EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163938 (Gene tree)
Gene ID: 26354
Gene Symbol: GNL3
Alias: C77032|E2IG3|MGC800|NS
Full Name: G protein nucleolar 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 13,342 bases
Position: chr3:52,681,156-52,694,497
Accession: 29931
RBP type: canonical RBP
Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000419895	GN3L_Grn1	PF08701.11	3.5e-22	1	1
ENSP00000419734	GN3L_Grn1	PF08701.11	1.8e-21	1	1
ENSP00000378278	GN3L_Grn1	PF08701.11	1.2e-20	1	1
ENSP00000395772	GN3L_Grn1	PF08701.11	1.3e-20	1	1
ENSP00000378278	MMR_HSR1	PF01926.23	1e-11	1	1
ENSP00000395772	MMR_HSR1	PF01926.23	1.1e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000468146	GNL3-205	533	-	-	- (aa)	-	-
ENST00000484022	GNL3-209	668	-	-	- (aa)	-	-
ENST00000418458	GNL3-202	2040	-	ENSP00000395772	549 (aa)	-	Q9BVP2
ENST00000492349	GNL3-210	729	-	ENSP00000420345	138 (aa)	-	B4DMU5
ENST00000462550	GNL3-204	597	-	-	- (aa)	-	-
ENST00000394799	GNL3-201	2041	-	ENSP00000378278	537 (aa)	-	Q9BVP2
ENST00000460073	GNL3-203	583	-	-	- (aa)	-	-
ENST00000468885	GNL3-206	263	-	-	- (aa)	-	-
ENST00000496254	GNL3-211	2118	-	-	- (aa)	-	-
ENST00000474423	GNL3-207	567	-	ENSP00000419895	96 (aa)	-	C9JYH9
ENST00000497356	GNL3-212	523	-	-	- (aa)	-	-
ENST00000479230	GNL3-208	547	-	ENSP00000419734	134 (aa)	-	C9JZT7

Gene Model

Click here to download ENSG00000163938's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163938	gamma-Globulins	5.3740000E-005	-
ENSG00000163938	gamma-Globulins	5.3740000E-005	-
ENSG00000163938	gamma-Globulins	5.3740000E-005	-
ENSG00000163938	Adiponectin	1E-13	22479202
ENSG00000163938	Osteoarthritis	5E-9	22763110
ENSG00000163938	Bipolar Disorder	2E-6	23092984

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163938	rs10865974	3	52684264	?	Bipolar disorder with mood-incongruent psychosis	23092984	[NR]	1.19	EFO_0000289
ENSG00000163938	rs11177	3	52687289	A	Osteoarthritis	22763110	[1.06-1.12]	1.09	EFO_0002506
ENSG00000163938	rs1108842	3	52686064	A	Intelligence (MTAG)	29326435	[0.011-0.023] unit decrease	0.016819207	EFO_0004337
ENSG00000163938	rs1108842	3	52686064	C	Adiponectin levels	22479202	[0.022-0.038] unit increase	0.03	EFO_0004502
ENSG00000163938	rs11177	3	52687289	A	Osteoarthritis (hip)	30374069	[NR]	1.0684	EFO_1000786
ENSG00000163938	rs10933	3	52685800	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000163938	rs565817433	3	52684168	C	Body fat distribution (leg fat ratio)	30664634	NR unit increase (replication)	0.01066	EFO_0004341
ENSG00000163938	rs565817433	3	52684168	C	Body fat distribution (trunk fat ratio)	30664634	NR unit decrease (replication)	0.02074	EFO_0004341
ENSG00000163938	rs565817433	3	52684168	C	Body fat distribution (trunk fat ratio)	30664634	NR unit decrease (replication)	0.01312	EFO_0004341
ENSG00000163938	rs565817433	3	52684168	C	Body fat distribution (leg fat ratio)	30664634	NR unit increase (replication)	0.01704	EFO_0004341

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163938's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000163938	GNL3	53	33.677	ENSG00000134697	GNL2	99	30.000
ENSG00000163938	GNL3	83	33.036	ENSG00000130119	GNL3L	71	38.647

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163938	GNL3	99	55.245	ENSAPOG00000004048	gnl3	99	46.316	Acanthochromis_polyacanthus
ENSG00000163938	GNL3	98	92.553	ENSAMEG00000008456	GNL3	100	80.797	Ailuropoda_melanoleuca
