EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163655 (Gene tree)
Gene ID: 8833
Gene Symbol: GMPS
Alias: GATD7
Full Name: guanine monophosphate synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 74,597 bases
Position: chr3:155,869,430-155,944,026
Accession: 4378
RBP type: canonical RBP
Summary: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000295920	tRNA_Me_trans	PF03054.16	2.6e-05	1	1
ENSP00000419851	tRNA_Me_trans	PF03054.16	3.4e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000295920	GMPS-201	2024	-	ENSP00000295920	594 (aa)	-	P49915
ENST00000476145	GMPS-202	570	-	-	- (aa)	-	-
ENST00000496455	GMPS-203	8751	XM_011513263	ENSP00000419851	693 (aa)	XP_011511565	P49915

Gene Model

Click here to download ENSG00000163655's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00983	Drug metabolism - other enzymes	KEGG
hsa01100	Metabolic pathways	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163655	rs3772116	3	155933374	?	General cognitive ability	29844566	z-score increase	4.491	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163655's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163655	GMPS	100	86.003	ENSAPOG00000010728	gmps	100	86.003	Acanthochromis_polyacanthus
ENSG00000163655	GMPS	100	99.134	ENSAMEG00000002551	GMPS	100	99.134	Ailuropoda_melanoleuca
ENSG00000163655	GMPS	100	85.185	ENSACIG00000012452	gmps	97	87.145	Amphilophus_citrinellus
ENSG00000163655	GMPS	100	86.436	ENSAOCG00000003292	gmps	100	86.436	Amphiprion_ocellaris
ENSG00000163655	GMPS	100	86.147	ENSAPEG00000020189	gmps	100	86.147	Amphiprion_percula
ENSG00000163655	GMPS	100	86.195	ENSATEG00000002414	gmps	99	86.082	Anabas_testudineus
ENSG00000163655	GMPS	99	94.737	ENSACAG00000000556	GMPS	99	94.737	Anolis_carolinensis
ENSG00000163655	GMPS	100	99.278	ENSANAG00000036394	GMPS	100	99.278	Aotus_nancymaae
ENSG00000163655	GMPS	100	86.291	ENSACLG00000003086	gmps	100	86.291	Astatotilapia_calliptera
ENSG00000163655	GMPS	100	86.580	ENSAMXG00000029474	gmps	100	86.580	Astyanax_mexicanus
ENSG00000163655	GMPS	100	98.846	ENSBTAG00000013013	GMPS	100	98.846	Bos_taurus
ENSG00000163655	GMPS	100	48.160	WBGene00010912	gmps-1	97	51.003	Caenorhabditis_elegans
ENSG00000163655	GMPS	100	99.134	ENSCJAG00000000863	GMPS	100	99.134	Callithrix_jacchus
ENSG00000163655	GMPS	100	97.315	ENSCAFG00000008780	GMPS	97	98.318	Canis_familiaris
ENSG00000163655	GMPS	100	98.701	ENSCAFG00020005568	GMPS	100	98.701	Canis_lupus_dingo
ENSG00000163655	GMPS	100	98.557	ENSCHIG00000022844	GMPS	100	98.557	Capra_hircus
ENSG00000163655	GMPS	100	97.475	ENSTSYG00000009457	GMPS	97	98.246	Carlito_syrichta
ENSG00000163655	GMPS	90	93.691	ENSCAPG00000008634	GMPS	85	93.691	Cavia_aperea
ENSG00000163655	GMPS	97	96.562	ENSCPOG00000011574	GMPS	98	96.562	Cavia_porcellus
