EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163491 (Gene tree)
Gene ID: 152110
Gene Symbol: NEK10
Alias: FLJ32685
Full Name: NIMA related kinase 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 262,125 bases
Position: chr3:27,107,336-27,369,460
Accession: 18592
RBP type: canonical RBP
Summary: NEK10 (NIMA Related Kinase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK6.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000412651	RIO1	PF01163.22	2.4e-05	1	1
ENSP00000392344	RIO1	PF01163.22	3.5e-05	1	1
ENSP00000343847	RIO1	PF01163.22	0.00026	1	1
ENSP00000395849	RIO1	PF01163.22	0.00052	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000435750	NEK10-208	671	-	ENSP00000395338	132 (aa)	-	C9JJN0
ENST00000424275	NEK10-205	743	-	ENSP00000392344	196 (aa)	-	H7C000
ENST00000341435	NEK10-202	2638	XM_006713002	ENSP00000343847	712 (aa)	XP_006713065	Q6ZWH5
ENST00000295720	NEK10-201	2871	-	ENSP00000295720	484 (aa)	-	Q6ZWH5
ENST00000460447	NEK10-209	654	-	-	- (aa)	-	-
ENST00000498182	NEK10-212	858	-	-	- (aa)	-	-
ENST00000474938	NEK10-210	451	-	-	- (aa)	-	-
ENST00000491627	NEK10-211	3713	-	-	- (aa)	-	-
ENST00000574215	NEK10-213	1601	-	-	- (aa)	-	-
ENST00000435584	NEK10-207	652	-	ENSP00000412651	166 (aa)	-	H7C3L8
ENST00000429845	NEK10-206	4250	XM_006712997	ENSP00000395849	1172 (aa)	XP_006713060	Q6ZWH5
ENST00000383771	NEK10-204	2023	-	ENSP00000373281	474 (aa)	-	Q6ZWH5
ENST00000383770	NEK10-203	1257	-	ENSP00000373280	418 (aa)	-	A0A0A0MRY8

Gene Model

Click here to download ENSG00000163491's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163491	Platelet Function Tests	3.2700000E-008	-
ENSG00000163491	Breast Neoplasms	5E-12	24493630
ENSG00000163491	Alzheimer Disease	7E-6	27770636
ENSG00000163491	Adenocarcinoma of lung	2E-9	27197191
ENSG00000163491	Breast Neoplasms	2E-9	27197191
ENSG00000163491	Carcinoma, Non-Small-Cell Lung	2E-9	27197191
ENSG00000163491	Lung Neoplasms	2E-9	27197191
ENSG00000163491	Ovarian Neoplasms	2E-9	27197191
ENSG00000163491	Prostatic Neoplasms	2E-9	27197191
ENSG00000163491	Colorectal Neoplasms	2E-9	27197191
ENSG00000163491	Carcinoma, Endometrioid	2E-9	27197191

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163491	rs481519	3	27285723	T	Cancer (pleiotropy)	27197191			EFO_0001071\|EFO_1000650\|EFO_0005842\|EFO_1001515\|EFO_0001663\|EFO_1001516\|EFO_0000305\|EFO_0001075\|EFO_0000571\|EFO_0000708
ENSG00000163491	rs148587130	3	27236975	T	Late-onset Alzheimer's disease	27770636	[0.2-0.52] unit increase	0.36	EFO_1001870
ENSG00000163491	rs653465	3	27302153	?	Breast cancer (early onset)	24493630	[1.12-1.23]	1.18	EFO_0000305
ENSG00000163491	rs1357245	3	27145111	G	Breast cancer	19330027	NR	1.06	EFO_0000305
ENSG00000163491	rs116303454	3	27253164	G	CTACK levels	27989323	[0.22-0.54] SD units decrease	0.383	EFO_0008082
ENSG00000163491	rs640065	3	27322446	A	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006335\|EFO_0004329
ENSG00000163491	rs640065	3	27322446	A	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006335\|EFO_0004329
ENSG00000163491	rs640065	3	27322446	A	Diastolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006336\|EFO_0004329
ENSG00000163491	rs640065	3	27322446	A	Pulse pressure x alcohol consumption interaction (2df test)	29912962			EFO_0005763\|EFO_0004329
ENSG00000163491	rs640065	3	27322446	A	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006340\|EFO_0004329
ENSG00000163491	rs479404	3	27321573	C	Uterine fibroids	30194396	[1.06-1.12]	1.09	EFO_0000731
ENSG00000163491	rs1388785	3	27330352	?	White blood cell count	30595370			EFO_0004308
ENSG00000163491	rs60936670	3	27290919	C	Breast cancer	29059683	[0.093-0.118] unit increase	0.1056	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163491's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163491	NEK10	92	83.553	ENSAPOG00000020436	nek10	98	72.973	Acanthochromis_polyacanthus
ENSG00000163491	NEK10	92	84.314	ENSACIG00000009594	nek10	85	66.350	Amphilophus_citrinellus
ENSG00000163491	NEK10	92	84.314	ENSAOCG00000014131	nek10	97	69.697	Amphiprion_ocellaris
