EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000163918 (Gene tree)
Gene ID: 5984
Gene Symbol: RFC4
Alias: A1|RFC37
Full Name: replication factor C subunit 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 17,179 bases
Position: chr3:186,789,880-186,807,058
Accession: 9972
RBP type: non-canonical RBP
Summary: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494047	RFC4-214	1393	-	-	- (aa)	-	-
ENST00000411792	RFC4-203	560	-	ENSP00000399314	43 (aa)	-	C9JW34
ENST00000489028	RFC4-213	533	-	-	- (aa)	-	-
ENST00000449502	RFC4-210	799	-	ENSP00000394870	97 (aa)	-	F8WE44
ENST00000296273	RFC4-201	1384	-	ENSP00000296273	363 (aa)	-	P35249
ENST00000448497	RFC4-209	453	-	ENSP00000415099	95 (aa)	-	C9JGY5
ENST00000433496	RFC4-207	1111	-	ENSP00000399769	336 (aa)	-	C9JZI1
ENST00000392481	RFC4-202	1448	-	ENSP00000376272	363 (aa)	-	P35249
ENST00000418288	RFC4-205	701	-	ENSP00000411300	214 (aa)	-	C9J8M3
ENST00000460408	RFC4-211	628	-	-	- (aa)	-	-
ENST00000427785	RFC4-206	485	-	ENSP00000407982	123 (aa)	-	C9JXZ7
ENST00000479307	RFC4-212	1043	-	-	- (aa)	-	-
ENST00000417876	RFC4-204	479	-	ENSP00000401429	111 (aa)	-	H7C1P0
ENST00000447345	RFC4-208	785	-	ENSP00000413065	167 (aa)	-	C9JTT7

Gene Model

Click here to download ENSG00000163918's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa03420	Nucleotide excision repair	KEGG
hsa03430	Mismatch repair	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163918	Adiponectin	1E-19	20876611
ENSG00000163918	Adiponectin	2E-22	24105470
ENSG00000163918	Adiponectin	4E-7	26299439
ENSG00000163918	Adiponectin	8E-6	26299439
ENSG00000163918	Adiponectin	3E-12	20011104
ENSG00000163918	Adiponectin	2E-42	22479202

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163918's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003689	DNA clamp loader activity	21873635.	IBA	Function
GO:0003689	DNA clamp loader activity	12930902.	IDA	Function
GO:0005515	protein binding	9488738.15655353.16189514.21516116.23277426.25416956.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005663	DNA replication factor C complex	21873635.	IBA	Component
GO:0005663	DNA replication factor C complex	9488738.	IDA	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006261	DNA-dependent DNA replication	21873635.	IBA	Process
GO:0006271	DNA strand elongation involved in DNA replication	7774928.	TAS	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	Process
GO:0019899	enzyme binding	-	IEA	Function
GO:0019985	translesion synthesis	-	TAS	Process
GO:0031390	Ctf18 RFC-like complex	12930902.	IDA	Component
GO:0031391	Elg1 RFC-like complex	23277426.	IDA	Component
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	Process
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0042276	error-prone translesion synthesis	-	TAS	Process
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	Process
GO:0043142	single-stranded DNA-dependent ATPase activity	12930902.	IDA	Function
GO:0070987	error-free translesion synthesis	-	TAS	Process
GO:1900264	positive regulation of DNA-directed DNA polymerase activity	12930902.	IDA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25407051	Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer.	J Transl Med	2014 Nov 19	Xiang J	doi: 10.1186/s12967-014-0320-0.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	186790225	Missense_Mutation	novel	Q305E	0.06
