EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163882 (Gene tree)
Gene ID: 5437
Gene Symbol: POLR2H
Alias: RPB8
Full Name: RNA polymerase II subunit H
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 6,883 bases
Position: chr3:184,361,714-184,368,596
Accession: 9195
RBP type: canonical RBP
Summary: The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000409065	RNA_pol_Rpb8	PF03870.15	2.3e-53	1	1
ENSP00000392913	RNA_pol_Rpb8	PF03870.15	2.4e-53	1	1
ENSP00000411883	RNA_pol_Rpb8	PF03870.15	6.8e-38	1	2
ENSP00000411883	RNA_pol_Rpb8	PF03870.15	6.8e-38	2	2
ENSP00000398622	RNA_pol_Rpb8	PF03870.15	4.1e-37	1	1
ENSP00000399882	RNA_pol_Rpb8	PF03870.15	4.1e-37	1	1
ENSP00000415536	RNA_pol_Rpb8	PF03870.15	1.1e-35	1	1
ENSP00000393773	RNA_pol_Rpb8	PF03870.15	5.8e-22	1	2
ENSP00000393773	RNA_pol_Rpb8	PF03870.15	5.8e-22	2	2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16632472	Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases.	J Biol Chem	2006 Jun 30	Kang X	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460083	POLR2H-209	439	-	-	- (aa)	-	-
ENST00000455712	POLR2H-207	823	-	ENSP00000409065	148 (aa)	-	C9JLU1
ENST00000430783	POLR2H-203	1159	XM_017006636	ENSP00000411883	122 (aa)	XP_016862125	P52434
ENST00000412877	POLR2H-201	836	-	ENSP00000403728	11 (aa)	-	C9JJJ9
ENST00000489043	POLR2H-212	433	-	-	- (aa)	-	-
ENST00000456318	POLR2H-208	1802	-	ENSP00000392913	150 (aa)	-	P52434
ENST00000429568	POLR2H-202	878	XM_006713666	ENSP00000415536	175 (aa)	XP_006713729	P52434
ENST00000443489	POLR2H-205	807	XM_017006637	ENSP00000393773	86 (aa)	XP_016862126	P52434
ENST00000490958	POLR2H-213	434	-	-	- (aa)	-	-
ENST00000488213	POLR2H-211	1035	-	-	- (aa)	-	-
ENST00000452961	POLR2H-206	791	XM_024453602	ENSP00000399882	114 (aa)	XP_024309370	P52434
ENST00000438240	POLR2H-204	994	-	ENSP00000398622	114 (aa)	-	P52434
ENST00000476003	POLR2H-210	648	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000163882's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa04623	Cytosolic DNA-sensing pathway	KEGG
hsa05016	Huntington disease	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163882	rs75389224	3	184365748	T	Plateletcrit	27863252	[0.066-0.088] unit increase	0.07660589	EFO_0007985

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163882's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163882	POLR2H	100	96.667	ENSAPOG00000023660	polr2h	100	96.667	Acanthochromis_polyacanthus
ENSG00000163882	POLR2H	100	100.000	ENSAMEG00000017011	POLR2H	100	100.000	Ailuropoda_melanoleuca
ENSG00000163882	POLR2H	100	94.737	ENSACIG00000013167	polr2h	100	94.737	Amphilophus_citrinellus
ENSG00000163882	POLR2H	100	96.667	ENSAOCG00000003084	polr2h	100	96.667	Amphiprion_ocellaris
ENSG00000163882	POLR2H	100	96.667	ENSAPEG00000002614	polr2h	100	96.667	Amphiprion_percula
ENSG00000163882	POLR2H	100	96.667	ENSATEG00000013227	polr2h	100	96.667	Anabas_testudineus