ENSG00000163491	NEK10	92	83.660	ENSAPEG00000023859	nek10	97	72.727	Amphiprion_percula
ENSG00000163491	NEK10	92	83.007	ENSATEG00000004240	nek10	99	65.531	Anabas_testudineus
ENSG00000163491	NEK10	100	96.846	ENSANAG00000020680	NEK10	100	96.846	Aotus_nancymaae
ENSG00000163491	NEK10	92	83.660	ENSACLG00000007364	nek10	89	64.946	Astatotilapia_calliptera
ENSG00000163491	NEK10	100	96.505	ENSCJAG00000004112	NEK10	100	96.505	Callithrix_jacchus
ENSG00000163491	NEK10	100	94.283	ENSCAFG00000005667	NEK10	100	94.283	Canis_familiaris
ENSG00000163491	NEK10	98	95.578	ENSCAFG00020024785	NEK10	100	93.962	Canis_lupus_dingo
ENSG00000163491	NEK10	99	93.437	ENSTSYG00000008515	NEK10	100	93.437	Carlito_syrichta
ENSG00000163491	NEK10	100	88.722	ENSCAPG00000010991	NEK10	100	77.954	Cavia_aperea
ENSG00000163491	NEK10	98	92.735	ENSCPOG00000004440	NEK10	99	86.372	Cavia_porcellus
ENSG00000163491	NEK10	100	96.249	ENSCCAG00000036698	NEK10	100	96.348	Cebus_capucinus
ENSG00000163491	NEK10	100	97.528	ENSCATG00000041855	NEK10	100	97.528	Cercocebus_atys
ENSG00000163491	NEK10	98	95.552	ENSCLAG00000011539	NEK10	100	92.065	Chinchilla_lanigera
ENSG00000163491	NEK10	100	97.335	ENSCANG00000037403	NEK10	100	97.335	Colobus_angolensis_palliatus
ENSG00000163491	NEK10	98	92.450	ENSCGRG00001023436	Nek10	100	85.860	Cricetulus_griseus_chok1gshd
ENSG00000163491	NEK10	98	92.450	ENSCGRG00000013312	Nek10	100	85.860	Cricetulus_griseus_crigri
ENSG00000163491	NEK10	92	79.085	ENSCVAG00000014206	nek10	94	65.000	Cyprinodon_variegatus
ENSG00000163491	NEK10	92	83.660	ENSDARG00000025335	nek10	98	62.044	Danio_rerio
ENSG00000163491	NEK10	100	90.930	ENSDNOG00000031050	-	100	94.751	Dasypus_novemcinctus
ENSG00000163491	NEK10	100	91.388	ENSDORG00000007870	Nek10	100	87.425	Dipodomys_ordii
ENSG00000163491	NEK10	92	98.026	ENSETEG00000017523	NEK10	82	97.059	Echinops_telfairi
ENSG00000163491	NEK10	100	94.737	ENSEASG00005006003	NEK10	100	88.276	Equus_asinus_asinus
ENSG00000163491	NEK10	100	93.985	ENSECAG00000020927	NEK10	98	92.918	Equus_caballus
ENSG00000163491	NEK10	100	93.985	ENSEEUG00000002393	NEK10	100	93.544	Erinaceus_europaeus
ENSG00000163491	NEK10	96	80.625	ENSELUG00000013730	nek10	92	61.578	Esox_lucius
ENSG00000163491	NEK10	98	95.983	ENSFCAG00000003130	NEK10	99	95.983	Felis_catus
ENSG00000163491	NEK10	98	95.157	ENSFDAG00000010177	NEK10	100	88.917	Fukomys_damarensis
ENSG00000163491	NEK10	98	82.235	ENSGALG00000011322	NEK10	99	79.050	Gallus_gallus
ENSG00000163491	NEK10	92	77.778	ENSGAFG00000007758	nek10	93	59.135	Gambusia_affinis
ENSG00000163491	NEK10	98	89.700	ENSGAGG00000008088	NEK10	100	86.806	Gopherus_agassizii
ENSG00000163491	NEK10	100	98.485	ENSGGOG00000002819	-	100	98.208	Gorilla_gorilla
ENSG00000163491	NEK10	92	83.660	ENSHBUG00000001070	nek10	91	62.500	Haplochromis_burtoni
ENSG00000163491	NEK10	98	95.299	ENSHGLG00000001531	NEK10	100	92.839	Heterocephalus_glaber_female
ENSG00000163491	NEK10	98	95.299	ENSHGLG00100005213	NEK10	100	92.839	Heterocephalus_glaber_male
ENSG00000163491	NEK10	92	78.947	ENSHCOG00000005982	nek10	98	60.000	Hippocampus_comes
ENSG00000163491	NEK10	92	83.007	ENSIPUG00000023337	nek10	90	62.954	Ictalurus_punctatus
ENSG00000163491	NEK10	98	95.442	ENSSTOG00000012142	NEK10	100	88.321	Ictidomys_tridecemlineatus
ENSG00000163491	NEK10	92	97.386	ENSJJAG00000020269	Nek10	100	84.536	Jaculus_jaculus
ENSG00000163491	NEK10	92	78.947	ENSKMAG00000019830	nek10	96	56.551	Kryptolebias_marmoratus
ENSG00000163491	NEK10	92	89.542	ENSLACG00000008084	NEK10	99	71.580	Latimeria_chalumnae
ENSG00000163491	NEK10	92	88.235	ENSLOCG00000006970	nek10	99	66.188	Lepisosteus_oculatus
ENSG00000163491	NEK10	92	98.693	ENSLAFG00000007538	NEK10	99	89.506	Loxodonta_africana
ENSG00000163491	NEK10	100	97.195	ENSMFAG00000039437	NEK10	100	97.195	Macaca_fascicularis
ENSG00000163491	NEK10	100	97.195	ENSMMUG00000019324	NEK10	100	97.195	Macaca_mulatta
ENSG00000163491	NEK10	100	97.335	ENSMNEG00000009822	NEK10	100	97.335	Macaca_nemestrina
ENSG00000163491	NEK10	100	96.241	ENSMLEG00000036201	NEK10	100	95.993	Mandrillus_leucophaeus