ENSG00000163938	GNL3	99	55.797	ENSACIG00000000545	gnl3	99	44.504	Amphilophus_citrinellus
ENSG00000163938	GNL3	100	53.571	ENSAOCG00000012879	gnl3	99	45.614	Amphiprion_ocellaris
ENSG00000163938	GNL3	99	55.944	ENSAPEG00000006146	gnl3	99	46.316	Amphiprion_percula
ENSG00000163938	GNL3	100	49.333	ENSATEG00000024242	gnl3	99	45.694	Anabas_testudineus
ENSG00000163938	GNL3	92	60.317	ENSAPLG00000005171	GNL3	100	50.369	Anas_platyrhynchos
ENSG00000163938	GNL3	100	63.636	ENSACAG00000007357	GNL3	100	53.014	Anolis_carolinensis
ENSG00000163938	GNL3	100	97.917	ENSANAG00000033209	GNL3	100	93.443	Aotus_nancymaae
ENSG00000163938	GNL3	100	50.370	ENSACLG00000007381	gnl3	99	44.784	Astatotilapia_calliptera
ENSG00000163938	GNL3	100	52.518	ENSAMXG00000020880	gnl3	100	44.444	Astyanax_mexicanus
ENSG00000163938	GNL3	98	89.362	ENSBTAG00000014549	GNL3	100	78.221	Bos_taurus
ENSG00000163938	GNL3	100	95.833	ENSCJAG00000006864	-	100	92.350	Callithrix_jacchus
ENSG00000163938	GNL3	100	95.833	ENSCJAG00000044256	-	100	92.532	Callithrix_jacchus
ENSG00000163938	GNL3	98	91.489	ENSCAFG00000009004	GNL3	100	81.159	Canis_familiaris
ENSG00000163938	GNL3	98	91.489	ENSCAFG00020002613	GNL3	95	83.768	Canis_lupus_dingo
ENSG00000163938	GNL3	97	89.247	ENSCHIG00000022181	GNL3	100	78.080	Capra_hircus
ENSG00000163938	GNL3	98	91.489	ENSTSYG00000006851	GNL3	100	82.514	Carlito_syrichta
ENSG00000163938	GNL3	99	88.421	ENSCPOG00000000282	GNL3	100	73.140	Cavia_porcellus
ENSG00000163938	GNL3	100	96.875	ENSCCAG00000033281	GNL3	100	92.714	Cebus_capucinus
ENSG00000163938	GNL3	100	98.958	ENSCATG00000040886	GNL3	100	95.993	Cercocebus_atys
ENSG00000163938	GNL3	99	85.263	ENSCLAG00000010109	-	100	77.717	Chinchilla_lanigera
ENSG00000163938	GNL3	100	100.000	ENSCSAG00000013315	GNL3	100	96.364	Chlorocebus_sabaeus
ENSG00000163938	GNL3	94	91.111	ENSCHOG00000002726	GNL3	100	77.419	Choloepus_hoffmanni
ENSG00000163938	GNL3	77	50.820	ENSCPBG00000018330	-	95	53.162	Chrysemys_picta_bellii
ENSG00000163938	GNL3	100	77.083	ENSCPBG00000018328	-	95	76.106	Chrysemys_picta_bellii
ENSG00000163938	GNL3	100	100.000	ENSCANG00000039969	GNL3	100	96.648	Colobus_angolensis_palliatus
ENSG00000163938	GNL3	97	89.247	ENSCGRG00001020950	Gnl3	100	73.732	Cricetulus_griseus_chok1gshd
ENSG00000163938	GNL3	97	89.247	ENSCGRG00000015225	Gnl3	100	73.732	Cricetulus_griseus_crigri
ENSG00000163938	GNL3	99	57.042	ENSCSEG00000005009	gnl3	100	44.894	Cynoglossus_semilaevis
ENSG00000163938	GNL3	100	52.482	ENSCVAG00000010679	gnl3	99	43.238	Cyprinodon_variegatus
ENSG00000163938	GNL3	100	52.941	ENSDARG00000006219	gnl3	100	44.112	Danio_rerio
ENSG00000163938	GNL3	98	88.298	ENSDNOG00000001037	GNL3	100	79.422	Dasypus_novemcinctus
ENSG00000163938	GNL3	99	85.263	ENSDORG00000000674	Gnl3	100	75.774	Dipodomys_ordii
ENSG00000163938	GNL3	100	63.455	ENSETEG00000016534	-	100	63.455	Echinops_telfairi
ENSG00000163938	GNL3	98	91.489	ENSEASG00005014636	GNL3	100	82.246	Equus_asinus_asinus
ENSG00000163938	GNL3	98	91.489	ENSECAG00000014850	GNL3	100	82.428	Equus_caballus
ENSG00000163938	GNL3	98	85.106	ENSEEUG00000004427	GNL3	100	73.260	Erinaceus_europaeus
ENSG00000163938	GNL3	99	55.556	ENSELUG00000008767	gnl3	99	46.060	Esox_lucius
ENSG00000163938	GNL3	98	91.489	ENSFCAG00000015719	GNL3	100	82.609	Felis_catus
ENSG00000163938	GNL3	85	81.707	ENSFALG00000008957	GNL3	99	52.888	Ficedula_albicollis