ENSG00000163882	POLR2H	100	99.333	ENSACAG00000002828	POLR2H	100	99.333	Anolis_carolinensis
ENSG00000163882	POLR2H	100	100.000	ENSANAG00000020244	POLR2H	100	100.000	Aotus_nancymaae
ENSG00000163882	POLR2H	100	96.667	ENSACLG00000026253	polr2h	100	96.667	Astatotilapia_calliptera
ENSG00000163882	POLR2H	100	96.000	ENSAMXG00000001800	polr2h	100	96.000	Astyanax_mexicanus
ENSG00000163882	POLR2H	100	100.000	ENSBTAG00000040199	POLR2H	100	100.000	Bos_taurus
ENSG00000163882	POLR2H	100	63.333	WBGene00017830	rpb-8	100	63.333	Caenorhabditis_elegans
ENSG00000163882	POLR2H	100	100.000	ENSCJAG00000014959	POLR2H	100	100.000	Callithrix_jacchus
ENSG00000163882	POLR2H	100	100.000	ENSCAFG00020002558	POLR2H	100	100.000	Canis_lupus_dingo
ENSG00000163882	POLR2H	100	100.000	ENSCHIG00000006695	POLR2H	100	100.000	Capra_hircus
ENSG00000163882	POLR2H	100	100.000	ENSTSYG00000007705	-	100	100.000	Carlito_syrichta
ENSG00000163882	POLR2H	100	90.435	ENSTSYG00000031988	-	100	84.768	Carlito_syrichta
ENSG00000163882	POLR2H	100	94.000	ENSTSYG00000031691	-	82	94.000	Carlito_syrichta
ENSG00000163882	POLR2H	100	99.333	ENSCPOG00000040303	POLR2H	100	99.333	Cavia_porcellus
ENSG00000163882	POLR2H	100	100.000	ENSCCAG00000035087	POLR2H	100	100.000	Cebus_capucinus
ENSG00000163882	POLR2H	100	100.000	ENSCATG00000045313	POLR2H	100	100.000	Cercocebus_atys
ENSG00000163882	POLR2H	100	99.333	ENSCLAG00000013016	POLR2H	100	99.333	Chinchilla_lanigera
ENSG00000163882	POLR2H	100	100.000	ENSCSAG00000013724	POLR2H	80	100.000	Chlorocebus_sabaeus
ENSG00000163882	POLR2H	75	100.000	ENSCHOG00000009216	POLR2H	100	100.000	Choloepus_hoffmanni
ENSG00000163882	POLR2H	100	100.000	ENSCPBG00000001462	POLR2H	100	100.000	Chrysemys_picta_bellii
ENSG00000163882	POLR2H	99	75.333	ENSCING00000011417	-	99	75.333	Ciona_intestinalis
ENSG00000163882	POLR2H	99	74.667	ENSCSAVG00000006151	-	99	74.667	Ciona_savignyi
ENSG00000163882	POLR2H	100	100.000	ENSCANG00000023708	POLR2H	100	100.000	Colobus_angolensis_palliatus
ENSG00000163882	POLR2H	100	100.000	ENSCGRG00001004900	Polr2h	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000163882	POLR2H	100	100.000	ENSCGRG00000014304	Polr2h	100	100.000	Cricetulus_griseus_crigri
ENSG00000163882	POLR2H	100	94.667	ENSCSEG00000015264	polr2h	100	94.667	Cynoglossus_semilaevis
ENSG00000163882	POLR2H	100	97.368	ENSCVAG00000012410	polr2h	100	97.333	Cyprinodon_variegatus
ENSG00000163882	POLR2H	100	97.368	ENSDARG00000038505	polr2h	100	97.333	Danio_rerio
ENSG00000163882	POLR2H	100	100.000	ENSDNOG00000044402	POLR2H	100	100.000	Dasypus_novemcinctus
ENSG00000163882	POLR2H	100	100.000	ENSDORG00000027475	Polr2h	100	100.000	Dipodomys_ordii
ENSG00000163882	POLR2H	100	78.000	FBgn0037121	Rpb8	100	78.000	Drosophila_melanogaster
ENSG00000163882	POLR2H	77	100.000	ENSETEG00000004231	-	60	100.000	Echinops_telfairi
ENSG00000163882	POLR2H	100	85.088	ENSEBUG00000008233	POLR2H	100	75.429	Eptatretus_burgeri