BLCA	chr3	186790246	Missense_Mutation	novel	D298H	0.17
BLCA	chr3	186794664	Missense_Mutation	rs764526307	R135H	0.18
BLCA	chr3	186792888	Missense_Mutation	NA	S157L	0.12
BLCA	chr3	186794734	Missense_Mutation	NA	D112N	0.14
BLCA	chr3	186789976	Missense_Mutation	novel	N362S	0.25
BLCA	chr3	186791704	Intron	novel		0.55
BLCA	chr3	186790014	Silent	rs754962980	I349I	0.13
BLCA	chr3	186790179	Missense_Mutation	novel	S320F	0.38
BLCA	chr3	186790354	Missense_Mutation	novel	S285C	0.35
BRCA	chr3	186801124	Missense_Mutation	NA	G68A	0.37
BRCA	chr3	186790329	Silent	rs200590902	V293V	0.22
BRCA	chr3	186790157	Silent	NA	I327I	0.17
BRCA	chr3	186790110	Splice_Site	novel	X332_splice	0.11
BRCA	chr3	186789978	Silent	NA	Q361Q	0.31
BRCA	chr3	186790155	Frame_Shift_Del	NA	*T328Kfs11**	0.25
BRCA	chr3	186790157	In_Frame_Del	novel	S325_I327del	0.23
CESC	chr3	186790064	Splice_Site	novel	X333_splice	0.13
CESC	chr3	186791712	Intron	novel		0.35
COAD	chr3	186794763	Missense_Mutation	rs777641769	R102Q	0.3
COAD	chr3	186790256	Splice_Site	NA	X295_splice	0.28
COAD	chr3	186794694	Missense_Mutation	NA	N125T	0.4
COAD	chr3	186804618	Frame_Shift_Ins	NA	*N32Kfs20**	0.29
COAD	chr3	186790255	Missense_Mutation	NA	D295H	0.2
COAD	chr3	186792933	Missense_Mutation	NA	P142L	0.29
COAD	chr3	186789987	Frame_Shift_Ins	NA	*L359Vfs8**	0.39
COAD	chr3	186797605	Missense_Mutation	NA	L74I	0.17
DLBC	chr3	186790159	Missense_Mutation	NA	I327V	0.09
GBM	chr3	186792524	Missense_Mutation	novel	I214T	0.55
GBM	chr3	186792886	Missense_Mutation	novel	A158T	0.34
GBM	chr3	186790382	In_Frame_Del	rs769831210	D275del	0.3
HNSC	chr3	186801138	Missense_Mutation	NA	K63N	0.19
HNSC	chr3	186794689	Frame_Shift_Del	novel	*A127Lfs3**	0.11
HNSC	chr3	186789958	3'UTR	novel		0.44
HNSC	chr3	186790208	Silent	novel	L310L	0.38
KIRC	chr3	186790384	Missense_Mutation	NA	D275G	0.1
KIRC	chr3	186790362	Silent	NA	Q282Q	0.09
KIRP	chr3	186790384	Missense_Mutation	NA	D275V	0.26
LAML	chr3	186790139	Splice_Region	rs754046613		0.26
LGG	chr3	186791769	Missense_Mutation	novel	G253C	0.25
LGG	chr3	186791830	Frame_Shift_Del	novel	*K232Sfs40**	0.12
LUAD	chr3	186797555	Silent	NA	A90A	0.13
LUAD	chr3	186790141	Splice_Site	rs370046824	X332_splice	0.69
LUAD	chr3	186792522	Missense_Mutation	NA	A215T	0.2
LUAD	chr3	186790176	Nonsense_Mutation	novel	*D321Vfs2**	0.13
LUAD	chr3	186790164	Missense_Mutation	novel	S325C	0.16
LUAD	chr3	186794710	Nonsense_Mutation	NA	R120*	0.2
LUAD	chr3	186790381	Missense_Mutation	NA	G276V	0.31
LUAD	chr3	186804664	Missense_Mutation	NA	T17S	0.75
LUSC	chr3	186789946	3'UTR	rs2066502		0.25
LUSC	chr3	186790391	Missense_Mutation	NA	K273E	0.18
LUSC	chr3	186792523	Silent	novel	I214I	0.04
LUSC	chr3	186792587	Missense_Mutation	NA	R193I	0.3
LUSC	chr3	186790017	Silent	novel	L348L	0.16
LUSC	chr3	186804673	Missense_Mutation	rs773156360	P14L	0.4
LUSC	chr3	186790208	Silent	novel	L310L	0.29
LUSC	chr3	186794661	Nonsense_Mutation	NA	S136*	0.05
LUSC	chr3	186791704	Intron	novel		0.23
LUSC	chr3	186790381	Missense_Mutation	NA	G276A	0.11
LUSC	chr3	186801191	Missense_Mutation	novel	P46T	0.44
LUSC	chr3	186804721	5'UTR	novel		0.26
MESO	chr3	186790381	Frame_Shift_Ins	novel	*G276Efs12**	0.37
OV	chr3	186794724	Nonsense_Mutation	novel	*G115Vfs2**	0.11
