000	Esox_lucius
ENSG00000163412	EIF4E3	100	100.000	ENSFCAG00000025548	EIF4E3	100	99.153	Felis_catus
ENSG00000163412	EIF4E3	100	90.909	ENSFALG00000013420	EIF4E3	91	80.729	Ficedula_albicollis
ENSG00000163412	EIF4E3	100	100.000	ENSFDAG00000006089	EIF4E3	99	91.304	Fukomys_damarensis
ENSG00000163412	EIF4E3	100	90.909	ENSFHEG00000017632	-	79	81.461	Fundulus_heteroclitus
ENSG00000163412	EIF4E3	100	90.909	ENSFHEG00000008279	eif4e3	83	80.899	Fundulus_heteroclitus
ENSG00000163412	EIF4E3	100	95.455	ENSGMOG00000007389	-	89	82.065	Gadus_morhua
ENSG00000163412	EIF4E3	100	90.909	ENSGMOG00000010140	eif4e3	82	79.775	Gadus_morhua
ENSG00000163412	EIF4E3	100	86.364	ENSGALG00000007780	EIF4E3	97	80.402	Gallus_gallus
ENSG00000163412	EIF4E3	100	90.909	ENSGAFG00000004090	eif4e3	83	79.775	Gambusia_affinis
ENSG00000163412	EIF4E3	100	90.909	ENSGAFG00000009003	EIF4E3	78	80.337	Gambusia_affinis
ENSG00000163412	EIF4E3	100	88.636	ENSGACG00000003392	eif4e3	84	79.330	Gasterosteus_aculeatus
ENSG00000163412	EIF4E3	100	93.182	ENSGACG00000011825	-	84	79.121	Gasterosteus_aculeatus
ENSG00000163412	EIF4E3	100	93.182	ENSGAGG00000022510	EIF4E3	87	87.629	Gopherus_agassizii
ENSG00000163412	EIF4E3	100	100.000	ENSGGOG00000042096	-	100	100.000	Gorilla_gorilla
ENSG00000163412	EIF4E3	100	88.636	ENSHBUG00000007849	eif4e3	81	79.775	Haplochromis_burtoni
ENSG00000163412	EIF4E3	100	93.182	ENSHBUG00000010777	EIF4E3	81	81.522	Haplochromis_burtoni
ENSG00000163412	EIF4E3	100	100.000	ENSHGLG00000019560	EIF4E3	100	96.610	Heterocephalus_glaber_female
ENSG00000163412	EIF4E3	100	100.000	ENSHGLG00100015788	EIF4E3	100	96.610	Heterocephalus_glaber_male
ENSG00000163412	EIF4E3	100	68.182	ENSHCOG00000012145	eif4e3	79	57.865	Hippocampus_comes
ENSG00000163412	EIF4E3	100	69.492	ENSHCOG00000010757	EIF4E3	78	75.281	Hippocampus_comes
ENSG00000163412	EIF4E3	100	93.182	ENSIPUG00000007049	eif4e3	80	83.240	Ictalurus_punctatus
ENSG00000163412	EIF4E3	100	97.727	ENSSTOG00000020469	EIF4E3	100	94.915	Ictidomys_tridecemlineatus
ENSG00000163412	EIF4E3	100	100.000	ENSJJAG00000002638	Eif4e3	88	97.590	Jaculus_jaculus
ENSG00000163412	EIF4E3	100	90.909	ENSKMAG00000010167	eif4e3	82	80.337	Kryptolebias_marmoratus
ENSG00000163412	EIF4E3	100	90.909	ENSKMAG00000004316	EIF4E3	78	82.584	Kryptolebias_marmoratus
ENSG00000163412	EIF4E3	100	90.909	ENSLBEG00000008251	eif4e3	81	81.461	Labrus_bergylta
ENSG00000163412	EIF4E3	100	78.814	ENSLACG00000005925	EIF4E3	85	77.895	Latimeria_chalumnae
ENSG00000163412	EIF4E3	100	93.182	ENSLOCG00000010001	eif4e3	85	79.581	Lepisosteus_oculatus
ENSG00000163412	EIF4E3	100	100.000	ENSLAFG00000001998	EIF4E3	100	97.647	Loxodonta_africana
ENSG00000163412	EIF4E3	100	100.000	ENSMFAG00000039909	EIF4E3	100	100.000	Macaca_fascicularis