ENSG00000163882	POLR2H	100	100.000	ENSEASG00005013088	POLR2H	100	100.000	Equus_asinus_asinus
ENSG00000163882	POLR2H	100	100.000	ENSECAG00000005828	POLR2H	100	100.000	Equus_caballus
ENSG00000163882	POLR2H	68	98.795	ENSEEUG00000006139	-	100	98.795	Erinaceus_europaeus
ENSG00000163882	POLR2H	100	95.614	ENSELUG00000006347	polr2h	100	95.333	Esox_lucius
ENSG00000163882	POLR2H	100	100.000	ENSFCAG00000007797	POLR2H	100	100.000	Felis_catus
ENSG00000163882	POLR2H	100	100.000	ENSFALG00000008177	POLR2H	100	100.000	Ficedula_albicollis
ENSG00000163882	POLR2H	100	100.000	ENSFDAG00000008781	POLR2H	100	100.000	Fukomys_damarensis
ENSG00000163882	POLR2H	100	97.368	ENSFHEG00000017819	polr2h	100	97.333	Fundulus_heteroclitus
ENSG00000163882	POLR2H	100	100.000	ENSGALG00000008534	POLR2H	100	100.000	Gallus_gallus
ENSG00000163882	POLR2H	100	97.368	ENSGAFG00000015424	polr2h	100	97.333	Gambusia_affinis
ENSG00000163882	POLR2H	100	95.333	ENSGACG00000009019	polr2h	100	95.333	Gasterosteus_aculeatus
ENSG00000163882	POLR2H	100	100.000	ENSGAGG00000009016	POLR2H	100	100.000	Gopherus_agassizii
ENSG00000163882	POLR2H	100	100.000	ENSGGOG00000002912	-	100	100.000	Gorilla_gorilla
ENSG00000163882	POLR2H	100	96.667	ENSHBUG00000006685	polr2h	100	96.667	Haplochromis_burtoni
ENSG00000163882	POLR2H	100	100.000	ENSHGLG00000012488	POLR2H	100	100.000	Heterocephalus_glaber_female
ENSG00000163882	POLR2H	100	100.000	ENSHGLG00100009576	POLR2H	100	100.000	Heterocephalus_glaber_male
ENSG00000163882	POLR2H	100	96.000	ENSHCOG00000010338	polr2h	100	96.000	Hippocampus_comes
ENSG00000163882	POLR2H	100	96.000	ENSHCOG00000010315	polr2h	100	96.000	Hippocampus_comes
ENSG00000163882	POLR2H	100	95.333	ENSIPUG00000024331	polr2h	100	95.333	Ictalurus_punctatus
ENSG00000163882	POLR2H	100	100.000	ENSSTOG00000008300	POLR2H	100	100.000	Ictidomys_tridecemlineatus
ENSG00000163882	POLR2H	100	100.000	ENSJJAG00000015574	Polr2h	100	100.000	Jaculus_jaculus
ENSG00000163882	POLR2H	100	96.667	ENSKMAG00000008353	polr2h	100	96.667	Kryptolebias_marmoratus
ENSG00000163882	POLR2H	100	96.667	ENSLBEG00000018905	polr2h	100	96.667	Labrus_bergylta
ENSG00000163882	POLR2H	100	97.368	ENSLACG00000015017	POLR2H	100	97.333	Latimeria_chalumnae
ENSG00000163882	POLR2H	76	95.536	ENSLOCG00000008946	polr2h	100	95.536	Lepisosteus_oculatus
ENSG00000163882	POLR2H	100	100.000	ENSLAFG00000003573	POLR2H	100	100.000	Loxodonta_africana
ENSG00000163882	POLR2H	100	100.000	ENSMFAG00000038115	POLR2H	100	100.000	Macaca_fascicularis
ENSG00000163882	POLR2H	100	100.000	ENSMMUG00000007524	POLR2H	100	100.000	Macaca_mulatta
ENSG00000163882	POLR2H	100	100.000	ENSMNEG00000037272	POLR2H	100	100.000	Macaca_nemestrina
ENSG00000163882	POLR2H	100	100.000	ENSMLEG00000039827	POLR2H	100	100.000	Mandrillus_leucophaeus
ENSG00000163882	POLR2H	100	96.000	ENSMAMG00000001923	polr2h	100	96.000	Mastacembelus_armatus
