EuRBPDB

Description

Ensembl ID: ENSG00000163625 (Gene tree)
Gene ID: 23001
Gene Symbol: WDFY3
Alias: KIAA0993|ALFY|ZFYVE25
Full Name: WD repeat and FYVE domain containing 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 296,855 bases
Position: chr4:84,669,537-84,966,391
Accession: 20751
RBP type: non-canonical RBP
Summary: This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000514071	WDFY3-211	240	-	ENSP00000426813	80 (aa)	-	H0YAD8
ENST00000295888	WDFY3-201	14247	XM_005262858	ENSP00000295888	3526 (aa)	XP_005262915	Q8IZQ1
ENST00000502713	WDFY3-204	425	-	ENSP00000422741	9 (aa)	-	A0A1D5RMR8
ENST00000426414	WDFY3-203	3428	-	-	- (aa)	-	-
ENST00000512267	WDFY3-210	545	-	-	- (aa)	-	-
ENST00000425179	WDFY3-202	1910	-	-	- (aa)	-	-
ENST00000509172	WDFY3-208	453	-	ENSP00000425699	60 (aa)	-	D6RJE4
ENST00000505923	WDFY3-207	482	-	-	- (aa)	-	-
ENST00000509825	WDFY3-209	783	-	-	- (aa)	-	-
ENST00000504990	WDFY3-206	505	-	-	- (aa)	-	-
ENST00000514711	WDFY3-212	1918	-	ENSP00000424987	639 (aa)	-	H0Y9T6
ENST00000504839	WDFY3-205	677	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163625	Child Development Disorders, Pervasive	1.1738000E-005	-
ENSG00000163625	Autistic Disorder	4.8575000E-006	-
ENSG00000163625	Autistic Disorder	4.9606000E-005	-
ENSG00000163625	Child Development Disorders, Pervasive	1.1738000E-005	-
ENSG00000163625	Autistic Disorder	4.8575000E-006	-
ENSG00000163625	Oropharyngeal Neoplasms	1E-6	27749845
ENSG00000163625	Amyloidosis, Cerebral, with Spongiform Encephalopathy	1E-7	26252872

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163625	rs6847067	4	84811016	A	Oropharynx cancer	27749845		1.1861	EFO_1001931
ENSG00000163625	rs76117213	4	84675083	G	Cerebral amyloid deposition (PET imaging)	26252872	[NR] unit decrease	0.2623	EFO_0007707

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	-	IEA	Function
GO:0005515	protein binding	18083104.20168092.20417604.22458338.24668264.25814554.	IPI	Function
GO:0005545	1-phosphatidylinositol binding	15292400.	IDA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005635	nuclear envelope	15292400.20417604.	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	15292400.20168092.	IDA	Component
GO:0005776	autophagosome	15292400.	IDA	Component
GO:0005776	autophagosome	20168092.	IMP	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0016234	inclusion body	20168092.	IDA	Component
GO:0016605	PML body	20168092.	IDA	Component
GO:0019898	extrinsic component of membrane	15292400.	IDA	Component
GO:0030424	axon	-	IEA	Component
GO:0031965	nuclear membrane	-	IEA	Component
GO:0034274	Atg12-Atg5-Atg16 complex	20417604.	IDA	Component
GO:0035973	aggrephagy	20168092.20417604.	IMP	Process
GO:0043204	perikaryon	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0097635	extrinsic component of autophagosome membrane	-	IEA	Component