ENSG00000163655	GMPS	100	99.158	ENSCCAG00000031267	GMPS	100	99.158	Cebus_capucinus
ENSG00000163655	GMPS	100	99.856	ENSCATG00000031121	GMPS	100	99.856	Cercocebus_atys
ENSG00000163655	GMPS	100	97.138	ENSCLAG00000007499	GMPS	100	97.661	Chinchilla_lanigera
ENSG00000163655	GMPS	100	99.856	ENSCSAG00000012022	GMPS	100	99.856	Chlorocebus_sabaeus
ENSG00000163655	GMPS	99	75.585	ENSCHOG00000008585	GMPS	100	75.585	Choloepus_hoffmanni
ENSG00000163655	GMPS	100	93.795	ENSCPBG00000018525	GMPS	100	93.795	Chrysemys_picta_bellii
ENSG00000163655	GMPS	99	88.450	ENSCANG00000027748	GMPS	97	98.280	Colobus_angolensis_palliatus
ENSG00000163655	GMPS	100	97.547	ENSCGRG00001018772	Gmps	100	97.547	Cricetulus_griseus_chok1gshd
ENSG00000163655	GMPS	100	97.547	ENSCGRG00000002986	Gmps	100	97.547	Cricetulus_griseus_crigri
ENSG00000163655	GMPS	100	85.017	ENSCSEG00000001844	gmps	100	84.704	Cynoglossus_semilaevis
ENSG00000163655	GMPS	100	86.364	ENSCVAG00000013802	gmps	100	86.291	Cyprinodon_variegatus
ENSG00000163655	GMPS	100	86.869	ENSDARG00000079848	gmps	100	86.869	Danio_rerio
ENSG00000163655	GMPS	100	98.990	ENSDNOG00000017772	GMPS	100	98.990	Dasypus_novemcinctus
ENSG00000163655	GMPS	100	98.124	ENSDORG00000014996	Gmps	100	98.124	Dipodomys_ordii
ENSG00000163655	GMPS	86	97.456	ENSETEG00000010604	-	100	97.456	Echinops_telfairi
ENSG00000163655	GMPS	100	97.691	ENSEASG00005022509	GMPS	100	97.691	Equus_asinus_asinus
ENSG00000163655	GMPS	100	97.980	ENSECAG00000023269	GMPS	100	97.980	Equus_caballus
ENSG00000163655	GMPS	99	97.515	ENSEEUG00000011718	GMPS	100	97.515	Erinaceus_europaeus
ENSG00000163655	GMPS	100	86.291	ENSELUG00000008772	gmps	100	86.291	Esox_lucius
ENSG00000163655	GMPS	100	99.158	ENSFCAG00000025327	GMPS	100	99.158	Felis_catus
ENSG00000163655	GMPS	99	93.704	ENSFALG00000004855	GMPS	99	93.704	Ficedula_albicollis
ENSG00000163655	GMPS	100	96.970	ENSFDAG00000009186	GMPS	99	97.106	Fukomys_damarensis
ENSG00000163655	GMPS	100	85.714	ENSFHEG00000023029	gmps	100	85.714	Fundulus_heteroclitus
ENSG00000163655	GMPS	100	83.670	ENSGMOG00000009029	gmps	98	85.650	Gadus_morhua
ENSG00000163655	GMPS	100	94.661	ENSGALG00000010284	GMPS	91	94.661	Gallus_gallus
ENSG00000163655	GMPS	100	83.333	ENSGACG00000007053	gmps	99	81.402	Gasterosteus_aculeatus
ENSG00000163655	GMPS	100	93.506	ENSGAGG00000019485	GMPS	100	93.506	Gopherus_agassizii
ENSG00000163655	GMPS	100	99.856	ENSGGOG00000017082	GMPS	100	99.856	Gorilla_gorilla
ENSG00000163655	GMPS	100	86.436	ENSHBUG00000000946	gmps	100	86.436	Haplochromis_burtoni
ENSG00000163655	GMPS	100	98.124	ENSHGLG00000019482	GMPS	100	98.124	Heterocephalus_glaber_female
ENSG00000163655	GMPS	100	97.306	ENSHGLG00100019096	-	100	98.099	Heterocephalus_glaber_male
ENSG00000163655	GMPS	100	85.354	ENSHCOG00000011768	gmps	100	85.137	Hippocampus_comes
ENSG00000163655	GMPS	100	82.155	ENSIPUG00000015059	gmps	99	83.043	Ictalurus_punctatus