ENSG00000163491	NEK10	92	81.579	ENSMAMG00000011360	nek10	91	62.712	Mastacembelus_armatus
ENSG00000163491	NEK10	92	83.660	ENSMZEG00005015752	nek10	89	65.082	Maylandia_zebra
ENSG00000163491	NEK10	98	96.844	ENSMICG00000048883	NEK10	100	96.844	Microcebus_murinus
ENSG00000163491	NEK10	98	93.447	ENSMOCG00000020582	Nek10	100	82.073	Microtus_ochrogaster
ENSG00000163491	NEK10	100	90.956	ENSMODG00000014978	NEK10	100	90.956	Monodelphis_domestica
ENSG00000163491	NEK10	98	91.869	ENSMUSG00000042567	Nek10	100	85.924	Mus_musculus
ENSG00000163491	NEK10	98	92.297	MGP_PahariEiJ_G0029979	Nek10	100	84.386	Mus_pahari
ENSG00000163491	NEK10	98	91.869	MGP_SPRETEiJ_G0019841	Nek10	100	85.924	Mus_spretus
ENSG00000163491	NEK10	100	95.226	ENSMPUG00000012071	NEK10	100	95.226	Mustela_putorius_furo
ENSG00000163491	NEK10	99	94.969	ENSMLUG00000001441	NEK10	100	92.972	Myotis_lucifugus
ENSG00000163491	NEK10	98	92.877	ENSNGAG00000023750	Nek10	99	91.824	Nannospalax_galili
ENSG00000163491	NEK10	92	84.314	ENSNBRG00000015691	nek10	94	69.199	Neolamprologus_brichardi
ENSG00000163491	NEK10	100	97.475	ENSNLEG00000003860	-	100	97.475	Nomascus_leucogenys
ENSG00000163491	NEK10	98	92.472	ENSODEG00000003264	NEK10	100	87.845	Octodon_degus
ENSG00000163491	NEK10	92	84.314	ENSONIG00000006494	nek10	88	61.779	Oreochromis_niloticus
ENSG00000163491	NEK10	100	92.668	ENSOCUG00000007846	NEK10	100	92.668	Oryctolagus_cuniculus
ENSG00000163491	NEK10	92	82.353	ENSORLG00000016378	nek10	94	59.854	Oryzias_latipes
ENSG00000163491	NEK10	92	81.699	ENSORLG00020012408	nek10	93	63.982	Oryzias_latipes_hni
ENSG00000163491	NEK10	92	82.237	ENSORLG00015018111	nek10	99	72.263	Oryzias_latipes_hsok
ENSG00000163491	NEK10	92	81.699	ENSOMEG00000022133	nek10	94	59.613	Oryzias_melastigma
ENSG00000163491	NEK10	100	99.147	ENSPPAG00000034616	-	100	99.147	Pan_paniscus
ENSG00000163491	NEK10	100	94.373	ENSPPRG00000007741	NEK10	100	94.373	Panthera_pardus
ENSG00000163491	NEK10	100	94.288	ENSPTIG00000014024	NEK10	100	94.288	Panthera_tigris_altaica
ENSG00000163491	NEK10	100	98.977	ENSPTRG00000014703	NEK10	100	98.977	Pan_troglodytes
ENSG00000163491	NEK10	100	97.616	ENSPANG00000009079	NEK10	100	97.616	Papio_anubis
ENSG00000163491	NEK10	92	73.684	ENSPKIG00000010756	nek10	99	63.255	Paramormyrops_kingsleyae
ENSG00000163491	NEK10	92	92.810	ENSPSIG00000006298	NEK10	100	85.192	Pelodiscus_sinensis
ENSG00000163491	NEK10	92	80.392	ENSPMGG00000019772	nek10	99	63.158	Periophthalmus_magnuspinnatus
ENSG00000163491	NEK10	98	93.162	ENSPEMG00000002287	Nek10	100	86.298	Peromyscus_maniculatus_bairdii
ENSG00000163491	NEK10	98	91.453	ENSPCIG00000026845	NEK10	100	90.242	Phascolarctos_cinereus
ENSG00000163491	NEK10	92	78.431	ENSPFOG00000004546	nek10	100	58.732	Poecilia_formosa
ENSG00000163491	NEK10	92	78.431	ENSPLAG00000013390	nek10	92	54.377	Poecilia_latipinna
ENSG00000163491	NEK10	92	78.431	ENSPREG00000001513	nek10	86	58.533	Poecilia_reticulata
ENSG00000163491	NEK10	100	96.241	ENSPCOG00000016215	NEK10	100	95.993	Propithecus_coquereli
ENSG00000163491	NEK10	92	83.660	ENSPNYG00000021708	nek10	89	65.082	Pundamilia_nyererei
ENSG00000163491	NEK10	92	83.007	ENSPNAG00000024773	nek10	99	59.927	Pygocentrus_nattereri
ENSG00000163491	NEK10	98	92.023	ENSRNOG00000005883	Nek10	100	85.579	Rattus_norvegicus
ENSG00000163491	NEK10	100	92.511	ENSRBIG00000038842	NEK10	98	96.595	Rhinopithecus_bieti
ENSG00000163491	NEK10	100	96.675	ENSRROG00000017949	NEK10	100	96.675	Rhinopithecus_roxellana
ENSG00000163491	NEK10	100	94.737	ENSSBOG00000030568	NEK10	100	93.862	Saimiri_boliviensis_boliviensis
ENSG00000163491	NEK10	92	84.314	ENSSFOG00015020979	nek10	99	64.698	Scleropages_formosus
ENSG00000163491	NEK10	92	82.353	ENSSMAG00000014146	nek10	94	59.955	Scophthalmus_maximus
ENSG00000163491	NEK10	92	84.314	ENSSDUG00000011771	nek10	91	64.493	Seriola_dumerili
ENSG00000163491	NEK10	92	83.660	ENSSLDG00000015712	nek10	99	65.992	Seriola_lalandi_dorsalis
ENSG00000163491	NEK10	92	83.007	ENSSPAG00000014548	nek10	95	65.077	Stegastes_partitus
ENSG00000163491	NEK10	98	93.305	ENSUAMG00000027547	NEK10	100	91.932	Ursus_americanus
