EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163468 (Gene tree)
Gene ID: 7203
Gene Symbol: CCT3
Alias: Cctg|TRIC5
Full Name: chaperonin containing TCP1 subunit 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 58,913 bases
Position: chr1:156,308,961-156,367,873
Accession: 1616
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489870	CCT3-213	827	-	-	- (aa)	-	-
ENST00000368261	CCT3-205	863	-	-	- (aa)	-	-
ENST00000368262	CCT3-206	2048	-	ENSP00000357245	54 (aa)	-	E9PRM9
ENST00000413555	CCT3-207	842	-	ENSP00000413308	276 (aa)	-	Q5SZX6
ENST00000295688	CCT3-201	2150	-	ENSP00000295688	545 (aa)	-	P49368
ENST00000533194	CCT3-216	581	-	ENSP00000434481	144 (aa)	-	E9PQ35
ENST00000496684	CCT3-215	748	-	ENSP00000434232	234 (aa)	-	E9PRC8
ENST00000463132	CCT3-210	610	-	-	- (aa)	-	-
ENST00000490221	CCT3-214	696	-	-	- (aa)	-	-
ENST00000368259	CCT3-204	1815	-	ENSP00000357242	507 (aa)	-	P49368
ENST00000368258	CCT3-203	1885	-	ENSP00000357241	40 (aa)	-	E9PRN0
ENST00000415548	CCT3-208	513	-	ENSP00000413431	161 (aa)	-	Q5SZX9
ENST00000472765	CCT3-211	1858	-	ENSP00000431543	500 (aa)	-	B4DUR8
ENST00000368256	CCT3-202	1063	-	-	- (aa)	-	-
ENST00000478640	CCT3-212	583	-	ENSP00000435026	154 (aa)	-	E9PM09
ENST00000446905	CCT3-209	593	-	ENSP00000388799	188 (aa)	-	Q5SZW8

Gene Model

Click here to download ENSG00000163468's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163468	Platelet Function Tests	1.0100000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163468	rs12132919	1	156348350	A	Glycated hemoglobin levels	28898252	[0.02-0.038] unit decrease	0.0289	EFO_0004541
ENSG00000163468	rs148046772	1	156314104	?	Red blood cell count	29403010	[0.031-0.052] unit decrease novel	0.04182	EFO_0004305
ENSG00000163468	rs148046772	1	156314104	?	Mean corpuscular volume	29403010	[0.046-0.066] unit increase novel	0.05597	EFO_0004526

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163468's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163468	CCT3	99	69.658	FBgn0015019	CCT3	99	69.104	Drosophila_melanogaster
ENSG00000163468	CCT3	100	97.248	ENSMUSG00000001416	Cct3	100	97.248	Mus_musculus
ENSG00000163468	CCT3	97	60.285	YJL014W	CCT3	99	59.699	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002199	zona pellucida receptor complex	-	IEA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	12620389.14532270.16189514.25416956.25467444.27705803.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005832	chaperonin-containing T-complex	21873635.	IBA	Component
GO:0005832	chaperonin-containing T-complex	23011926.	IDA	Component
GO:0005832	chaperonin-containing T-complex	25467444.	TAS	Component
GO:0005856	cytoskeleton	8001976.	TAS	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006457	protein folding	-	TAS	Process
GO:0007339	binding of sperm to zona pellucida	-	IEA	Process