ENSG00000163882	POLR2H	100	96.667	ENSMZEG00005017494	polr2h	100	96.667	Maylandia_zebra
ENSG00000163882	POLR2H	100	100.000	ENSMAUG00000016338	Polr2h	100	100.000	Mesocricetus_auratus
ENSG00000163882	POLR2H	100	100.000	ENSMICG00000048991	-	100	100.000	Microcebus_murinus
ENSG00000163882	POLR2H	89	90.196	ENSMICG00000033578	-	100	77.333	Microcebus_murinus
ENSG00000163882	POLR2H	100	98.246	ENSMICG00000027485	-	94	98.611	Microcebus_murinus
ENSG00000163882	POLR2H	100	100.000	ENSMOCG00000004886	Polr2h	100	100.000	Microtus_ochrogaster
ENSG00000163882	POLR2H	100	96.667	ENSMMOG00000008575	polr2h	100	96.667	Mola_mola
ENSG00000163882	POLR2H	100	100.000	ENSMODG00000002570	POLR2H	100	100.000	Monodelphis_domestica
ENSG00000163882	POLR2H	100	96.000	ENSMALG00000015108	polr2h	100	96.000	Monopterus_albus
ENSG00000163882	POLR2H	100	100.000	MGP_CAROLIEiJ_G0020589	Polr2h	100	100.000	Mus_caroli
ENSG00000163882	POLR2H	100	100.000	ENSMUSG00000021018	Polr2h	100	100.000	Mus_musculus
ENSG00000163882	POLR2H	100	100.000	MGP_SPRETEiJ_G0021486	Polr2h	100	100.000	Mus_spretus
ENSG00000163882	POLR2H	100	100.000	ENSMPUG00000002852	POLR2H	100	100.000	Mustela_putorius_furo
ENSG00000163882	POLR2H	100	100.000	ENSMLUG00000022295	POLR2H	100	100.000	Myotis_lucifugus
ENSG00000163882	POLR2H	100	100.000	ENSNGAG00000023997	-	100	100.000	Nannospalax_galili
ENSG00000163882	POLR2H	100	83.333	ENSNGAG00000015806	-	100	78.667	Nannospalax_galili
ENSG00000163882	POLR2H	100	96.667	ENSNBRG00000001133	polr2h	100	96.667	Neolamprologus_brichardi
ENSG00000163882	POLR2H	100	100.000	ENSNLEG00000029447	POLR2H	100	100.000	Nomascus_leucogenys
ENSG00000163882	POLR2H	79	100.000	ENSMEUG00000014141	-	100	100.000	Notamacropus_eugenii
ENSG00000163882	POLR2H	68	100.000	ENSOPRG00000015024	-	100	100.000	Ochotona_princeps
ENSG00000163882	POLR2H	100	99.333	ENSODEG00000013008	-	100	99.333	Octodon_degus
ENSG00000163882	POLR2H	100	99.333	ENSODEG00000020005	-	100	99.333	Octodon_degus
ENSG00000163882	POLR2H	100	96.667	ENSONIG00000012493	polr2h	100	96.667	Oreochromis_niloticus
ENSG00000163882	POLR2H	100	100.000	ENSOANG00000010454	POLR2H	100	100.000	Ornithorhynchus_anatinus
ENSG00000163882	POLR2H	100	100.000	ENSOCUG00000007078	POLR2H	100	100.000	Oryctolagus_cuniculus
ENSG00000163882	POLR2H	100	95.333	ENSORLG00000023347	polr2h	100	95.333	Oryzias_latipes
ENSG00000163882	POLR2H	100	95.333	ENSORLG00020017770	polr2h	100	95.333	Oryzias_latipes_hni
ENSG00000163882	POLR2H	100	95.333	ENSORLG00015013505	polr2h	100	95.333	Oryzias_latipes_hsok
ENSG00000163882	POLR2H	100	95.333	ENSOMEG00000021100	polr2h	100	95.333	Oryzias_melastigma
ENSG00000163882	POLR2H	100	100.000	ENSOGAG00000001599	POLR2H	100	100.000	Otolemur_garnettii
ENSG00000163882	POLR2H	100	100.000	ENSOARG00000020584	POLR2H	100	100.000	Ovis_aries
ENSG00000163882	POLR2H	100	100.000	ENSPPAG00000035658	-	100	100.000	Pan_paniscus