ENSG00000163412	EIF4E3	100	63.559	ENSMFAG00000044935	-	90	72.340	Macaca_fascicularis
ENSG00000163412	EIF4E3	98	96.552	ENSMMUG00000007780	EIF4E3	98	96.552	Macaca_mulatta
ENSG00000163412	EIF4E3	100	90.196	ENSMNEG00000043302	-	91	81.538	Macaca_nemestrina
ENSG00000163412	EIF4E3	100	100.000	ENSMNEG00000035212	-	100	100.000	Macaca_nemestrina
ENSG00000163412	EIF4E3	100	92.473	ENSMLEG00000035876	-	92	85.859	Mandrillus_leucophaeus
ENSG00000163412	EIF4E3	100	100.000	ENSMLEG00000038551	-	100	100.000	Mandrillus_leucophaeus
ENSG00000163412	EIF4E3	100	95.455	ENSMAMG00000023426	EIF4E3	81	82.609	Mastacembelus_armatus
ENSG00000163412	EIF4E3	100	88.636	ENSMAMG00000024180	EIF4E3	68	81.461	Mastacembelus_armatus
ENSG00000163412	EIF4E3	100	88.636	ENSMZEG00005026251	eif4e3	81	79.775	Maylandia_zebra
ENSG00000163412	EIF4E3	100	90.909	ENSMZEG00005008767	EIF4E3	81	80.978	Maylandia_zebra
ENSG00000163412	EIF4E3	100	86.364	ENSMGAG00000009619	EIF4E3	100	85.542	Meleagris_gallopavo
ENSG00000163412	EIF4E3	100	100.000	ENSMAUG00000019824	Eif4e3	93	93.782	Mesocricetus_auratus
ENSG00000163412	EIF4E3	100	100.000	ENSMICG00000001125	EIF4E3	94	89.305	Microcebus_murinus
ENSG00000163412	EIF4E3	100	97.727	ENSMOCG00000020297	Eif4e3	93	94.330	Microtus_ochrogaster
ENSG00000163412	EIF4E3	100	90.909	ENSMMOG00000011660	eif4e3	82	80.337	Mola_mola
ENSG00000163412	EIF4E3	100	90.909	ENSMMOG00000010583	EIF4E3	93	80.723	Mola_mola
ENSG00000163412	EIF4E3	100	95.455	ENSMODG00000003899	EIF4E3	91	86.957	Monodelphis_domestica
ENSG00000163412	EIF4E3	100	90.909	ENSMALG00000010770	eif4e3	81	80.899	Monopterus_albus
ENSG00000163412	EIF4E3	100	90.909	ENSMALG00000008769	EIF4E3	79	82.682	Monopterus_albus
ENSG00000163412	EIF4E3	100	100.000	MGP_CAROLIEiJ_G0028685	Eif4e3	93	93.814	Mus_caroli
ENSG00000163412	EIF4E3	100	100.000	ENSMUSG00000093661	Eif4e3	92	95.789	Mus_musculus
ENSG00000163412	EIF4E3	100	100.000	MGP_PahariEiJ_G0022436	Eif4e3	92	95.789	Mus_pahari
ENSG00000163412	EIF4E3	100	100.000	MGP_SPRETEiJ_G0029713	Eif4e3	92	95.789	Mus_spretus
ENSG00000163412	EIF4E3	100	100.000	ENSMPUG00000017002	EIF4E3	62	99.394	Mustela_putorius_furo
ENSG00000163412	EIF4E3	100	100.000	ENSMLUG00000004758	EIF4E3	100	92.473	Myotis_lucifugus
ENSG00000163412	EIF4E3	100	100.000	ENSNGAG00000000837	Eif4e3	93	95.918	Nannospalax_galili
ENSG00000163412	EIF4E3	100	93.182	ENSNBRG00000023984	EIF4E3	81	81.522	Neolamprologus_brichardi
ENSG00000163412	EIF4E3	100	88.636	ENSNBRG00000012239	eif4e3	81	79.775	Neolamprologus_brichardi
ENSG00000163412	EIF4E3	100	99.153	ENSNLEG00000002684	-	100	99.153	Nomascus_leucogenys
ENSG00000163412	EIF4E3	100	95.455	ENSOPRG00000014732	EIF4E3	100	94.545	Ochotona_princeps
ENSG00000163412	EIF4E3	100	98.039	ENSODEG00000006191	EIF4E3	86	97.802	Octodon_degus
