EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163659 (Gene tree)
Gene ID: 25976
Gene Symbol: TIPARP
Alias: DKFZP434J214|DKFZp686N0351|DDF1|PARP7|PARP-7|PARP-1|pART14|RM1
Full Name: TCDD inducible poly(ADP-ribose) polymerase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 33,536 bases
Position: chr3:156,673,235-156,706,770
Accession: 23696
RBP type: canonical RBP
Summary: This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000420141	PARP	PF00644.20	2.3e-34	1	1
ENSP00000295924	PARP	PF00644.20	3.8e-34	1	1
ENSP00000418757	PARP	PF00644.20	3.8e-34	1	1
ENSP00000420612	PARP	PF00644.20	3.8e-34	1	1
ENSP00000438345	PARP	PF00644.20	3.8e-34	1	1
ENSP00000418829	PARP	PF00644.20	3.9e-34	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21712449	Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy.	Clin Cancer Res	2011 Aug 15	Siddique HR	doi: 10.1158/1078-0432.CCR-11-0916

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000495891	TIPARP-206	2700	-	ENSP00000420141	360 (aa)	-	H7C5K7
ENST00000486483	TIPARP-205	2150	-	ENSP00000418757	657 (aa)	-	Q7Z3E1
ENST00000295924	TIPARP-201	4109	-	ENSP00000295924	657 (aa)	-	Q7Z3E1
ENST00000473702	TIPARP-203	1770	-	ENSP00000419982	506 (aa)	-	C9JXM5
ENST00000461166	TIPARP-202	4181	-	ENSP00000420612	657 (aa)	-	Q7Z3E1
ENST00000542783	TIPARP-207	3681	-	ENSP00000438345	657 (aa)	-	Q7Z3E1
ENST00000481853	TIPARP-204	2035	-	ENSP00000418829	654 (aa)	-	G5E9W1

Gene Model

Click here to download ENSG00000163659's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163659	Autistic Disorder	1.7050000E-005	-
ENSG00000163659	Autistic Disorder	1.7050000E-005	-
ENSG00000163659	Autistic Disorder	1.7050000E-005	-
ENSG00000163659	Ovarian Neoplasms	6E-51	25581431
ENSG00000163659	Ovarian Neoplasms	7E-6	23544013
ENSG00000163659	Ovarian Neoplasms	2E-34	23535730
ENSG00000163659	Ovarian Neoplasms	2E-29	23535730
ENSG00000163659	Ovarian Neoplasms	3E-7	20852632

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163659	rs7651446	3	156689208	?	Ovarian cancer	23535730	[1.35-1.54]	1.44	EFO_0001075
ENSG00000163659	rs7651446	3	156689208	?	Ovarian cancer	23535730	[1.48-1.71]	1.59	EFO_0001075
ENSG00000163659	rs2665390	3	156679960	C	Ovarian cancer in BRCA1 mutation carriers	23544013	[1.25-1.71]	1.46	EFO_0001075
ENSG00000163659	rs2665390	3	156679960	C	Ovarian cancer	20852632	[1.11-1.27]	1.19	EFO_0001075
ENSG00000163659	rs7651446	3	156689208	A	Epithelial ovarian cancer	25581431	[1.48-1.70]	1.59	Orphanet_398934
ENSG00000163659	rs7636965	3	156700615	?	Heel bone mineral density	30048462	[0.014-0.022] unit decrease	0.0181061	EFO_0009270
ENSG00000163659	rs345985	3	156679385	?	Age at menopause	30595370			EFO_0004704

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163659's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000163659	TIPARP	54	44.615	ENSG00000059378	PARP12	87	50.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163659	TIPARP	97	60.582	ENSAPOG00000020007	TIPARP	96	49.717	Acanthochromis_polyacanthus
ENSG00000163659	TIPARP	98	98.575	ENSAMEG00000003118	TIPARP	100	94.977	Ailuropoda_melanoleuca
ENSG00000163659	TIPARP	98	61.247	ENSACIG00000012575	TIPARP	99	49.642	Amphilophus_citrinellus
ENSG00000163659	TIPARP	73	40.152	ENSACIG00000003039	-	94	34.266	Amphilophus_citrinellus
ENSG00000163659	TIPARP	98	60.471	ENSAOCG00000003328	TIPARP	96	50.000	Amphiprion_ocellaris
ENSG00000163659	TIPARP	94	32.759	ENSAOCG00000012493	-	98	33.666	Amphiprion_ocellaris
ENSG00000163659	TIPARP	71	37.500	ENSAPEG00000020727	-	79	32.452	Amphiprion_percula
ENSG00000163659	TIPARP	98	60.471	ENSAPEG00000020094	TIPARP	96	50.142	Amphiprion_percula
