EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163516 (Gene tree)
Gene ID: 55139
Gene Symbol: ANKZF1
Alias: FLJ10415|ZNF744
Full Name: ankyrin repeat and zinc finger domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 6,913 bases
Position: chr2:219,229,757-219,236,669
Accession: 25527
RBP type: non-canonical RBP
Summary: (Ankyrin Repeat And Zinc Finger Domain Containing 1) is a Protein Coding gene.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490526	ANKZF1-222	516	-	-	- (aa)	-	-
ENST00000460966	ANKZF1-209	873	-	-	- (aa)	-	-
ENST00000496346	ANKZF1-226	1290	-	-	- (aa)	-	-
ENST00000323348	ANKZF1-201	2579	XM_005246663	ENSP00000321617	726 (aa)	XP_005246720	Q9H8Y5
ENST00000461731	ANKZF1-210	1566	-	-	- (aa)	-	-
ENST00000467884	ANKZF1-214	1090	-	-	- (aa)	-	-
ENST00000409849	ANKZF1-202	2155	-	ENSP00000386815	516 (aa)	-	B8ZZS4
ENST00000464763	ANKZF1-212	647	-	-	- (aa)	-	-
ENST00000494886	ANKZF1-225	588	-	-	- (aa)	-	-
ENST00000465550	ANKZF1-213	2793	-	-	- (aa)	-	-
ENST00000416565	ANKZF1-204	552	-	ENSP00000406514	59 (aa)	-	C9J5H7
ENST00000436226	ANKZF1-206	571	-	ENSP00000394652	90 (aa)	-	C9JQZ3
ENST00000483188	ANKZF1-219	529	-	-	- (aa)	-	-
ENST00000435521	ANKZF1-205	576	-	ENSP00000404113	53 (aa)	-	F8WD44
ENST00000463792	ANKZF1-211	3245	-	-	- (aa)	-	-
ENST00000486203	ANKZF1-220	993	-	-	- (aa)	-	-
ENST00000477479	ANKZF1-218	2940	-	-	- (aa)	-	-
ENST00000489580	ANKZF1-221	570	-	-	- (aa)	-	-
ENST00000474225	ANKZF1-216	900	-	-	- (aa)	-	-
ENST00000491181	ANKZF1-223	623	-	-	- (aa)	-	-
ENST00000493563	ANKZF1-224	571	-	-	- (aa)	-	-
ENST00000410034	ANKZF1-203	2486	-	ENSP00000386337	726 (aa)	-	Q9H8Y5
ENST00000453432	ANKZF1-208	511	-	ENSP00000394359	115 (aa)	-	C9JS61
ENST00000468387	ANKZF1-215	561	-	-	- (aa)	-	-
ENST00000447157	ANKZF1-207	537	-	ENSP00000399667	140 (aa)	-	C9K022
ENST00000475202	ANKZF1-217	576	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000163516's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163516's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163516	ANKZF1	70	35.450	WBGene00019457	vms-1	77	34.500	Caenorhabditis_elegans
ENSG00000163516	ANKZF1	100	83.478	ENSMUSG00000026199	Ankzf1	95	78.291	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0005515	protein binding	22190034.	IPI	Function
GO:0005737	cytoplasm	28302725.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0030433	ubiquitin-dependent ERAD pathway	21873635.	IBA	Process
GO:0036266	Cdc48p-Npl4p-Vms1p AAA ATPase complex	21873635.	IBA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0070301	cellular response to hydrogen peroxide	28302725.	IMP	Process
GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	21873635.	IBA	Process
GO:0072671	mitochondria-associated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	219233790	Missense_Mutation	novel	P299A	0.22
BLCA	chr2	219232577	Missense_Mutation	novel	F151C	0.11
BLCA	chr2	219233722	Missense_Mutation	NA	R276P	0.47
BLCA	chr2	219230273	Missense_Mutation	NA	D6N	0.16
BLCA	chr2	219234942	Missense_Mutation	novel	R441G	0.06