GO:0032212	positive regulation of telomere maintenance via telomerase	25467444.	IMP	Process
GO:0044297	cell body	-	IEA	Component
GO:0046931	pore complex assembly	-	IEA	Process
GO:0050821	protein stabilization	25467444.	IMP	Process
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:1901998	toxin transport	-	IEA	Process
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	156333602	Silent	novel	I83I	0.31
BLCA	chr1	156312182	Silent	NA	L338L	0.32
BLCA	chr1	156335849	Missense_Mutation	novel	S24C	0.29
BLCA	chr1	156312131	Silent	novel	I355I	0.43
BLCA	chr1	156325040	Missense_Mutation	NA	H118Q	0.32
BLCA	chr1	156309266	Missense_Mutation	NA	S524L	0.17
BLCA	chr1	156317528	Missense_Mutation	rs542700328	R260Q	0.25
BLCA	chr1	156310992	Silent	NA	Q453Q	0.09
BLCA	chr1	156320874	Missense_Mutation	novel	E192Q	0.18
BLCA	chr1	156311142	Silent	novel	L403L	0.38
BRCA	chr1	156309125	3'UTR	novel		0.19
BRCA	chr1	156310644	Missense_Mutation	NA	E483K	0.14
BRCA	chr1	156309302	Missense_Mutation	rs763340746	T512M	0.09
BRCA	chr1	156335839	Silent	NA	I27I	0.1
BRCA	chr1	156333640	Nonsense_Mutation	NA	Q71*	0.16
BRCA	chr1	156324992	Silent	novel	I134I	0.13
BRCA	chr1	156338309	5'UTR	novel		0.12
BRCA	chr1	156318917	Missense_Mutation	rs746245572	R237H	0.58
BRCA	chr1	156317534	Missense_Mutation	NA	I258S	0.42
BRCA	chr1	156309031	3'UTR	novel		0.09
CESC	chr1	156338213	5'UTR	novel		0.27
CESC	chr1	156318939	Missense_Mutation	rs375964353	R230W	0.13
CESC	chr1	156321010	Silent	NA	I146I	0.21
CESC	chr1	156311040	Silent	novel	Y437Y	0.12
CESC	chr1	156309155	3'UTR	rs779595127		0.24
COAD	chr1	156338158	Silent	NA	V9V	0.38
COAD	chr1	156320857	Frame_Shift_Del	NA	*K197Nfs23**	0.17
COAD	chr1	156312061	Frame_Shift_Del	novel	*A379Lfs9**	0.21
COAD	chr1	156312212	Silent	novel	G328G	0.64
COAD	chr1	156320948	Missense_Mutation	rs771827407	R167Q	0.34
COAD	chr1	156312146	Frame_Shift_Ins	novel	*L350Ffs9**	0.49
COAD	chr1	156310952	Missense_Mutation	rs747605804	R467W	0.37
COAD	chr1	156309270	Missense_Mutation	rs373870763	V523I	0.36
COAD	chr1	156312104	Silent	novel	T364T	0.19
COAD	chr1	156335861	Missense_Mutation	novel	R20I	0.05
ESCA	chr1	156309223	Silent	novel	G538G	0.08
GBM	chr1	156311076	Silent	novel	K425K	0.21
GBM	chr1	156320904	Missense_Mutation	novel	M182V	0.14
HNSC	chr1	156320995	Missense_Mutation	novel	M151I	0.07
HNSC	chr1	156310947	Splice_Region	novel		0.08
KIRP	chr1	156333552	Missense_Mutation	novel	I100T	0.49
KIRP	chr1	156325067	Silent	NA	A109A	0.46
KIRP	chr1	156309228	Missense_Mutation	novel	G537R	0.21
LAML	chr1	156309143	3'UTR	novel		0.08
LGG	chr1	156317510	Missense_Mutation	rs376476578	R266Q	0.14
LIHC	chr1	156333565	Missense_Mutation	novel	T96S	0.63
LIHC	chr1	156311155	Missense_Mutation	rs758436442	R399H	0.15
LIHC	chr1	156324981	Missense_Mutation	NA	K138R	0.65
LIHC	chr1	156333597	Missense_Mutation	NA	R85P	0.09