ENSG00000163659	TIPARP	98	60.367	ENSATEG00000002945	TIPARP	96	49.930	Anabas_testudineus
ENSG00000163659	TIPARP	98	76.880	ENSAPLG00000010788	TIPARP	99	66.667	Anas_platyrhynchos
ENSG00000163659	TIPARP	98	77.374	ENSACAG00000001488	TIPARP	99	64.042	Anolis_carolinensis
ENSG00000163659	TIPARP	100	98.478	ENSANAG00000036588	TIPARP	100	98.478	Aotus_nancymaae
ENSG00000163659	TIPARP	95	35.674	ENSACLG00000019033	-	68	35.374	Astatotilapia_calliptera
ENSG00000163659	TIPARP	98	58.779	ENSACLG00000003294	TIPARP	96	50.000	Astatotilapia_calliptera
ENSG00000163659	TIPARP	98	99.715	ENSBTAG00000012120	TIPARP	100	94.825	Bos_taurus
ENSG00000163659	TIPARP	100	98.326	ENSCJAG00000004657	TIPARP	100	98.326	Callithrix_jacchus
ENSG00000163659	TIPARP	98	99.145	ENSCAFG00000008875	TIPARP	100	95.129	Canis_familiaris
ENSG00000163659	TIPARP	98	99.145	ENSCAFG00020005619	TIPARP	100	95.129	Canis_lupus_dingo
ENSG00000163659	TIPARP	98	99.430	ENSCHIG00000018721	TIPARP	100	94.977	Capra_hircus
ENSG00000163659	TIPARP	98	99.430	ENSTSYG00000009874	TIPARP	100	96.043	Carlito_syrichta
ENSG00000163659	TIPARP	98	93.447	ENSCAPG00000014614	TIPARP	100	93.852	Cavia_aperea
ENSG00000163659	TIPARP	98	98.860	ENSCPOG00000000345	TIPARP	100	93.617	Cavia_porcellus
ENSG00000163659	TIPARP	100	98.478	ENSCCAG00000029051	TIPARP	100	98.478	Cebus_capucinus
ENSG00000163659	TIPARP	100	99.391	ENSCATG00000030375	TIPARP	100	99.391	Cercocebus_atys
ENSG00000163659	TIPARP	98	98.860	ENSCLAG00000002423	TIPARP	100	94.681	Chinchilla_lanigera
ENSG00000163659	TIPARP	100	98.935	ENSCSAG00000012060	TIPARP	100	98.935	Chlorocebus_sabaeus
ENSG00000163659	TIPARP	67	99.324	ENSCHOG00000008634	TIPARP	69	99.324	Choloepus_hoffmanni
ENSG00000163659	TIPARP	98	33.616	ENSCPBG00000022321	-	78	35.535	Chrysemys_picta_bellii
ENSG00000163659	TIPARP	98	76.860	ENSCPBG00000018420	TIPARP	99	67.852	Chrysemys_picta_bellii
ENSG00000163659	TIPARP	100	98.935	ENSCANG00000031967	TIPARP	100	98.935	Colobus_angolensis_palliatus
ENSG00000163659	TIPARP	98	95.726	ENSCGRG00001011123	Tiparp	100	92.553	Cricetulus_griseus_chok1gshd
ENSG00000163659	TIPARP	98	95.726	ENSCGRG00000002020	Tiparp	100	92.553	Cricetulus_griseus_crigri
ENSG00000163659	TIPARP	98	59.021	ENSCSEG00000001795	TIPARP	92	77.397	Cynoglossus_semilaevis
ENSG00000163659	TIPARP	95	33.708	ENSCSEG00000007641	-	69	33.333	Cynoglossus_semilaevis
ENSG00000163659	TIPARP	98	61.538	ENSCVAG00000011906	TIPARP	96	51.312	Cyprinodon_variegatus
ENSG00000163659	TIPARP	98	63.686	ENSDARG00000061841	tiparp	99	53.333	Danio_rerio
ENSG00000163659	TIPARP	98	98.011	ENSDNOG00000006676	TIPARP	98	93.323	Dasypus_novemcinctus
ENSG00000163659	TIPARP	98	95.455	ENSDORG00000013554	Tiparp	100	88.671	Dipodomys_ordii
ENSG00000163659	TIPARP	96	44.944	ENSEBUG00000009796	TIPARP	93	44.150	Eptatretus_burgeri
ENSG00000163659	TIPARP	98	99.145	ENSEASG00005012401	TIPARP	100	95.586	Equus_asinus_asinus
ENSG00000163659	TIPARP	98	99.145	ENSECAG00000024048	TIPARP	100	95.294	Equus_caballus
ENSG00000163659	TIPARP	98	88.889	ENSEEUG00000004395	TIPARP	77	97.727	Erinaceus_europaeus
ENSG00000163659	TIPARP	98	60.109	ENSELUG00000008647	TIPARP	94	51.032	Esox_lucius
ENSG00000163659	TIPARP	98	99.715	ENSFCAG00000013314	TIPARP	100	95.738	Felis_catus
ENSG00000163659	TIPARP	98	75.487	ENSFALG00000004781	TIPARP	99	66.314	Ficedula_albicollis
ENSG00000163659	TIPARP	98	98.006	ENSFDAG00000008747	TIPARP	100	94.225	Fukomys_damarensis
ENSG00000163659	TIPARP	98	61.600	ENSFHEG00000001493	TIPARP	96	49.853	Fundulus_heteroclitus
ENSG00000163659	TIPARP	98	61.559	ENSGMOG00000009093	TIPARP	100	61.559	Gadus_morhua
