EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163684 (Gene tree)
Gene ID: 11102
Gene Symbol: RPP14
Alias: P14
Full Name: ribonuclease P/MRP subunit p14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 18,451 bases
Position: chr3:58,306,245-58,324,695
Accession: 30327
RBP type: canonical RBP
Summary: This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000295959	RNase_P_Rpp14	PF01900.19	1.5e-08	1	1
ENSP00000412894	RNase_P_Rpp14	PF01900.19	1.5e-08	1	1
ENSP00000419909	RNase_P_Rpp14	PF01900.19	1.5e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461797	RPP14-203	531	-	-	- (aa)	-	-
ENST00000462046	RPP14-204	794	-	-	- (aa)	-	-
ENST00000445193	RPP14-202	7985	-	ENSP00000412894	124 (aa)	-	O95059
ENST00000463550	RPP14-205	658	-	-	- (aa)	-	-
ENST00000466547	RPP14-206	805	-	ENSP00000419909	124 (aa)	-	O95059
ENST00000295959	RPP14-201	3121	-	ENSP00000295959	124 (aa)	-	O95059

Gene Model

Click here to download ENSG00000163684's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163684	Arthritis, Rheumatoid	5E-8	24390342

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163684	rs73081554	3	58317208	A	Rheumatoid arthritis (ACPA-positive)	24532676	[1.13-1.29]	1.21	EFO_0000685
ENSG00000163684	rs73081554	3	58317208	T	Rheumatoid arthritis	24390342	[1.11-1.25]	1.18	EFO_0000685
ENSG00000163684	rs73081554	3	58317208	T	Rheumatoid arthritis	30423114	[0.11-0.23] unit increase	0.16616	EFO_0000685

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163684's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163684	RPP14	96	60.504	ENSAPOG00000005690	rpp14	93	60.504	Acanthochromis_polyacanthus
ENSG00000163684	RPP14	100	95.968	ENSAMEG00000011997	RPP14	100	95.968	Ailuropoda_melanoleuca
ENSG00000163684	RPP14	97	60.833	ENSACIG00000009835	rpp14	93	60.833	Amphilophus_citrinellus
ENSG00000163684	RPP14	96	59.664	ENSAOCG00000009434	RPP14	93	59.664	Amphiprion_ocellaris
ENSG00000163684	RPP14	96	59.664	ENSAOCG00000002310	rpp14	92	59.664	Amphiprion_ocellaris
ENSG00000163684	RPP14	96	59.664	ENSAOCG00000017737	-	92	59.664	Amphiprion_ocellaris
ENSG00000163684	RPP14	90	53.153	ENSAPEG00000023583	rpp14	76	53.153	Amphiprion_percula
ENSG00000163684	RPP14	97	63.333	ENSATEG00000002903	rpp14	93	63.333	Anabas_testudineus
ENSG00000163684	RPP14	56	79.710	ENSAPLG00000006272	RPP14	100	79.710	Anas_platyrhynchos
ENSG00000163684	RPP14	97	69.167	ENSACAG00000011880	RPP14	97	69.167	Anolis_carolinensis
ENSG00000163684	RPP14	100	94.355	ENSANAG00000020129	-	100	94.355	Aotus_nancymaae
ENSG00000163684	RPP14	90	92.857	ENSANAG00000028778	-	100	92.857	Aotus_nancymaae
ENSG00000163684	RPP14	97	61.667	ENSACLG00000006157	rpp14	93	61.667	Astatotilapia_calliptera
ENSG00000163684	RPP14	97	62.500	ENSAMXG00000042078	rpp14	94	62.500	Astyanax_mexicanus
ENSG00000163684	RPP14	100	92.742	ENSBTAG00000019987	RPP14	100	92.742	Bos_taurus
ENSG00000163684	RPP14	100	95.968	ENSCJAG00000048347	RPP14	100	95.968	Callithrix_jacchus
ENSG00000163684	RPP14	100	92.742	ENSCAFG00020010128	RPP14	95	92.742	Canis_lupus_dingo
ENSG00000163684	RPP14	100	92.742	ENSCHIG00000019415	RPP14	100	92.742	Capra_hircus