BLCA	chr2	219232681	Nonsense_Mutation	novel	Q186*	0.6
BLCA	chr2	219232621	Missense_Mutation	novel	L166V	0.85
BLCA	chr2	219234829	Missense_Mutation	rs747740100	S403L	0.14
BLCA	chr2	219235858	Missense_Mutation	NA	L652F	0.31
BRCA	chr2	219233867	Silent	NA	I324I	0.22
BRCA	chr2	219235540	Silent	novel	R586R	0.15
BRCA	chr2	219233102	Silent	novel	L194L	0.07
BRCA	chr2	219234132	Splice_Site	NA	X350_splice	0.18
BRCA	chr2	219235826	Missense_Mutation	rs540477795	R641H	0.11
BRCA	chr2	219234951	Missense_Mutation	NA	K444E	0.24
BRCA	chr2	219234434	Intron	novel		0.27
CESC	chr2	219234861	Missense_Mutation	NA	E414Q	0.05
CESC	chr2	219234896	Silent	novel	L425L	0.31
CESC	chr2	219231830	Intron	novel		0.38
CESC	chr2	219235821	Silent	novel	E639E	0.46
CHOL	chr2	219234968	Missense_Mutation	novel	D449E	0.11
COAD	chr2	219236377	Missense_Mutation	NA	D705N	0.31
COAD	chr2	219234273	Nonsense_Mutation	novel	E397*	0.05
COAD	chr2	219230359	Silent	NA	H34H	0.47
COAD	chr2	219234819	Splice_Region	novel		0.42
COAD	chr2	219235753	Missense_Mutation	rs768432915	R617W	0.33
COAD	chr2	219233352	Missense_Mutation	novel	Q246H	0.15
COAD	chr2	219235732	Missense_Mutation	novel	M610L	0.09
COAD	chr2	219236352	Missense_Mutation	NA	Q696H	0.21
COAD	chr2	219235780	Missense_Mutation	rs575269311	R626W	0.28
ESCA	chr2	219235233	Missense_Mutation	novel	L538F	0.52
ESCA	chr2	219236487	3'UTR	novel		0.27
ESCA	chr2	219231830	Intron	novel		0.92
ESCA	chr2	219229782	5'UTR	novel		0.47
GBM	chr2	219235007	Silent	novel	T462T	0.11
GBM	chr2	219233130	Missense_Mutation	novel	P204S	0.05
GBM	chr2	219230332	Silent	novel	V25V	0.3
GBM	chr2	219232616	Missense_Mutation	rs776602507	R164Q	0.55
GBM	chr2	219235284	Silent	novel	L555L	0.5
GBM	chr2	219232606	In_Frame_Del	novel	Y161del	0.06
GBM	chr2	219235762	Nonsense_Mutation	novel	E620*	0.44
GBM	chr2	219234151	Frame_Shift_Ins	novel	*V357Kfs14**	0.13
HNSC	chr2	219233797	Missense_Mutation	novel	S301F	0.36
HNSC	chr2	219235240	Missense_Mutation	novel	H540L	0.3
HNSC	chr2	219236444	Silent	novel	*727*	0.25
HNSC	chr2	219234463	Intron	novel		0.33
HNSC	chr2	219233385	Silent	novel	H257H	0.25
HNSC	chr2	219233844	Missense_Mutation	novel	G317R	0.09
HNSC	chr2	219230282	Missense_Mutation	novel	P9S	0.39
HNSC	chr2	219234313	Intron	novel		0.12
HNSC	chr2	219234969	Missense_Mutation	novel	Q450K	0.2
KIRC	chr2	219234368	Intron	novel		0.37
KIRC	chr2	219234926	Missense_Mutation	NA	K435N	0.05
KIRP	chr2	219235106	Missense_Mutation	NA	W495C	0.4
KIRP	chr2	219235084	Frame_Shift_Del	novel	*P489Lfs22**	0.28
KIRP	chr2	219234512	Intron	novel		0.43
KIRP	chr2	219235034	Silent	novel	S471S	0.53
LAML	chr2	219231842	Intron	novel		0.53
LAML	chr2	219234700	Intron	novel		0.5
LAML	chr2	219236325	Silent	novel	R687R	0.04
LAML	chr2	219235505	Missense_Mutation	novel	A575T	0.08
LIHC	chr2	219230288	Missense_Mutation	NA	P11A	0.27
LIHC	chr2	219234915	Missense_Mutation	NA	V432L	0.23
LIHC	chr2	219232270	Missense_Mutation	novel	Y91C	0.55
LIHC	chr2	219231281	Intron	novel		0.4
LUAD	chr2	219233382	Silent	NA	S256S	0.35
LUAD	chr2	219234225	Missense_Mutation	NA	I381V	0.09