ENSG00000163655	GMPS	99	98.392	ENSSTOG00000026541	GMPS	100	98.392	Ictidomys_tridecemlineatus
ENSG00000163655	GMPS	100	98.701	ENSJJAG00000023127	Gmps	100	98.701	Jaculus_jaculus
ENSG00000163655	GMPS	100	86.003	ENSKMAG00000020846	gmps	100	86.003	Kryptolebias_marmoratus
ENSG00000163655	GMPS	100	86.027	ENSLBEG00000011676	gmps	100	86.003	Labrus_bergylta
ENSG00000163655	GMPS	100	90.572	ENSLACG00000007529	GMPS	99	91.336	Latimeria_chalumnae
ENSG00000163655	GMPS	100	88.456	ENSLOCG00000003174	gmps	100	88.456	Lepisosteus_oculatus
ENSG00000163655	GMPS	100	97.114	ENSLAFG00000012230	GMPS	100	97.114	Loxodonta_africana
ENSG00000163655	GMPS	100	99.832	ENSMFAG00000039350	GMPS	100	99.832	Macaca_fascicularis
ENSG00000163655	GMPS	100	99.832	ENSMMUG00000007324	GMPS	100	99.832	Macaca_mulatta
ENSG00000163655	GMPS	99	88.081	ENSMNEG00000029760	GMPS	100	88.081	Macaca_nemestrina
ENSG00000163655	GMPS	100	86.580	ENSMAMG00000003973	gmps	100	86.580	Mastacembelus_armatus
ENSG00000163655	GMPS	100	86.291	ENSMZEG00005012210	gmps	100	86.291	Maylandia_zebra
ENSG00000163655	GMPS	100	93.603	ENSMGAG00000010733	GMPS	98	94.075	Meleagris_gallopavo
ENSG00000163655	GMPS	100	98.822	ENSMICG00000049568	GMPS	100	98.822	Microcebus_murinus
ENSG00000163655	GMPS	100	97.403	ENSMOCG00000021456	Gmps	100	97.403	Microtus_ochrogaster
ENSG00000163655	GMPS	100	84.680	ENSMMOG00000004360	gmps	100	84.416	Mola_mola
ENSG00000163655	GMPS	99	96.204	ENSMODG00000015770	GMPS	99	96.204	Monodelphis_domestica
ENSG00000163655	GMPS	100	86.147	ENSMALG00000009440	gmps	100	86.147	Monopterus_albus
ENSG00000163655	GMPS	100	98.124	MGP_CAROLIEiJ_G0025038	Gmps	100	98.124	Mus_caroli
ENSG00000163655	GMPS	100	97.980	ENSMUSG00000027823	Gmps	100	97.980	Mus_musculus
ENSG00000163655	GMPS	100	97.691	MGP_PahariEiJ_G0026482	Gmps	100	97.691	Mus_pahari
ENSG00000163655	GMPS	75	97.885	MGP_SPRETEiJ_G0025978	-	98	97.885	Mus_spretus
ENSG00000163655	GMPS	100	98.846	ENSMPUG00000002781	GMPS	100	98.846	Mustela_putorius_furo
ENSG00000163655	GMPS	100	96.296	ENSMLUG00000015442	GMPS	100	96.248	Myotis_lucifugus
ENSG00000163655	GMPS	100	97.403	ENSNGAG00000019127	Gmps	100	97.403	Nannospalax_galili
ENSG00000163655	GMPS	100	86.291	ENSNBRG00000001913	gmps	100	86.291	Neolamprologus_brichardi
ENSG00000163655	GMPS	100	99.832	ENSNLEG00000003856	GMPS	100	99.832	Nomascus_leucogenys
ENSG00000163655	GMPS	100	96.465	ENSODEG00000005062	GMPS	100	97.432	Octodon_degus
ENSG00000163655	GMPS	100	86.436	ENSONIG00000005518	gmps	100	86.436	Oreochromis_niloticus
ENSG00000163655	GMPS	99	96.075	ENSOANG00000013670	GMPS	100	96.252	Ornithorhynchus_anatinus
ENSG00000163655	GMPS	100	98.701	ENSOCUG00000001480	GMPS	100	98.701	Oryctolagus_cuniculus
ENSG00000163655	GMPS	100	84.512	ENSORLG00000012593	gmps	100	84.127	Oryzias_latipes