ENSG00000163659	TIPARP	98	77.072	ENSGALG00000010256	TIPARP	99	67.359	Gallus_gallus
ENSG00000163659	TIPARP	98	61.968	ENSGAFG00000002709	TIPARP	96	51.105	Gambusia_affinis
ENSG00000163659	TIPARP	96	32.961	ENSGAFG00000016878	-	88	30.769	Gambusia_affinis
ENSG00000163659	TIPARP	98	62.022	ENSGACG00000007095	TIPARP	100	62.022	Gasterosteus_aculeatus
ENSG00000163659	TIPARP	98	35.613	ENSGAGG00000018429	-	78	35.747	Gopherus_agassizii
ENSG00000163659	TIPARP	98	76.584	ENSGAGG00000012968	TIPARP	99	67.852	Gopherus_agassizii
ENSG00000163659	TIPARP	100	99.848	ENSGGOG00000026270	TIPARP	100	99.848	Gorilla_gorilla
ENSG00000163659	TIPARP	98	58.779	ENSHBUG00000001162	TIPARP	96	49.587	Haplochromis_burtoni
ENSG00000163659	TIPARP	95	35.112	ENSHBUG00000011412	-	68	34.921	Haplochromis_burtoni
ENSG00000163659	TIPARP	98	92.308	ENSHGLG00000016026	-	100	84.347	Heterocephalus_glaber_female
ENSG00000163659	TIPARP	98	98.575	ENSHGLG00000010960	TIPARP	100	93.313	Heterocephalus_glaber_female
ENSG00000163659	TIPARP	98	92.308	ENSHGLG00100007196	-	100	84.347	Heterocephalus_glaber_male
ENSG00000163659	TIPARP	98	98.575	ENSHGLG00100012625	-	100	93.009	Heterocephalus_glaber_male
ENSG00000163659	TIPARP	98	58.995	ENSHCOG00000011891	TIPARP	94	51.642	Hippocampus_comes
ENSG00000163659	TIPARP	98	61.702	ENSIPUG00000015335	tiparp	95	50.604	Ictalurus_punctatus
ENSG00000163659	TIPARP	98	98.291	ENSSTOG00000027682	TIPARP	97	94.833	Ictidomys_tridecemlineatus
ENSG00000163659	TIPARP	98	97.436	ENSJJAG00000014369	Tiparp	100	92.401	Jaculus_jaculus
ENSG00000163659	TIPARP	98	60.590	ENSKMAG00000020703	TIPARP	65	62.924	Kryptolebias_marmoratus
ENSG00000163659	TIPARP	95	33.051	ENSKMAG00000011655	-	73	31.277	Kryptolebias_marmoratus
ENSG00000163659	TIPARP	73	40.909	ENSLBEG00000025908	-	62	32.787	Labrus_bergylta
ENSG00000163659	TIPARP	98	60.428	ENSLBEG00000011510	TIPARP	72	63.214	Labrus_bergylta
ENSG00000163659	TIPARP	93	44.886	ENSLACG00000008813	-	99	45.140	Latimeria_chalumnae
ENSG00000163659	TIPARP	97	37.222	ENSLACG00000015620	-	99	39.120	Latimeria_chalumnae
ENSG00000163659	TIPARP	98	69.916	ENSLACG00000011215	TIPARP	95	57.186	Latimeria_chalumnae
ENSG00000163659	TIPARP	96	38.440	ENSLACG00000018517	-	99	39.913	Latimeria_chalumnae
ENSG00000163659	TIPARP	96	41.076	ENSLOCG00000013687	-	99	41.244	Lepisosteus_oculatus
ENSG00000163659	TIPARP	98	65.574	ENSLOCG00000003293	TIPARP	95	54.268	Lepisosteus_oculatus
ENSG00000163659	TIPARP	96	35.574	ENSLOCG00000016551	-	77	36.199	Lepisosteus_oculatus
ENSG00000163659	TIPARP	99	33.424	ENSLOCG00000005034	-	74	33.703	Lepisosteus_oculatus
ENSG00000163659	TIPARP	98	98.575	ENSLAFG00000008210	TIPARP	100	94.377	Loxodonta_africana
ENSG00000163659	TIPARP	100	99.391	ENSMFAG00000040611	TIPARP	100	99.391	Macaca_fascicularis
ENSG00000163659	TIPARP	100	99.391	ENSMMUG00000000366	TIPARP	100	99.391	Macaca_mulatta
ENSG00000163659	TIPARP	100	99.087	ENSMNEG00000041085	TIPARP	100	99.087	Macaca_nemestrina
ENSG00000163659	TIPARP	100	99.391	ENSMLEG00000043232	TIPARP	100	99.391	Mandrillus_leucophaeus
ENSG00000163659	TIPARP	98	60.106	ENSMAMG00000004108	TIPARP	94	51.704	Mastacembelus_armatus
ENSG00000163659	TIPARP	96	34.078	ENSMZEG00005002496	-	79	33.945	Maylandia_zebra
ENSG00000163659	TIPARP	98	58.779	ENSMZEG00005011128	TIPARP	96	49.587	Maylandia_zebra
ENSG00000163659	TIPARP	73	40.824	ENSMZEG00005002354	-	79	34.018	Maylandia_zebra
ENSG00000163659	TIPARP	98	75.350	ENSMGAG00000010699	TIPARP	99	67.273	Meleagris_gallopavo
ENSG00000163659	TIPARP	98	95.726	ENSMAUG00000013170	Tiparp	100	91.185	Mesocricetus_auratus
ENSG00000163659	TIPARP	98	99.430	ENSMICG00000049557	TIPARP	100	96.049	Microcebus_murinus