ENSG00000163412	EIF4E3	100	90.909	ENSONIG00000016959	eif4e3	81	80.337	Oreochromis_niloticus
ENSG00000163412	EIF4E3	100	90.909	ENSONIG00000020266	EIF4E3	81	80.978	Oreochromis_niloticus
ENSG00000163412	EIF4E3	100	90.909	ENSOANG00000013094	EIF4E3	100	86.471	Ornithorhynchus_anatinus
ENSG00000163412	EIF4E3	100	100.000	ENSOCUG00000000259	EIF4E3	100	95.181	Oryctolagus_cuniculus
ENSG00000163412	EIF4E3	100	88.636	ENSORLG00000013391	EIF4E3	92	80.120	Oryzias_latipes
ENSG00000163412	EIF4E3	100	86.364	ENSORLG00000010970	-	79	81.564	Oryzias_latipes
ENSG00000163412	EIF4E3	100	86.364	ENSORLG00020003751	-	79	81.564	Oryzias_latipes_hni
ENSG00000163412	EIF4E3	100	88.636	ENSORLG00020015316	EIF4E3	84	79.670	Oryzias_latipes_hni
ENSG00000163412	EIF4E3	100	86.364	ENSORLG00015021121	-	79	81.564	Oryzias_latipes_hsok
ENSG00000163412	EIF4E3	100	88.636	ENSORLG00015009312	EIF4E3	88	79.670	Oryzias_latipes_hsok
ENSG00000163412	EIF4E3	100	86.364	ENSOMEG00000004650	eif4e3	86	80.899	Oryzias_melastigma
ENSG00000163412	EIF4E3	100	86.364	ENSOMEG00000001240	-	79	80.447	Oryzias_melastigma
ENSG00000163412	EIF4E3	100	100.000	ENSOGAG00000014590	EIF4E3	100	100.000	Otolemur_garnettii
ENSG00000163412	EIF4E3	100	98.077	ENSOARG00000009622	EIF4E3	100	98.193	Ovis_aries
ENSG00000163412	EIF4E3	100	100.000	ENSPPAG00000035020	-	92	86.885	Pan_paniscus
ENSG00000163412	EIF4E3	100	100.000	ENSPPRG00000004898	EIF4E3	100	99.153	Panthera_pardus
ENSG00000163412	EIF4E3	100	100.000	ENSPTIG00000012645	EIF4E3	100	99.153	Panthera_tigris_altaica
ENSG00000163412	EIF4E3	100	100.000	ENSPTRG00000015102	EIF4E3	100	100.000	Pan_troglodytes
ENSG00000163412	EIF4E3	100	92.373	ENSPANG00000012765	-	100	92.373	Papio_anubis
ENSG00000163412	EIF4E3	100	99.153	ENSPANG00000024441	-	97	98.165	Papio_anubis
ENSG00000163412	EIF4E3	100	90.909	ENSPKIG00000024547	eif4e3	79	80.899	Paramormyrops_kingsleyae
ENSG00000163412	EIF4E3	100	90.909	ENSPKIG00000021599	-	89	79.058	Paramormyrops_kingsleyae
ENSG00000163412	EIF4E3	100	95.455	ENSPSIG00000016957	EIF4E3	100	91.525	Pelodiscus_sinensis
ENSG00000163412	EIF4E3	100	95.455	ENSPMGG00000008853	EIF4E3	79	82.123	Periophthalmus_magnuspinnatus
ENSG00000163412	EIF4E3	100	88.636	ENSPMGG00000009868	eif4e3	82	83.708	Periophthalmus_magnuspinnatus
ENSG00000163412	EIF4E3	100	97.727	ENSPEMG00000015380	Eif4e3	86	93.855	Peromyscus_maniculatus_bairdii
ENSG00000163412	EIF4E3	100	95.455	ENSPCIG00000011825	EIF4E3	89	90.816	Phascolarctos_cinereus
ENSG00000163412	EIF4E3	100	90.909	ENSPFOG00000001273	-	78	80.899	Poecilia_formosa
ENSG00000163412	EIF4E3	100	90.909	ENSPFOG00000007551	eif4e3	83	79.558	Poecilia_formosa
ENSG00000163412	EIF4E3	100	90.909	ENSPLAG00000008729	eif4e3	82	80.337	Poecilia_latipinna
ENSG00000163412	EIF4E3	100	90.909	ENSPLAG00000005792	-	67	85.507	Poecilia_latipinna