ENSG00000163655	GMPS	100	84.175	ENSORLG00020012393	gmps	100	83.838	Oryzias_latipes_hni
ENSG00000163655	GMPS	100	84.512	ENSORLG00015020602	gmps	100	84.127	Oryzias_latipes_hsok
ENSG00000163655	GMPS	100	85.690	ENSOMEG00000004911	gmps	100	85.281	Oryzias_melastigma
ENSG00000163655	GMPS	99	96.459	ENSOGAG00000008523	GMPS	99	96.959	Otolemur_garnettii
ENSG00000163655	GMPS	100	97.691	ENSOARG00000003146	GMPS	100	97.691	Ovis_aries
ENSG00000163655	GMPS	100	99.711	ENSPPAG00000042787	GMPS	100	99.711	Pan_paniscus
ENSG00000163655	GMPS	100	99.158	ENSPPRG00000024889	GMPS	100	99.158	Panthera_pardus
ENSG00000163655	GMPS	99	97.810	ENSPTIG00000012623	GMPS	100	97.810	Panthera_tigris_altaica
ENSG00000163655	GMPS	100	99.856	ENSPANG00000017625	GMPS	100	99.856	Papio_anubis
ENSG00000163655	GMPS	100	84.271	ENSPKIG00000024697	gmps	100	84.271	Paramormyrops_kingsleyae
ENSG00000163655	GMPS	100	93.651	ENSPSIG00000007196	GMPS	100	93.651	Pelodiscus_sinensis
ENSG00000163655	GMPS	100	85.690	ENSPMGG00000015771	gmps	100	85.570	Periophthalmus_magnuspinnatus
ENSG00000163655	GMPS	99	97.657	ENSPEMG00000009799	Gmps	99	97.657	Peromyscus_maniculatus_bairdii
ENSG00000163655	GMPS	100	96.825	ENSPCIG00000000036	GMPS	100	96.825	Phascolarctos_cinereus
ENSG00000163655	GMPS	100	85.354	ENSPLAG00000015928	gmps	100	85.137	Poecilia_latipinna
ENSG00000163655	GMPS	100	85.714	ENSPREG00000016715	gmps	100	85.714	Poecilia_reticulata
ENSG00000163655	GMPS	100	90.017	ENSPPYG00000014229	GMPS	100	91.587	Pongo_abelii
ENSG00000163655	GMPS	100	98.822	ENSPCOG00000024460	GMPS	100	98.822	Propithecus_coquereli
ENSG00000163655	GMPS	100	92.641	ENSPVAG00000017458	GMPS	88	92.641	Pteropus_vampyrus
ENSG00000163655	GMPS	100	86.291	ENSPNYG00000010788	gmps	100	86.291	Pundamilia_nyererei
ENSG00000163655	GMPS	100	86.291	ENSPNAG00000014256	gmps	100	86.291	Pygocentrus_nattereri
ENSG00000163655	GMPS	100	94.000	ENSRNOG00000051151	Gmps	100	97.722	Rattus_norvegicus
ENSG00000163655	GMPS	100	99.832	ENSRBIG00000019515	GMPS	100	99.832	Rhinopithecus_bieti
ENSG00000163655	GMPS	100	99.856	ENSRROG00000035915	GMPS	100	99.856	Rhinopithecus_roxellana
ENSG00000163655	GMPS	100	97.980	ENSSBOG00000033046	GMPS	100	97.698	Saimiri_boliviensis_boliviensis
ENSG00000163655	GMPS	100	95.118	ENSSHAG00000010345	GMPS	99	96.093	Sarcophilus_harrisii
ENSG00000163655	GMPS	100	86.580	ENSSFOG00015001520	gmps	100	86.580	Scleropages_formosus
ENSG00000163655	GMPS	100	85.690	ENSSMAG00000020489	gmps	97	87.145	Scophthalmus_maximus
ENSG00000163655	GMPS	100	85.690	ENSSDUG00000011961	gmps	95	87.294	Seriola_dumerili
ENSG00000163655	GMPS	100	86.003	ENSSLDG00000017360	gmps	100	86.003	Seriola_lalandi_dorsalis
ENSG00000163655	GMPS	100	94.661	ENSSPUG00000015523	-	100	94.661	Sphenodon_punctatus
ENSG00000163655	GMPS	100	86.291	ENSSPAG00000017294	gmps	100	86.291	Stegastes_partitus