ENSG00000163938	GNL3	99	88.421	ENSFDAG00000020679	GNL3	100	76.321	Fukomys_damarensis
ENSG00000163938	GNL3	91	61.364	ENSFHEG00000020897	gnl3	99	43.563	Fundulus_heteroclitus
ENSG00000163938	GNL3	99	41.208	ENSGMOG00000001745	gnl3	99	41.208	Gadus_morhua
ENSG00000163938	GNL3	85	86.585	ENSGALG00000001613	GNL3	100	52.487	Gallus_gallus
ENSG00000163938	GNL3	100	39.259	ENSGAFG00000007184	gnl3	99	38.919	Gambusia_affinis
ENSG00000163938	GNL3	100	48.551	ENSGACG00000000309	gnl3	99	44.386	Gasterosteus_aculeatus
ENSG00000163938	GNL3	100	77.083	ENSGAGG00000021592	-	56	78.704	Gopherus_agassizii
ENSG00000163938	GNL3	80	51.333	ENSGAGG00000021579	-	99	53.125	Gopherus_agassizii
ENSG00000163938	GNL3	100	99.254	ENSGGOG00000011444	GNL3	100	99.089	Gorilla_gorilla
ENSG00000163938	GNL3	99	53.147	ENSHBUG00000001340	gnl3	99	44.797	Haplochromis_burtoni
ENSG00000163938	GNL3	99	87.368	ENSHGLG00000018299	GNL3	100	79.385	Heterocephalus_glaber_female
ENSG00000163938	GNL3	99	87.368	ENSHGLG00100017053	-	99	81.752	Heterocephalus_glaber_male
ENSG00000163938	GNL3	100	48.921	ENSHCOG00000009446	gnl3	99	43.828	Hippocampus_comes
ENSG00000163938	GNL3	100	55.147	ENSIPUG00000023677	gnl3	99	43.942	Ictalurus_punctatus
ENSG00000163938	GNL3	99	91.579	ENSSTOG00000000356	GNL3	100	79.928	Ictidomys_tridecemlineatus
ENSG00000163938	GNL3	99	88.421	ENSJJAG00000021993	Gnl3	100	73.588	Jaculus_jaculus
ENSG00000163938	GNL3	100	49.630	ENSKMAG00000005965	gnl3	99	45.341	Kryptolebias_marmoratus
ENSG00000163938	GNL3	100	51.095	ENSLBEG00000011394	gnl3	99	44.207	Labrus_bergylta
ENSG00000163938	GNL3	100	67.407	ENSLACG00000001259	GNL3	99	50.530	Latimeria_chalumnae
ENSG00000163938	GNL3	99	58.621	ENSLOCG00000010542	gnl3	86	48.247	Lepisosteus_oculatus
ENSG00000163938	GNL3	98	90.426	ENSLAFG00000016056	GNL3	100	77.658	Loxodonta_africana
ENSG00000163938	GNL3	100	98.958	ENSMFAG00000000613	GNL3	100	96.539	Macaca_fascicularis
ENSG00000163938	GNL3	100	98.958	ENSMMUG00000012511	GNL3	100	96.276	Macaca_mulatta
ENSG00000163938	GNL3	100	98.958	ENSMNEG00000041979	GNL3	100	96.462	Macaca_nemestrina
ENSG00000163938	GNL3	100	98.958	ENSMLEG00000027696	GNL3	100	95.993	Mandrillus_leucophaeus
ENSG00000163938	GNL3	99	52.448	ENSMAMG00000008904	gnl3	99	45.184	Mastacembelus_armatus
ENSG00000163938	GNL3	100	50.000	ENSMZEG00005014957	-	97	44.890	Maylandia_zebra
ENSG00000163938	GNL3	99	53.147	ENSMZEG00005014857	gnl3	99	44.974	Maylandia_zebra
ENSG00000163938	GNL3	97	42.014	ENSMGAG00000000848	GNL3	99	42.237	Meleagris_gallopavo
ENSG00000163938	GNL3	97	84.946	ENSMAUG00000020178	Gnl3	100	72.678	Mesocricetus_auratus
ENSG00000163938	GNL3	98	94.681	ENSMICG00000016373	GNL3	100	80.108	Microcebus_murinus
ENSG00000163938	GNL3	97	88.172	ENSMOCG00000018437	Gnl3	100	73.091	Microtus_ochrogaster
ENSG00000163938	GNL3	100	51.111	ENSMMOG00000002815	gnl3	99	42.883	Mola_mola
ENSG00000163938	GNL3	97	74.194	ENSMODG00000011257	GNL3	100	61.011	Monodelphis_domestica
ENSG00000163938	GNL3	100	47.407	ENSMALG00000021043	gnl3	99	39.060	Monopterus_albus
ENSG00000163938	GNL3	99	88.421	MGP_CAROLIEiJ_G0019063	Gnl3	100	71.585	Mus_caroli
ENSG00000163938	GNL3	99	88.421	ENSMUSG00000042354	Gnl3	100	83.108	Mus_musculus
ENSG00000163938	GNL3	99	89.474	MGP_PahariEiJ_G0030080	Gnl3	100	73.224	Mus_pahari
ENSG00000163938	GNL3	99	88.421	MGP_SPRETEiJ_G0019948	Gnl3	100	71.767	Mus_spretus