OV	chr3	186792882	Frame_Shift_Ins	novel	*A159Vfs32**	0.08
OV	chr3	186804623	Nonsense_Mutation	novel	E31*	0.07
PAAD	chr3	186801162	Silent	novel	Q55Q	0.17
PRAD	chr3	186804714	5'UTR	novel		0.05
READ	chr3	186790017	Silent	NA	L348L	0.67
SKCM	chr3	186792827	Silent	novel	C177C	0.29
SKCM	chr3	186790063	Missense_Mutation	novel	E333G	0.19
SKCM	chr3	186804672	Silent	novel	P14P	0.31
SKCM	chr3	186789982	Missense_Mutation	novel	S360Y	0.53
SKCM	chr3	186791743	Silent	NA	V261V	0.19
SKCM	chr3	186797570	Silent	NA	T85T	0.29
STAD	chr3	186791832	Missense_Mutation	NA	K232E	0.05
STAD	chr3	186804641	Missense_Mutation	novel	S25G	0.07
UCEC	chr3	186789920	3'UTR	novel		0.53
UCEC	chr3	186790057	Missense_Mutation	NA	D335G	0.51
UCEC	chr3	186794705	Missense_Mutation	novel	E121D	0.37
UCEC	chr3	186791783	Missense_Mutation	novel	A248D	0.38
UCEC	chr3	186794693	Missense_Mutation	novel	N125K	0.38
UCEC	chr3	186792897	Missense_Mutation	novel	S154C	0.12
UCEC	chr3	186791727	Missense_Mutation	novel	G267R	0.05
UCEC	chr3	186794758	Missense_Mutation	novel	R104G	0.06
UCEC	chr3	186791679	Intron	novel		0.35
UCEC	chr3	186792546	Missense_Mutation	NA	Q207E	0.56
UCEC	chr3	186791793	Missense_Mutation	novel	L245V	0.05
UCEC	chr3	186791804	Missense_Mutation	novel	A241V	0.39
UCEC	chr3	186792939	Missense_Mutation	rs560784172	P140L	0.31
UCEC	chr3	186794752	Missense_Mutation	novel	L106I	0.35
UCEC	chr3	186790220	Silent	rs531700146	L306L	0.33
UCEC	chr3	186791793	Missense_Mutation	novel	L245I	0.42
UCEC	chr3	186794695	Missense_Mutation	novel	N125H	0.28
UCEC	chr3	186801193	Missense_Mutation	novel	R45H	0.32
UCEC	chr3	186801136	Missense_Mutation	novel	K64T	0.12
UCEC	chr3	186792573	Missense_Mutation	rs765207894	R198C	0.38
UCEC	chr3	186791786	Missense_Mutation	novel	S247N	0.09
UCEC	chr3	186792845	Silent	rs201652361	S171S	0.34
UCEC	chr3	186790142	Splice_Region	novel	A332A	0.19
UCEC	chr3	186790248	Missense_Mutation	novel	I297K	0.4
UCEC	chr3	186789936	3'UTR	rs765080673		0.61
UCEC	chr3	186790157	Silent	NA	I327I	0.51
UCEC	chr3	186804611	Missense_Mutation	NA	A35T	0.19
UCEC	chr3	186801134	Frame_Shift_Ins	rs776828891	*S65Ifs9**	0.41
UCEC	chr3	186790017	Silent	NA	L348L	0.13
UCS	chr3	186792585	Missense_Mutation	novel	C194R	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4387	0.0018563
KIRC	AMP	0.1193	2.0306e-05
KIRP	AMP	0.3194	0.15981
LUAD	DEL	0.1841	0.010111
PAAD	AMP	0.1033	0.16151
SARC	DEL	0.1556	0.0086757
TGCT	AMP	0.2533	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00013	Kaplan-Meier Survival Analysis
STAD	0.022	Kaplan-Meier Survival Analysis
MESO	0.0031	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
SKCM	0.042	Kaplan-Meier Survival Analysis
PRAD	0.041	Kaplan-Meier Survival Analysis
LUSC	0.017	Kaplan-Meier Survival Analysis
KIRP	0.001	Kaplan-Meier Survival Analysis
PAAD	0.0011	Kaplan-Meier Survival Analysis
PCPG	0.02	Kaplan-Meier Survival Analysis
CESC	0.00065	Kaplan-Meier Survival Analysis
KICH	0.0024	Kaplan-Meier Survival Analysis
UCEC	0.00014	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.0073	Kaplan-Meier Survival Analysis
LGG	0.0032	Kaplan-Meier Survival Analysis
LUAD	0.0038	Kaplan-Meier Survival Analysis
UVM	0.041	Kaplan-Meier Survival Analysis
OV	0.0087	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742