ENSG00000163655	GMPS	100	99.278	ENSSSCG00000028855	GMPS	100	99.278	Sus_scrofa
ENSG00000163655	GMPS	100	93.651	ENSTGUG00000011256	GMPS	100	93.651	Taeniopygia_guttata
ENSG00000163655	GMPS	100	86.147	ENSTRUG00000006141	gmps	100	86.147	Takifugu_rubripes
ENSG00000163655	GMPS	100	85.092	ENSTNIG00000003339	gmps	100	84.914	Tetraodon_nigroviridis
ENSG00000163655	GMPS	99	90.936	ENSTBEG00000000630	GMPS	100	90.936	Tupaia_belangeri
ENSG00000163655	GMPS	100	99.134	ENSUAMG00000015465	GMPS	100	99.134	Ursus_americanus
ENSG00000163655	GMPS	99	97.515	ENSUMAG00000011640	GMPS	99	97.515	Ursus_maritimus
ENSG00000163655	GMPS	100	85.522	ENSVPAG00000008478	GMPS	100	84.211	Vicugna_pacos
ENSG00000163655	GMPS	100	97.811	ENSVVUG00000019829	GMPS	99	98.113	Vulpes_vulpes
ENSG00000163655	GMPS	100	88.745	ENSXETG00000033049	GMPS	100	88.745	Xenopus_tropicalis
ENSG00000163655	GMPS	100	85.859	ENSXMAG00000017018	gmps	100	85.714	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003921	GMP synthase activity	21873635.	IBA	Function
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity	7706277.	EXP	Function
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006177	GMP biosynthetic process	21873635.	IBA	Process
GO:0006177	GMP biosynthetic process	-	IEA	Process
GO:0006541	glutamine metabolic process	-	IEA	Process
GO:0009113	purine nucleobase biosynthetic process	8089153.	TAS	Process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	-	TAS	Process
GO:0016462	pyrophosphatase activity	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	155893678	Missense_Mutation	novel	A63V	0.3
BLCA	chr3	155916136	Missense_Mutation	rs748546400	E386K	0.23
BLCA	chr3	155914542	Missense_Mutation	NA	R337T	0.09
BLCA	chr3	155931840	Silent	novel	L546L	0.06
BLCA	chr3	155916174	Silent	NA	I398I	0.32
BLCA	chr3	155898011	Missense_Mutation	NA	K98N	0.51
BLCA	chr3	155916023	Frame_Shift_Del	novel	*N349Mfs3**	0.41
BLCA	chr3	155937699	3'UTR	novel		0.28
BLCA	chr3	155937661	Nonsense_Mutation	novel	S684*	0.24
BRCA	chr3	155935022	Missense_Mutation	NA	A595P	0.28
BRCA	chr3	155906209	Missense_Mutation	NA	D158H	0.27
BRCA	chr3	155903958	Missense_Mutation	NA	F140L	0.14
BRCA	chr3	155893697	Missense_Mutation	NA	F69L	0.18
BRCA	chr3	155934947	Nonsense_Mutation	NA	E570*	0.15
CESC	chr3	155914437	Missense_Mutation	NA	S302F	0.25	tRNA_Me_trans
CESC	chr3	155870778	5'UTR	novel		0.47
CESC	chr3	155910847	Nonsense_Mutation	rs749556827	R228*	0.1
CESC	chr3	155893581	Missense_Mutation	novel	L31V	0.1
CESC	chr3	155936443	Missense_Mutation	NA	R638Q	0.35
CESC	chr3	155903918	Missense_Mutation	novel	G127A	0.22
CESC	chr3	155934950	Missense_Mutation	novel	P571S	0.28
COAD	chr3	155910859	Nonsense_Mutation	NA	E232*	0.3
COAD	chr3	155910832	Nonsense_Mutation	novel	E223*	0.4
COAD	chr3	155911184	Missense_Mutation	novel	Q264R	0.22	tRNA_Me_trans