ENSG00000163659	TIPARP	98	94.017	ENSMOCG00000011217	Tiparp	100	90.426	Microtus_ochrogaster
ENSG00000163659	TIPARP	98	59.788	ENSMMOG00000003779	TIPARP	99	48.232	Mola_mola
ENSG00000163659	TIPARP	96	34.971	ENSMMOG00000000841	-	91	32.258	Mola_mola
ENSG00000163659	TIPARP	99	67.474	ENSMODG00000015744	TIPARP	99	67.319	Monodelphis_domestica
ENSG00000163659	TIPARP	98	62.032	ENSMALG00000009322	TIPARP	96	50.997	Monopterus_albus
ENSG00000163659	TIPARP	98	96.296	MGP_CAROLIEiJ_G0025044	Tiparp	100	92.097	Mus_caroli
ENSG00000163659	TIPARP	98	96.581	ENSMUSG00000034640	Tiparp	100	92.553	Mus_musculus
ENSG00000163659	TIPARP	98	96.296	MGP_PahariEiJ_G0026487	Tiparp	100	92.401	Mus_pahari
ENSG00000163659	TIPARP	98	96.581	MGP_SPRETEiJ_G0025986	Tiparp	100	92.401	Mus_spretus
ENSG00000163659	TIPARP	98	99.145	ENSMPUG00000002811	TIPARP	100	95.282	Mustela_putorius_furo
ENSG00000163659	TIPARP	100	93.874	ENSMLUG00000006995	TIPARP	100	90.107	Myotis_lucifugus
ENSG00000163659	TIPARP	98	97.721	ENSNGAG00000024372	Tiparp	100	93.009	Nannospalax_galili
ENSG00000163659	TIPARP	51	38.251	ENSNBRG00000010331	-	79	38.251	Neolamprologus_brichardi
ENSG00000163659	TIPARP	100	99.087	ENSNLEG00000003977	TIPARP	100	99.087	Nomascus_leucogenys
ENSG00000163659	TIPARP	98	81.250	ENSMEUG00000011326	TIPARP	100	75.705	Notamacropus_eugenii
ENSG00000163659	TIPARP	98	90.598	ENSOPRG00000003961	-	100	87.671	Ochotona_princeps
ENSG00000163659	TIPARP	98	98.006	ENSODEG00000003454	TIPARP	100	94.073	Octodon_degus
ENSG00000163659	TIPARP	70	80.876	ENSOANG00000015317	-	98	80.876	Ornithorhynchus_anatinus
ENSG00000163659	TIPARP	100	93.491	ENSOCUG00000014910	TIPARP	83	94.139	Oryctolagus_cuniculus
ENSG00000163659	TIPARP	98	61.804	ENSORLG00000023309	TIPARP	96	48.933	Oryzias_latipes
ENSG00000163659	TIPARP	98	60.847	ENSORLG00020012576	TIPARP	95	49.138	Oryzias_latipes_hni
ENSG00000163659	TIPARP	98	60.847	ENSORLG00015020733	TIPARP	96	49.006	Oryzias_latipes_hsok
ENSG00000163659	TIPARP	98	60.317	ENSOMEG00000004712	TIPARP	96	48.939	Oryzias_melastigma
ENSG00000163659	TIPARP	98	97.436	ENSOGAG00000003455	TIPARP	100	94.689	Otolemur_garnettii
ENSG00000163659	TIPARP	98	99.430	ENSOARG00000002923	TIPARP	100	94.977	Ovis_aries
ENSG00000163659	TIPARP	100	99.012	ENSPPAG00000029528	TIPARP	100	98.935	Pan_paniscus
ENSG00000163659	TIPARP	98	100.000	ENSPPRG00000017076	TIPARP	100	95.738	Panthera_pardus
ENSG00000163659	TIPARP	98	100.000	ENSPTIG00000014258	TIPARP	100	95.738	Panthera_tigris_altaica
ENSG00000163659	TIPARP	100	99.407	ENSPTRG00000015561	TIPARP	100	99.239	Pan_troglodytes
ENSG00000163659	TIPARP	100	99.391	ENSPANG00000007235	TIPARP	100	99.391	Papio_anubis
ENSG00000163659	TIPARP	97	32.222	ENSPKIG00000003548	-	72	33.409	Paramormyrops_kingsleyae
ENSG00000163659	TIPARP	98	65.479	ENSPKIG00000024616	tiparp	99	55.994	Paramormyrops_kingsleyae
ENSG00000163659	TIPARP	99	33.244	ENSPSIG00000014291	-	100	35.045	Pelodiscus_sinensis
ENSG00000163659	TIPARP	96	31.034	ENSPSIG00000017627	-	99	33.102	Pelodiscus_sinensis
ENSG00000163659	TIPARP	96	31.519	ENSPSIG00000013221	-	100	32.644	Pelodiscus_sinensis
ENSG00000163659	TIPARP	98	77.716	ENSPSIG00000005160	TIPARP	99	67.809	Pelodiscus_sinensis
ENSG00000163659	TIPARP	97	43.417	ENSPSIG00000010090	-	82	45.455	Pelodiscus_sinensis
ENSG00000163659	TIPARP	96	35.112	ENSPSIG00000006564	-	99	35.455	Pelodiscus_sinensis
ENSG00000163659	TIPARP	98	60.989	ENSPMGG00000016670	TIPARP	99	51.923	Periophthalmus_magnuspinnatus
ENSG00000163659	TIPARP	98	95.442	ENSPEMG00000014866	Tiparp	100	91.185	Peromyscus_maniculatus_bairdii