ENSG00000163491	NEK10	98	93.447	ENSUMAG00000019592	NEK10	100	87.478	Ursus_maritimus
ENSG00000163491	NEK10	100	91.667	ENSVVUG00000028110	NEK10	98	92.970	Vulpes_vulpes
ENSG00000163491	NEK10	92	77.124	ENSXCOG00000007295	nek10	94	56.180	Xiphophorus_couchianus
ENSG00000163491	NEK10	92	77.778	ENSXMAG00000018731	nek10	90	55.583	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004672	protein kinase activity	20956560.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0006468	protein phosphorylation	20956560.	IDA	Process
GO:0031954	positive regulation of protein autophosphorylation	20956560.	IDA	Process
GO:0043406	positive regulation of MAP kinase activity	21873635.	IBA	Process
GO:0043406	positive regulation of MAP kinase activity	20956560.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0070372	regulation of ERK1 and ERK2 cascade	20956560.	IMP	Process
GO:1902749	regulation of cell cycle G2/M phase transition	21873635.	IBA	Process
GO:1902749	regulation of cell cycle G2/M phase transition	20956560.	IMP	Process
GO:1902911	protein kinase complex	20956560.	IDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	27202513	Missense_Mutation	novel	V712A	0.79
BLCA	chr3	27304868	Missense_Mutation	NA	D303N	0.5
BLCA	chr3	27256299	Missense_Mutation	novel	S696F	0.43
BLCA	chr3	27284635	Missense_Mutation	NA	I661V	0.46	RIO1
BLCA	chr3	27192150	Missense_Mutation	NA	S795C	0.3
BLCA	chr3	27284898	Missense_Mutation	rs372441033	S618Y	0.15	RIO1
BLCA	chr3	27291556	Missense_Mutation	novel	F468L	0.1
BLCA	chr3	27291531	Missense_Mutation	NA	D477N	0.17
BLCA	chr3	27284928	Frame_Shift_Ins	novel	*E608Vfs14**	0.07	RIO1
BLCA	chr3	27307915	Silent	novel	L249L	0.13
BLCA	chr3	27162715	Missense_Mutation	novel	S952L	0.38
BLCA	chr3	27119814	Missense_Mutation	novel	H1103N	0.31
BLCA	chr3	27192031	Missense_Mutation	novel	H835Y	0.31
BLCA	chr3	27174465	Nonsense_Mutation	novel	S917*	0.21
BLCA	chr3	27119802	Missense_Mutation	rs147586444	R1107C	0.36
BRCA	chr3	27119856	Missense_Mutation	rs771050920	S1089T	0.04
BRCA	chr3	27202432	Missense_Mutation	novel	T739I	0.07
BRCA	chr3	27174502	Missense_Mutation	NA	E905K	0.16
BRCA	chr3	27291521	Missense_Mutation	novel	A480G	0.35
BRCA	chr3	27352876	Frame_Shift_Del	novel	*P2Ifs6**	0.11
BRCA	chr3	27256327	Missense_Mutation	novel	T687S	0.08
BRCA	chr3	27174461	Missense_Mutation	rs770055117	S918R	0.07
BRCA	chr3	27162479	Nonsense_Mutation	NA	R998*	0.1
BRCA	chr3	27192183	Nonsense_Mutation	NA	S784*	0.18
BRCA	chr3	27202487	Missense_Mutation	novel	Q721E	0.35
BRCA	chr3	27291328	Silent	NA	L513L	0.12
BRCA	chr3	27352825	Nonsense_Mutation	NA	E20*	0.26
BRCA	chr3	27162732	Silent	NA	F946F	0.23
BRCA	chr3	27352826	Missense_Mutation	NA	Q19H	0.31
CESC	chr3	27111083	3'UTR	novel		0.13
CESC	chr3	27291259	Splice_Region	novel		0.48
CESC	chr3	27256331	Missense_Mutation	NA	K685N	0.24
CESC	chr3	27192028	Splice_Site	rs768160759	X835_splice	0.43
CESC	chr3	27162309	Intron	novel		0.56
CESC	chr3	27111137	3'UTR	novel		0.47
CESC	chr3	27119801	Missense_Mutation	rs764433352	R1107H	0.49
CESC	chr3	27192086	Frame_Shift_Del	novel	*F816Lfs28**	0.08
CESC	chr3	27291536	Missense_Mutation	novel	V475A	0.37
CESC	chr3	27346148	Silent	NA	G67G	0.4
CESC	chr3	27290658	Missense_Mutation	rs370504122	V568I	0.42
CESC	chr3	27301749	Nonsense_Mutation	NA	S372*	0.32
COAD	chr3	27201564	Missense_Mutation	NA	Y746F	0.11
COAD	chr3	27295660	Frame_Shift_Ins	novel	*I421Dfs6**	0.03
COAD	chr3	27295662	Frame_Shift_Ins	novel	*L420Sfs2**	0.03
COAD	chr3	27346162	Missense_Mutation	NA	A63T	0.41
COAD	chr3	27111291	Missense_Mutation	NA	N1167I	0.37
COAD	chr3	27192115	Missense_Mutation	rs373926434	R807W	0.06
COAD	chr3	27290720	Missense_Mutation	NA	M547T	0.47
COAD	chr3	27304853	Missense_Mutation	NA	L308I	0.28
COAD	chr3	27346199	Silent	NA	F50F	0.1
COAD	chr3	27174696	Silent	rs753032028	D881D	0.26
COAD	chr3	27304896	Missense_Mutation	NA	I293M	0.13
COAD	chr3	27352505	Missense_Mutation	NA	R31I	0.23
COAD	chr3	27201574	Missense_Mutation	NA	E743Q	0.35
COAD	chr3	27162349	Intron	novel		0.5
COAD	chr3	27111009	3'UTR	novel		0.16