ENSG00000163684	RPP14	100	95.161	ENSTSYG00000013343	RPP14	100	95.161	Carlito_syrichta
ENSG00000163684	RPP14	100	91.129	ENSCPOG00000004281	RPP14	100	91.129	Cavia_porcellus
ENSG00000163684	RPP14	100	99.194	ENSCCAG00000033002	RPP14	100	99.194	Cebus_capucinus
ENSG00000163684	RPP14	100	100.000	ENSCATG00000044209	RPP14	100	100.000	Cercocebus_atys
ENSG00000163684	RPP14	57	98.592	ENSCSAG00000012176	RPP14	100	98.592	Chlorocebus_sabaeus
ENSG00000163684	RPP14	100	100.000	ENSCANG00000034713	RPP14	100	100.000	Colobus_angolensis_palliatus
ENSG00000163684	RPP14	97	85.833	ENSCGRG00001000931	Rpp14	98	85.833	Cricetulus_griseus_chok1gshd
ENSG00000163684	RPP14	97	84.167	ENSCGRG00000005816	Rpp14	98	84.167	Cricetulus_griseus_crigri
ENSG00000163684	RPP14	94	54.701	ENSCSEG00000018570	rpp14	90	54.701	Cynoglossus_semilaevis
ENSG00000163684	RPP14	85	52.830	ENSCVAG00000013824	-	89	52.830	Cyprinodon_variegatus
ENSG00000163684	RPP14	94	61.538	ENSDARG00000011152	rpp14	94	61.538	Danio_rerio
ENSG00000163684	RPP14	100	90.323	ENSDNOG00000043534	-	100	90.323	Dasypus_novemcinctus
ENSG00000163684	RPP14	99	85.366	ENSETEG00000009095	RPP14	99	85.366	Echinops_telfairi
ENSG00000163684	RPP14	93	46.087	ENSEBUG00000007571	rpp14	84	46.087	Eptatretus_burgeri
ENSG00000163684	RPP14	100	91.129	ENSEASG00005001253	RPP14	100	91.129	Equus_asinus_asinus
ENSG00000163684	RPP14	100	91.129	ENSECAG00000006471	RPP14	100	91.129	Equus_caballus
ENSG00000163684	RPP14	99	92.683	ENSEEUG00000000410	RPP14	100	92.683	Erinaceus_europaeus
ENSG00000163684	RPP14	86	56.075	ENSELUG00000014879	rpp14	90	56.075	Esox_lucius
ENSG00000163684	RPP14	100	95.161	ENSFCAG00000033032	RPP14	100	95.161	Felis_catus
ENSG00000163684	RPP14	94	68.103	ENSFALG00000013148	RPP14	90	65.854	Ficedula_albicollis
ENSG00000163684	RPP14	66	65.854	ENSFHEG00000010443	-	77	72.857	Fundulus_heteroclitus
ENSG00000163684	RPP14	96	59.664	ENSGMOG00000010625	RPP14	99	59.664	Gadus_morhua
ENSG00000163684	RPP14	86	56.075	ENSGALG00000048543	RPP14	80	56.075	Gallus_gallus
ENSG00000163684	RPP14	98	55.738	ENSGAFG00000008126	-	94	55.738	Gambusia_affinis
ENSG00000163684	RPP14	98	61.157	ENSGACG00000003941	rpp14	98	61.157	Gasterosteus_aculeatus
ENSG00000163684	RPP14	99	75.610	ENSGAGG00000000329	RPP14	93	75.610	Gopherus_agassizii
ENSG00000163684	RPP14	100	100.000	ENSGGOG00000016164	RPP14	100	100.000	Gorilla_gorilla
ENSG00000163684	RPP14	97	60.833	ENSHBUG00000014383	rpp14	93	60.833	Haplochromis_burtoni
ENSG00000163684	RPP14	100	87.097	ENSHGLG00100015266	RPP14	100	87.097	Heterocephalus_glaber_male
ENSG00000163684	RPP14	94	58.120	ENSHCOG00000013696	rpp14	91	58.120	Hippocampus_comes
ENSG00000163684	RPP14	98	65.289	ENSIPUG00000010066	rpp14	99	65.289	Ictalurus_punctatus
ENSG00000163684	RPP14	100	92.742	ENSSTOG00000015394	-	100	92.742	Ictidomys_tridecemlineatus
ENSG00000163684	RPP14	100	87.903	ENSJJAG00000017703	Rpp14	100	87.903	Jaculus_jaculus
ENSG00000163684	RPP14	97	58.333	ENSLBEG00000026713	rpp14	93	58.333	Labrus_bergylta
ENSG00000163684	RPP14	94	64.655	ENSLOCG00000013207	rpp14	97	64.655	Lepisosteus_oculatus