ENSG00000163659	TIPARP	59	56.279	ENSPMAG00000001724	-	100	56.279	Petromyzon_marinus
ENSG00000163659	TIPARP	58	51.196	ENSPMAG00000002134	-	100	51.196	Petromyzon_marinus
ENSG00000163659	TIPARP	98	79.121	ENSPCIG00000003641	TIPARP	99	73.485	Phascolarctos_cinereus
ENSG00000163659	TIPARP	98	61.436	ENSPFOG00000008850	TIPARP	96	50.735	Poecilia_formosa
ENSG00000163659	TIPARP	96	32.022	ENSPFOG00000016905	-	100	32.118	Poecilia_formosa
ENSG00000163659	TIPARP	96	31.933	ENSPLAG00000012034	-	69	31.648	Poecilia_latipinna
ENSG00000163659	TIPARP	98	61.436	ENSPLAG00000009297	TIPARP	96	50.735	Poecilia_latipinna
ENSG00000163659	TIPARP	96	32.402	ENSPMEG00000004973	-	70	32.018	Poecilia_mexicana
ENSG00000163659	TIPARP	98	61.436	ENSPMEG00000002480	TIPARP	96	50.735	Poecilia_mexicana
ENSG00000163659	TIPARP	96	33.894	ENSPREG00000022348	-	67	34.411	Poecilia_reticulata
ENSG00000163659	TIPARP	98	61.436	ENSPREG00000016895	TIPARP	96	50.515	Poecilia_reticulata
ENSG00000163659	TIPARP	100	99.239	ENSPPYG00000014234	TIPARP	100	99.239	Pongo_abelii
ENSG00000163659	TIPARP	98	77.208	ENSPCAG00000002482	TIPARP	100	80.813	Procavia_capensis
ENSG00000163659	TIPARP	98	98.291	ENSPCOG00000018471	TIPARP	100	95.593	Propithecus_coquereli
ENSG00000163659	TIPARP	98	98.295	ENSPVAG00000001903	TIPARP	100	94.073	Pteropus_vampyrus
ENSG00000163659	TIPARP	98	58.779	ENSPNYG00000010697	TIPARP	93	49.654	Pundamilia_nyererei
ENSG00000163659	TIPARP	69	41.036	ENSPNYG00000018003	-	70	41.036	Pundamilia_nyererei
ENSG00000163659	TIPARP	97	64.578	ENSPNAG00000013979	TIPARP	95	52.049	Pygocentrus_nattereri
ENSG00000163659	TIPARP	98	96.296	ENSRNOG00000011238	Tiparp	100	92.249	Rattus_norvegicus
ENSG00000163659	TIPARP	100	99.209	ENSRBIG00000022299	TIPARP	96	99.213	Rhinopithecus_bieti
ENSG00000163659	TIPARP	100	99.391	ENSRROG00000041667	TIPARP	100	99.391	Rhinopithecus_roxellana
ENSG00000163659	TIPARP	100	98.021	ENSSBOG00000030511	TIPARP	100	98.021	Saimiri_boliviensis_boliviensis
ENSG00000163659	TIPARP	98	78.273	ENSSHAG00000018924	TIPARP	100	71.922	Sarcophilus_harrisii
ENSG00000163659	TIPARP	97	34.615	ENSSFOG00015022974	-	69	35.650	Scleropages_formosus
ENSG00000163659	TIPARP	98	61.518	ENSSMAG00000020479	TIPARP	99	60.823	Scophthalmus_maximus
ENSG00000163659	TIPARP	96	34.831	ENSSDUG00000018796	-	62	36.156	Seriola_dumerili
ENSG00000163659	TIPARP	98	60.000	ENSSDUG00000012080	TIPARP	96	49.508	Seriola_dumerili
ENSG00000163659	TIPARP	98	60.000	ENSSLDG00000017252	TIPARP	96	49.508	Seriola_lalandi_dorsalis
ENSG00000163659	TIPARP	71	98.649	ENSSARG00000011613	-	73	98.649	Sorex_araneus
ENSG00000163659	TIPARP	95	44.857	ENSSPUG00000016837	-	99	45.245	Sphenodon_punctatus
ENSG00000163659	TIPARP	98	75.346	ENSSPUG00000015764	TIPARP	100	64.636	Sphenodon_punctatus
ENSG00000163659	TIPARP	93	33.828	ENSSPAG00000008458	-	69	33.411	Stegastes_partitus
ENSG00000163659	TIPARP	98	58.568	ENSSPAG00000017423	TIPARP	96	49.298	Stegastes_partitus
ENSG00000163659	TIPARP	98	99.715	ENSSSCG00000027646	TIPARP	100	96.499	Sus_scrofa
ENSG00000163659	TIPARP	98	75.487	ENSTGUG00000017448	TIPARP	100	66.821	Taeniopygia_guttata
ENSG00000163659	TIPARP	98	60.317	ENSTRUG00000022644	TIPARP	76	61.814	Takifugu_rubripes
ENSG00000163659	TIPARP	98	100.000	ENSTTRG00000003102	TIPARP	100	95.434	Tursiops_truncatus
ENSG00000163659	TIPARP	98	98.860	ENSUAMG00000018074	TIPARP	100	95.586	Ursus_americanus
ENSG00000163659	TIPARP	98	98.860	ENSUMAG00000011453	TIPARP	100	95.586	Ursus_maritimus
ENSG00000163659	TIPARP	98	99.430	ENSVPAG00000008484	TIPARP	100	95.586	Vicugna_pacos
ENSG00000163659	TIPARP	98	99.145	ENSVVUG00000019862	TIPARP	100	95.129	Vulpes_vulpes