COAD	chr3	27304803	Silent	NA	T324T	0.09
COAD	chr3	27174695	Missense_Mutation	rs371393406	E882K	0.28
COAD	chr3	27310962	Missense_Mutation	rs777808906	S208I	0.31
COAD	chr3	27174456	Missense_Mutation	NA	L920P	0.21
COAD	chr3	27192028	Splice_Site	rs768160759	X835_splice	0.9
COAD	chr3	27192108	Missense_Mutation	rs775535920	R809Q	0.19
COAD	chr3	27301828	Missense_Mutation	NA	N346H	0.25
COAD	chr3	27304935	Silent	NA	E280E	0.13
COAD	chr3	27131965	Nonsense_Mutation	NA	L1056*	0.24
COAD	chr3	27192171	In_Frame_Ins	novel	M788delinsNRL	0.05
COAD	chr3	27352914	5'UTR	rs763922507		0.26
DLBC	chr3	27174690	Silent	novel	I883I	0.39
DLBC	chr3	27192103	Missense_Mutation	rs774551711	R811C	0.27
ESCA	chr3	27293598	Missense_Mutation	rs200628958	L455V	0.71
ESCA	chr3	27310987	Missense_Mutation	novel	D200Y	0.48
GBM	chr3	27174696	Silent	rs753032028	D881D	0.42
GBM	chr3	27192064	Missense_Mutation	rs374938616	V824I	0.55
GBM	chr3	27174481	Missense_Mutation	novel	S912T	0.2
GBM	chr3	27119858	Missense_Mutation	NA	G1088E	0.13
GBM	chr3	27141521	Missense_Mutation	novel	Q1034H	0.24
GBM	chr3	27192181	Missense_Mutation	novel	D785Y	0.29
GBM	chr3	27308978	Missense_Mutation	rs774892094	D222Y	0.25
GBM	chr3	27162524	Missense_Mutation	novel	L983I	0.14
GBM	chr3	27116073	Splice_Site	novel	X1138_splice	0.37
GBM	chr3	27192192	Missense_Mutation	NA	S781L	0.18
GBM	chr3	27304951	Missense_Mutation	rs768893065	R275H	0.07
GBM	chr3	27192117	Missense_Mutation	NA	E806A	0.35
HNSC	chr3	27202479	Silent	rs765884651	A723A	0.22
HNSC	chr3	27312153	Missense_Mutation	novel	Y172H	0.29
HNSC	chr3	27162476	Missense_Mutation	novel	N999Y	0.34
HNSC	chr3	27174655	Missense_Mutation	novel	E895G	0.29
HNSC	chr3	27192144	Missense_Mutation	novel	S797C	0.29
HNSC	chr3	27307905	Missense_Mutation	novel	E253Q	0.62
HNSC	chr3	27202522	Missense_Mutation	novel	K709T	0.43
HNSC	chr3	27116112	Missense_Mutation	rs111622636	I1126T	0.24
HNSC	chr3	27141548	Silent	novel	V1025V	0.11
KICH	chr3	27192103	Missense_Mutation	rs774551711	R811C	0.17
KIRC	chr3	27291504	In_Frame_Ins	novel	S486_K487insSTS	0.04
KIRP	chr3	27119794	In_Frame_Ins	novel	S1109dup	0.39
KIRP	chr3	27256307	Silent	NA	I693I	0.36
KIRP	chr3	27256308	Missense_Mutation	NA	I693N	0.33
KIRP	chr3	27304783	Frame_Shift_Ins	novel	*W331Lfs20**	0.32
KIRP	chr3	27192027	Splice_Site	NA	X835_splice	0.32
LAML	chr3	27174788	Missense_Mutation	novel	A851T	0.03
LGG	chr3	27202536	Silent	novel	E704E	0.32
LGG	chr3	27162730	Missense_Mutation	novel	T947I	0.19
LGG	chr3	27162376	Intron	novel		0.3
LGG	chr3	27311008	Nonsense_Mutation	NA	Q193*	0.26
LIHC	chr3	27111289	Missense_Mutation	NA	H1168Y	0.4
LIHC	chr3	27119772	Missense_Mutation	rs368155143	N1117D	0.17
LIHC	chr3	27111322	Splice_Site	novel	X1157_splice	0.56
LIHC	chr3	27174733	Missense_Mutation	novel	Q869L	0.47
LIHC	chr3	27304930	Missense_Mutation	NA	Q282L	0.39
LIHC	chr3	27308931	Silent	novel	A237A	0.04
LUAD	chr3	27304812	Silent	NA	D321D	0.29
LUAD	chr3	27171818	Splice_Site	rs752305967	X944_splice	0.56
LUAD	chr3	27174650	Missense_Mutation	NA	D897Y	0.84
LUAD	chr3	27256327	Missense_Mutation	novel	T687A	0.38
LUAD	chr3	27291530	Missense_Mutation	novel	D477A	0.1
LUAD	chr3	27287715	Missense_Mutation	novel	Y591F	0.12
LUAD	chr3	27192244	Splice_Site	NA	X764_splice	0.39
LUAD	chr3	27291291	Nonsense_Mutation	NA	G526*	0.48
LUAD	chr3	27174704	Missense_Mutation	novel	A879T	0.24
LUAD	chr3	27304962	Silent	rs376340921	A271A	0.3
LUAD	chr3	27162511	Missense_Mutation	NA	W987L	0.06
LUAD	chr3	27119785	Missense_Mutation	novel	N1112K	0.48
LUAD	chr3	27111291	Missense_Mutation	novel	N1167S	0.08
LUAD	chr3	27162587	Missense_Mutation	NA	D962N	0.09
LUAD	chr3	27202485	Missense_Mutation	novel	Q721H	0.09
LUAD	chr3	27111158	3'UTR	novel		0.27
LUAD	chr3	27291504	Frame_Shift_Ins	novel	*S486Kfs7**	0.12
LUAD	chr3	27119824	Silent	NA	T1099T	0.14
LUAD	chr3	27284627	Missense_Mutation	novel	L663F	0.39	RIO1
LUAD	chr3	27119771	Missense_Mutation	novel	N1117I	0.41
LUAD	chr3	27346157	Silent	novel	I64I	0.15
LUAD	chr3	27162499	Missense_Mutation	novel	S991I	0.1
LUSC	chr3	27171843	Missense_Mutation	novel	G936E	0.18