ENSG00000163412	EIF4E3	100	90.909	ENSPMEG00000009131	eif4e3	82	80.899	Poecilia_mexicana
ENSG00000163412	EIF4E3	100	90.909	ENSPMEG00000013473	-	78	81.461	Poecilia_mexicana
ENSG00000163412	EIF4E3	100	90.909	ENSPREG00000000653	EIF4E3	78	81.461	Poecilia_reticulata
ENSG00000163412	EIF4E3	100	90.909	ENSPREG00000004801	EIF4E3	71	78.443	Poecilia_reticulata
ENSG00000163412	EIF4E3	100	100.000	ENSPPYG00000013721	-	100	99.394	Pongo_abelii
ENSG00000163412	EIF4E3	100	100.000	ENSPCAG00000002861	EIF4E3	100	98.667	Procavia_capensis
ENSG00000163412	EIF4E3	100	100.000	ENSPCOG00000022529	EIF4E3	100	100.000	Propithecus_coquereli
ENSG00000163412	EIF4E3	100	100.000	ENSPVAG00000005661	EIF4E3	100	99.333	Pteropus_vampyrus
ENSG00000163412	EIF4E3	100	90.909	ENSPNYG00000003711	-	81	80.978	Pundamilia_nyererei
ENSG00000163412	EIF4E3	100	88.636	ENSPNYG00000017704	eif4e3	81	79.775	Pundamilia_nyererei
ENSG00000163412	EIF4E3	100	95.455	ENSPNAG00000029186	eif4e3	79	83.708	Pygocentrus_nattereri
ENSG00000163412	EIF4E3	100	100.000	ENSRNOG00000010301	Eif4e3	93	94.845	Rattus_norvegicus
ENSG00000163412	EIF4E3	100	100.000	ENSRBIG00000028060	EIF4E3	86	99.405	Rhinopithecus_bieti
ENSG00000163412	EIF4E3	100	95.699	ENSRROG00000037656	-	100	94.068	Rhinopithecus_roxellana
ENSG00000163412	EIF4E3	100	100.000	ENSRROG00000014883	EIF4E3	100	100.000	Rhinopithecus_roxellana
ENSG00000163412	EIF4E3	100	100.000	ENSSBOG00000020647	EIF4E3	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000163412	EIF4E3	100	95.455	ENSSHAG00000008775	EIF4E3	100	93.976	Sarcophilus_harrisii
ENSG00000163412	EIF4E3	100	95.455	ENSSFOG00015016279	eif4e3	79	85.475	Scleropages_formosus
ENSG00000163412	EIF4E3	100	93.182	ENSSFOG00015020539	eif4e3	89	75.622	Scleropages_formosus
ENSG00000163412	EIF4E3	100	90.909	ENSSMAG00000006112	eif4e3	66	79.775	Scophthalmus_maximus
ENSG00000163412	EIF4E3	100	93.182	ENSSMAG00000016095	EIF4E3	84	75.135	Scophthalmus_maximus
ENSG00000163412	EIF4E3	100	90.909	ENSSDUG00000020316	eif4e3	83	79.670	Seriola_dumerili
ENSG00000163412	EIF4E3	100	93.182	ENSSDUG00000012045	EIF4E3	78	84.270	Seriola_dumerili
ENSG00000163412	EIF4E3	100	90.909	ENSSLDG00000007755	eif4e3	83	79.670	Seriola_lalandi_dorsalis
ENSG00000163412	EIF4E3	100	93.182	ENSSLDG00000013831	EIF4E3	78	83.708	Seriola_lalandi_dorsalis
ENSG00000163412	EIF4E3	100	86.275	ENSSARG00000008020	-	100	86.508	Sorex_araneus
ENSG00000163412	EIF4E3	100	93.182	ENSSPUG00000011580	EIF4E3	87	82.051	Sphenodon_punctatus
ENSG00000163412	EIF4E3	100	93.182	ENSSPAG00000021234	EIF4E3	78	84.270	Stegastes_partitus
ENSG00000163412	EIF4E3	100	90.909	ENSSPAG00000019336	eif4e3	81	83.146	Stegastes_partitus
ENSG00000163412	EIF4E3	100	100.000	ENSSSCG00000011516	EIF4E3	100	98.305	Sus_scrofa