ENSG00000163659	TIPARP	98	76.136	ENSXETG00000012260	tiparp	99	61.756	Xenopus_tropicalis
ENSG00000163659	TIPARP	59	46.479	ENSXETG00000032370	-	93	42.126	Xenopus_tropicalis
ENSG00000163659	TIPARP	98	61.702	ENSXCOG00000000447	TIPARP	96	51.026	Xiphophorus_couchianus
ENSG00000163659	TIPARP	96	31.373	ENSXCOG00000013837	-	71	39.906	Xiphophorus_couchianus
ENSG00000163659	TIPARP	62	39.904	ENSXMAG00000022584	-	70	39.437	Xiphophorus_maculatus
ENSG00000163659	TIPARP	98	61.968	ENSXMAG00000022705	TIPARP	96	51.026	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001570	vasculogenesis	-	IEA	Process
GO:0001822	kidney development	-	IEA	Process
GO:0003950	NAD+ ADP-ribosyltransferase activity	23275542.	IDA	Function
GO:0005634	nucleus	23275542.30373764.	IDA	Component
GO:0006471	protein ADP-ribosylation	30373764.	IDA	Process
GO:0008209	androgen metabolic process	-	IEA	Process
GO:0008210	estrogen metabolic process	-	IEA	Process
GO:0008585	female gonad development	-	IEA	Process
GO:0009791	post-embryonic development	-	IEA	Process
GO:0010629	negative regulation of gene expression	23275542.	IMP	Process
GO:0030097	hemopoiesis	-	IEA	Process
GO:0035326	enhancer binding	23275542.	IDA	Function
GO:0045732	positive regulation of protein catabolic process	23275542.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	IEA	Process
GO:0048705	skeletal system morphogenesis	-	IEA	Process
GO:0048745	smooth muscle tissue development	-	IEA	Process
GO:0060021	roof of mouth development	-	IEA	Process
GO:0060325	face morphogenesis	-	IEA	Process
GO:0070213	protein auto-ADP-ribosylation	30373764.	IDA	Process
GO:0071407	cellular response to organic cyclic compound	23275542.	IDA	Process
GO:1904612	response to 2,3,7,8-tetrachlorodibenzodioxine	-	IEA	Process
GO:1990404	protein ADP-ribosylase activity	25043379.30373764.	IDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20852632	A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.	Nat Genet	2010 Oct	Goode EL	doi: 10.1038/ng.668

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	156695982	Nonsense_Mutation	novel	R402*	0.29
BLCA	chr3	156677683	5'UTR	novel		0.32
BLCA	chr3	156678565	Missense_Mutation	NA	E290K	0.65
BLCA	chr3	156677805	Silent	NA	L36L	0.11
BLCA	chr3	156678273	Frame_Shift_Del	novel	*N192Kfs15**	0.37
BLCA	chr3	156678327	Silent	novel	L210L	0.42
BLCA	chr3	156704893	Missense_Mutation	novel	S579F	0.44	PARP
BLCA	chr3	156677980	Missense_Mutation	novel	E95K	0.14
BLCA	chr3	156678049	Missense_Mutation	novel	G118R	0.38
BRCA	chr3	156677941	Missense_Mutation	NA	E82K	0.13
BRCA	chr3	156704888	Missense_Mutation	NA	K577N	0.25	PARP
BRCA	chr3	156678140	Missense_Mutation	novel	S148I	0.13
BRCA	chr3	156678483	Silent	NA	T262T	0.24
CESC	chr3	156704935	Missense_Mutation	novel	T593M	0.13	PARP
CESC	chr3	156678177	Silent	NA	Q160Q	0.21
CESC	chr3	156695875	Missense_Mutation	rs745377501	R366Q	0.27
CESC	chr3	156705747	3'UTR	novel		0.22
CESC	chr3	156674687	5'UTR	novel		0.3
CHOL	chr3	156706265	3'UTR	novel		0.43
COAD	chr3	156695995	Missense_Mutation	rs771589802	R406H	0.47
COAD	chr3	156678094	Nonsense_Mutation	novel	R133*	0.3
COAD	chr3	156677711	Missense_Mutation	novel	T5S	0.12
COAD	chr3	156678087	Silent	novel	A130A	0.08
COAD	chr3	156694125	Frame_Shift_Del	NA	*I342Tfs25**	0.42
COAD	chr3	156677903	Missense_Mutation	novel	L69R	0.25
COAD	chr3	156678095	Missense_Mutation	rs147956353	R133Q	0.08
COAD	chr3	156705138	3'UTR	novel		0.18
COAD	chr3	156678095	Missense_Mutation	rs147956353	R133Q	0.17
COAD	chr3	156678468	In_Frame_Ins	novel	C257_L258insKTVF	0.1
COAD	chr3	156705111	Frame_Shift_Ins	novel	*S652Ifs15**	0.08
ESCA	chr3	156706014	3'UTR	novel		0.07