LUSC	chr3	27202481	Missense_Mutation	NA	A723T	0.37
LUSC	chr3	27202557	Splice_Region	NA	C697C	0.51
LUSC	chr3	27116086	Missense_Mutation	novel	E1135Q	0.24
LUSC	chr3	27202551	Missense_Mutation	novel	E699D	0.44
LUSC	chr3	27291365	Missense_Mutation	NA	E501V	0.41
LUSC	chr3	27352485	Missense_Mutation	NA	V38F	0.36
LUSC	chr3	27297211	Missense_Mutation	novel	L400V	0.11
LUSC	chr3	27287730	Missense_Mutation	novel	N586I	0.76
LUSC	chr3	27119836	Silent	novel	P1095P	0.36
LUSC	chr3	27141546	Missense_Mutation	novel	R1026L	0.4
LUSC	chr3	27307898	Missense_Mutation	novel	L255P	0.26
LUSC	chr3	27287735	Missense_Mutation	NA	H584Q	0.22
LUSC	chr3	27192232	Missense_Mutation	novel	P768A	0.33
LUSC	chr3	27346106	Silent	novel	A81A	0.97
LUSC	chr3	27131928	Silent	novel	L1068L	0.5
OV	chr3	27111093	3'UTR	rs183286766		0.13
OV	chr3	27174716	Missense_Mutation	NA	D875Y	0.19
OV	chr3	27290658	Missense_Mutation	rs370504122	V568I	0.44
OV	chr3	27284928	Missense_Mutation	novel	E608V	0.06	RIO1
OV	chr3	27291583	Silent	NA	L459L	0.48
OV	chr3	27119788	Silent	novel	G1111G	0.12
OV	chr3	27215719	Intron	novel		0.11
OV	chr3	27287737	Missense_Mutation	novel	H584Y	0.35
OV	chr3	27346199	Missense_Mutation	NA	F50L	0.13
OV	chr3	27174746	Missense_Mutation	rs761822059	P865A	0.37
OV	chr3	27119795	Missense_Mutation	NA	S1109Y	0.23
OV	chr3	27174786	Silent	rs777599695	A851A	0.32
OV	chr3	27162527	Missense_Mutation	NA	E982Q	0.46
PAAD	chr3	27256341	Missense_Mutation	novel	E682G	0.1	RIO1
PAAD	chr3	27284605	Missense_Mutation	NA	V671I	0.13	RIO1
PAAD	chr3	27284890	Nonsense_Mutation	novel	E621*	0.2	RIO1
PAAD	chr3	27344278	Missense_Mutation	novel	I119K	0.46
READ	chr3	27174476	Silent	NA	S913S	0.65
READ	chr3	27287714	Nonsense_Mutation	novel	Y591*	0.1
READ	chr3	27192121	Missense_Mutation	NA	L805V	0.11
READ	chr3	27301824	Missense_Mutation	NA	F347C	0.08
READ	chr3	27162345	Intron	novel		0.39
READ	chr3	27174695	Missense_Mutation	rs371393406	E882K	0.31
READ	chr3	27284689	Nonsense_Mutation	rs776635841	R643*	0.39	RIO1
READ	chr3	27301756	Missense_Mutation	NA	H370N	0.5
READ	chr3	27344350	Missense_Mutation	NA	R95I	0.44
READ	chr3	27116089	Missense_Mutation	novel	Y1134H	0.22
READ	chr3	27290678	Missense_Mutation	novel	K561T	0.08
SARC	chr3	27174695	Missense_Mutation	rs371393406	E882K	0.31
SKCM	chr3	27304911	Silent	NA	K288K	0.21
SKCM	chr3	27304900	Missense_Mutation	rs746167699	G292E	0.35
SKCM	chr3	27293632	Silent	novel	L443L	0.53
SKCM	chr3	27284609	Silent	NA	V669V	0.08
SKCM	chr3	27131984	Missense_Mutation	novel	P1050S	0.23
SKCM	chr3	27290617	Splice_Region	novel	Q581Q	0.23
SKCM	chr3	27304854	Silent	NA	L307L	0.44
SKCM	chr3	27344301	Silent	rs150437265	T111T	0.41
SKCM	chr3	27162601	Missense_Mutation	NA	A957V	0.22
SKCM	chr3	27291556	Silent	NA	F468F	0.32
SKCM	chr3	27301709	Silent	NA	F385F	0.19
SKCM	chr3	27308956	Missense_Mutation	NA	S229F	0.25
SKCM	chr3	27352500	Missense_Mutation	rs762125428	R33W	0.51
SKCM	chr3	27192223	Missense_Mutation	NA	E771K	0.08
SKCM	chr3	27304933	Missense_Mutation	NA	P281L	0.44
SKCM	chr3	27162564	Silent	novel	P969P	0.16
SKCM	chr3	27174780	Silent	NA	L853L	0.31
SKCM	chr3	27116072	Splice_Region	novel		0.23
SKCM	chr3	27119802	Missense_Mutation	rs147586444	R1107C	0.14
SKCM	chr3	27284890	Missense_Mutation	NA	E621K	0.55	RIO1
SKCM	chr3	27174487	Missense_Mutation	NA	D910N	0.32
SKCM	chr3	27111302	Nonsense_Mutation	rs780017659	W1163*	0.33
SKCM	chr3	27284689	Nonsense_Mutation	rs776635841	R643*	0.45	RIO1
SKCM	chr3	27174739	Missense_Mutation	NA	G867D	0.27
SKCM	chr3	27284879	Silent	NA	H624H	0.63
SKCM	chr3	27346151	Silent	novel	A66A	0.24
SKCM	chr3	27162447	Intron	NA		0.43
SKCM	chr3	27192131	Missense_Mutation	novel	L801F	0.39
SKCM	chr3	27352482	Nonsense_Mutation	NA	Q39*	0.24
SKCM	chr3	27162478	Missense_Mutation	rs770154187	R998Q	0.22
SKCM	chr3	27291290	Missense_Mutation	NA	G526E	0.28
SKCM	chr3	27162348	Intron	rs117148524		0.42
SKCM	chr3	27287737	Missense_Mutation	novel	H584Y	0.25
SKCM	chr3	27174488	Silent	rs764123485	S909S	0.33
SKCM	chr3	27291481	Splice_Region	novel		0.15
SKCM	chr3	27174780	Silent	NA	L853L	0.53
SKCM	chr3	27291579	Missense_Mutation	NA	P461S	0.16