ENSG00000163882	POLR2H	100	100.000	ENSPPRG00000004001	POLR2H	100	100.000	Panthera_pardus
ENSG00000163882	POLR2H	100	100.000	ENSPTIG00000010551	POLR2H	100	100.000	Panthera_tigris_altaica
ENSG00000163882	POLR2H	100	100.000	ENSPTRG00000047600	-	100	100.000	Pan_troglodytes
ENSG00000163882	POLR2H	100	100.000	ENSPANG00000020585	POLR2H	100	100.000	Papio_anubis
ENSG00000163882	POLR2H	100	96.667	ENSPKIG00000022836	polr2h	100	96.667	Paramormyrops_kingsleyae
ENSG00000163882	POLR2H	100	100.000	ENSPSIG00000017108	POLR2H	100	100.000	Pelodiscus_sinensis
ENSG00000163882	POLR2H	100	96.667	ENSPMGG00000004693	polr2h	94	96.667	Periophthalmus_magnuspinnatus
ENSG00000163882	POLR2H	100	92.667	ENSPMAG00000008230	-	100	92.667	Petromyzon_marinus
ENSG00000163882	POLR2H	100	97.368	ENSPFOG00000024200	polr2h	100	97.333	Poecilia_formosa
ENSG00000163882	POLR2H	100	97.368	ENSPLAG00000024033	polr2h	100	97.333	Poecilia_latipinna
ENSG00000163882	POLR2H	100	97.368	ENSPMEG00000005909	polr2h	100	97.333	Poecilia_mexicana
ENSG00000163882	POLR2H	100	97.368	ENSPREG00000007275	polr2h	100	97.333	Poecilia_reticulata
ENSG00000163882	POLR2H	100	100.000	ENSPPYG00000014357	-	100	100.000	Pongo_abelii
ENSG00000163882	POLR2H	100	68.667	ENSPCAG00000015035	-	100	68.667	Procavia_capensis
ENSG00000163882	POLR2H	100	100.000	ENSPCOG00000021194	POLR2H	100	100.000	Propithecus_coquereli
ENSG00000163882	POLR2H	92	100.000	ENSPVAG00000004869	POLR2H	100	86.000	Pteropus_vampyrus
ENSG00000163882	POLR2H	100	96.667	ENSPNYG00000020592	polr2h	100	96.667	Pundamilia_nyererei
ENSG00000163882	POLR2H	100	94.667	ENSPNAG00000010676	polr2h	100	94.667	Pygocentrus_nattereri
ENSG00000163882	POLR2H	100	100.000	ENSRNOG00000001748	LOC100912534	100	100.000	Rattus_norvegicus
ENSG00000163882	POLR2H	100	100.000	ENSRNOG00000049116	Polr2h	100	100.000	Rattus_norvegicus
ENSG00000163882	POLR2H	100	100.000	ENSRBIG00000032148	POLR2H	100	100.000	Rhinopithecus_bieti
ENSG00000163882	POLR2H	100	100.000	ENSRROG00000040465	POLR2H	100	100.000	Rhinopithecus_roxellana
ENSG00000163882	POLR2H	99	35.065	YOR224C	RPB8	100	35.065	Saccharomyces_cerevisiae
ENSG00000163882	POLR2H	100	100.000	ENSSBOG00000033101	POLR2H	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000163882	POLR2H	100	100.000	ENSSHAG00000006304	POLR2H	91	100.000	Sarcophilus_harrisii
ENSG00000163882	POLR2H	100	96.000	ENSSFOG00015014221	polr2h	100	96.000	Scleropages_formosus
ENSG00000163882	POLR2H	100	96.667	ENSSMAG00000001049	polr2h	100	96.667	Scophthalmus_maximus
ENSG00000163882	POLR2H	100	96.667	ENSSDUG00000005936	polr2h	100	96.667	Seriola_dumerili
ENSG00000163882	POLR2H	100	96.667	ENSSLDG00000002246	polr2h	100	96.667	Seriola_lalandi_dorsalis
ENSG00000163882	POLR2H	100	99.333	ENSSARG00000003429	POLR2H	100	99.333	Sorex_araneus
ENSG00000163882	POLR2H	100	99.123	ENSSPUG00000014013	-	100	99.123	Sphenodon_punctatus
ENSG00000163882	POLR2H	100	96.667	ENSSPAG00000012297	polr2h	100	96.667	Stegastes_partitus