LUAD	chr2	219231975	Frame_Shift_Del	novel	*M66Wfs35**	0.16
LUAD	chr2	219233172	Missense_Mutation	NA	A218P	0.29
LUAD	chr2	219233824	Missense_Mutation	NA	K310T	0.25
LUAD	chr2	219235489	Silent	novel	R569R	0.32
LUAD	chr2	219234144	Missense_Mutation	rs764559758	R354W	0.06
LUSC	chr2	219232592	Missense_Mutation	novel	R156P	0.24
LUSC	chr2	219233375	Missense_Mutation	novel	G254V	0.11
LUSC	chr2	219235106	Missense_Mutation	rs758245062	W495C	0.14
LUSC	chr2	219233408	Missense_Mutation	NA	R265L	0.26
OV	chr2	219231691	Intron	novel		0.29
OV	chr2	219234927	Missense_Mutation	rs771781981	R436W	0.27
OV	chr2	219232673	Nonsense_Mutation	novel	*P184Vfs2**	0.08
OV	chr2	219233845	Missense_Mutation	NA	G317V	0.41
OV	chr2	219233330	Missense_Mutation	rs754953343	R239Q	0.09
OV	chr2	219234256	Missense_Mutation	novel	A391G	0.08
OV	chr2	219232617	Silent	novel	R164R	0.03
OV	chr2	219234440	Intron	novel		0.05
OV	chr2	219232314	Frame_Shift_Ins	novel	*D106Vfs11**	0.14
OV	chr2	219234383	Intron	novel		0.13
OV	chr2	219231858	Intron	novel		0.2
OV	chr2	219230237	5'UTR	novel		0.19
OV	chr2	219234826	Missense_Mutation	novel	G402D	0.11
OV	chr2	219235119	Missense_Mutation	NA	A500P	0.16
PAAD	chr2	219235535	Nonsense_Mutation	rs370396125	R585*	0.19
PAAD	chr2	219236491	3'UTR	novel		0.14
PRAD	chr2	219233408	Missense_Mutation	rs762023095	R265H	0.33
READ	chr2	219233329	Missense_Mutation	rs750431702	R239W	0.33
READ	chr2	219234717	Intron	novel		0.27
READ	chr2	219230331	Missense_Mutation	novel	V25A	0.22
READ	chr2	219231825	Intron	novel		0.48
READ	chr2	219234423	Intron	novel		0.39
READ	chr2	219232603	Missense_Mutation	NA	F160L	0.24
SARC	chr2	219234135	Missense_Mutation	rs375422658	E351K	0.26
SARC	chr2	219231312	Intron	novel		0.6
SARC	chr2	219229798	5'UTR	novel		0.29
SKCM	chr2	219233350	Nonsense_Mutation	NA	Q246*	0.32
SKCM	chr2	219233852	Silent	NA	P319P	0.33
SKCM	chr2	219233853	Nonsense_Mutation	rs555146150	R320*	0.33
SKCM	chr2	219232615	Nonsense_Mutation	rs370400955	R164*	0.28
SKCM	chr2	219234875	Silent	NA	V418V	0.2
SKCM	chr2	219235547	Missense_Mutation	novel	E589K	0.64
SKCM	chr2	219233192	Splice_Site	NA	X224_splice	0.35
SKCM	chr2	219233331	Silent	novel	R239R	0.09
SKCM	chr2	219234813	Intron	novel		0.47
SKCM	chr2	219235472	Splice_Site	novel	X564_splice	0.13
SKCM	chr2	219235567	Silent	rs140463651	Y595Y	0.45
SKCM	chr2	219234229	Missense_Mutation	NA	R382K	0.22
SKCM	chr2	219233385	Silent	novel	H257H	0.38
SKCM	chr2	219232042	Splice_Site	novel	X87_splice	0.37
STAD	chr2	219235764	Silent	NA	E620E	0.11
STAD	chr2	219233873	Silent	rs201436138	L326L	0.27
STAD	chr2	219232508	Missense_Mutation	rs768829938	S128L	0.21
STAD	chr2	219234996	Missense_Mutation	NA	L459F	0.53
STAD	chr2	219234426	Intron	novel		0.32
STAD	chr2	219234511	Intron	novel		0.27
STAD	chr2	219233838	Nonsense_Mutation	NA	Q315*	0.29
STAD	chr2	219236399	Missense_Mutation	novel	R712H	0.48
THCA	chr2	219233077	Splice_Site	novel	X187_splice	0.34
UCEC	chr2	219230256	5'UTR	novel		0.6
UCEC	chr2	219231955	Missense_Mutation	NA	R59I	0.32
UCEC	chr2	219235107	Missense_Mutation	novel	N496D	0.09