SKCM	chr3	27352814	Splice_Region	NA	I23I	0.26
SKCM	chr3	27141573	Missense_Mutation	NA	G1017E	0.41
SKCM	chr3	27202535	Missense_Mutation	NA	P705S	0.16
SKCM	chr3	27162324	Intron	novel		0.33
STAD	chr3	27119832	Missense_Mutation	NA	F1097L	0.05
STAD	chr3	27174669	In_Frame_Del	novel	E882_N890del	0.06
STAD	chr3	27143467	Missense_Mutation	NA	Q1006H	0.34
STAD	chr3	27141577	Missense_Mutation	NA	A1016T	0.3
STAD	chr3	27304769	Nonsense_Mutation	NA	Q336*	0.43
STAD	chr3	27192047	Silent	novel	E829E	0.06
STAD	chr3	27291267	Missense_Mutation	novel	Y534H	0.44
STAD	chr3	27162717	Silent	NA	G951G	0.08
STAD	chr3	27174729	Silent	NA	A870A	0.11
STAD	chr3	27284918	Silent	rs758416963	P611P	0.14
STAD	chr3	27174714	Silent	rs547219395	D875D	0.32
STAD	chr3	27284839	Splice_Site	NA	X637_splice	0.22
STAD	chr3	27284916	Missense_Mutation	NA	L612P	0.19	RIO1
STAD	chr3	27256309	Missense_Mutation	NA	I693L	0.2
STAD	chr3	27111289	Missense_Mutation	NA	H1168Y	0.15
STAD	chr3	27119854	Silent	NA	S1089S	0.32
STAD	chr3	27174656	Missense_Mutation	NA	E895K	0.07
STAD	chr3	27119846	Missense_Mutation	novel	P1092Q	0.4
STAD	chr3	27284605	Missense_Mutation	NA	V671I	0.06	RIO1
STAD	chr3	27304956	Silent	novel	L273L	0.29
STAD	chr3	27202480	Missense_Mutation	rs781114388	A723V	0.3
STAD	chr3	27174815	Missense_Mutation	NA	S842R	0.23
STAD	chr3	27111311	Silent	NA	S1160S	0.25
STAD	chr3	27202517	Missense_Mutation	NA	D711Y	0.3
TGCT	chr3	27115957	Nonsense_Mutation	rs768169562	Y1151*	0.37
TGCT	chr3	27284639	Missense_Mutation	novel	N659K	0.24	RIO1
THCA	chr3	27291272	Missense_Mutation	NA	C532S	0.15
UCEC	chr3	27162479	Nonsense_Mutation	NA	R998*	0.27
UCEC	chr3	27110925	3'UTR	novel		0.35
UCEC	chr3	27174695	Missense_Mutation	rs371393406	E882K	0.39
UCEC	chr3	27304907	Missense_Mutation	NA	Y290H	0.31
UCEC	chr3	27174713	Missense_Mutation	rs141419403	E876K	0.14
UCEC	chr3	27162597	Silent	rs771583230	L958L	0.21
UCEC	chr3	27162309	Intron	novel		0.42
UCEC	chr3	27174731	Missense_Mutation	novel	A870T	0.22
UCEC	chr3	27291281	Missense_Mutation	novel	A529V	0.44
UCEC	chr3	27284919	Frame_Shift_Del	novel	*P611Rfs9**	0.1	RIO1
UCEC	chr3	27141542	Missense_Mutation	NA	Q1027H	0.56
UCEC	chr3	27162467	Missense_Mutation	NA	D1002Y	0.22
UCEC	chr3	27192160	Missense_Mutation	novel	D792Y	0.06
UCEC	chr3	27291326	Missense_Mutation	novel	K514R	0.44
UCEC	chr3	27295640	Missense_Mutation	NA	K427N	0.04
UCEC	chr3	27202512	Silent	novel	V712V	0.38
UCEC	chr3	27192192	Missense_Mutation	NA	S781L	0.4
UCEC	chr3	27295664	Missense_Mutation	novel	K419N	0.34
UCEC	chr3	27312133	Silent	novel	E178E	0.2
UCEC	chr3	27352913	5'UTR	novel		0.46
UCEC	chr3	27287731	Missense_Mutation	novel	N586D	0.24
UCEC	chr3	27174489	Missense_Mutation	rs570187206	S909L	0.32
UCEC	chr3	27192192	Missense_Mutation	NA	S781L	0.09
UCEC	chr3	27115963	Silent	NA	G1149G	0.18
UCEC	chr3	27131932	Missense_Mutation	NA	S1067F	0.19
UCEC	chr3	27256323	Missense_Mutation	NA	S688F	0.2
UCEC	chr3	27284839	Splice_Site	novel	X637_splice	0.09
UCEC	chr3	27291569	Nonsense_Mutation	novel	D463_L464ins*	0.06
UCEC	chr3	27174512	Missense_Mutation	NA	E901D	0.15
UCEC	chr3	27202553	Missense_Mutation	NA	E699K	0.3
UCEC	chr3	27291569	Nonsense_Mutation	novel	D463_L464ins*	0.05
UCEC	chr3	27290658	Missense_Mutation	rs370504122	V568I	0.03
UCEC	chr3	27291569	Nonsense_Mutation	novel	D463_L464ins*	0.03
UCEC	chr3	27192072	Missense_Mutation	rs377025826	R821Q	0.47
UCEC	chr3	27284909	Silent	NA	E614E	0.47
UCEC	chr3	27174440	Splice_Region	NA	F925F	0.55
UCEC	chr3	27291569	Nonsense_Mutation	novel	D463_L464ins*	0.03
UCEC	chr3	27110910	3'UTR	novel		0.2
UCEC	chr3	27295640	Missense_Mutation	NA	K427N	0.28
UCEC	chr3	27304951	Missense_Mutation	rs768893065	R275H	0.46
UCEC	chr3	27110931	3'UTR	novel		0.47
UCEC	chr3	27119811	Missense_Mutation	novel	L1104V	0.09
UCEC	chr3	27174451	Nonsense_Mutation	novel	E922*	0.5
UCEC	chr3	27297184	Missense_Mutation	rs773753208	V409F	0.53
UCEC	chr3	27192134	Silent	novel	S800S	0.24
UCEC	chr3	27290659	Silent	novel	S567S	0.18
UCEC	chr3	27215880	Intron	NA		0.19
UCEC	chr3	27171861	Missense_Mutation	novel	R930K	0.13