ENSG00000163938	GNL3	98	91.489	ENSMPUG00000016777	GNL3	100	80.909	Mustela_putorius_furo
ENSG00000163938	GNL3	93	91.011	ENSMLUG00000000728	GNL3	100	76.449	Myotis_lucifugus
ENSG00000163938	GNL3	97	90.426	ENSNGAG00000017202	Gnl3	100	76.993	Nannospalax_galili
ENSG00000163938	GNL3	100	49.306	ENSNBRG00000013161	gnl3	100	42.629	Neolamprologus_brichardi
ENSG00000163938	GNL3	100	100.000	ENSNLEG00000007173	GNL3	100	97.450	Nomascus_leucogenys
ENSG00000163938	GNL3	99	43.956	ENSMEUG00000011502	-	100	43.956	Notamacropus_eugenii
ENSG00000163938	GNL3	81	70.252	ENSOPRG00000009356	GNL3	99	70.252	Ochotona_princeps
ENSG00000163938	GNL3	99	88.421	ENSODEG00000009492	GNL3	100	76.993	Octodon_degus
ENSG00000163938	GNL3	99	51.701	ENSONIG00000019335	gnl3	99	45.184	Oreochromis_niloticus
ENSG00000163938	GNL3	100	72.917	ENSOANG00000013437	GNL3	100	55.773	Ornithorhynchus_anatinus
ENSG00000163938	GNL3	97	87.097	ENSOCUG00000009841	GNL3	100	77.455	Oryctolagus_cuniculus
ENSG00000163938	GNL3	100	50.000	ENSORLG00000016030	gnl3	99	45.263	Oryzias_latipes
ENSG00000163938	GNL3	100	50.000	ENSORLG00020014358	gnl3	99	45.922	Oryzias_latipes_hni
ENSG00000163938	GNL3	100	50.000	ENSORLG00015009489	gnl3	99	45.326	Oryzias_latipes_hsok
ENSG00000163938	GNL3	100	49.630	ENSOMEG00000005462	gnl3	99	45.167	Oryzias_melastigma
ENSG00000163938	GNL3	98	94.681	ENSOGAG00000004101	GNL3	100	82.671	Otolemur_garnettii
ENSG00000163938	GNL3	98	89.362	ENSOARG00000002470	GNL3	100	77.617	Ovis_aries
ENSG00000163938	GNL3	100	99.271	ENSPPAG00000019253	GNL3	100	99.271	Pan_paniscus
ENSG00000163938	GNL3	98	90.426	ENSPPRG00000009550	GNL3	100	81.636	Panthera_pardus
ENSG00000163938	GNL3	98	90.426	ENSPTIG00000009356	GNL3	100	81.455	Panthera_tigris_altaica
ENSG00000163938	GNL3	100	99.271	ENSPTRG00000015009	GNL3	100	99.271	Pan_troglodytes
ENSG00000163938	GNL3	100	98.958	ENSPANG00000016579	GNL3	100	92.532	Papio_anubis
ENSG00000163938	GNL3	100	54.074	ENSPKIG00000024295	gnl3	99	45.699	Paramormyrops_kingsleyae
ENSG00000163938	GNL3	100	77.083	ENSPSIG00000011486	GNL3	100	54.693	Pelodiscus_sinensis
ENSG00000163938	GNL3	100	52.593	ENSPMGG00000008210	gnl3	99	44.909	Periophthalmus_magnuspinnatus
ENSG00000163938	GNL3	97	88.172	ENSPEMG00000017577	Gnl3	100	74.727	Peromyscus_maniculatus_bairdii
ENSG00000163938	GNL3	81	58.824	ENSPMAG00000001073	-	99	51.556	Petromyzon_marinus
ENSG00000163938	GNL3	100	71.875	ENSPCIG00000018642	GNL3	98	58.273	Phascolarctos_cinereus
ENSG00000163938	GNL3	100	52.899	ENSPFOG00000017601	gnl3	98	46.947	Poecilia_formosa
ENSG00000163938	GNL3	100	52.174	ENSPLAG00000016968	gnl3	99	45.390	Poecilia_latipinna
ENSG00000163938	GNL3	100	49.275	ENSPMEG00000018775	gnl3	99	43.942	Poecilia_mexicana
ENSG00000163938	GNL3	100	50.735	ENSPREG00000002909	gnl3	99	43.920	Poecilia_reticulata
ENSG00000163938	GNL3	100	100.000	ENSPPYG00000013800	GNL3	100	97.641	Pongo_abelii
ENSG00000163938	GNL3	96	91.304	ENSPCAG00000002006	GNL3	100	72.131	Procavia_capensis
ENSG00000163938	GNL3	98	92.553	ENSPCOG00000026637	GNL3	100	84.517	Propithecus_coquereli
ENSG00000163938	GNL3	100	90.625	ENSPVAG00000012586	GNL3	100	80.399	Pteropus_vampyrus
ENSG00000163938	GNL3	90	44.158	ENSPNYG00000005130	gnl3	99	44.158	Pundamilia_nyererei
ENSG00000163938	GNL3	100	54.676	ENSPNAG00000013096	gnl3	100	43.717	Pygocentrus_nattereri
ENSG00000163938	GNL3	99	88.421	ENSRNOG00000028461	Gnl3	100	74.681	Rattus_norvegicus