LIHC	chr1	156317462	Missense_Mutation	NA	I282N	0.13
LIHC	chr1	156320971	Silent	novel	S159S	0.33
LIHC	chr1	156317241	Missense_Mutation	novel	A300D	0.29
LIHC	chr1	156317448	Missense_Mutation	NA	P287S	0.09
LUAD	chr1	156311025	Missense_Mutation	NA	Q442H	0.1
LUAD	chr1	156338181	Missense_Mutation	NA	M2V	0.16
LUAD	chr1	156320962	Silent	NA	T162T	0.24
LUAD	chr1	156310612	Silent	novel	L493L	0.35
LUAD	chr1	156310952	Frame_Shift_Del	novel	*R467Gfs9**	0.21
LUSC	chr1	156320913	Missense_Mutation	novel	A179S	0.34
LUSC	chr1	156318985	Silent	NA	V214V	0.29
LUSC	chr1	156311195	In_Frame_Ins	novel	S385_E386insLWVPGILS	0.05
LUSC	chr1	156312222	Splice_Site	novel	X325_splice	0.06
LUSC	chr1	156309237	Missense_Mutation	novel	S534G	0.32
LUSC	chr1	156325000	Missense_Mutation	novel	D132H	0.2
LUSC	chr1	156311145	Silent	rs760598581	L402L	0.14
OV	chr1	156318894	Missense_Mutation	NA	L245V	0.26
OV	chr1	156312202	Missense_Mutation	NA	V332L	0.15
PAAD	chr1	156309247	Silent	rs777489338	G530G	0.18
PAAD	chr1	156319006	Silent	novel	G207G	0.09
PAAD	chr1	156311155	Missense_Mutation	rs758436442	R399H	0.11
PAAD	chr1	156312060	Frame_Shift_Ins	novel	*A379Gfs2**	0.09
PRAD	chr1	156318917	Missense_Mutation	rs746245572	R237H	0.35
PRAD	chr1	156309247	Silent	rs777489338	G530G	0.32
READ	chr1	156312046	Missense_Mutation	rs746203604	L384I	0.16
READ	chr1	156310952	Missense_Mutation	rs747605804	R467W	0.19
READ	chr1	156317181	Missense_Mutation	NA	N320T	0.38
SARC	chr1	156310640	Missense_Mutation	rs777799358	T484M	0.28
SARC	chr1	156338346	5'UTR	novel		0.14
SARC	chr1	156338205	5'UTR	novel		0.45
SKCM	chr1	156309114	3'UTR	novel		0.48
SKCM	chr1	156325058	Silent	NA	F112F	0.18
SKCM	chr1	156309068	3'UTR	novel		0.69
SKCM	chr1	156333608	Silent	NA	I81I	0.24
SKCM	chr1	156309153	3'UTR	novel		0.48
SKCM	chr1	156311145	Silent	NA	L402L	0.52
SKCM	chr1	156334758	Missense_Mutation	novel	M54I	0.22
SKCM	chr1	156309271	Silent	NA	I522I	0.07
SKCM	chr1	156317426	Missense_Mutation	novel	K294M	0.73
SKCM	chr1	156312079	Missense_Mutation	NA	T373A	0.37
STAD	chr1	156333607	Missense_Mutation	NA	E82K	0.24
STAD	chr1	156309303	Missense_Mutation	NA	T512A	0.54
STAD	chr1	156317193	Missense_Mutation	NA	R316L	0.42
STAD	chr1	156318975	Missense_Mutation	novel	V218I	0.08
STAD	chr1	156320857	Frame_Shift_Del	NA	*K197Nfs23**	0.1
STAD	chr1	156320857	Frame_Shift_Del	NA	*K197Nfs23**	0.19
STAD	chr1	156318889	Silent	NA	E246E	0.11
THYM	chr1	156319003	Silent	novel	I208I	0.11
UCEC	chr1	156309246	Missense_Mutation	rs755790063	D531N	0.26
UCEC	chr1	156338174	Frame_Shift_Ins	novel	*H4Pfs57**	0.18
UCEC	chr1	156310969	Missense_Mutation	rs201507712	R461H	0.21
UCEC	chr1	156325036	Missense_Mutation	NA	T120A	0.3
UCEC	chr1	156309271	Silent	NA	I522I	0.15
UCEC	chr1	156310598	Missense_Mutation	novel	P498L	0.22
UCEC	chr1	156317446	Silent	novel	P287P	0.4
