EuRBPDB

Description

Ensembl ID: ENSG00000163902 (Gene tree)
Gene ID: 6184
Gene Symbol: RPN1
Alias: OST1
Full Name: ribophorin I
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 61,106 bases
Position: chr3:128,619,970-128,681,075
Accession: 10381
RBP type: non-canonical RBP
Summary: This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25063809	Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum.	J Biol Chem	2014 Sep 12	Jagannathan S	doi: 10.1074/jbc.M114.580688

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000479113	RPN1-203	558	-	-	- (aa)	-	-
ENST00000476931	RPN1-202	526	-	ENSP00000419384	121 (aa)	-	F8WF32
ENST00000497289	RPN1-207	2137	-	ENSP00000417529	435 (aa)	-	B7Z4L4
ENST00000495462	RPN1-206	566	-	-	- (aa)	-	-
ENST00000296255	RPN1-201	2314	-	ENSP00000296255	607 (aa)	-	P04843
ENST00000497415	RPN1-208	547	-	-	- (aa)	-	-
ENST00000490166	RPN1-205	573	-	-	- (aa)	-	-
ENST00000481168	RPN1-204	751	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00510	N-Glycan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163902	Eosinophils	7.6840000E-006	21738480
ENSG00000163902	Monocytes	2E-16	23314186

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163902	rs55683935	3	128630533	G	Monocyte count	27863252	[0.1-0.14] unit decrease	0.1206489	EFO_0005091
ENSG00000163902	rs2712417	3	128626336	G	Blood protein levels	29875488	[0.3-0.38] unit decrease	0.34	EFO_0007937
ENSG00000163902	rs55683935	3	128630533	G	Monocyte percentage of white cells	27863252	[0.092-0.128] unit decrease	0.1097044	EFO_0007989
ENSG00000163902	rs13315649	3	128672379	A	Sum eosinophil basophil counts	27863252	[0.031-0.046] unit increase	0.03856084	EFO_0005090\|EFO_0004842
ENSG00000163902	rs7650934	3	128673530	C	Blood protein levels	30072576	[0.19-0.29] unit decrease	0.239	EFO_0007937
ENSG00000163902	rs34198449	3	128662427	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163902	RPN1	100	97.241	ENSMUSG00000030062	Rpn1	100	94.901	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	21873635.	IBA	Function
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	15835887.	TAS	Function
GO:0005515	protein binding	19167329.22988243.25416956.30021884.	IPI	Function
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005791	rough endoplasmic reticulum	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006464	cellular protein modification process	10660554.	TAS	Process
GO:0008250	oligosaccharyltransferase complex	15835887.	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0018279	protein N-linked glycosylation via asparagine	21873635.	IBA	Process
GO:0018279	protein N-linked glycosylation via asparagine	17264154.	IMP	Process
GO:0018279	protein N-linked glycosylation via asparagine	15835887.	TAS	Process
GO:0042470	melanosome	-	IEA	Component