ENSG00000163684	RPP14	78	89.691	ENSLAFG00000031481	RPP14	93	78.761	Loxodonta_africana
ENSG00000163684	RPP14	100	100.000	ENSMFAG00000003971	RPP14	100	100.000	Macaca_fascicularis
ENSG00000163684	RPP14	100	99.194	ENSMNEG00000028567	RPP14	100	99.194	Macaca_nemestrina
ENSG00000163684	RPP14	100	100.000	ENSMLEG00000025255	RPP14	100	100.000	Mandrillus_leucophaeus
ENSG00000163684	RPP14	94	61.538	ENSMAMG00000014525	rpp14	91	61.538	Mastacembelus_armatus
ENSG00000163684	RPP14	97	60.833	ENSMZEG00005016843	rpp14	93	60.833	Maylandia_zebra
ENSG00000163684	RPP14	57	69.014	ENSMGAG00000015512	RPP14	100	69.014	Meleagris_gallopavo
ENSG00000163684	RPP14	98	82.645	ENSMAUG00000017489	Rpp14	99	82.645	Mesocricetus_auratus
ENSG00000163684	RPP14	100	94.355	ENSMICG00000036730	RPP14	100	94.355	Microcebus_murinus
ENSG00000163684	RPP14	98	85.950	ENSMOCG00000015810	Rpp14	99	85.950	Microtus_ochrogaster
ENSG00000163684	RPP14	97	65.000	ENSMMOG00000013629	rpp14	93	65.000	Mola_mola
ENSG00000163684	RPP14	98	79.675	ENSMODG00000002344	RPP14	98	79.675	Monodelphis_domestica
ENSG00000163684	RPP14	97	63.333	ENSMALG00000022651	rpp14	87	63.333	Monopterus_albus
ENSG00000163684	RPP14	98	85.950	ENSMUSG00000023156	Rpp14	99	85.950	Mus_musculus
ENSG00000163684	RPP14	85	93.396	ENSMPUG00000016880	RPP14	80	93.396	Mustela_putorius_furo
ENSG00000163684	RPP14	100	93.548	ENSMLUG00000007998	RPP14	100	93.548	Myotis_lucifugus
ENSG00000163684	RPP14	100	88.710	ENSNGAG00000020216	Rpp14	100	88.710	Nannospalax_galili
ENSG00000163684	RPP14	97	60.833	ENSNBRG00000013614	rpp14	93	60.833	Neolamprologus_brichardi
ENSG00000163684	RPP14	100	100.000	ENSNLEG00000034186	RPP14	100	100.000	Nomascus_leucogenys
ENSG00000163684	RPP14	100	80.645	ENSMEUG00000010883	RPP14	99	80.645	Notamacropus_eugenii
ENSG00000163684	RPP14	100	84.677	ENSODEG00000019114	-	100	84.677	Octodon_degus
ENSG00000163684	RPP14	94	74.138	ENSOANG00000022513	-	97	74.138	Ornithorhynchus_anatinus
ENSG00000163684	RPP14	94	79.310	ENSOCUG00000027202	RPP14	94	79.310	Oryctolagus_cuniculus
ENSG00000163684	RPP14	98	60.656	ENSORLG00000028025	RPP14	90	60.656	Oryzias_latipes
ENSG00000163684	RPP14	95	61.864	ENSORLG00020020932	RPP14	94	61.864	Oryzias_latipes_hni
ENSG00000163684	RPP14	95	61.864	ENSORLG00015017271	RPP14	94	61.864	Oryzias_latipes_hsok
ENSG00000163684	RPP14	94	54.310	ENSOMEG00000023907	rpp14	72	54.310	Oryzias_melastigma
ENSG00000163684	RPP14	81	95.000	ENSOGAG00000004476	-	100	95.000	Otolemur_garnettii
ENSG00000163684	RPP14	100	92.742	ENSOARG00000012424	-	100	92.742	Ovis_aries
ENSG00000163684	RPP14	99	88.618	ENSOARG00000008106	-	99	88.618	Ovis_aries
ENSG00000163684	RPP14	100	100.000	ENSPPAG00000041153	RPP14	100	100.000	Pan_paniscus
ENSG00000163684	RPP14	100	95.161	ENSPPRG00000019524	RPP14	100	95.161	Panthera_pardus
ENSG00000163684	RPP14	100	95.161	ENSPTIG00000020506	RPP14	100	95.161	Panthera_tigris_altaica
ENSG00000163684	RPP14	100	100.000	ENSPTRG00000048740	RPP14	100	100.000	Pan_troglodytes
ENSG00000163684	RPP14	100	99.194	ENSPANG00000006374	RPP14	100	99.194	Papio_anubis