UCEC	chr1	156311156	Missense_Mutation	rs751780408	R399C	0.46
UCEC	chr1	156334877	Silent	novel	S45S	0.45
UCEC	chr1	156325006	Silent	rs772349487	L130L	0.36
UCEC	chr1	156318981	Missense_Mutation	novel	R216C	0.57
UCEC	chr1	156312157	Missense_Mutation	NA	A347T	0.25
UCEC	chr1	156317505	Missense_Mutation	NA	L268I	0.13
UCEC	chr1	156335866	Silent	rs762586313	S18S	0.23
UCEC	chr1	156320857	Frame_Shift_Del	NA	*K197Nfs23**	0.18
UCEC	chr1	156318918	Missense_Mutation	rs772429212	R237C	0.25
UCEC	chr1	156338210	5'UTR	novel		0.21
UCEC	chr1	156317452	Silent	novel	L285L	0.17
UCEC	chr1	156320880	Missense_Mutation	novel	R190W	0.53
UCEC	chr1	156309133	3'UTR	novel		0.22
UCEC	chr1	156338335	5'UTR	novel		0.5
UCEC	chr1	156312107	Silent	novel	I363I	0.17
UCEC	chr1	156317513	Missense_Mutation	rs750440755	T265I	0.09
UCEC	chr1	156321015	Missense_Mutation	rs753353685	D145N	0.29
UCEC	chr1	156309284	Missense_Mutation	rs745774938	R518Q	0.14
UCEC	chr1	156309126	3'UTR	novel		0.2
UCEC	chr1	156309275	Missense_Mutation	novel	D521G	0.25
UCEC	chr1	156319019	Splice_Site	novel	X204_splice	0.49
UCEC	chr1	156310640	Missense_Mutation	rs777799358	T484M	0.46
UCEC	chr1	156309086	3'UTR	novel		0.2
UCEC	chr1	156320857	Frame_Shift_Del	NA	*K197Nfs23**	0.51
UCEC	chr1	156310982	Frame_Shift_Del	novel	*A457Pfs24**	0.38
UCEC	chr1	156318935	Missense_Mutation	rs138692004	R231H	0.18
UCEC	chr1	156320857	Frame_Shift_Del	NA	*K197Nfs23**	0.29
UCEC	chr1	156309227	Missense_Mutation	NA	G537V	0.27
UCEC	chr1	156319018	Splice_Site	NA	X204_splice	0.26
UCEC	chr1	156334734	Missense_Mutation	novel	D62E	0.26
UCEC	chr1	156335874	Missense_Mutation	novel	R16C	0.47
UCEC	chr1	156312083	Silent	novel	A371A	0.21
UCEC	chr1	156318945	Missense_Mutation	NA	R228C	0.23
UCEC	chr1	156334900	Nonsense_Mutation	novel	R38*	0.3
UCS	chr1	156312140	Missense_Mutation	novel	I352M	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3913	0.0022446
KIRC	AMP	0.0928	0.059566
LGG	AMP	0.0702	0.029503
PAAD	AMP	0.2283	0.085665
READ	AMP	0.2667	0.025154
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.34	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.011	Kaplan-Meier Survival Analysis
MESO	0.00075	Kaplan-Meier Survival Analysis
ACC	0.0011	Kaplan-Meier Survival Analysis
HNSC	0.009	Kaplan-Meier Survival Analysis
SKCM	0.023	Kaplan-Meier Survival Analysis
ESCA	0.0018	Kaplan-Meier Survival Analysis
KIRP	0.00014	Kaplan-Meier Survival Analysis
CESC	0.018	Kaplan-Meier Survival Analysis
LAML	0.00098	Kaplan-Meier Survival Analysis
KICH	0.033	Kaplan-Meier Survival Analysis
UCEC	0.0038	Kaplan-Meier Survival Analysis
GBM	0.0018	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.00023	Kaplan-Meier Survival Analysis
THCA	0.032	Kaplan-Meier Survival Analysis
LUAD	0.00011	Kaplan-Meier Survival Analysis
UVM	0.0064	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742