ENSG00000163938	GNL3	100	98.958	ENSRBIG00000031778	GNL3	100	96.721	Rhinopithecus_bieti
ENSG00000163938	GNL3	100	98.958	ENSRROG00000030086	GNL3	100	96.721	Rhinopithecus_roxellana
ENSG00000163938	GNL3	100	97.015	ENSSBOG00000019990	GNL3	100	93.078	Saimiri_boliviensis_boliviensis
ENSG00000163938	GNL3	100	67.164	ENSSHAG00000006141	GNL3	99	58.364	Sarcophilus_harrisii
ENSG00000163938	GNL3	99	53.623	ENSSFOG00015021228	gnl3	99	45.683	Scleropages_formosus
ENSG00000163938	GNL3	100	51.429	ENSSMAG00000006662	gnl3	99	43.816	Scophthalmus_maximus
ENSG00000163938	GNL3	100	50.725	ENSSDUG00000000972	gnl3	99	44.902	Seriola_dumerili
ENSG00000163938	GNL3	99	53.191	ENSSLDG00000008692	gnl3	92	44.328	Seriola_lalandi_dorsalis
ENSG00000163938	GNL3	100	77.612	ENSSARG00000002226	GNL3	100	74.128	Sorex_araneus
ENSG00000163938	GNL3	100	67.391	ENSSPUG00000003582	GNL3	100	54.707	Sphenodon_punctatus
ENSG00000163938	GNL3	99	54.545	ENSSPAG00000020180	gnl3	99	46.454	Stegastes_partitus
ENSG00000163938	GNL3	93	89.888	ENSSSCG00000011449	GNL3	99	79.673	Sus_scrofa
ENSG00000163938	GNL3	85	82.927	ENSTGUG00000005774	GNL3	100	54.496	Taeniopygia_guttata
ENSG00000163938	GNL3	99	55.634	ENSTRUG00000005552	gnl3	99	43.571	Takifugu_rubripes
ENSG00000163938	GNL3	99	51.007	ENSTNIG00000007263	gnl3	99	42.226	Tetraodon_nigroviridis
ENSG00000163938	GNL3	93	88.764	ENSTBEG00000017518	GNL3	100	76.779	Tupaia_belangeri
ENSG00000163938	GNL3	98	86.170	ENSTTRG00000008574	-	100	73.469	Tursiops_truncatus
ENSG00000163938	GNL3	98	92.553	ENSUAMG00000012347	GNL3	100	81.341	Ursus_americanus
ENSG00000163938	GNL3	98	92.553	ENSUMAG00000021001	GNL3	100	81.522	Ursus_maritimus
ENSG00000163938	GNL3	98	89.362	ENSVPAG00000007379	-	53	90.566	Vicugna_pacos
ENSG00000163938	GNL3	85	89.024	ENSVVUG00000003975	-	93	80.851	Vulpes_vulpes
ENSG00000163938	GNL3	98	89.362	ENSVVUG00000024536	-	100	85.507	Vulpes_vulpes
ENSG00000163938	GNL3	100	53.623	ENSXCOG00000018425	gnl3	95	47.758	Xiphophorus_couchianus
ENSG00000163938	GNL3	100	54.348	ENSXMAG00000022565	gnl3	99	45.406	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	16097049.17932509.19487455.21132010.21988832.22641345.24550003.24965446.	IPI	Function
GO:0005525	GTP binding	-	ISS	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	22641345.	IDA	Component
GO:0005730	nucleolus	-	ISS	Component
GO:0008283	cell proliferation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0017145	stem cell division	25522312.	IDA	Process
GO:0019827	stem cell population maintenance	25522312.	IMP	Process
GO:0032206	positive regulation of telomere maintenance	22641345.	IMP	Process
GO:0033235	positive regulation of protein sumoylation	22641345.	IMP	Process
GO:0042127	regulation of cell proliferation	-	ISS	Process
GO:0048027	mRNA 5'-UTR binding	16213212.	IDA	Function
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	25569094.	IMP	Process
GO:1904816	positive regulation of protein localization to chromosome, telomeric region	22641345.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28849076	Upregulation of GNL3 expression promotes colon cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.	Oncol Rep	2017 Oct	Tang X	doi: 10.3892/or.2017.5923
30817632	Nucleostemin expression in breast cancer is a marker of more aggressive phenotype and unfavorable patients' outcome: A STROBE-compliant article.	Medicine (Baltimore)	2019 Mar	Sami MM	doi: 10.1097/MD.0000000000014744.
