EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163636 (Gene tree)
Gene ID: 9861
Gene Symbol: PSMD6
Alias: S10|p44S10|KIAA0107|Rpn7
Full Name: proteasome 26S subunit, non-ATPase 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 13,462 bases
Position: chr3:64,010,549-64,024,010
Accession: 9564
RBP type: non-canonical RBP
Summary: This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000480205	PSMD6-208	657	-	ENSP00000418843	138 (aa)	-	H7C531
ENST00000475036	PSMD6-205	1045	-	-	- (aa)	-	-
ENST00000394431	PSMD6-202	1349	XM_024453841	ENSP00000377952	351 (aa)	XP_024309609	Q15008
ENST00000478185	PSMD6-207	469	-	ENSP00000418303	144 (aa)	-	C9J7B7
ENST00000476464	PSMD6-206	2052	-	-	- (aa)	-	-
ENST00000463139	PSMD6-203	2621	-	-	- (aa)	-	-
ENST00000492933	PSMD6-210	1495	XM_011534288	ENSP00000418695	442 (aa)	XP_011532590	Q15008
ENST00000295901	PSMD6-201	1430	XM_005265619	ENSP00000295901	389 (aa)	XP_005265676	Q15008
ENST00000497315	PSMD6-211	701	-	-	- (aa)	-	-
ENST00000497323	PSMD6-212	717	-	ENSP00000418887	226 (aa)	-	C9J0E9
ENST00000467853	PSMD6-204	4583	-	-	- (aa)	-	-
ENST00000482510	PSMD6-209	1176	-	ENSP00000419227	350 (aa)	-	Q15008

Gene Model

Click here to download ENSG00000163636's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163636	Stroke	4.9108607E-004	19369658
ENSG00000163636	Platelet Function Tests	1.8523800E-005	-
ENSG00000163636	Child Development Disorders, Pervasive	5.8000000E-005	-
ENSG00000163636	Diabetes Mellitus, Type 2	8E-11	22158537
ENSG00000163636	13,16,19-docosatrienoic acid	8E-6	23934736
ENSG00000163636	Diabetes Mellitus, Type 2	1E-7	26818947

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163636	rs9828933	3	64017221	T	Type 2 diabetes	26818947	[1.05659-1.12766]	1.09155	EFO_0001360

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163636's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163636	PSMD6	99	49.858	WBGene00004463	rpn-7	96	47.342	Caenorhabditis_elegans
ENSG00000163636	PSMD6	99	71.552	FBgn0028688	Rpn7	100	70.180	Drosophila_melanogaster
ENSG00000163636	PSMD6	99	38.298	YPR108W		94	37.101	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005838	proteasome regulatory particle	21873635.	IBA	Component
GO:0006508	proteolysis	10723133.	NAS	Process
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	10723133.	NAS	Function
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0030234	enzyme regulator activity	-	IEA	Function
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050790	regulation of catalytic activity	-	IEA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component