ENSG00000163882	POLR2H	100	100.000	ENSSSCG00000022507	POLR2H	100	100.000	Sus_scrofa
ENSG00000163882	POLR2H	100	100.000	ENSTGUG00000010383	POLR2H	99	100.000	Taeniopygia_guttata
ENSG00000163882	POLR2H	100	96.667	ENSTRUG00000007619	polr2h	100	96.667	Takifugu_rubripes
ENSG00000163882	POLR2H	100	97.368	ENSTNIG00000012183	polr2h	100	97.333	Tetraodon_nigroviridis
ENSG00000163882	POLR2H	74	100.000	ENSTBEG00000005571	-	60	100.000	Tupaia_belangeri
ENSG00000163882	POLR2H	100	100.000	ENSTTRG00000011254	POLR2H	100	100.000	Tursiops_truncatus
ENSG00000163882	POLR2H	100	100.000	ENSUAMG00000004615	POLR2H	100	100.000	Ursus_americanus
ENSG00000163882	POLR2H	100	100.000	ENSUMAG00000005255	POLR2H	100	100.000	Ursus_maritimus
ENSG00000163882	POLR2H	100	80.667	ENSVPAG00000009011	-	100	80.667	Vicugna_pacos
ENSG00000163882	POLR2H	100	100.000	ENSVVUG00000012241	POLR2H	100	100.000	Vulpes_vulpes
ENSG00000163882	POLR2H	100	98.246	ENSXETG00000017291	polr2h	100	98.000	Xenopus_tropicalis
ENSG00000163882	POLR2H	100	97.368	ENSXCOG00000003501	polr2h	100	97.333	Xiphophorus_couchianus
ENSG00000163882	POLR2H	100	97.368	ENSXMAG00000005861	polr2h	100	97.333	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0001054	RNA polymerase I activity	21873635.	IBA	Function
GO:0001055	RNA polymerase II activity	21873635.	IBA	Function
GO:0001056	RNA polymerase III activity	21873635.	IBA	Function
GO:0003697	single-stranded DNA binding	16632472.	IDA	Function
GO:0005634	nucleus	9852112.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005665	RNA polymerase II, core complex	21873635.	IBA	Component
GO:0005665	RNA polymerase II, core complex	9852112.	IDA	Component
GO:0005666	RNA polymerase III complex	21873635.	IBA	Component
GO:0005736	RNA polymerase I complex	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006351	transcription, DNA-templated	-	TAS	Process
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	Process
GO:0006362	transcription elongation from RNA polymerase I promoter	-	TAS	Process
GO:0006363	termination of RNA polymerase I transcription	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	9852112.	IDA	Process
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0006383	transcription by RNA polymerase III	-	IEA	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032993	protein-DNA complex	16632472.	IDA	Component
GO:0035019	somatic stem cell population maintenance	-	TAS	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	Process
GO:0050434	positive regulation of viral transcription	-	TAS	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	184365220	Missense_Mutation	novel	P82L	0.75	RNA_pol_Rpb8
BLCA	chr3	184368284	Missense_Mutation	novel	L148P	0.27
BRCA	chr3	184364989	Missense_Mutation	NA	E33K	0.15
BRCA	chr3	184368317	3'UTR	novel		0.44
CESC	chr3	184365144	Missense_Mutation	NA	R57W	0.48	RNA_pol_Rpb8
COAD	chr3	184363403	5'UTR	novel		0.42