24763828	Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric adenocarcinoma.	Tumour Biol	2014 Jul	Asadi MH	doi: 10.1007/s13277-014-1966-1
15112336	Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies.	World J Gastroenterol	2004 May 1	Liu SJ	-
21730156	Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.	Proc Natl Acad Sci U S A	2011 Dec 20	Okamoto N	doi: 10.1073/pnas.1015171108
16012751	Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells.	Int J Mol Med	2005 Aug	Han C	-
20572164	Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors.	Mol Carcinog	2010 Sep	Malakootian M	doi: 10.1002/mc.20658.
26722529	Guanine nucleotide binding protein-like 3 is a potential prognosis indicator of gastric cancer.	Int J Clin Exp Pathol	2015 Oct 1	Chen J	-
16670719	Nucleostemin mRNA is expressed in both normal and malignant renal tissues.	Br J Cancer	2006 Jun 5	Fan Y	-
24762489	Comparison of nucleostemin gene expression in CD133+ and CD133- cell population in colon cancer cell line HT29.	J Cancer Res Ther	2014 Jan-Mar	Zia-Jahromi N	doi: 10.4103/0973-1482.131375.
20021940	[Gene profiling after knocking-down the expression of NS gene in prostate cancer PC-3 cells].	Zhonghua Zhong Liu Za Zhi	2009 Aug	Liu RL	-
26429724	GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes.	Clin Exp Metastasis	2015 Dec	Lee M	doi: 10.1007/s10585-015-9745-y
20664182	Downregulation of nucleostemin causes G1 cell cycle arrest via a p53-independent pathway in prostate cancer PC-3 cells.	Urol Int	2010	Liu R	doi: 10.1159/000315968
19706044	Differential effects of Nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710.	Cell Prolif	2009 Dec	Nikpour P	doi: 10.1111/j.1365-2184.2009.00635.x
25347121	The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress.	Elife	2014 Oct 27	Zhang Q	doi: 10.7554/eLife.03077.
21045149	Tumor-initiating function of nucleostemin-enriched mammary tumor cells.	Cancer Res	2010 Nov 15	Lin T	doi: 10.1158/0008-5472.CAN-10-2159
22174890	An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.	PLoS One	2011	Gil-Ranedo J	doi: 10.1371/journal.pone.0028753
22050045	Nucleostemin and TWIST as predictive markers for recurrence after neoadjuvant chemotherapy for esophageal carcinoma.	Cancer Sci	2012 Feb	Nakajima TE	doi: 10.1111/j.1349-7006.2011.02142.x
28412352	Knockdown of Nucleostemin in an ovarian cancer SKOV-3cell line and its effects on cell malignancy.	Biochem Biophys Res Commun	2017 May 27	Wang J	doi: 10.1016/j.bbrc.2017.04.046

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	52690818	Intron	novel		0.33
BLCA	chr3	52690959	Missense_Mutation	novel	K223N	0.28
BLCA	chr3	52686794	Missense_Mutation	novel	M13I	0.09
BLCA	chr3	52687508	Nonsense_Mutation	novel	E73*	0.24
BLCA	chr3	52693451	Missense_Mutation	novel	P411A	0.53
BLCA	chr3	52690740	Intron	novel		0.68
BLCA	chr3	52689306	Intron	novel		0.1
BLCA	chr3	52689185	Missense_Mutation	novel	V174L	0.11
BLCA	chr3	52693431	Missense_Mutation	novel	H404L	0.45
BLCA	chr3	52690589	Splice_Region	novel		0.29
BLCA	chr3	52691620	Missense_Mutation	NA	G287E	0.15	GN3L_Grn1
BLCA	chr3	52692923	Silent	novel	P307P	0.29
BRCA	chr3	52693226	Silent	novel	L362L	0.23