ENSG00000163684	RPP14	100	68.548	ENSPKIG00000025282	rpp14	100	68.548	Paramormyrops_kingsleyae
ENSG00000163684	RPP14	56	82.609	ENSPSIG00000017212	RPP14	100	82.609	Pelodiscus_sinensis
ENSG00000163684	RPP14	98	56.557	ENSPFOG00000015042	rpp14	90	56.557	Poecilia_formosa
ENSG00000163684	RPP14	95	55.932	ENSPLAG00000022768	rpp14	94	55.932	Poecilia_latipinna
ENSG00000163684	RPP14	95	55.932	ENSPMEG00000022010	rpp14	94	55.932	Poecilia_mexicana
ENSG00000163684	RPP14	98	53.600	ENSPREG00000021863	rpp14	94	53.600	Poecilia_reticulata
ENSG00000163684	RPP14	100	100.000	ENSPPYG00000013762	RPP14	100	100.000	Pongo_abelii
ENSG00000163684	RPP14	100	96.774	ENSPCOG00000027150	RPP14	100	96.774	Propithecus_coquereli
ENSG00000163684	RPP14	85	57.547	ENSPNYG00000022453	rpp14	80	57.547	Pundamilia_nyererei
ENSG00000163684	RPP14	98	64.463	ENSPNAG00000029880	rpp14	98	64.463	Pygocentrus_nattereri
ENSG00000163684	RPP14	98	84.298	ENSRNOG00000039829	Rpp14	99	84.298	Rattus_norvegicus
ENSG00000163684	RPP14	100	99.194	ENSRBIG00000031797	RPP14	100	99.194	Rhinopithecus_bieti
ENSG00000163684	RPP14	100	99.194	ENSRROG00000045678	RPP14	100	99.194	Rhinopithecus_roxellana
ENSG00000163684	RPP14	56	98.571	ENSSBOG00000034247	RPP14	100	98.571	Saimiri_boliviensis_boliviensis
ENSG00000163684	RPP14	100	57.364	ENSSFOG00015002893	rpp14	100	57.364	Scleropages_formosus
ENSG00000163684	RPP14	97	63.333	ENSSMAG00000003394	rpp14	93	63.333	Scophthalmus_maximus
ENSG00000163684	RPP14	97	67.500	ENSSDUG00000020222	rpp14	93	67.500	Seriola_dumerili
ENSG00000163684	RPP14	97	66.667	ENSSLDG00000019624	rpp14	93	66.667	Seriola_lalandi_dorsalis
ENSG00000163684	RPP14	56	92.857	ENSSARG00000010537	-	100	92.857	Sorex_araneus
ENSG00000163684	RPP14	56	94.286	ENSSARG00000009383	-	100	94.286	Sorex_araneus
ENSG00000163684	RPP14	98	72.727	ENSSPUG00000004221	RPP14	92	72.727	Sphenodon_punctatus
ENSG00000163684	RPP14	96	61.345	ENSSPAG00000018672	rpp14	93	61.345	Stegastes_partitus
ENSG00000163684	RPP14	56	78.261	ENSTGUG00000009157	RPP14	100	78.261	Taeniopygia_guttata
ENSG00000163684	RPP14	96	59.664	ENSTRUG00000003139	rpp14	93	59.664	Takifugu_rubripes
ENSG00000163684	RPP14	100	95.968	ENSUAMG00000027125	RPP14	95	95.968	Ursus_americanus
ENSG00000163684	RPP14	100	95.968	ENSUMAG00000023130	RPP14	95	95.968	Ursus_maritimus
ENSG00000163684	RPP14	85	91.509	ENSVPAG00000000935	RPP14	100	91.509	Vicugna_pacos
ENSG00000163684	RPP14	100	91.935	ENSVVUG00000016087	-	65	91.935	Vulpes_vulpes
ENSG00000163684	RPP14	98	56.557	ENSXCOG00000017384	-	85	56.557	Xiphophorus_couchianus
ENSG00000163684	RPP14	98	56.557	ENSXMAG00000009056	RPP14	85	56.557	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001682	tRNA 5'-leader removal	16723659.30454648.	IDA	Process
GO:0001682	tRNA 5'-leader removal	-	TAS	Process
GO:0003723	RNA binding	10024167.	TAS	Function
GO:0004526	ribonuclease P activity	16723659.30454648.	IDA	Function
GO:0005634	nucleus	10024167.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0030681	multimeric ribonuclease P complex	16723659.30454648.	IDA	Component
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process