UCEC	chr2	219230245	5'UTR	novel		0.43
UCEC	chr2	219234988	Missense_Mutation	rs751709088	R456Q	0.3
UCEC	chr2	219231965	Silent	NA	L62L	0.41
UCEC	chr2	219231989	Missense_Mutation	novel	E70D	0.43
UCEC	chr2	219230325	Missense_Mutation	novel	A23V	0.5
UCEC	chr2	219232685	Splice_Site	novel	X186_splice	0.3
UCEC	chr2	219235549	Silent	novel	E589E	0.33
UCEC	chr2	219236500	3'UTR	novel		0.35
UCEC	chr2	219231716	Intron	novel		0.25
UCEC	chr2	219231946	Missense_Mutation	novel	S56N	0.3
UCEC	chr2	219236481	3'UTR	novel		0.11
UCEC	chr2	219231380	Intron	novel		0.21
UCEC	chr2	219235171	Missense_Mutation	novel	S517N	0.23
UCEC	chr2	219234921	Missense_Mutation	novel	P434S	0.47
UCEC	chr2	219232357	Missense_Mutation	NA	S120F	0.44
UCEC	chr2	219235584	Missense_Mutation	novel	Q601R	0.25
UCEC	chr2	219231883	Intron	novel		0.26
UCEC	chr2	219233405	Missense_Mutation	novel	R264M	0.32
UCEC	chr2	219236490	3'UTR	novel		0.36
UCEC	chr2	219231272	Intron	novel		0.5
UCEC	chr2	219233907	Missense_Mutation	rs761842964	R338C	0.43
UCEC	chr2	219233082	Frame_Shift_Del	novel	*P189Qfs40**	0.36
UCEC	chr2	219232684	Splice_Site	rs763682835	X186_splice	0.31
UCEC	chr2	219234812	Intron	novel		0.5
UCEC	chr2	219236370	Silent	novel	H702H	0.36
UCEC	chr2	219236323	Missense_Mutation	rs199744152	R687C	0.3
UCEC	chr2	219233938	Missense_Mutation	novel	V348G	0.13
UCEC	chr2	219232288	Missense_Mutation	rs761017394	R97Q	0.43
UCEC	chr2	219236533	3'UTR	novel		0.26
UCEC	chr2	219234257	Silent	rs779054428	A391A	0.67
UCEC	chr2	219231898	Intron	novel		0.4
UCEC	chr2	219236376	Silent	rs755375379	L704L	0.35
UCEC	chr2	219235158	Nonsense_Mutation	novel	Q513*	0.28
UCEC	chr2	219235073	Silent	novel	D484D	0.29
UCEC	chr2	219236425	Missense_Mutation	novel	A721T	0.29
UCEC	chr2	219236506	3'UTR	novel		0.07
UCEC	chr2	219235055	Silent	NA	P478P	0.2
UCEC	chr2	219235754	Frame_Shift_Del	novel	*R619Gfs80**	0.07
UCEC	chr2	219231867	Intron	novel		0.55
UCEC	chr2	219233794	Missense_Mutation	rs376160430	R300H	0.41
UCEC	chr2	219233324	Missense_Mutation	rs371915106	T237M	0.2
UCEC	chr2	219234744	Intron	novel		0.16
UCEC	chr2	219235217	Silent	novel	G532G	0.18
UCEC	chr2	219236376	Silent	rs755375379	L704L	0.38
UCEC	chr2	219235786	Missense_Mutation	rs747660271	R628W	0.34
UCEC	chr2	219231942	Nonsense_Mutation	novel	E55*	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	DEL	0.2165	1.278e-25
KIRP	DEL	0.0382	5.174e-05
LUSC	DEL	0.2395	1.3904e-19
MESO	DEL	0.1149	0.014499
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.038	0.2014
THCA	DEL	0.024	0.040844
THYM	DEL	0.0163	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.015	Kaplan-Meier Survival Analysis
ACC	0.00046	Kaplan-Meier Survival Analysis
HNSC	0.046	Kaplan-Meier Survival Analysis
PRAD	0.014	Kaplan-Meier Survival Analysis
COAD	0.0034	Kaplan-Meier Survival Analysis
PAAD	0.0023	Kaplan-Meier Survival Analysis
BLCA	0.0085	Kaplan-Meier Survival Analysis
KICH	0.038	Kaplan-Meier Survival Analysis
LIHC	0.00016	Kaplan-Meier Survival Analysis
DLBC	0.024	Kaplan-Meier Survival Analysis
OV	0.0065	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742