BRCA	chr3	52689091	Silent	novel	D142D	0.12
BRCA	chr3	52690752	Intron	NA		0.6
BRCA	chr3	52692922	Missense_Mutation	NA	P307L	0.26	GN3L_Grn1
BRCA	chr3	52688122	Missense_Mutation	novel	C113S	0.35
BRCA	chr3	52694234	Missense_Mutation	NA	E537K	0.12
BRCA	chr3	52690787	Intron	NA		0.24
BRCA	chr3	52690608	Silent	NA	E186E	0.35
CESC	chr3	52690646	Missense_Mutation	novel	L199W	0.13
CESC	chr3	52689080	Missense_Mutation	novel	E139K	0.22
CESC	chr3	52685963	5'UTR	novel		0.18
COAD	chr3	52694472	3'UTR	novel		0.5
COAD	chr3	52686813	Missense_Mutation	novel	K20Q	0.23
COAD	chr3	52685936	5'UTR	novel		0.38
COAD	chr3	52686112	Splice_Region	novel		0.33
COAD	chr3	52690953	Missense_Mutation	NA	K221N	0.09
COAD	chr3	52689078	Missense_Mutation	NA	I138S	0.25
COAD	chr3	52694361	3'UTR	novel		0.28
COAD	chr3	52693234	Missense_Mutation	NA	F364L	0.33
COAD	chr3	52689201	Missense_Mutation	NA	K179T	0.31
COAD	chr3	52692969	Nonsense_Mutation	rs745733070	R323*	0.31
COAD	chr3	52690608	Silent	NA	E186E	0.15
COAD	chr3	52690605	Missense_Mutation	novel	K185N	0.09
COAD	chr3	52689282	Intron	novel		0.1
ESCA	chr3	52690770	Intron	novel		0.61
ESCA	chr3	52686820	Frame_Shift_Del	NA	*K24Rfs9**	0.27
GBM	chr3	52691016	Missense_Mutation	novel	K242N	0.06
GBM	chr3	52693767	Missense_Mutation	novel	D487G	0.05
GBM	chr3	52691564	Missense_Mutation	novel	S268R	0.05	GN3L_Grn1
GBM	chr3	52690686	Missense_Mutation	novel	D212E	0.88
GBM	chr3	52691543	Splice_Region	novel	G261G	0.05
HNSC	chr3	52686803	Silent	rs772280295	H16H	0.77
HNSC	chr3	52689154	Silent	novel	E163E	0.14
HNSC	chr3	52686060	5'UTR	novel		0.21
KIRC	chr3	52689093	Missense_Mutation	novel	V143A	0.04
KIRC	chr3	52694418	3'UTR	novel		0.6
LAML	chr3	52693767	Missense_Mutation	novel	D487G	0.09
LAML	chr3	52690604	Missense_Mutation	novel	K185M	0.09
LGG	chr3	52693046	Splice_Region	NA	Q348Q	0.1
LIHC	chr3	52686056	5'UTR	novel		0.76
LIHC	chr3	52693650	Nonsense_Mutation	novel	L448*	0.43
LIHC	chr3	52690641	Missense_Mutation	novel	K197N	0.31
LUAD	chr3	52685994	5'UTR	novel		0.38
LUAD	chr3	52692869	Splice_Region	novel		0.09
LUSC	chr3	52693212	Missense_Mutation	novel	G357D	0.18
OV	chr3	52694244	Frame_Shift_Ins	novel	*A541Tfs42**	0.07
OV	chr3	52694245	Missense_Mutation	novel	D540E	0.03
OV	chr3	52693465	Silent	novel	F415F	0.04
OV	chr3	52693761	Frame_Shift_Del	novel	*E485Gfs94**	0.02
OV	chr3	52689155	Missense_Mutation	novel	A164T	0.21
OV	chr3	52693767	Missense_Mutation	novel	D487G	0.08
PAAD	chr3	52692978	Missense_Mutation	novel	A326S	0.1
PAAD	chr3	52692979	Missense_Mutation	novel	A326V	0.1
PAAD	chr3	52694206	Silent	novel	T527T	0.16
PCPG	chr3	52690815	Intron	novel		0.64
PRAD	chr3	52686828	Splice_Site	rs759941039	X24_splice	0.2
PRAD	chr3	52686829	Splice_Site	novel	X24_splice	0.23
SARC	chr3	52686136	Intron	novel		0.12
SKCM	chr3	52687271	Missense_Mutation	NA	R33I	0.41
SKCM	chr3	52687287	Missense_Mutation	novel	K38N	0.14
SKCM	chr3	52690768	Intron	novel		0.39
SKCM	chr3	52690972	Missense_Mutation	rs375232066	P228S	0.38
SKCM	chr3	52690973	Missense_Mutation	rs761275727	P228L	0.36
SKCM	chr3	52693544	Missense_Mutation	NA	A442T	0.26
SKCM	chr3	52689153	Missense_Mutation	NA	E163G	0.25
SKCM	chr3	52687384	Splice_Site	NA	X70_splice	0.32