COAD	chr3	184365183	Missense_Mutation	NA	L70V	0.31	RNA_pol_Rpb8
COAD	chr3	184363547	Missense_Mutation	NA	G19S	0.18
COAD	chr3	184363511	Nonsense_Mutation	NA	E7*	0.41
ESCA	chr3	184368246	Silent	rs776845280	F135F	0.29
GBM	chr3	184363437	5'UTR	novel		0.23
HNSC	chr3	184365185	Frame_Shift_Del	novel	D71*	0.09	RNA_pol_Rpb8
KIRC	chr3	184365203	Silent	NA	N76N	0.23
LUAD	chr3	184368291	Missense_Mutation	novel	F150L	0.06
LUAD	chr3	184363505	Silent	rs752698223	L5L	0.12
LUAD	chr3	184365007	Missense_Mutation	NA	L39V	0.14
LUAD	chr3	184368402	3'UTR	novel		0.44
LUAD	chr3	184363543	Silent	rs765439305	P17P	0.1
LUSC	chr3	184368355	3'UTR	novel		0.09
MESO	chr3	184363500	Missense_Mutation	novel	G3A	0.39
OV	chr3	184363463	5'UTR	novel		0.35
OV	chr3	184363562	Nonsense_Mutation	NA	R24*	0.21
OV	chr3	184366717	Splice_Region	novel	R84R	0.11
OV	chr3	184363468	5'UTR	novel		0.17
READ	chr3	184363523	Missense_Mutation	novel	D11N	0.2
READ	chr3	184365208	Missense_Mutation	novel	T78I	0.14	RNA_pol_Rpb8
SKCM	chr3	184368212	Missense_Mutation	novel	R124K	0.12
SKCM	chr3	184368213	Silent	novel	R124R	0.12
SKCM	chr3	184368192	Silent	NA	S117S	0.44
SKCM	chr3	184368240	Missense_Mutation	NA	H133Q	0.57
UCEC	chr3	184363278	5'UTR	novel		0.29
UCEC	chr3	184368182	Missense_Mutation	NA	A114V	0.05
UCEC	chr3	184368246	Silent	rs776845280	F135F	0.47
UCEC	chr3	184366714	Splice_Region	novel		0.33
UCEC	chr3	184365217	Missense_Mutation	novel	R81K	0.45	RNA_pol_Rpb8
UCEC	chr3	184366716	Splice_Site	NA	X84_splice	0.32
UCEC	chr3	184368205	Missense_Mutation	NA	L122F	0.27
UCEC	chr3	184366746	Missense_Mutation	novel	G94E	0.11
UCEC	chr3	184368431	3'UTR	novel		0.37
UCEC	chr3	184363548	Missense_Mutation	novel	G19D	0.1
UCEC	chr3	184368186	Silent	rs150492338	Y115Y	0.3
UCEC	chr3	184364982	Silent	novel	C30C	0.37
UCEC	chr3	184368470	3'UTR	novel		0.5
UCEC	chr3	184365144	Missense_Mutation	NA	R57W	0.25	RNA_pol_Rpb8
UCEC	chr3	184366797	Missense_Mutation	rs376240144	R111H	0.28
UCEC	chr3	184365186	Missense_Mutation	novel	D71N	0.45	RNA_pol_Rpb8

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4412	0.0018563
KIRC	AMP	0.1193	2.0306e-05
KIRP	AMP	0.3264	0.15981
LGG	AMP	0.0331	0.0013532
LUAD	DEL	0.1764	0.010111
PAAD	AMP	0.1033	0.16151
SARC	DEL	0.1556	0.0086757
TGCT	AMP	0.2533	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
ACC	0.00065	Kaplan-Meier Survival Analysis
HNSC	0.023	Kaplan-Meier Survival Analysis
PRAD	0.016	Kaplan-Meier Survival Analysis
LUSC	0.00093	Kaplan-Meier Survival Analysis
COAD	0.036	Kaplan-Meier Survival Analysis
BLCA	0.0087	Kaplan-Meier Survival Analysis
CESC	0.0022	Kaplan-Meier Survival Analysis
KICH	0.037	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.01	Kaplan-Meier Survival Analysis
LGG	0.017	Kaplan-Meier Survival Analysis
LUAD	0.012	Kaplan-Meier Survival Analysis
UVM	0.00035	Kaplan-Meier Survival Analysis
OV	0.037	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742