COAD	chr3	155922281	Frame_Shift_Del	NA	*S473Lfs26**	0.37
COAD	chr3	155914449	Missense_Mutation	NA	G306V	0.3
COAD	chr3	155937668	Silent	NA	P686P	0.23
COAD	chr3	155937650	Silent	novel	Y680Y	0.11
COAD	chr3	155937647	Missense_Mutation	novel	M679I	0.31
COAD	chr3	155910778	Missense_Mutation	novel	N205H	0.12
COAD	chr3	155897953	Missense_Mutation	NA	N79T	0.23
COAD	chr3	155910874	Missense_Mutation	NA	S237P	0.39
COAD	chr3	155935005	Missense_Mutation	NA	R589H	0.35
COAD	chr3	155903956	In_Frame_Ins	novel	F140delinsSV	0.05
COAD	chr3	155897974	Missense_Mutation	NA	A86V	0.18
ESCA	chr3	155893618	Missense_Mutation	rs749180762	R43Q	0.2
ESCA	chr3	155937632	Silent	novel	G674G	0.09
ESCA	chr3	155919251	Missense_Mutation	novel	L411V	0.18
GBM	chr3	155911165	Missense_Mutation	novel	R258C	0.49	tRNA_Me_trans
HNSC	chr3	155906207	Missense_Mutation	novel	V157A	0.46
HNSC	chr3	155910822	Silent	novel	V219V	0.12
HNSC	chr3	155914483	Silent	novel	R317R	0.29
HNSC	chr3	155936438	Silent	novel	V636V	0.12
HNSC	chr3	155914437	Missense_Mutation	novel	S302C	0.16	tRNA_Me_trans
HNSC	chr3	155936385	Missense_Mutation	novel	H619Y	0.05
HNSC	chr3	155935005	Missense_Mutation	novel	R589L	0.26
HNSC	chr3	155914473	Missense_Mutation	rs377527627	D314G	0.08
HNSC	chr3	155916057	Silent	novel	P359P	0.2
KIRP	chr3	155936413	Missense_Mutation	NA	Q628L	0.3
LAML	chr3	155911260	Silent	novel	K289K	0.06
LIHC	chr3	155937590	Splice_Site	novel	X661_splice	0.52
LIHC	chr3	155922231	Missense_Mutation	novel	I455V	0.34
LIHC	chr3	155922288	Missense_Mutation	rs375802837	A474S	0.33
LIHC	chr3	155925301	Missense_Mutation	NA	M499L	0.68
LIHC	chr3	155925301	Missense_Mutation	NA	M499L	0.11
LUAD	chr3	155925240	Splice_Site	novel	X479_splice	0.14
LUAD	chr3	155893548	Missense_Mutation	novel	G20R	0.13
LUAD	chr3	155914490	Silent	rs771766942	R320R	0.3
LUAD	chr3	155893645	Missense_Mutation	novel	S52F	0.13
LUAD	chr3	155937685	Missense_Mutation	NA	W692L	0.39
LUAD	chr3	155893633	Missense_Mutation	NA	L48Q	0.58
LUAD	chr3	155898038	Missense_Mutation	NA	M107I	0.26
LUAD	chr3	155910726	Silent	NA	A187A	0.15
LUAD	chr3	155931781	Missense_Mutation	NA	Y526C	0.36
LUAD	chr3	155898036	Missense_Mutation	NA	M107V	0.2
LUAD	chr3	155931788	Nonsense_Mutation	novel	Y528*	0.19
LUAD	chr3	155931809	Missense_Mutation	NA	K535N	0.37
LUAD	chr3	155911122	Silent	novel	L243L	0.1
LUSC	chr3	155925238	Splice_Region	novel		0.18
LUSC	chr3	155897957	Silent	novel	S80S	0.18
LUSC	chr3	155893630	Missense_Mutation	novel	E47V	0.1
LUSC	chr3	155893697	Splice_Region	novel	F69F	0.14
LUSC	chr3	155911225	Nonsense_Mutation	novel	R278*	0.19	tRNA_Me_trans
LUSC	chr3	155914459	Silent	novel	T309T	0.22
LUSC	chr3	155936486	Silent	novel	T652T	0.38
LUSC	chr3	155936366	Silent	NA	P612P	0.28
LUSC	chr3	155935006	Silent	novel	R589R	0.11
MESO	chr3	155919339	Splice_Site	novel	X440_splice	0.3