SKCM	chr3	52688177	Silent	novel	C131C	0.26
SKCM	chr3	52688178	Nonsense_Mutation	novel	Q132*	0.26
SKCM	chr3	52687578	Missense_Mutation	NA	P96L	0.36
SKCM	chr3	52687345	Missense_Mutation	NA	E58K	0.2
STAD	chr3	52691606	Silent	NA	V282V	0.15
STAD	chr3	52687334	Missense_Mutation	NA	A54V	0.44
STAD	chr3	52686820	Frame_Shift_Del	NA	*K24Rfs9**	0.44
STAD	chr3	52686167	Intron	novel		0.31
STAD	chr3	52694077	Missense_Mutation	NA	E514G	0.1
THYM	chr3	52694231	Missense_Mutation	novel	I536V	0.36
UCEC	chr3	52686820	Frame_Shift_Del	NA	*K24Rfs9**	0.26
UCEC	chr3	52693440	Missense_Mutation	NA	T407I	0.43
UCEC	chr3	52693248	Missense_Mutation	NA	A369D	0.39
UCEC	chr3	52693678	Silent	rs181190077	S457S	0.56
UCEC	chr3	52693275	Missense_Mutation	novel	G378D	0.22
UCEC	chr3	52686820	Frame_Shift_Del	NA	*K24Rfs9**	0.25
UCEC	chr3	52687378	Frame_Shift_Ins	NA	*L71Rfs6**	0.44
UCEC	chr3	52687310	Missense_Mutation	NA	K46R	0.05
UCEC	chr3	52690773	Intron	novel		0.26
UCEC	chr3	52693224	Missense_Mutation	novel	S361Y	0.28
UCEC	chr3	52692970	Missense_Mutation	NA	R323Q	0.22
UCEC	chr3	52688113	Missense_Mutation	NA	F110C	0.26
UCEC	chr3	52687588	Silent	NA	K99K	0.22
UCEC	chr3	52693518	Frame_Shift_Del	novel	*K434Rfs7**	0.47
UCEC	chr3	52692768	Intron	novel		0.28
UCEC	chr3	52693021	Missense_Mutation	NA	I340S	0.41
UCEC	chr3	52686820	Frame_Shift_Del	NA	*K24Rfs9**	0.12
UCEC	chr3	52687529	Missense_Mutation	rs138566929	L80F	0.33
UCEC	chr3	52690801	Intron	novel		0.27
UCEC	chr3	52693727	Missense_Mutation	novel	P474S	0.35
UCEC	chr3	52687577	Missense_Mutation	novel	P96S	0.43
UCEC	chr3	52694219	Missense_Mutation	novel	L532V	0.29
UCEC	chr3	52694286	3'UTR	novel		0.44
UCEC	chr3	52692944	Silent	novel	L314L	0.36
UCEC	chr3	52692902	Missense_Mutation	novel	Q300H	0.31	GN3L_Grn1
UCEC	chr3	52689257	Intron	novel		0.5
UCEC	chr3	52693538	Missense_Mutation	novel	I440V	0.4
UCEC	chr3	52692933	Missense_Mutation	rs746795082	V311I	0.22	GN3L_Grn1
UCEC	chr3	52694073	Frame_Shift_Del	novel	*E514Rfs65**	0.43
UCEC	chr3	52694261	Missense_Mutation	novel	T546A	0.06
UCEC	chr3	52693222	Missense_Mutation	rs753758837	N360K	0.06
UCEC	chr3	52693018	Missense_Mutation	novel	A339V	0.2
UCEC	chr3	52693186	Splice_Site	novel	X349_splice	0.15
UCEC	chr3	52685919	5'Flank	novel		0.35
UCEC	chr3	52689089	Missense_Mutation	novel	D142N	0.28
UCEC	chr3	52690791	Intron	novel		0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.7778	0.016387
GBM	DEL	0.0832	0.056565
LGG	DEL	0.0799	0.00089193
LUAD	DEL	0.3314	0.0021265
PAAD	DEL	0.1902	0.030662
SARC	DEL	0.2179	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	AMP	0.1467	0.23596
THYM	DEL	0.0813	0.037527
UCS	DEL	0.5	4.5515e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00012	Kaplan-Meier Survival Analysis
SARC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00024	Kaplan-Meier Survival Analysis
SKCM	0.031	Kaplan-Meier Survival Analysis
PRAD	0.013	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
KIRP	0.0015	Kaplan-Meier Survival Analysis
COAD	0.028	Kaplan-Meier Survival Analysis
PAAD	0.0019	Kaplan-Meier Survival Analysis
READ	0.0021	Kaplan-Meier Survival Analysis
KICH	0.02	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742