GBM	chr3	156705182	3'UTR	novel		0.32
GBM	chr3	156678120	Silent	novel	S141S	0.04
GBM	chr3	156678095	Missense_Mutation	rs147956353	R133Q	0.35
GBM	chr3	156677947	Missense_Mutation	novel	S84C	0.51
GBM	chr3	156704832	Missense_Mutation	novel	F559L	0.04	PARP
GBM	chr3	156704740	Missense_Mutation	novel	R528T	0.09	PARP
GBM	chr3	156704829	Missense_Mutation	rs766769030	M558V	0.21	PARP
GBM	chr3	156677921	Missense_Mutation	novel	S75C	0.34
GBM	chr3	156704977	Missense_Mutation	novel	P607L	0.58	PARP
GBM	chr3	156694115	Missense_Mutation	rs148252230	N338S	0.11
HNSC	chr3	156694162	Missense_Mutation	novel	H354Y	0.07
HNSC	chr3	156678413	Missense_Mutation	novel	G239E	0.15
HNSC	chr3	156694170	Silent	novel	G356G	0.25
KIRC	chr3	156703570	Missense_Mutation	NA	V465D	0.13
KIRC	chr3	156677679	5'UTR	novel		0.75
LGG	chr3	156694188	Missense_Mutation	novel	E362D	0.05
LGG	chr3	156704740	Missense_Mutation	novel	R528T	0.08	PARP
LGG	chr3	156705219	3'UTR	novel		0.34
LIHC	chr3	156704689	Missense_Mutation	novel	K511T	0.27	PARP
LIHC	chr3	156705179	3'UTR	novel		0.5
LIHC	chr3	156678254	Missense_Mutation	novel	P186L	0.05
LUAD	chr3	156705162	3'UTR	novel		0.19
LUAD	chr3	156677851	Missense_Mutation	novel	T52S	0.04
LUAD	chr3	156695972	Missense_Mutation	rs746549290	E398D	0.1
LUAD	chr3	156678336	Silent	novel	D213D	0.26
LUAD	chr3	156677679	5'UTR	novel		0.09
LUSC	chr3	156678581	Missense_Mutation	novel	N295S	0.25
LUSC	chr3	156677993	Nonsense_Mutation	NA	S99*	0.18
LUSC	chr3	156677789	Missense_Mutation	novel	E31G	0.21
OV	chr3	156703610	Silent	NA	Y478Y	0.42
OV	chr3	156678517	In_Frame_Ins	novel	T274delinsRNPVA	0.04
OV	chr3	156678520	Frame_Shift_Del	novel	*T275Lfs27**	0.03
OV	chr3	156677715	Silent	rs190841318	T6T	0.18
PAAD	chr3	156695927	Missense_Mutation	novel	M383I	0.2
PAAD	chr3	156703568	Silent	rs755772516	Q464Q	0.09
PAAD	chr3	156704810	Silent	novel	V551V	0.16
PCPG	chr3	156703503	Missense_Mutation	novel	V443I	0.06
PRAD	chr3	156694138	Missense_Mutation	NA	V346I	0.38
PRAD	chr3	156694121	Missense_Mutation	novel	N340S	0.37
READ	chr3	156678295	Missense_Mutation	novel	L200M	0.36
READ	chr3	156678423	Missense_Mutation	NA	I242M	0.42
READ	chr3	156678565	Missense_Mutation	NA	E290K	0.36
READ	chr3	156694027	Nonsense_Mutation	NA	E309*	0.28
SARC	chr3	156678561	Silent	novel	H288H	0.52
SARC	chr3	156706260	3'UTR	novel		0.15
SKCM	chr3	156678031	Missense_Mutation	novel	P112S	0.05
SKCM	chr3	156677796	Silent	NA	I33I	0.12
SKCM	chr3	156678159	Silent	NA	S154S	0.3
SKCM	chr3	156677801	Missense_Mutation	novel	P35L	0.24
SKCM	chr3	156677912	Missense_Mutation	rs373659607	V72A	0.38
SKCM	chr3	156695916	Nonsense_Mutation	NA	R380*	0.34
SKCM	chr3	156704968	Missense_Mutation	NA	R604K	0.13	PARP
SKCM	chr3	156705213	3'UTR	novel		0.41
SKCM	chr3	156705214	3'UTR	novel		0.4
SKCM	chr3	156677963	Missense_Mutation	NA	M89R	0.61
SKCM	chr3	156678177	Silent	NA	Q160Q	0.34
SKCM	chr3	156677800	Missense_Mutation	NA	P35S	0.12
SKCM	chr3	156705096	Nonsense_Mutation	novel	Q647*	0.5	PARP
SKCM	chr3	156704714	Silent	NA	F519F	0.35
SKCM	chr3	156678604	Missense_Mutation	novel	M303V	0.08
SKCM	chr3	156704884	Missense_Mutation	NA	S576F	0.42	PARP
SKCM	chr3	156678364	Missense_Mutation	novel	V223L	0.39
SKCM	chr3	156704974	Missense_Mutation	rs267599664	P606L	0.4	PARP
SKCM	chr3	156678175	Nonsense_Mutation	NA	Q160*	0.32
SKCM	chr3	156678108	Silent	novel	I137I	0.32
SKCM	chr3	156705035	Silent	NA	F626F	0.24
STAD	chr3	156705284	3'UTR	rs185161634		0.57
STAD	chr3	156677715	Silent	rs190841318	T6T	0.36
STAD	chr3	156678507	Frame_Shift_Ins	novel	*R272Kfs13**	0.09
STAD	chr3	156695888	Missense_Mutation	NA	E370D	0.13
STAD	chr3	156695994	Missense_Mutation	rs17854621	R406C	0.34