OV	chr3	155936418	Missense_Mutation	novel	S630A	0.16
OV	chr3	155911239	Silent	novel	S282S	0.21
OV	chr3	155906161	Missense_Mutation	NA	G142C	0.21
OV	chr3	155916055	Missense_Mutation	NA	P359A	0.48
OV	chr3	155925345	Silent	NA	P513P	0.2
OV	chr3	155922228	Missense_Mutation	novel	Y454H	0.06
OV	chr3	155916073	Missense_Mutation	novel	A365T	0.04
OV	chr3	155936406	Nonsense_Mutation	NA	Q626*	0.26
PRAD	chr3	155931788	Silent	NA	Y528Y	0.25
READ	chr3	155937640	Missense_Mutation	NA	R677Q	0.44
READ	chr3	155925346	Missense_Mutation	rs761594481	I514V	0.15
READ	chr3	155898023	Silent	NA	G102G	0.26
READ	chr3	155934947	Nonsense_Mutation	NA	E570*	0.31
SARC	chr3	155931779	Silent	novel	S525S	0.1
SKCM	chr3	155937627	Missense_Mutation	NA	P673S	0.24
SKCM	chr3	155893552	Missense_Mutation	novel	H21L	0.2
SKCM	chr3	155911116	Splice_Region	novel	V241V	0.35
SKCM	chr3	155925343	Missense_Mutation	NA	P513S	0.49
SKCM	chr3	155931858	Missense_Mutation	NA	R552C	0.25
SKCM	chr3	155937639	Nonsense_Mutation	rs773175391	R677*	0.48
SKCM	chr3	155937639	Nonsense_Mutation	rs773175391	R677*	0.35
SKCM	chr3	155936364	Missense_Mutation	NA	P612S	0.44
SKCM	chr3	155925332	Missense_Mutation	NA	A509V	0.08
SKCM	chr3	155914468	Silent	NA	I312I	0.22
SKCM	chr3	155914470	Missense_Mutation	NA	S313L	0.22
SKCM	chr3	155911238	Missense_Mutation	NA	S282F	0.24	tRNA_Me_trans
SKCM	chr3	155893655	Silent	novel	F55F	0.44
STAD	chr3	155893682	Missense_Mutation	novel	I64M	0.36
STAD	chr3	155937683	Silent	novel	E691E	0.46
STAD	chr3	155906162	Missense_Mutation	novel	G142D	0.38
STAD	chr3	155931848	Missense_Mutation	NA	R548S	0.34
STAD	chr3	155916153	Silent	rs770187764	H391H	0.21
STAD	chr3	155935027	Silent	NA	H596H	0.12
STAD	chr3	155935005	Missense_Mutation	NA	R589H	0.22
STAD	chr3	155911175	Missense_Mutation	rs762639569	N261S	0.17	tRNA_Me_trans
STAD	chr3	155922193	Missense_Mutation	NA	G442D	0.15
UCEC	chr3	155937640	Missense_Mutation	NA	R677Q	0.26
UCEC	chr3	155893566	Nonsense_Mutation	novel	G26*	0.28
UCEC	chr3	155911197	Silent	novel	V268V	0.16
UCEC	chr3	155935004	Missense_Mutation	NA	R589C	0.34
UCEC	chr3	155893638	Missense_Mutation	rs745389093	V50M	0.23
UCEC	chr3	155916166	Nonsense_Mutation	NA	E396*	0.51
UCEC	chr3	155898009	Missense_Mutation	novel	K98E	0.46
UCEC	chr3	155931854	Missense_Mutation	rs190602670	I550M	0.15
UCEC	chr3	155893647	Nonsense_Mutation	NA	E53*	0.45
UCEC	chr3	155893671	Missense_Mutation	novel	A61S	0.35
UCEC	chr3	155897970	Missense_Mutation	novel	D85Y	0.28
UCEC	chr3	155922301	Missense_Mutation	novel	K478T	0.32
UCEC	chr3	155893698	Missense_Mutation	rs557093697	R70C	0.41
UCEC	chr3	155910847	Nonsense_Mutation	rs749556827	R228*	0.21
UCEC	chr3	155897965	Missense_Mutation	NA	A83V	0.03
UCEC	chr3	155911274	Missense_Mutation	NA	V294A	0.08	tRNA_Me_trans