ENSG00000163412	EIF4E3	100	88.636	ENSTGUG00000009923	EIF4E3	100	84.393	Taeniopygia_guttata
ENSG00000163412	EIF4E3	100	90.909	ENSTRUG00000020181	eif4e3	83	79.096	Takifugu_rubripes
ENSG00000163412	EIF4E3	100	88.636	ENSTRUG00000022670	-	78	79.213	Takifugu_rubripes
ENSG00000163412	EIF4E3	100	90.909	ENSTNIG00000012566	eif4e3	81	79.096	Tetraodon_nigroviridis
ENSG00000163412	EIF4E3	100	93.182	ENSTNIG00000007358	-	78	82.022	Tetraodon_nigroviridis
ENSG00000163412	EIF4E3	100	78.814	ENSTTRG00000005076	EIF4E3	100	84.848	Tursiops_truncatus
ENSG00000163412	EIF4E3	100	100.000	ENSUAMG00000027960	EIF4E3	100	99.153	Ursus_americanus
ENSG00000163412	EIF4E3	100	100.000	ENSUMAG00000024023	EIF4E3	100	99.153	Ursus_maritimus
ENSG00000163412	EIF4E3	92	99.083	ENSVVUG00000013947	-	92	99.083	Vulpes_vulpes
ENSG00000163412	EIF4E3	100	88.636	ENSXETG00000015908	eif4e3	100	85.542	Xenopus_tropicalis
ENSG00000163412	EIF4E3	80	91.429	ENSXCOG00000012981	eif4e3	89	77.064	Xiphophorus_couchianus
ENSG00000163412	EIF4E3	100	90.909	ENSXCOG00000010474	EIF4E3	80	72.821	Xiphophorus_couchianus
ENSG00000163412	EIF4E3	100	90.909	ENSXMAG00000002188	EIF4E3	78	80.899	Xiphophorus_maculatus
ENSG00000163412	EIF4E3	100	90.909	ENSXMAG00000024672	eif4e3	82	79.775	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000340	RNA 7-methylguanosine cap binding	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005845	mRNA cap binding complex	-	ISS	Component
GO:0006413	translational initiation	-	IEA	Process
GO:0006417	regulation of translation	-	IEA	Process
GO:0016281	eukaryotic translation initiation factor 4F complex	21873635.	IBA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	71684698	Missense_Mutation	novel	G220V	0.13
BLCA	chr3	71693930	Missense_Mutation	NA	W139C	0.22
BLCA	chr3	71684674	3'UTR	novel		0.37
BLCA	chr3	71690056	Missense_Mutation	novel	I194M	0.4
BLCA	chr3	71696487	Nonsense_Mutation	novel	W126*	0.31
BRCA	chr3	71699707	Missense_Mutation	novel	I84R	0.07
BRCA	chr3	71684648	3'UTR	novel		0.28
CESC	chr3	71699628	Missense_Mutation	NA	E110D	0.35
CESC	chr3	71684442	3'UTR	novel		0.63
CESC	chr3	71728515	5'Flank	rs753960357		0.41
COAD	chr3	71696492	Missense_Mutation	rs770648457	V125I	0.32
COAD	chr3	71684590	3'UTR	novel		0.17
COAD	chr3	71710481	Silent	NA	S60S	0.29
COAD	chr3	71699624	Nonsense_Mutation	rs149437626	R112*	0.46
COAD	chr3	71699624	Nonsense_Mutation	rs149437626	R112*	0.2
COAD	chr3	71684465	3'UTR	novel		0.6
COAD	chr3	71684508	3'UTR	novel		0.26
COAD	chr3	71684465	3'UTR	novel		0.67
ESCA	chr3	71682963	3'UTR	novel		0.12
ESCA	chr3	71684512	3'UTR	novel		0.5
GBM	chr3	71690033	Missense_Mutation	novel	T202I	0.28
HNSC	chr3	71690163	Missense_Mutation	novel	D159N	0.13
LAML	chr3	71684585	3'UTR	novel		0.08
LUAD	chr3	71699700	Missense_Mutation	NA	W86C	0.24