UCEC	chr3	27256352	Silent	rs778365293	K678K	0.5
UCEC	chr3	27304794	Missense_Mutation	novel	E327D	0.44
UCEC	chr3	27174497	Frame_Shift_Ins	novel	*L906Ffs6**	0.39
UCEC	chr3	27287744	Splice_Site	novel	X582_splice	0.42
UCEC	chr3	27352862	Frame_Shift_Ins	novel	*V8Gfs9**	0.43
UCEC	chr3	27352913	5'UTR	novel		0.52
UCEC	chr3	27110937	3'UTR	novel		0.43
UCEC	chr3	27162419	Intron	novel		0.44
UCEC	chr3	27110925	3'UTR	novel		0.48
UCEC	chr3	27284653	Missense_Mutation	novel	D655N	0.34	RIO1
UCEC	chr3	27301763	Missense_Mutation	NA	Q367H	0.38
UCEC	chr3	27344326	Missense_Mutation	rs200401044	R103H	0.27
UCEC	chr3	27293618	Missense_Mutation	novel	S448T	0.57
UCEC	chr3	27215815	Intron	novel		0.47
UCEC	chr3	27110964	3'UTR	novel		0.24
UCEC	chr3	27284689	Nonsense_Mutation	rs776635841	R643*	0.44	RIO1
UCEC	chr3	27291493	Missense_Mutation	novel	N489K	0.29
UCEC	chr3	27352893	5'UTR	novel		0.36
UCEC	chr3	27307872	Missense_Mutation	novel	L264V	0.36
UCEC	chr3	27291569	Nonsense_Mutation	novel	D463_L464ins*	0.08
UCEC	chr3	27174695	Missense_Mutation	rs371393406	E882K	0.22
UCEC	chr3	27344326	Missense_Mutation	rs200401044	R103H	0.35
UCEC	chr3	27110957	3'UTR	novel		0.22
UCEC	chr3	27192192	Missense_Mutation	NA	S781L	0.4
UCEC	chr3	27352500	Missense_Mutation	rs762125428	R33W	0.43
UCEC	chr3	27162736	Missense_Mutation	novel	D945A	0.38
UCEC	chr3	27284840	Splice_Region	novel	Q637Q	0.09
UCEC	chr3	27304789	Missense_Mutation	rs371174806	R329H	0.41
UCEC	chr3	27352500	Missense_Mutation	rs762125428	R33W	0.33
UCEC	chr3	27344365	Missense_Mutation	NA	N90S	0.05
UCEC	chr3	27295621	Missense_Mutation	novel	L434I	0.29
UCEC	chr3	27352845	Missense_Mutation	novel	K13T	0.41
UCEC	chr3	27301709	Missense_Mutation	NA	F385L	0.22
UCEC	chr3	27295640	Missense_Mutation	NA	K427N	0.26
UCEC	chr3	27301738	Missense_Mutation	novel	S376G	0.11
UCEC	chr3	27352919	Splice_Region	novel		0.09
UCEC	chr3	27110960	3'UTR	novel		0.28
UCEC	chr3	27192029	Splice_Region	rs781667676	H835H	0.21
UCEC	chr3	27304951	Missense_Mutation	rs768893065	R275H	0.42
UCEC	chr3	27162452	Intron	novel		0.42
UCEC	chr3	27162362	Intron	novel		0.41
UCEC	chr3	27322190	Missense_Mutation	NA	D145A	0.34
UCEC	chr3	27171861	Missense_Mutation	NA	R930I	0.2
UCEC	chr3	27295640	Missense_Mutation	NA	K427N	0.31
UCEC	chr3	27291531	Missense_Mutation	novel	D477Y	0.31
UCEC	chr3	27308993	Missense_Mutation	rs764217005	L217V	0.36
UCEC	chr3	27171822	Missense_Mutation	novel	T943I	0.4
UCEC	chr3	27174713	Missense_Mutation	rs141419403	E876K	0.44
UCEC	chr3	27192188	Missense_Mutation	novel	M782I	0.05
UCEC	chr3	27290650	Silent	novel	N570N	0.09
UCEC	chr3	27307859	Missense_Mutation	novel	R268I	0.17
UCEC	chr3	27284860	Missense_Mutation	novel	L631I	0.29	RIO1
UCEC	chr3	27290625	Missense_Mutation	novel	K579E	0.38
UCEC	chr3	27304823	Missense_Mutation	rs776763681	V318F	0.33
UCEC	chr3	27344350	Missense_Mutation	NA	R95I	0.4
UCEC	chr3	27162386	Intron	novel		0.33
UCEC	chr3	27297195	Missense_Mutation	rs751581268	A405V	0.11
UCEC	chr3	27344326	Missense_Mutation	rs200401044	R103H	0.23
UCEC	chr3	27310967	Silent	novel	T206T	0.32
UCEC	chr3	27192039	Missense_Mutation	novel	V832G	0.4
UCEC	chr3	27284948	Silent	novel	Y601Y	0.35
UCEC	chr3	27290620	Silent	rs755568973	E580E	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.75	0.02241
LUAD	DEL	0.3217	0.068154
SKCM	DEL	0.1526	0.13887
TGCT	DEL	0.2	0.08422
THYM	DEL	0.0976	0.037527

Survival Analysis

Cancer	P-value	Q-value
THYM	0.029	Kaplan-Meier Survival Analysis
KIRC	0.0007	Kaplan-Meier Survival Analysis
STAD	0.024	Kaplan-Meier Survival Analysis
MESO	0.0013	Kaplan-Meier Survival Analysis
ACC	0.0036	Kaplan-Meier Survival Analysis
SKCM	0.0044	Kaplan-Meier Survival Analysis
BRCA	0.00077	Kaplan-Meier Survival Analysis
PAAD	0.0043	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
LAML	0.037	Kaplan-Meier Survival Analysis
KICH	0.031	Kaplan-Meier Survival Analysis
UCEC	0.017	Kaplan-Meier Survival Analysis
LGG	0.00052	Kaplan-Meier Survival Analysis
THCA	0.017	Kaplan-Meier Survival Analysis
UVM	0.024	Kaplan-Meier Survival Analysis
OV	0.031	Kaplan-Meier Survival Analysis