UCEC	chr3	155936442	Nonsense_Mutation	novel	R638*	0.38
UCEC	chr3	155910697	Missense_Mutation	novel	A178S	0.13
UCEC	chr3	155911204	Missense_Mutation	novel	D271Y	0.17	tRNA_Me_trans
UCEC	chr3	155931788	Silent	NA	Y528Y	0.35
UCEC	chr3	155919279	Missense_Mutation	novel	R420I	0.39
UCEC	chr3	155893640	Silent	novel	V50V	0.42
UCEC	chr3	155922259	Missense_Mutation	novel	N464S	0.57
UCEC	chr3	155893602	Missense_Mutation	rs780286753	G38R	0.46
UCEC	chr3	155914497	Missense_Mutation	NA	R322I	0.33
UCEC	chr3	155910705	Missense_Mutation	NA	E180D	0.35
UCEC	chr3	155893689	Nonsense_Mutation	NA	Q67*	0.13
UCEC	chr3	155916040	Nonsense_Mutation	novel	E354*	0.27
UCEC	chr3	155910777	Missense_Mutation	novel	K204N	0.33
UCEC	chr3	155914509	Missense_Mutation	rs761130622	T326M	0.34
UCEC	chr3	155919324	Missense_Mutation	novel	R435M	0.18
UCEC	chr3	155914492	Silent	novel	R320R	0.32
UCEC	chr3	155934947	Nonsense_Mutation	NA	E570*	0.04
UCEC	chr3	155911236	Missense_Mutation	novel	Q281H	0.21	tRNA_Me_trans
UCEC	chr3	155919255	Missense_Mutation	novel	K412T	0.07
UCEC	chr3	155911204	Missense_Mutation	novel	D271N	0.26	tRNA_Me_trans
UCEC	chr3	155919325	Missense_Mutation	novel	R435S	0.37
UCEC	chr3	155931882	Splice_Site	novel	X559_splice	0.09
UCEC	chr3	155934913	Splice_Region	novel		0.24
UCEC	chr3	155935005	Missense_Mutation	NA	R589H	0.38
UCEC	chr3	155922194	Silent	NA	G442G	0.55
UCEC	chr3	155914497	Missense_Mutation	NA	R322I	0.43
UCEC	chr3	155919245	Nonsense_Mutation	novel	E409*	0.31
UCEC	chr3	155906217	Silent	novel	V160V	0.41
UCEC	chr3	155911140	Silent	novel	S249S	0.19
UCEC	chr3	155914478	Missense_Mutation	NA	D316Y	0.17
UCEC	chr3	155937718	3'UTR	rs552940763		0.48
UCEC	chr3	155922208	Missense_Mutation	novel	V447A	0.4
UCEC	chr3	155903897	Missense_Mutation	novel	K120T	0.45
UCEC	chr3	155937689	Silent	novel	E693E	0.27
UCS	chr3	155893650	Missense_Mutation	novel	I54L	0.4
UCS	chr3	155934942	Missense_Mutation	novel	V568A	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.108	0.11092
KIRP	AMP	0.3125	0.15981
PAAD	AMP	0.1087	0.16151

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0032	Kaplan-Meier Survival Analysis
MESO	0.00044	Kaplan-Meier Survival Analysis
ACC	0.0002	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
KIRP	0.0083	Kaplan-Meier Survival Analysis
COAD	0.022	Kaplan-Meier Survival Analysis
PAAD	0.00012	Kaplan-Meier Survival Analysis
PCPG	0.019	Kaplan-Meier Survival Analysis
CESC	0.014	Kaplan-Meier Survival Analysis
READ	0.044	Kaplan-Meier Survival Analysis
KICH	0.0095	Kaplan-Meier Survival Analysis
UCEC	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
DLBC	0.04	Kaplan-Meier Survival Analysis
THCA	0.038	Kaplan-Meier Survival Analysis
LUAD	0.00011	Kaplan-Meier Survival Analysis
UVM	0.00027	Kaplan-Meier Survival Analysis
OV	0.037	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742