LUAD	chr3	71684695	Missense_Mutation	rs760948130	R221L	0.15
LUSC	chr3	71690064	Missense_Mutation	NA	E192Q	0.25
LUSC	chr3	71696513	Nonsense_Mutation	NA	E118*	0.58
PRAD	chr3	71696460	Splice_Region	rs530682446	T135T	0.25
READ	chr3	71684595	3'UTR	novel		0.27
READ	chr3	71710454	Silent	rs190555571	C69C	0.22
READ	chr3	71684464	3'UTR	novel		0.58
READ	chr3	71710447	Missense_Mutation	NA	N72H	0.09
SKCM	chr3	71693911	Missense_Mutation	NA	T146A	0.15
SKCM	chr3	71684582	3'UTR	novel		0.45
SKCM	chr3	71684558	3'UTR	novel		0.48
SKCM	chr3	71684559	3'UTR	novel		0.43
STAD	chr3	71696522	Splice_Site	NA	X115_splice	0.16
STAD	chr3	71699646	Silent	rs201139826	Y104Y	0.16
UCEC	chr3	71684442	3'UTR	novel		0.5
UCEC	chr3	71684662	3'UTR	novel		0.3
UCEC	chr3	71728507	5'Flank	novel		0.39
UCEC	chr3	71684442	3'UTR	novel		0.68
UCEC	chr3	71682921	3'UTR	novel		0.47
UCEC	chr3	71684696	Missense_Mutation	rs752533191	R221C	0.48
UCEC	chr3	71684566	3'UTR	novel		0.2
UCEC	chr3	71728485	5'Flank	novel		0.23
UCEC	chr3	71684300	3'UTR	novel		0.31
UCEC	chr3	71684678	3'UTR	novel		0.21
UCEC	chr3	71684441	3'UTR	novel		0.72
UCEC	chr3	71684667	3'UTR	novel		0.44
UCEC	chr3	71699705	Missense_Mutation	novel	F85V	0.29
UCEC	chr3	71684148	3'UTR	novel		0.34
UCEC	chr3	71684442	3'UTR	novel		0.54
UCEC	chr3	71684227	3'UTR	novel		0.05
UCEC	chr3	71684328	3'UTR	novel		0.16
UCEC	chr3	71684667	3'UTR	novel		0.41
UCEC	chr3	71684058	3'UTR	novel		0.7
UCEC	chr3	71684210	3'UTR	novel		0.32
UCEC	chr3	71684595	3'UTR	novel		0.16
UCEC	chr3	71682802	3'UTR	novel		0.39
UCEC	chr3	71684078	3'UTR	novel		0.33
UCEC	chr3	71684618	3'UTR	novel		0.23
UCEC	chr3	71690133	Missense_Mutation	rs145879433	R169W	0.47
UCEC	chr3	71693920	Silent	novel	L143L	0.15
UCEC	chr3	71696469	Missense_Mutation	novel	K132N	0.2
UCEC	chr3	71684442	3'UTR	novel		0.42
UCEC	chr3	71690134	Silent	novel	V168V	0.36
UCEC	chr3	71684540	3'UTR	novel		0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.75	0.016387
LAML	DEL	0.0419	0.020059
TGCT	AMP	0.1733	0.23596
THYM	DEL	0.0894	0.037527

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00012	Kaplan-Meier Survival Analysis
MESO	0.00043	Kaplan-Meier Survival Analysis
ACC	0.0076	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
BRCA	0.0025	Kaplan-Meier Survival Analysis
KIRP	0.043	Kaplan-Meier Survival Analysis
COAD	0.047	Kaplan-Meier Survival Analysis
BLCA	0.029	Kaplan-Meier Survival Analysis
CESC	0.024	Kaplan-Meier Survival Analysis
LAML	0.028	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
GBM	0.041	Kaplan-Meier Survival Analysis
LIHC	0.046	Kaplan-Meier Survival Analysis
LGG	0.0019	Kaplan-Meier Survival Analysis
CHOL	0.0043	Kaplan-Meier Survival Analysis
LUAD	0.0015	Kaplan-Meier Survival Analysis
UVM	0.002	Kaplan-Meier Survival Analysis
OV	0.00011	Kaplan-Meier Survival Analysis