STAD	chr3	156678411	Silent	rs764150149	N238N	0.32
STAD	chr3	156705006	Missense_Mutation	rs757500372	D617N	0.29	PARP
STAD	chr3	156705079	Missense_Mutation	NA	Y641C	0.19	PARP
STAD	chr3	156677837	Missense_Mutation	NA	R47K	0.35
STAD	chr3	156678397	Missense_Mutation	NA	T234P	0.08
THCA	chr3	156703428	Missense_Mutation	rs1137515	L418F	0.13
UCEC	chr3	156677739	Silent	novel	V14V	0.13
UCEC	chr3	156694065	Missense_Mutation	novel	E321D	0.4
UCEC	chr3	156678576	Silent	rs771093974	Y293Y	0.35
UCEC	chr3	156694145	Missense_Mutation	novel	K348T	0.22
UCEC	chr3	156678504	Silent	novel	Q269Q	0.08
UCEC	chr3	156706678	3'UTR	novel		0.16
UCEC	chr3	156678091	Missense_Mutation	novel	E132K	0.21
UCEC	chr3	156678363	Silent	novel	L222L	0.32
UCEC	chr3	156678561	Missense_Mutation	novel	H288Q	0.39
UCEC	chr3	156703437	Missense_Mutation	novel	V421I	0.38
UCEC	chr3	156704922	Missense_Mutation	novel	A589S	0.43	PARP
UCEC	chr3	156706545	3'UTR	novel		0.31
UCEC	chr3	156678364	Missense_Mutation	rs759242586	V223M	0.43
UCEC	chr3	156705826	3'UTR	novel		0.56
UCEC	chr3	156678529	Missense_Mutation	novel	W278R	0.47
UCEC	chr3	156705783	3'UTR	NA		0.44
UCEC	chr3	156704975	Silent	novel	P606P	0.28
UCEC	chr3	156703600	Missense_Mutation	NA	R475Q	0.42	PARP
UCEC	chr3	156677826	Missense_Mutation	novel	K43N	0.47
UCEC	chr3	156705667	3'UTR	novel		0.34
UCEC	chr3	156678095	Missense_Mutation	rs147956353	R133Q	0.11
UCEC	chr3	156695973	Missense_Mutation	novel	I399V	0.36
UCEC	chr3	156695886	Nonsense_Mutation	novel	E370*	0.19
UCEC	chr3	156703691	Missense_Mutation	novel	E505D	0.24	PARP
UCEC	chr3	156705776	3'UTR	novel		0.44
UCEC	chr3	156678461	Missense_Mutation	novel	R255K	0.34
UCEC	chr3	156704906	Silent	novel	V583V	0.33
UCEC	chr3	156694088	Missense_Mutation	novel	R329Q	0.1
UCEC	chr3	156694072	Nonsense_Mutation	novel	E324*	0.06
UCEC	chr3	156694022	Missense_Mutation	novel	G307E	0.26
UCEC	chr3	156704806	Missense_Mutation	novel	R550Q	0.1	PARP
UCEC	chr3	156706341	3'UTR	novel		0.23
UCEC	chr3	156704974	Missense_Mutation	novel	P606H	0.24	PARP
UCEC	chr3	156678269	Frame_Shift_Del	novel	*N192Tfs15**	0.07
UCEC	chr3	156704732	Missense_Mutation	novel	I525M	0.03	PARP
UCEC	chr3	156677742	Silent	novel	Q15Q	0.3
UCEC	chr3	156705083	Frame_Shift_Ins	novel	*Y643Ifs7**	0.18	PARP
UCEC	chr3	156705085	Missense_Mutation	novel	Y643C	0.18	PARP
UCEC	chr3	156678547	Missense_Mutation	NA	D284Y	0.39
UCEC	chr3	156704751	Missense_Mutation	novel	H532N	0.11	PARP
UCEC	chr3	156694095	Silent	rs143106868	L331L	0.34
UCEC	chr3	156705893	3'UTR	novel		0.08
UCEC	chr3	156678567	Silent	NA	E290E	0.34
UCEC	chr3	156678425	Missense_Mutation	novel	C243Y	0.55
UCEC	chr3	156694179	Missense_Mutation	novel	E359D	0.22
UCEC	chr3	156704686	Missense_Mutation	novel	K510I	0.14	PARP
UCEC	chr3	156705173	3'UTR	novel		0.24
UCEC	chr3	156705066	Missense_Mutation	novel	D637Y	0.39	PARP
UCEC	chr3	156705785	3'UTR	novel		0.31
UCEC	chr3	156704725	Missense_Mutation	rs775538386	R523K	0.31	PARP
UCEC	chr3	156705943	3'UTR	novel		0.5

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.108	0.11092
KIRP	AMP	0.3125	0.15981
PAAD	AMP	0.1033	0.16151

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0017	Kaplan-Meier Survival Analysis
HNSC	0.033	Kaplan-Meier Survival Analysis
SKCM	0.00048	Kaplan-Meier Survival Analysis
LUSC	0.041	Kaplan-Meier Survival Analysis
BRCA	0.013	Kaplan-Meier Survival Analysis
PAAD	0.0029	Kaplan-Meier Survival Analysis
LGG	0.028	Kaplan-Meier Survival Analysis
THCA	0.016	Kaplan-Meier Survival Analysis
UVM	0.00015	Kaplan-Meier Survival Analysis
OV	0.045	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742